etidronate and Asthma studies

Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
etidronic acid : A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

Excerpt	Relevance	Reference
"The study was designed to establish the effects of HRT on osteoporosis and fractures over five years in postmenopausal women with asthma receiving regular glucocorticoids and to compare with etidronate."	9.14	Hormone replacement therapy (HRT) or etidronate for osteoporosis in postmenopausal asthmatics on glucocorticoids: a randomised factorial trial. ( Campbell, IA; Douglas, JG; Francis, RM; Prescott, RJ; Reid, DM, 2009)
" A randomised study was performed to determine whether treatment with cyclical etidronate and/or calcium for 5 years prevents fractures or reverses/reduces bone loss in patients receiving glucocorticoid treatment for asthma."	9.11	Five year study of etidronate and/or calcium as prevention and treatment for osteoporosis and fractures in patients with asthma receiving long term oral and/or inhaled glucocorticoids. ( Campbell, IA; Douglas, JG; Francis, RM; Prescott, RJ; Reid, DM, 2004)
"The study was designed to establish the effects of HRT on osteoporosis and fractures over five years in postmenopausal women with asthma receiving regular glucocorticoids and to compare with etidronate."	5.14	Hormone replacement therapy (HRT) or etidronate for osteoporosis in postmenopausal asthmatics on glucocorticoids: a randomised factorial trial. ( Campbell, IA; Douglas, JG; Francis, RM; Prescott, RJ; Reid, DM, 2009)
" A randomised study was performed to determine whether treatment with cyclical etidronate and/or calcium for 5 years prevents fractures or reverses/reduces bone loss in patients receiving glucocorticoid treatment for asthma."	5.11	Five year study of etidronate and/or calcium as prevention and treatment for osteoporosis and fractures in patients with asthma receiving long term oral and/or inhaled glucocorticoids. ( Campbell, IA; Douglas, JG; Francis, RM; Prescott, RJ; Reid, DM, 2004)
"The results show that intermittent cyclical etidronate therapy with calcium and vitamin D supplementation significantly increases lumbar spine BMD in patients with osteoporosis resulting from long-term treatment with corticosteroids."	5.08	A double blind placebo controlled study to determine the effects of intermittent cyclical etidronate on bone mineral density in patients on long-term oral corticosteroid treatment. ( Li, F; Moniz, C; Pack, S; Pitt, P; Todd, P; Webber, D, 1998)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (50.00)	18.2507
2000's	4 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Campbell, IA	2
Douglas, JG	2
Francis, RM	2
Prescott, RJ	2
Reid, DM	2
Ortego-Centeno, N	1
Muñoz-Torres, M	1
Callejas-Rubio, JL	1
Riera-Montes, M	1
Rolla, G	1
Bucca, C	1
Brussino, L	1
Worth, H	1
Stammen, D	1
Keck, E	1
Pitt, P	1
Li, F	1
Todd, P	1
Webber, D	1
Pack, S	1
Moniz, C	1
Goldstein, MF	1
Fallon, JJ	1
Harning, R	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
HRT and/or Etidronate in the Prevention and Treatment of Osteoporosis and Fractures in Post-Menopausal Patients With Asthma Receiving Long-Term Oral and/or Inhaled Glucocorticoids:a Randomised Factorial Trial[NCT00376662]			Phase 4	750 participants	Interventional	1992-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Hormone replacement therapy (HRT) or etidronate for osteoporosis in postmenopausal asthmatics on glucocorticoids: a randomised factorial trial. Scottish medical journal, 2009, Volume: 54, Issue:1 Topics: Anti-Asthmatic Agents; Asthma; Bone Density Conservation Agents; Cohort Studies; Estrogen Replacemen	2009
Five year study of etidronate and/or calcium as prevention and treatment for osteoporosis and fractures in patients with asthma receiving long term oral and/or inhaled glucocorticoids. Thorax, 2004, Volume: 59, Issue:9 Topics: Administration, Inhalation; Administration, Oral; Asthma; Bone Density; Calcium; Etidronic Acid; Fem	2004
Etidronate and glucocorticoid induced osteoporosis. The Journal of rheumatology, 2005, Volume: 32, Issue:1 Topics: Asthma; Bone Density; Budesonide; Drug Therapy, Combination; Etidronic Acid; Glucocorticoids; Humans	2005
Therapy of steroid-induced bone loss in adult asthmatics with calcium, vitamin D, and a diphosphonate. American journal of respiratory and critical care medicine, 1994, Volume: 150, Issue:2 Topics: Adrenal Cortex Hormones; Asthma; Bone Density; Calcium; Drug Therapy, Combination; Etidronic Acid; F	1994
A double blind placebo controlled study to determine the effects of intermittent cyclical etidronate on bone mineral density in patients on long-term oral corticosteroid treatment. Thorax, 1998, Volume: 53, Issue:5 Topics: Aged; Asthma; Bone Density; Calcium; Double-Blind Method; Drug Therapy, Combination; Etidronic Acid;	1998

Article	Year
[Asthma--prevention of glucocorticoid-induced osteoporosis with etidronate and calcium]. Pneumologie (Stuttgart, Germany), 2005, Volume: 59, Issue:2 Topics: Asthma; Calcium; Etidronic Acid; Glucocorticoids; Humans; Osteoporosis	2005
Bisphosphonate-induced bronchoconstriction in aspirin-sensitive asthma. Lancet (London, England), 1994, Feb-12, Volume: 343, Issue:8894 Topics: Aspirin; Asthma; Clodronic Acid; Etidronic Acid; Female; Humans; Middle Aged	1994

etidronate and Asthma

Research Excerpts

Research

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Clinical Trials (1)

Trial Overview

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