etidronate has been researched along with Metastase in 27 studies
Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
etidronic acid : A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Therapy with rhenium-186 HEDP can be used complementarily to analgesic therapy in patients with painful, disseminated bone metastases." | 9.08 | [Pain therapy with rhenium-186 HEDP in multiple bone metastases]. ( Bender, H; Biersack, HJ; Dierke-Dzierzon, C; Grünwald, F; Mallmann, P; Palmedo, H; Reichmann, K; Schomburg, A; Schöneich, G; Zamorra, P, 1996) |
| "The aim of this study was to compare pain response and hematologic toxicity between single and multiple therapies with (186)Re-HEDP under zoledronic acid in patients suffering from painful osseous metastases from prostate or breast cancer." | 7.75 | Management of metastatic bone pain with repeated doses of rhenium 186-HEDP in patients under therapy with zoledronic acid: a safe and additively effective practice. ( Baziotis, N; Limouris, GS; Zafeirakis, A; Zissimopoulos, A, 2009) |
| "The aims of the present study were to determine whether patients with painful bone metastases from primary cancer sites showed a higher level of a bone resorption marker than those with no evidence of skeletal-related events, and to clarify the efficacy of oral administration of etidronate for pain due to bone metastases and bone resorption." | 7.71 | Transient relief of metastatic cancer bone pain by oral administration of etidronate. ( Ichimura, S; Iwamoto, J; Takeda, T, 2002) |
| "Therapy with rhenium-186 HEDP can be used complementarily to analgesic therapy in patients with painful, disseminated bone metastases." | 5.08 | [Pain therapy with rhenium-186 HEDP in multiple bone metastases]. ( Bender, H; Biersack, HJ; Dierke-Dzierzon, C; Grünwald, F; Mallmann, P; Palmedo, H; Reichmann, K; Schomburg, A; Schöneich, G; Zamorra, P, 1996) |
| "The aim of this study was to compare pain response and hematologic toxicity between single and multiple therapies with (186)Re-HEDP under zoledronic acid in patients suffering from painful osseous metastases from prostate or breast cancer." | 3.75 | Management of metastatic bone pain with repeated doses of rhenium 186-HEDP in patients under therapy with zoledronic acid: a safe and additively effective practice. ( Baziotis, N; Limouris, GS; Zafeirakis, A; Zissimopoulos, A, 2009) |
| "The aims of the present study were to determine whether patients with painful bone metastases from primary cancer sites showed a higher level of a bone resorption marker than those with no evidence of skeletal-related events, and to clarify the efficacy of oral administration of etidronate for pain due to bone metastases and bone resorption." | 3.71 | Transient relief of metastatic cancer bone pain by oral administration of etidronate. ( Ichimura, S; Iwamoto, J; Takeda, T, 2002) |
| " In both dose levels, cabazitaxel (4 cycles of cabazitaxel 25 mg/m + 2 cycles of cabazitaxel 20 mg/m in level 1, and 6 cycles of cabazitaxel 25 mg/m in level 2) were combined with 2 cycles of Re-HEDP 40 MBq/kg (1." | 2.84 | A Phase 1 Trial of Cabazitaxel Combined With 188Re-Hydroxyethylidene Diphosphonate in Patients With Metastatic Castration-Resistant Prostate Cancer Who Progressed on or After a Docetaxel-Containing Treatment: The ReCab Trial. ( Bloemendal, HJ; Bouman-Wammes, EW; de Klerk, JMH; van den Eertwegh, AJM; van Dodewaard-de Jong, JM; Verheul, HMW, 2017) |
