Page last updated: 2024-10-26

etidronate and Calcinosis

etidronate has been researched along with Calcinosis in 95 studies

Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
etidronic acid : A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.

Calcinosis: Pathologic deposition of calcium salts in tissues.

Research Excerpts

ExcerptRelevanceReference
" We report a beneficial effect of high-dose etidronate, one of the bisphosphonates, on periarticular calcinosis in a case of arterial and periarticular BCP crystal deposition disease."7.72[Beneficial effect of high-dose etidronate on periarticular calcinosis associated with arterial and periarticular basic calcium phosphate (BCP) crystal deposition disease]. ( Ide, M; Ito, G; Ozaki, S; Suzuki, Y; Uehara, R, 2003)
"The use of disodium etidronate (EHDP) for the treatment of calcinosis is complicated by the threat of drug-induced inhibition of skeletal mineralization."7.66Focal mineralization defect during disodium etidronate treatment of calcinosis. ( Weinstein, RS, 1982)
"Oral etidronate has been used for 3 weeks, after failure of classical treatment."5.34[Etidronate per os in subcutaneous fat necrosis with hypercalcemia and nephrocalcinosis]. ( Bottu, J; Trullemans, B; Van Nieuwenhuyse, JP, 2007)
" We report a beneficial effect of high-dose etidronate, one of the bisphosphonates, on periarticular calcinosis in a case of arterial and periarticular BCP crystal deposition disease."3.72[Beneficial effect of high-dose etidronate on periarticular calcinosis associated with arterial and periarticular basic calcium phosphate (BCP) crystal deposition disease]. ( Ide, M; Ito, G; Ozaki, S; Suzuki, Y; Uehara, R, 2003)
"The use of disodium etidronate (EHDP) for the treatment of calcinosis is complicated by the threat of drug-induced inhibition of skeletal mineralization."3.66Focal mineralization defect during disodium etidronate treatment of calcinosis. ( Weinstein, RS, 1982)
"A 46-year-old woman with the CRST variant of scleroderma (calcinosis, Raynaud's phenomenon, sclerodactyly, and telangiectasis) was treated with a diphosphonate (disodium etidronate) in an effort to reduce her dystrophic calcifications or retard their progression."3.65Appearance of a gastric ulcer during diphosphonate therapy in a woman with CRST syndrome. ( Saunders, RL, 1977)
"Statins are not effective in reducing atherosclerotic plaques of the abdominal aorta, and accumulating evidence suggests that bisphosphonates have the potential to induce the regression of atherosclerotic plaques of the abdominal aorta."2.78Atorvastatin, etidronate, or both in patients at high risk for atherosclerotic aortic plaques: a randomized, controlled trial. ( Inazu, T; Kawahara, C; Kawahara, T; Nishikawa, M; Sakai, K; Suzuki, G, 2013)
"Etidronate was given orally at the dose of 200 mg just before sleep on the day of dialysis, which was performed three times per week."2.71Inhibitory effects of etidronate on the progression of vascular calcification in hemodialysis patients. ( Aizawa, S; Hashiba, H; Kogo, H; Shigematsu, T; Tamura, K, 2004)
"Hypercalcemia was confirmed by laboratory examination."2.53Systemic lupus erythematosus-related hypercalcemia with ectopic calcinosis. ( Huang, L; Zhang, X; Zhao, L, 2016)
"Treatment with etidronate, 400 mg daily, induced total regression of severe, disabling periarticular calcifications during a treatment period of 42 months in a patient with chronic kidney disease on dialysis treatment."1.36[Regression of severe periarticular calcifications during treatment with bisphosphonate in a dialysis patient]. ( Larsen, NA; Obad, D; Pedersen, EB, 2010)
"Thirteen Japanese type 2 diabetes postmenopausal women with newly diagnosed osteoporosis (osteoporosis group) and 13 age- and weight-matched diabetic women with normal bone mineral density (control group) were enrolled in this 1-year prospective study."1.36Effects of treatment with risedronate and alfacalcidol on progression of atherosclerosis in postmenopausal women with type 2 diabetes mellitus accompanied with osteoporosis. ( Hayashi, K; Kanazawa, I; Shimizu, T; Sugimoto, T; Takase, H; Yamaguchi, T, 2010)
"Oral etidronate has been used for 3 weeks, after failure of classical treatment."1.34[Etidronate per os in subcutaneous fat necrosis with hypercalcemia and nephrocalcinosis]. ( Bottu, J; Trullemans, B; Van Nieuwenhuyse, JP, 2007)
" Our data show that ED at a dosage that suppresses bone metabolism markedly inhibits vascular calcification in rats with renal failure."1.33Effect of etidronate on aortic calcification and bone metabolism in calcitriol-treated rats with subtotal nephrectomy. ( Aizawa, S; Hashiba, H; Kogo, H; Suzuki, Y; Tamura, H; Tamura, K, 2005)
"Calciphylaxis is a local tissue calcific reaction at the site of an injection of challenger substance given a critical time period after the oral administration of a sensitizer substance such as dihydrotachysterol (DHT), vitamin D or parathormone."1.27Cutaneous calciphylactic reactions in the mouse and the rat and the effects of diphosphonates on the reaction in the rat. ( McClure, J; Miller, S; Vernon-Roberts, E, 1984)
"Calcium content was high in thrombus and increased in all zones with time, in both groups, but the deposition was less in the group treated with hydroxyethylene diphosphonate."1.27Quantification of regional platelet and calcium deposition on pericardial tissue valve prostheses in calves and effect of hydroxyethylene diphosphonate. ( Chesebro, JH; Dewanjee, MK; Didisheim, P; Edwards, WD; Kaye, MP; Lenker, J; Mackey, ST; Solis, E; Zollman, PE, 1986)
" Animals received daily subcutaneous injections of the drug (1, 5, 10, 15, or 25 mg/kg/24 hr) for 21 days with maximal inhibition of bioprosthetic heart valve calcification at a dosage of 15 mg/kg/24 hr (calcium level of diphosphonate-treated bioprostheses 3."1.27Prevention of leaflet calcification of bioprosthetic heart valves with diphosphonate injection therapy. Experimental studies of optimal dosages and therapeutic durations. ( Levy, RJ; Lund, SA; Schoen, FJ; Smith, MS, 1987)
"Transient hypercalcemia was attributed to immobilization."1.26Tumoral calcinosis. Observations during six years. ( Haas, HG; Lauffenburger, T; Leicht, E; Seeliger, H; Tkocz, HJ, 1980)