| "Skeletal metastases are often complicated by pain." | 2.44 | Bone seeking radiopharmaceuticals for palliation of pain in cancer patients with osseous metastases. ( de Klerk, JM; Lam, MG; van Rijk, PP; Zonnenberg, BA, 2007) |
| "33 patients (30 prostate carcinoma, 3 breast carcinoma) were treated with 150 MBq 89SrCl2 (9 patients), 1295 MBq 186Re-HEDP (12 patients) or 37 MBq/kg 153Sm-EDTMP (12 patients)." | 1.35 | Radiation safety considerations for the bone seeking radiopharmaceuticals. 89SrCl2, 186Re-HEDP and 153Sm-EDTMP. ( de Klerk, JM; Hoekstra, A; Lam, MG; van Rijk, PP; Zonnenberg, BA, 2009) |
| "Here, in a new approach for bone metastasis prevention, we employed poly-l-lysine covalently grafted with beta-cyclodextrin as a polycationic vector (PLL-CD) for the antitumor bisphosphonate drug risedronate (RIS)." | 1.35 | Nanostructured polyelectrolyte multilayer drug delivery systems for bone metastasis prevention. ( Atmani, H; Benkirane-Jessel, N; Clézardin, P; Cortial, D; Daubiné, F; Haïkel, Y; Ladam, G; Voegel, JC, 2009) |
| "Patients with skeletal metastases from hormone-refractory prostate cancer have shown variable responses to high-activity therapy with (186)Re-HEDP and peripheral stem cell support." | 1.33 | The potential use of 99mTc-MDP bone scans to plan high-activity 186Re-HEDP targeted therapy of bony metastases from prostate cancer. ( Binnie, D; Dearnaley, D; Divoli, A; Flux, G; McCready, VR, 2005) |
| "Human breast cancer frequently metastasizes to the skeleton to cause osteolysis and subsequent pain, pathological fracture, and hypercalcemia." | 1.29 | Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice. ( Boyce, BF; Boyce, R; Chapman, M; Mundy, GR; Sasaki, A; Story, B; Wright, KR; Yoneda, T, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (59.26) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Dodewaard-de Jong, JM | 1 |
| Bouman-Wammes, EW | 1 |
| Bloemendal, HJ | 1 |
| Verheul, HMW | 1 |
| de Klerk, JMH | 1 |
| van den Eertwegh, AJM | 1 |
| Lam, MG | 2 |
| Hoekstra, A | 1 |
| de Klerk, JM | 2 |
| van Rijk, PP | 2 |
| Zonnenberg, BA | 2 |
| Daubiné, F | 1 |
| Cortial, D | 1 |
| Ladam, G | 1 |
| Atmani, H | 1 |
| Haïkel, Y | 1 |
| Voegel, JC | 1 |
| Clézardin, P | 1 |
| Benkirane-Jessel, N | 1 |
| Zafeirakis, A | 1 |
| Zissimopoulos, A | 1 |
| Baziotis, N | 1 |
| Limouris, GS | 1 |
| Cheng, A | 1 |
| Chen, S | 1 |
| Zhang, Y | 1 |
| Yin, D | 1 |
| Dong, M | 1 |
| Iwamoto, J | 1 |
| Takeda, T | 1 |
| Ichimura, S | 1 |
| Binnie, D | 1 |
| Divoli, A | 1 |
| McCready, VR | 1 |
| Dearnaley, D | 1 |
| Flux, G | 1 |
| Kirchner, PT | 1 |
| Simon, MA | 1 |
| Sasaki, A | 1 |
| Boyce, BF | 1 |
| Story, B | 1 |
| Wright, KR | 1 |
| Chapman, M | 1 |
| Boyce, R | 1 |
| Mundy, GR | 1 |
| Yoneda, T | 1 |
| Palmedo, H | 1 |
| Bender, H | 1 |
| Schomburg, A | 1 |
| Grünwald, F | 1 |
| Schöneich, G | 1 |
| Zamorra, P | 1 |
| Reichmann, K | 1 |
| Dierke-Dzierzon, C | 1 |
| Mallmann, P | 1 |
| Biersack, HJ | 1 |
| Hsieh, BT | 1 |
| Hsieh, JF | 1 |
| Tsai, SC | 1 |
| Lin, WY | 1 |
| Wang, SJ | 1 |
| Ting, G | 1 |
| Yamamoto, I | 2 |
| Fogelman, I | 1 |
| Goll, C | 1 |
| McKillop, JH | 1 |
| Citrin, DL | 4 |
| Greig, WR | 2 |
| Creutzig, H | 1 |
| Hughes, SP | 1 |
| Benson, MK | 1 |
| Ell, PJ | 1 |
| Britton, KE | 1 |
| Jung, A | 1 |
| Barras, C | 1 |
| Mermillod, B | 1 |
| Courvoisier, B | 1 |
| Bessent, RG | 2 |
| Tuohy, JB | 1 |
| Elms, ST | 1 |
| McGinlay, E | 1 |