Research

Studies (95)

TimeframeStudies, this research(%)All Research%
pre-199045 (47.37)18.7374
1990's17 (17.89)18.2507
2000's18 (18.95)29.6817
2010's15 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pomozi, V2
Brampton, C1
van de Wetering, K1
Zoll, J1
Calio, B1
Pham, K1
Owens, JB1
Marh, J1
Moisyadi, S1
Váradi, A1
Martin, L1
Bauer, C2
Erdmann, J2
Aherrahrou, Z2
Le Saux, O2
Aherrahrou, R1
Kriesen, R1
Stölting, S1
Liebers, A1
Kessler, T1
Schunkert, H1
Kawahara, T2
Nishikawa, M1
Kawahara, C1
Inazu, T1
Sakai, K1
Suzuki, G1
King, A1
de Graaf, P1
Schicht, IM1
Pauwels, EK3
Souverijn, JH1
de Graeff, J1
Apschner, A1
Huitema, LF1
Ponsioen, B1
Peterson-Maduro, J1
Schulte-Merker, S1
Rathan, S1
Yoganathan, AP1
O'Neill, CW1
Cakir, E1
Gedik, AH1
Özdemir, A1
Buyukpınarbasili, N1
Bilgin, M1
Ozgen, IT1
Zhao, L1
Huang, L1
Zhang, X1
Saito, A1
McCormack, FX1
Emiralioglu, N1
Beken, B1
Ozcan, HN1
Yalcin, E1
Dogru, D1
Ozcelik, U1
Haliloglu, M1
Kiper, N2
Lomashvili, KA1
Monier-Faugere, MC1
Wang, X1
Malluche, HH1
O'Neill, WC1
Neven, EG1
De Broe, ME1
D'Haese, PC1
Obad, D1
Larsen, NA1
Pedersen, EB1
Kanazawa, I1
Yamaguchi, T1
Hayashi, K1
Takase, H1
Shimizu, T1
Sugimoto, T1
Okada, Y4
Mori, H3
Tanaka, Y4
Hashimoto, O1
Mackenzie, NC1
Zhu, D1
Longley, L1
Patterson, CS1
Kommareddy, S1
MacRae, VE1
Yamaoka, K1
Saito, K2
Ito, G1
Suzuki, Y3
Uehara, R1
Ide, M1
Ozaki, S1
Grases, F2
Perelló, J2
Prieto, RM2
Simonet, BM1
Torres, JJ2
Hashiba, H3
Aizawa, S4
Tamura, K4
Shigematsu, T2
Kogo, H4
Tamura, H1
Honjo, S1
Yokote, K1
Takada, A1
Maezawa, Y1
Kobayashi, K1
Tokuyama, T1
Sonezaki, K1
Saito, Y1
Neau-Cransac, M1
Lepreux, S1
Labreze, C1
Quinart, A1
Revel, P1
Saric, J1
Bioulac-Sage, P1
Loeb, JA2
Sohrab, SA1
Huq, M1
Fuerst, DR1
Trullemans, B1
Bottu, J1
Van Nieuwenhuyse, JP1
Ariyoshi, T1
Eishi, K1
Sakamoto, I1
Matsukuma, S1
Odate, T1
Matsushita, M1
Fujii, H1
Miyaura, C1
Kishikawa, H1
Sanchis, P1
Isern, B1
Fernández-Palomeque, C1
McClure, J5
Miller, S1
Vernon-Roberts, E1
Martin-Simmerman, P1
Cohen, MD1
Siddiqui, A1
Mirkin, D1
Provisor, A1
Fleisch, H3
Dirksen, G1
Sachs, M1
Held, T1
Nowotzin, C1
Hänichen, T1
Meyer, J1
Rambeck, WA1
Zucker, H1
Leicht, E1
Tkocz, HJ1
Seeliger, H1
Lauffenburger, T1
Haas, HG1
Klemm, G1
Putzke, HP1
Ibels, LS2
Alfrey, AC1
Caughey, JE1
Gray, P1
Weinstein, RS1
Hirsch, D2
Drader, J1
Pathak, YV1
Yee, R1
Schoen, FJ9
Levy, RJ10
Kawaguchi, Y1
Hasegawa, T1
Kubo, H1
Yamamoto, H1
Nakayama, M1
Van Gelder, JM1
Breuer, E1
Schlossman, A1
Ornoy, A1
Mönkkönen, J1
Similä, J1
Klenner, T1
Stadler, H1
Krempien, B1
Patlas, N1
Golomb, G4
Jono, S2
Nishizawa, Y2
Shioi, A2
Morii, H2
Mori, K1
Naito, T1
Nitta, K1
Kimata, N1
Honda, K1
Yoshida, T1
Koinuma, M1
Ikeda, Y1
Kato, Y1
Nihei, H1
Goldstein, MR1
Price, PA1
Faus, SA1
Williamson, MK1
Schneider, VS1
LeBlanc, A1
Huntoon, CL1
Zucchelli, P1
Fusaroli, M1
Fabbri, L1
Pavlica, P1
Casanova, S1
Viglietta, G1
Sasdelli, M1
Schäfer, HJ1
Riesner, K1
Schlangen, JT1
Doyle, DV1
Dunn, CJ1
Willoughby, DA1
Reimann, E1
Münzenberg, KJ1
Gebhardt, M1
Russell, RG2
Uttley, WS2
Belton, NR1
Syme, J2
Sheppard, H2
O'Hara, JP1
Jowsey, J1
Williams, GA1
Newsome, AL1
Harley, JP1
Saunders, RL1
Kramsch, DM1
Chan, CT1
Meradji, M1
de Villeneuve, VH1
Huber, J1
de Bruijn, WC1
Pearse, RG1
Rabens, SF1
Bethune, JE1
Smith, R1
Woods, CG1
Goel, KM1
Shanks, RA1
Allen, SH1
Shah, JH1
Bellah, RD1
Zawodniak, L1
Librizzi, RJ1
Harris, MC1
Göcmen, A1
Toppare, MF1
Büyükpamukcu, N1
de Jonge, FA1
Hamdy, NA1
Kingma, JG1
Roy, PE1
Stuart, G1
Wren, C1
Bain, H1
Morris, DC1
Anderson, HC1
Yoshikawa, H1
Nakahara, H1
Takaoka, K1
Ono, K1
Dewanjee, MK1
Solis, E1
Mackey, ST1
Lenker, J1
Edwards, WD1
Didisheim, P1
Chesebro, JH1
Zollman, PE1
Kaye, MP1
Dixon, M1
Smith, MS2
Lund, SA4
Schneider, HG1
Minne, HW1
Raue, F1
Fichtner, HJ1
Baldauf, G1
Ziegler, R1
Webb, CL1
Benedict, JJ1
Linden, JA1
Johnston, TP1
Barbarash, LS1
Zhuravleva, IIu1
Medvedeva, VM1
Shaposhnikov, AN1
Hawley, MA2
Liu, PY1
Wolfrum, J2
Langer, R2
Spiro, J1
Gordon, B1
Raper, RF1
Metzger, AL1
Singer, FR1
Bluestone, R1
Pearson, CM1
Belton, N1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intestinal Microbiota and Vitamin K Levels in PXE Patients (IMPROVE Study)[NCT03813550]20 participants (Anticipated)Interventional2019-01-21Recruiting
Value of Oral Phytate (InsP6) in the Prevention of Progression of the Cardiovascular Calcifications[NCT01000233]Phase 2/Phase 3250 participants (Anticipated)Interventional2009-08-31Recruiting
Effect of Vitamin K2 Supplementation on Vascular Calcification in Hemodialysis Patients: a Controlled Randomized Trial.[NCT04539418]Phase 459 participants (Actual)Interventional2016-12-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for etidronate and Calcinosis