| Blumgart, LH | 1 |
| Oppenheim, BE | 1 |
| Cantez, S | 1 |
| Silberstein, EB | 1 |
| Maxon, HR | 1 |
| Alexander, GW | 1 |
| Rauf, C | 1 |
| Bahr, GK | 1 |
| Nakano, S | 1 |
| Hasegawa, Y | 1 |
| Komatsubara, Y | 1 |
| Kajita, A | 1 |
| Ishigami, S | 1 |
| Tsuchimitsu, S | 1 |
| Fukunaga, M | 1 |
| Morita, R | 1 |
| Fujita, T | 1 |
| Potsaid, MS | 1 |
| Irwin, RJ | 1 |
| Castronovo, FP | 1 |
| Prout, GR | 1 |
| Harvey, WJ | 2 |
| Francis, MD | 2 |
| Tofe, AJ | 2 |
| Zamenhof, RG | 1 |
| Grames, GM | 1 |
| Jansen, C | 1 |
| Carlsen, EN | 1 |
| Davidson, TR | 1 |
| McDougall, IR | 1 |
| McGinley, E | 1 |
| Gordon, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Neoadjuvant Chemotherapy With or Without Zometa on Occult Micrometastases and Bone Density in Women With Locally Advanced Breast Cancer[NCT00242203] | Phase 2 | 120 participants (Actual) | Interventional | 2002-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for etidronate and Metastase
| Article | Year |
|---|---|
Bone seeking radiopharmaceuticals for palliation of pain in cancer patients with osseous metastases.
Topics: Bone Neoplasms; Clinical Trials as Topic; Etidronic Acid; Humans; Medical Oncology; Models, Chemical | 2007 |
3 trials available for etidronate and Metastase
| Article | Year |
|---|---|
A Phase 1 Trial of Cabazitaxel Combined With 188Re-Hydroxyethylidene Diphosphonate in Patients With Metastatic Castration-Resistant Prostate Cancer Who Progressed on or After a Docetaxel-Containing Treatment: The ReCab Trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Disease Progression; Docetaxel; Etidronic Acid; Huma | 2017 |
The tolerance and therapeutic efficacy of rhenium-188 hydroxyethylidene diphosphonate in advanced cancer patients with painful osseous metastases.
Topics: Blood Cell Count; Bone Neoplasms; Electrocardiography; Etidronic Acid; Female; Follow-Up Studies; Hu | 2011 |
[Pain therapy with rhenium-186 HEDP in multiple bone metastases].
Topics: Bone Neoplasms; Breast Neoplasms; Diphosphonates; Etidronic Acid; Female; Humans; Male; Neoplasm Met | 1996 |
23 other studies available for etidronate and Metastase
| Article | Year |
|---|---|
Radiation safety considerations for the bone seeking radiopharmaceuticals. 89SrCl2, 186Re-HEDP and 153Sm-EDTMP.
Topics: Adult; Aged; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Etidronic Acid; Female; Humans; Male; | 2009 |
Nanostructured polyelectrolyte multilayer drug delivery systems for bone metastasis prevention.
Topics: Animals; Antinematodal Agents; beta-Cyclodextrins; Bone Neoplasms; Drug Delivery Systems; Etidronic | 2009 |
Management of metastatic bone pain with repeated doses of rhenium 186-HEDP in patients under therapy with zoledronic acid: a safe and additively effective practice.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Bone Neoplasms; Breast Neoplasms; Diphosphonates; Etidro | 2009 |
Transient relief of metastatic cancer bone pain by oral administration of etidronate.
Topics: Administration, Oral; Aged; Alkaline Phosphatase; Analgesics, Non-Narcotic; Biomarkers; Bone and Bon | 2002 |
The potential use of 99mTc-MDP bone scans to plan high-activity 186Re-HEDP targeted therapy of bony metastases from prostate cancer.
Topics: Bone and Bones; Bone Neoplasms; Etidronic Acid; Humans; Image Processing, Computer-Assisted; Male; N | 2005 |
The clinical value of bone and gallium scintigraphy for soft-tissue sarcomas of the extremities.