ArticleYear
Systemic lupus erythematosus-related hypercalcemia with ectopic calcinosis.
    Rheumatology international, 2016, Volume: 36, Issue:7

    Topics: Adult; Biomarkers; Bone Density Conservation Agents; Calcinosis; Calcitonin; Cyclophosphamide; Drug

2016
Pulmonary Alveolar Microlithiasis.
    Clinics in chest medicine, 2016, Volume: 37, Issue:3

    Topics: Bone Density Conservation Agents; Calcinosis; Calcium Phosphates; Etidronic Acid; Genetic Diseases,

2016
[Positioning of bisphosphonates for vascular calcification].
    Clinical calcium, 2010, Volume: 20, Issue:11

    Topics: Animals; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Calcinosis; Clinical Trial

2010
Diphosphonates: history and mechanisms of action.
    Metabolic bone disease & related research, 1981, Volume: 3, Issue:4-5

    Topics: Animals; Bone Resorption; Calcification, Physiologic; Calcinosis; Calcium Phosphates; Clodronic Acid

1981
Current issues of continuous ambulatory peritoneal dialysis.
    Artificial organs, 1995, Volume: 19, Issue:12

    Topics: Adult; Calcinosis; Cohort Studies; Etidronic Acid; Female; Humans; Japan; Male; Middle Aged; Nutriti

1995
Pyrophosphate and diphosphonates in skeletal metabolism. Physiological, clinical and therapeutic aspects.
    Clinical orthopaedics and related research, 1975, Issue:108

    Topics: Animals; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calcinosis; Calcium; Calcium M

1975
Calcinosis and metastatic calcification due to vitamin D intoxication. A case report and review.
    Hormone research, 1992, Volume: 37, Issue:1-2

    Topics: Adult; Aluminum Hydroxide; Calcinosis; Ergocalciferols; Etidronic Acid; Humans; Joint Diseases; Male

1992
Scintigraphy in the clinical evaluation of disorders of mineral and skeletal metabolism in renal failure.
    European journal of nuclear medicine, 1991, Volume: 18, Issue:10

    Topics: Amyloidosis; Calcinosis; Chronic Kidney Disease-Mineral and Bone Disorder; Etidronic Acid; Humans; K

1991
[Pathogenesis and prevention of calcinosis of bioprostheses].
    Grudnaia i serdechno-sosudistaia khirurgiia, 1991, Issue:10

    Topics: Animals; Bioprosthesis; Calcinosis; Disease Models, Animal; Etidronic Acid; Heart Valve Prosthesis;

1991
[Biphosphonate as a therapeutic drug--experimental studies and clinical application].
    Therapeutische Umschau. Revue therapeutique, 1985, Volume: 42, Issue:6

    Topics: Animals; Calcinosis; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Hypercalcemia; Hyperpar

1985

Trials

5 trials available for etidronate and Calcinosis

ArticleYear
Atorvastatin, etidronate, or both in patients at high risk for atherosclerotic aortic plaques: a randomized, controlled trial.
    Circulation, 2013, Jun-11, Volume: 127, Issue:23

    Topics: Adult; Aged; Aged, 80 and over; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Atorvastatin; Bo

2013
Inhibitory effects of etidronate on the progression of vascular calcification in hemodialysis patients.
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2004, Volume: 8, Issue:3

    Topics: Aged; Aorta; Bone Density; Calcinosis; Calcium; Etidronic Acid; Female; Humans; Male; Middle Aged; P

2004
Brain calcifications induce neurological dysfunction that can be reversed by a bone drug.
    Journal of the neurological sciences, 2006, Apr-15, Volume: 243, Issue:1-2

    Topics: Bone Density Conservation Agents; Brain; Brain Damage, Chronic; Brain Diseases; Calcinosis; Calcium

2006
Inhibition of the progression of aortic calcification by etidronate treatment in hemodialysis patients: long-term effects.
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2006, Volume: 10, Issue:1

    Topics: Aortic Diseases; Bone Density; Bone Density Conservation Agents; Calcinosis; Disease Progression; Et

2006
Effect of etidronic acid on arterial calcification in dialysis patients.
    Clinical drug investigation, 2006, Volume: 26, Issue:4

    Topics: Aged; Aorta, Abdominal; Aorta, Thoracic; Bone Density Conservation Agents; Calcinosis; Coronary Vess

2006

Other Studies

80 other studies available for etidronate and Calcinosis

ArticleYear
Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice.
    The American journal of pathology, 2017, Volume: 187, Issue:6

    Topics: Acute Disease; Animals; ATP-Binding Cassette Transporters; Calcinosis; Chronic Disease; Diphosphates

2017
Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation.
    Scientific reports, 2018, 04-11, Volume: 8, Issue:1

    Topics: Animals; Bone Density Conservation Agents; Calcinosis; Cardiovascular Diseases; Cell Aggregation; Ce

2018
Vascular disease: aortic plaque--dual therapy for a heterogeneous disease.
    Nature reviews. Cardiology, 2013, Volume: 10, Issue:7

    Topics: Aortic Diseases; Calcinosis; Etidronic Acid; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-

2013
Bone scintigraphy in uremic pulmonary calcification.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1979, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Bone and Bones; Calcinosis; Etidronic Acid; Female; Humans; Kidney Failure, Chron

1979
Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE).
    Disease models & mechanisms, 2014, Volume: 7, Issue:7

    Topics: Animals; Biomarkers; Calcinosis; Calcium; Choristoma; Etidronic Acid; Fibroblast Growth Factor-23; H

2014
The role of inorganic pyrophosphate in aortic valve calcification.
    The Journal of heart valve disease, 2014, Volume: 23, Issue:4

    Topics: Alkaline Phosphatase; Animals; Aortic Valve; Aortic Valve Stenosis; Calcinosis; Diphosphates; Etidro

2014
Response to Disodium Etidronate Treatment in Three Siblings with Pulmonary Alveolar Microlithiasis.
    Respiration; international review of thoracic diseases, 2015, Volume: 89, Issue:6

    Topics: Bone Density Conservation Agents; Calcinosis; Child; Child, Preschool; Etidronic Acid; Female; Genet

2015
Diagnosis and treatment of pulmonary alveolar microlithiasis.
    Pediatrics international : official journal of the Japan Pediatric Society, 2016, Volume: 58, Issue:8

    Topics: Adolescent; Biopsy; Bone Density Conservation Agents; Calcinosis; Child; Etidronic Acid; Genetic Dis

2016
Effect of bisphosphonates on vascular calcification and bone metabolism in experimental renal failure.
    Kidney international, 2009, Volume: 75, Issue:6

    Topics: Animals; Aortic Diseases; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calcinosis; D

2009
Prevention of vascular calcification with bisphosphonates without affecting bone mineralization: a new challenge?
    Kidney international, 2009, Volume: 75, Issue:6

    Topics: Animals; Aortic Diseases; Calcification, Physiologic; Calcinosis; Diphosphonates; Etidronic Acid; Hu

2009
[Regression of severe periarticular calcifications during treatment with bisphosphonate in a dialysis patient].
    Ugeskrift for laeger, 2010, Mar-01, Volume: 172, Issue:9

    Topics: Bone Density Conservation Agents; Calcinosis; Etidronic Acid; Humans; Kidney Failure, Chronic; Male;