Topics: Adolescent; Adult; Aged; Bone and Bones; Child; Diphosphonates; Etidronic Acid; Female; Gallium Radi | 1984 |
Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.
Topics: Animals; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cachexia; Diphosphonates; Etidronic Acid | 1995 |
Comparison of various rhenium-188-labeled diphosphonates for the treatment of bone metastases.
Topics: Animals; Bone and Bones; Bone Neoplasms; Diphosphonates; Etidronic Acid; Injections, Intravenous; Is | 1999 |
[Clinical evaluation of bone scintigraphy with 99mTc-labeled phosphate compounds. I. Metastatic bone tumor (author's transl].
Topics: Adult; Aged; Bone and Bones; Bone Neoplasms; Etidronic Acid; Evaluation Studies as Topic; Female; Hu | 1978 |
A clinical comparison of 2 h and 4 h bone scans obtained with 99Tc H.E.D.P.
Topics: Adult; Aged; Bone Neoplasms; Breast Neoplasms; Etidronic Acid; Female; Humans; Male; Middle Aged; Ne | 1978 |
[Comparative investigations concerning osteotropic radiopharmaceuticals. III. Scanning with 18F and 99mTc-malignant diseases (author's transl)].
Topics: Abscess; Bone Diseases; Bone Neoplasms; Etidronic Acid; Female; Fluorine; Humans; Inflammation; Join | 1975 |
The use of 99mc-EHDP as a scanning agent in the detection of metastases from osteosarcoma.
Topics: Adolescent; Adult; Aged; Amputation Stumps; Bone Neoplasms; Child; Epiphyses; Etidronic Acid; Female | 1977 |
[Effect of 2 phosphonates on the osteolysis induced by tumor extracts].
Topics: Animals; Animals, Newborn; Clodronic Acid; Diphosphonates; Etidronic Acid; Mice; Neoplasm Metastasis | 1979 |
Comparison of 99mTc-labelled polyphosphate, pyrophosphate and ethane hydroxy diphosphonate in patients with skeletal metastases and in normal subjects.
Topics: Bone Neoplasms; Diphosphates; Etidronic Acid; Humans; Neoplasm Metastasis; Organophosphorus Compound | 1975 |
What causes lower neck uptake in bone scans?
Topics: Adult; Cervical Vertebrae; Diphosphates; Etidronic Acid; Humans; Laryngeal Cartilages; Neoplasm Meta | 1977 |
Clinical comparison of technetium-99m diphosphonate and pyrophosphate in bone scintigraphy: concise communication.
Topics: Bone Neoplasms; Diphosphates; Etidronic Acid; Evaluation Studies as Topic; Humans; Neoplasm Metastas | 1978 |
[Bone scanning by whole body camera of metastatic bone tumors with Tc-99m EDHP].
Topics: Aged; Bone and Bones; Bone Neoplasms; Etidronic Acid; Female; Humans; Male; Middle Aged; Neoplasm Me | 1977 |
[Clinical evaluation of bone scintigraphy using a commercial 99mTc-EHDP preparation].
Topics: Adolescent; Adult; Aged; Bone Neoplasms; Child; Child, Preschool; Etidronic Acid; Female; Humans; Ma | 1977 |
[32P] diphosphonate dose determination in patients with bone metastases from prostatic carcinoma.
Topics: Adenocarcinoma; Aged; Bone Neoplasms; Etidronic Acid; Humans; Male; Middle Aged; Neoplasm Metastasis | 1978 |
The abnormal bone scan in intracranial lesions.
Topics: Adult; Aged; Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Cerebral Angiography; Choroid Plex | 1975 |
Bone scanning: the current position.
Topics: Bone Neoplasms; Etidronic Acid; Humans; Neoplasm Metastasis; Radionuclide Imaging; Technetium | 1975 |
Dynamic studies with 99mTc-HEDP in normal subjects and in patients with bone tumors.
Topics: Adult; Aged; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Etidronic Acid; Female; Humans; Lung | 1975 |
Correlation of neoplasms with incidence and localization of skeletal metastases: An analysis of 1,355 diphosphonate bone scans.
Topics: Bone Neoplasms; Breast Neoplasms; Etidronic Acid; Female; Humans; Lung Neoplasms; Male; Neoplasm Met | 1975 |