2010
Effects of treatment with risedronate and alfacalcidol on progression of atherosclerosis in postmenopausal women with type 2 diabetes mellitus accompanied with osteoporosis.
    The American journal of the medical sciences, 2010, Volume: 339, Issue:6

    Topics: Aged; Aorta, Abdominal; Atherosclerosis; Body Mass Index; Bone Density Conservation Agents; Calcinos

2010
MOVAS-1 cell line: a new in vitro model of vascular calcification.
    International journal of molecular medicine, 2011, Volume: 27, Issue:5

    Topics: Alkaline Phosphatase; Animals; Anthraquinones; Bone Density Conservation Agents; Calcinosis; Calcium

2011
Marked improvement of calcinosis in adult dermatomyositis with etidronate therapy.
    Journal of bone and mineral metabolism, 2012, Volume: 30, Issue:1

    Topics: Adult; Alkaline Phosphatase; Bone Density; Calcinosis; Collagen Type I; Dermatomyositis; Etidronic A

2012
[Beneficial effect of high-dose etidronate on periarticular calcinosis associated with arterial and periarticular basic calcium phosphate (BCP) crystal deposition disease].
    Ryumachi. [Rheumatism], 2003, Volume: 43, Issue:4

    Topics: Calcinosis; Calcium Phosphates; Crystallization; Etidronic Acid; Female; Humans; Joint Diseases; Mid

2003
Dietary myo-inositol hexaphosphate prevents dystrophic calcifications in soft tissues: a pilot study in Wistar rats.
    Life sciences, 2004, May-21, Volume: 75, Issue:1

    Topics: Administration, Oral; Animals; Calcinosis; Diet; Disease Models, Animal; Etidronic Acid; Injections,

2004
Effect of etidronate on aortic calcification and bone metabolism in calcitriol-treated rats with subtotal nephrectomy.
    Journal of pharmacological sciences, 2005, Volume: 99, Issue:1

    Topics: Amino Acids; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Body Weight; Bone and Bone

2005
Etidronate ameliorates painful soft-tissue calcification in Werner syndrome.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:11

    Topics: Adenosine Triphosphatases; Calcinosis; Connective Tissue; DNA Helicases; DNA Mutational Analysis; Et

2005
Uncommon localization of calcinosis cutis after liver transplantation.
    Dermatology (Basel, Switzerland), 2005, Volume: 211, Issue:4

    Topics: Adult; Bone Density Conservation Agents; Calcinosis; Etidronic Acid; Graft Rejection; Humans; Hyperc

2005
[Etidronate per os in subcutaneous fat necrosis with hypercalcemia and nephrocalcinosis].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2007, Volume: 14, Issue:2

    Topics: Adipose Tissue; Calcinosis; Etidronic Acid; Female; Humans; Hypercalcemia; Infant; Kidney Diseases;

2007
Prevention of aortic calcification by etidronate in the renal failure rat model.
    European journal of pharmacology, 2007, Mar-08, Volume: 558, Issue:1-3

    Topics: Animals; Aortic Diseases; Bone Density; Calcinosis; Calcium; Calcium-Binding Proteins; Disease Model

2007
A case of blue rubber bleb nevus syndrome treated by etidronate.
    Journal of bone and mineral metabolism, 2007, Volume: 25, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conservation Agents; Calcinosis; Colono

2007
Effect of crystallization inhibitors on vascular calcifications induced by vitamin D: a pilot study in Sprague-Dawley rats.
    Circulation journal : official journal of the Japanese Circulation Society, 2007, Volume: 71, Issue:7

    Topics: Animals; Aorta; Atherosclerosis; Bone Density Conservation Agents; Calcinosis; Calcium; Crystallizat

2007
Etidronate for the treatment of progressive tumoral calcinosis in hemodialysis patients.
    Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:17

    Topics: Adult; Bone Density Conservation Agents; Calcinosis; Disease Progression; Etidronic Acid; Humans; Ki

2007
Skeletal muscle calcergy.
    The Journal of pathology, 1982, Volume: 137, Issue:1

    Topics: Animals; Calcinosis; Clodronic Acid; Etidronic Acid; Hexadimethrine Bromide; Male; Mice; Muscles; Mu

1982
The effects of disodium ethane-hydroxy-1,1-diphosphonate and disodium dichloromethylene diphosphonate on lanthanide-induced calcergy.
    The Journal of pathology, 1982, Volume: 137, Issue:2

    Topics: Animals; Calcinosis; Clodronic Acid; Diphosphonates; Disease Models, Animal; Etidronic Acid; Hydroca

1982
The effects of various anti-calcific, anti-rheumatic and anti-inflammatory drugs on local (simple) calcergy induced by lead acetate in the mouse.
    The Journal of pathology, 1982, Volume: 137, Issue:3

    Topics: Animals; Calcinosis; Clodronic Acid; Connective Tissue; Connective Tissue Diseases; Diphosphonates;

1982
Cutaneous calciphylactic reactions in the mouse and the rat and the effects of diphosphonates on the reaction in the rat.
    The Journal of pathology, 1984, Volume: 142, Issue:1

    Topics: Animals; Calcinosis; Calciphylaxis; Chlorides; Clodronic Acid; Dihydrotachysterol; Diphosphonates; D

1984
Calcification and uptake of Tc-99m diphosphonates in neuroblastomas: concise communication.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1984, Volume: 25, Issue:6

    Topics: Abdominal Neoplasms; Bone and Bones; Calcinosis; Diphosphonates; Etidronic Acid; Female; Homovanilli

1984
[Effect of aluminum hydroxide and l-hydroxyethane-1,1-diphosphonate (EHDP) on the calcinogenic effect of Trisetum flavescens (L.,P.B.) in sheep].
    Zentralblatt fur Veterinarmedizin. Reihe A, 1983, Volume: 30, Issue:9

    Topics: Aluminum Hydroxide; Animals; Calcinosis; Etidronic Acid; Female; Male; Plant Poisoning; Plants, Toxi

1983
Tumoral calcinosis. Observations during six years.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1980, Volume: 12, Issue:6

    Topics: Amyloidosis; Biopsy; Calcinosis; Etidronic Acid; Female; Humans; Hypercalcemia; Lipoproteins, VLDL;

1980
[Inhibitory action of diphosphonate on the development of pancreatic concrements (experiment with EHDP (author's transl)].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1981, Volume: 41, Issue:3

    Topics: Animals; Calcinosis; Calculi; Etidronic Acid; Female; Iron-Dextran Complex; Pancreas; Pancreatic Dis

1981
Effects of thyroparathyroidectomy, phosphate depletion and diphosphonate therapy on acute uraemic extra-osseous calcification in the rat.
    Clinical science (London, England : 1979), 1981, Volume: 61, Issue:5

    Topics: Animals; Calcinosis; Calcium; Etidronic Acid; Male; Parathyroid Glands; Phosphates; Rats; Rats, Inbr

1981
Heterotopic calcification complicating infectious polyneuritis.
    The New Zealand medical journal, 1982, Jan-27, Volume: 95, Issue:700

    Topics: Adult; Alkaline Phosphatase; Calcinosis; Etidronic Acid; Hip; Humans; Male; Paraplegia; Polyneuropat

1982
Focal mineralization defect during disodium etidronate treatment of calcinosis.
    Calcified tissue international, 1982, Volume: 34, Issue:3

    Topics: Bone Diseases; Calcinosis; Child; Dermatomyositis; Etidronic Acid; Female; Humans

1982
Synergistic inhibition of the calcification of glutaraldehyde pretreated bovine pericardium in a rat subdermal model by FeCl3 and ethanehydroxydiphosphonate: preincubation and polymeric controlled release studies.
    Biomaterials, 1993, Volume: 14, Issue:9

    Topics: Animals; Bioprosthesis; Calcinosis; Cattle; Chlorides; Delayed-Action Preparations; Disease Models,

1993
Effects of metallic ions and diphosphonates on inhibition of pericardial bioprosthetic tissue calcification and associated alkaline phosphatase activity.
    Biomaterials, 1993, Volume: 14, Issue:5

    Topics: Alkaline Phosphatase; Animals; Bioprosthesis; Calcinosis; Cattle; Diphosphonates; Etidronic Acid; Gl

1993
In vitro and in vivo effects of tetrakisphosphonates on bone resorption, tumor osteolysis, ectopic calcification, and macrophages.
    Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:3

    Topics: Animals; Bioprosthesis; Bone Resorption; Calcinosis; Carcinoma 256, Walker; Cell Line; Cell Survival

1997
Parathyroid hormone-related peptide as a local regulator of vascular calcification. Its inhibitory action on in vitro calcification by bovine vascular smooth muscle cells.
    Arteriosclerosis, thrombosis, and vascular biology, 1997, Volume: 17, Issue:6

    Topics: Alkaline Phosphatase; Animals; Calcinosis; Calcium; Cattle; Cells, Cultured; Cyclic AMP-Dependent Pr

1997
Functional improvement in a patient with cerebral calcinosis using a bisphosphonate.
    Movement disorders : official journal of the Movement Disorder Society, 1998, Volume: 13, Issue:2

    Topics: Basal Ganglia Diseases; Brain Mapping; Calcinosis; Etidronic Acid; Gait; Humans; Male; Middle Aged;

1998
Expression of matrix Gla protein (MGP) in an in vitro model of vascular calcification.
    FEBS letters, 1998, Aug-14, Volume: 433, Issue:1-2

    Topics: Alendronate; Animals; Blotting, Northern; Calcinosis; Calcium; Calcium-Binding Proteins; Cattle; Cel

1998
Progressive tumoral calcinosis as the presenting feature of sarcoidosis in a patient on haemodialysis treatment.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1999, Volume: 14, Issue:11

    Topics: Adult; Calcinosis; Calcitonin; Drug Therapy, Combination; Etidronic Acid; Glucocorticoids; Humans; L

1999
Bisphosphonate therapy and vascular calcification.
    JAMA, 2000, Mar-15, Volume: 283, Issue:11

    Topics: Blood Vessels; Calcification, Physiologic; Calcinosis; Calcium Channel Blockers; Cardiovascular Dise

2000
Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption.
    Arteriosclerosis, thrombosis, and vascular biology, 2001, Volume: 21, Issue:5

    Topics: Alendronate; Animals; Aortic Diseases; Bone Resorption; Calcification, Physiologic; Calcinosis; Diph

2001
Prevention of space flight induced soft tissue calcification and disuse osteoporosis.
    Acta astronautica, 1993, Volume: 29, Issue:2

    Topics: Bed Rest; Bone and Bones; Bone Demineralization, Pathologic; Calcinosis; Calcium; Clodronic Acid; Et

1993
Treatment of ectopic calcification in uremia.
    Kidney international. Supplement, 1978, Issue:8

    Topics: Adult; Biopsy; Calcinosis; Etidronic Acid; Female; Humans; Ilium; Male; Middle Aged; Remission, Spon

1978
[Calcium kinetics of myocardium in experimental hypercalcemia and isoproterenol lesions--ultrastructural and roentgen microanalytical findings].
    Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1978, Volume: 62

    Topics: Animals; Calcinosis; Calcium; Dihydrotachysterol; Etidronic Acid; Heart; Hypercalcemia; Isoprotereno

1978
[The diagnosis of pulmonary calcinosis by scintigraphy (author's transl)].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1976, Volume: 124, Issue:2

    Topics: Adolescent; Adult; Aged; Calcinosis; Diagnosis, Differential; Etidronic Acid; Female; Glomerulonephr

1976
Potassium permanganate induced calcergy: a model to study the effects of drugs on hydroxyapatite crystal deposition.
    The Journal of pathology, 1979, Volume: 128, Issue:2

    Topics: Animals; Calcinosis; Clodronic Acid; Dexamethasone; Disease Models, Animal; Etidronic Acid; Hydroxya

1979
[On the effect of methane-bis--phosphonate in vivo (author's transl)].
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:10

    Topics: Animals; Apatites; Calcinosis; Clodronic Acid; Diphosphonates; Etidronic Acid; Injections, Subcutane

1978
Calcium balance in children treated with diphosphonates.
    Archives of disease in childhood, 1975, Volume: 50, Issue:3

    Topics: Adenosine Monophosphate; Adrenocorticotropic Hormone; Bone and Bones; Calcinosis; Calcium; Child; Ch

1975
Effects of dichloromethylene diphosphonate, ethane-1-hydroxy-1,1-diphosphonate, and rickets in rats.
    The Journal of laboratory and clinical medicine, 1975, Volume: 86, Issue:5

    Topics: Acetates; Animals; Bone and Bones; Bone Development; Bone Resorption; Calcinosis; Calcium; Diet; Eti

1975
Trichinella spiralis: acceleration and inhibition of cyst calcification in rats.
    Experientia, 1978, Dec-15, Volume: 34, Issue:12

    Topics: Animals; Calcinosis; Cholecalciferol; Etidronic Acid; Larva; Male; Rats; Trichinella; Trichinellosis

1978
A comparison of the inhibitory effects of disodium pyrophosphate and disodium ethane-hydroxy-1, 1-diphosphonate on simple calcergy.
    The Journal of pathology, 1979, Volume: 129, Issue:3

    Topics: Animals; Calcinosis; Diphosphates; Etidronic Acid; Lead; Male; Mice; Skin; Time Factors

1979
Appearance of a gastric ulcer during diphosphonate therapy in a woman with CRST syndrome.
    Southern medical journal, 1977, Volume: 70, Issue:11

    Topics: Calcinosis; Etidronic Acid; Female; Humans; Middle Aged; Radiography; Raynaud Disease; Scleroderma,

1977
The effect of agents interfering with soft tissue calcification and cell proliferation on calcific fibrous-fatty plaques in rabbits.
    Circulation research, 1978, Volume: 42, Issue:4

    Topics: Animals; Aorta; Arteriosclerosis; Calcinosis; Cholesterol; Demecolcine; Diet, Atherogenic; Elastin;

1978
Idiopathic infantile arterial calcification in siblings: radiologic diagnosis and successful treatment.
    The Journal of pediatrics, 1978, Volume: 92, Issue:3

    Topics: Arteriosclerosis; Calcinosis; Coronary Disease; Etidronic Acid; Female; Humans; Infant, Newborn; Inf

1978
Disodium etidronate therapy for dystrophic cutaneous calcification.
    Archives of dermatology, 1975, Volume: 111, Issue:3

    Topics: Abscess; Administration, Oral; Calcinosis; Elbow; Etidronic Acid; Female; Humans; Knee; Middle Aged;

1975
Myositis ossificans progressiva. Clinical features of eight patients and their response to treatment.
    The Journal of bone and joint surgery. British volume, 1976, Volume: 58, Issue:1

    Topics: Adolescent; Adult; Calcinosis; Child; Etidronic Acid; Female; Humans; Male; Myositis Ossificans; Org

1976
Dermatomyositis in childhood. Review of eight cases.
    Archives of disease in childhood, 1976, Volume: 51, Issue:7

    Topics: Biopsy; Calcinosis; Child; Child, Preschool; Dermatomyositis; Etidronic Acid; Female; Follow-Up Stud

1976
Idiopathic arterial calcification of infancy: prenatal and postnatal effects of therapy in an infant.
    The Journal of pediatrics, 1992, Volume: 121, Issue:6

    Topics: Arterial Occlusive Diseases; Calcinosis; Etidronic Acid; Female; Heart Failure; Humans; Infant; Nitr

1992
Treatment of pulmonary alveolar microlithiasis with a diphosphonate--preliminary results of a case.
    Respiration; international review of thoracic diseases, 1992, Volume: 59, Issue:4

    Topics: Calcinosis; Calculi; Child, Preschool; Etidronic Acid; Female; Humans; Lung Diseases; Pulmonary Alve

1992
Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation.
    Journal of experimental pathology (Oxford, England), 1990, Volume: 71, Issue:2

    Topics: Animals; Aorta, Thoracic; Aortic Diseases; Calcinosis; Ergocalciferols; Etidronic Acid; Male; Micros

1990
Idiopathic infantile arterial calcification in two siblings: failure of treatment with diphosphonate.
    British heart journal, 1990, Volume: 64, Issue:2

    Topics: Calcinosis; Consanguinity; Echocardiography; Etidronic Acid; Female; Fetal Diseases; Humans; Infant,

1990
Matrix vesicle calcification of ectopically induced osteoid tissue in 1-hydroxethylidene-1,1-bisphosphonate (HEBP)-treated mice.
    Bone, 1990, Volume: 11, Issue:4

    Topics: Animals; Bone Morphogenetic Proteins; Calcinosis; Etidronic Acid; Extracellular Matrix; Injections,

1990
Quantification of regional platelet and calcium deposition on pericardial tissue valve prostheses in calves and effect of hydroxyethylene diphosphonate.
    The Journal of thoracic and cardiovascular surgery, 1986, Volume: 92, Issue:3 Pt 1

    Topics: Animals; Calcinosis; Calcium; Calcium Phosphates; Cattle; Cell Survival; Etidronic Acid; Heart Valve

1986
Controlled-release drug delivery of diphosphonates to inhibit bioprosthetic heart valve calcification: release rate modulation with silicone matrices via drug solubility and membrane coating.
    Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:4

    Topics: Animals; Bioprosthesis; Calcinosis; Delayed-Action Preparations; Etidronic Acid; Heart Valve Prosthe

1987
Prevention of leaflet calcification of bioprosthetic heart valves with diphosphonate injection therapy. Experimental studies of optimal dosages and therapeutic durations.
    The Journal of thoracic and cardiovascular surgery, 1987, Volume: 94, Issue:4

    Topics: Animals; Bioprosthesis; Calcinosis; Diphosphonates; Dose-Response Relationship, Drug; Drug Evaluatio

1987
[Extraosseous calcification in juvenile dermatomyositis. The ineffectiveness of EHDP].
    Deutsche medizinische Wochenschrift (1946), 1988, Aug-19, Volume: 113, Issue:33

    Topics: Adult; Calcinosis; Chronic Disease; Dermatomyositis; Drug Evaluation; Drug Therapy, Combination; Eti

1988
Inhibition of bioprosthetic heart valve calcification with aminodiphosphonate covalently bound to residual aldehyde groups.
    The Annals of thoracic surgery, 1988, Volume: 46, Issue:3

    Topics: Aldehydes; Animals; Aortic Valve Stenosis; Bioprosthesis; Calcinosis; Cattle; Diphosphonates; Diseas

1988
Controlled release of diphosphonates from synthetic polymers to inhibit calcification.
    Journal of biomaterials applications, 1987, Volume: 2, Issue:2

    Topics: Animals; Bioprosthesis; Calcinosis; Diphosphonates; Etidronic Acid; Heart Valve Prosthesis; Male; Ma

1987
Prevention of calcification of bioprosthetic heart valve leaflets by Ca2+ diphosphonate pretreatment.
    Journal of pharmaceutical sciences, 1988, Volume: 77, Issue:9

    Topics: Animals; Bone and Bones; Calcinosis; Cattle; Diphosphonates; Drug Implants; Etidronic Acid; Heart Va

1988
[Ways to prevent the calcification of heart valve bioprostheses].
    Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 106, Issue:12

    Topics: Animals; Aortic Valve; Bioprosthesis; Calcinosis; Diphosphonates; Drug Evaluation, Preclinical; Etid

1988
Inhibition by diphosphonate compounds of calcification of porcine bioprosthetic heart valve cusps implanted subcutaneously in rats.
    Circulation, 1985, Volume: 71, Issue:2

    Topics: Animals; Bioprosthesis; Calcinosis; Diphosphonates; Etidronic Acid; Femur; Heart Valve Prosthesis; H

1985
Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate.
    Science (New York, N.Y.), 1985, Apr-12, Volume: 228, Issue:4696

    Topics: Animals; Bioprosthesis; Bone Development; Calcinosis; Delayed-Action Preparations; Etidronic Acid; H

1985
Calcinosis universalis treated with disodium etidronate.
    Clinical and experimental dermatology, 1985, Volume: 10, Issue:2

    Topics: Calcinosis; Child; Etidronic Acid; Female; Humans

1985
Osteosclerotic myeloma complicated by diffuse arteritis, vascular calcification and extensive cutaneous necrosis.
    Nephron, 1985, Volume: 39, Issue:4

    Topics: Adult; Aluminum Hydroxide; Arteritis; Bone Neoplasms; Calcinosis; Cyclophosphamide; Etidronic Acid;

1985
Local controlled-release of diphosphonates from ethylenevinylacetate matrices prevents bioprosthetic heart valve calcification.
    Transactions - American Society for Artificial Internal Organs, 1985, Volume: 31

    Topics: Animals; Bone Development; Calcinosis; Calcium; Delayed-Action Preparations; Etidronic Acid; Heart V

1985
Failure of disodium etidronate in calcinosis due to dermatomyositis and scleroderma.
    The New England journal of medicine, 1974, Dec-12, Volume: 291, Issue:24

    Topics: Administration, Oral; Calcinosis; Dermatomyositis; Etidronic Acid; Female; Humans; Male; Organophosp

1974
Proceedings: Use of diphosphonates in diseases associated with ectopic calcification.
    Archives of disease in childhood, 1974, Volume: 49, Issue:10

    Topics: Apatites; Calcinosis; Calcium; Etidronic Acid; Humans; Organophosphorus Compounds; Ossification, Het

1974