ethylnitrosourea has been researched along with Disease Models, Animal in 200 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 25 (12.50) | 18.7374 |
1990's | 15 (7.50) | 18.2507 |
2000's | 78 (39.00) | 29.6817 |
2010's | 77 (38.50) | 24.3611 |
2020's | 5 (2.50) | 2.80 |
Authors | Studies |
---|---|
Debnath, M; Debnath, R; Maiti, D; Majumder, D; Nath, P; Singh Sekhawat, S | 1 |
Beutler, B; McAlpine, W; Murray, AR; Russell, J; Turer, E | 1 |
Gabriel, G; Lantz, B; Liu, X; Lo, CWY; Szabo-Rogers, HL; Wan, Y; White, C | 1 |
Fischer, C; Heupel, J; Kindler-Röhrborn, A; Koch, A; Koelsch, B; Kutritz, A; Mergener, S; Schmid, KW; Staniszewska, M; Theurer, S; Walk, F | 1 |
Carrera-González, MP; Martínez-Martos, JM; Ramírez-Expósito, MJ | 1 |
Bhattacharyya, S; Law, S | 1 |
Chatterjee, R; Gupta, S; Law, S | 1 |
Brown, FC; Conway, AJ; Curtis, DJ; Fullinfaw, RO; Jane, SM; Kile, BT | 1 |
Ball, G; Bhutta, MF; Brown, SDM; Burton, MJ; Crompton, M; Dean, CH; Gale, R; Hardisty-Hughes, RE; Mallon, AM; Parker, A; Purnell, T; Simon, MM; Tateossian, H; Tyrer, HE; Wells, S; Williams, D | 1 |
Amizuka, N; Arimatsu, K; Beutler, B; Crozat, K; Du, X; Hasegawa, T; Hoebe, K; Ida, T; Kaku, M; Maekawa, T; Matsuda, Y; Miyauchi, S; Moresco, EMY; Ohno, K; Tabeta, K; Takahashi, N; Yamazaki, K; Yokoji, M; Yoshie, H | 1 |
Cao, C; Hai, T; Hong, Q; Huang, J; Jia, Q; Li, Y; Liu, F; Liu, Z; Luo, A; Meng, A; Qin, G; Shi, G; Wang, H; Wang, X; Wang, Y; Wei, H; Xue, Y; Yao, J; Ying, H; Zhang, N; Zhang, R; Zhang, Y; Zhao, J; Zheng, Q; Zhou, Q | 1 |
Brown, SD; Cox, RD; Gorvin, CM; Hannan, FM; Hough, TA; Howles, SA; Nesbit, MA; Paudyal, A; Piret, SE; Stewart, M; Thakker, RV; Wells, S | 1 |
Cao, C; Chen, ZY; Guo, W; Hai, T; Hong, Q; Huang, J; Jia, Q; Jin, W; Li, Y; Luo, A; Meng, A; Qi, M; Qin, G; Shang, H; Wang, D; Wang, H; Wang, X; Wei, H; Yang, S; Yao, J; Zhang, H; Zhang, R; Zhang, T; Zhang, Y; Zhao, J; Zheng, Q; Zhou, Q | 1 |
Adams, DJ; Beltran, S; Breuss, M; Dürnberger, G; Edwards, A; Flint, J; Gstrein, T; Gut, I; Gut, M; Hansen, AH; Hochstoeger, T; Honzik, T; Keane, TM; Keays, DA; Kmoch, S; Landler, L; Leca, I; Mechtler, K; Pilat-Carotta, S; Přistoupilová, A; Repic, M; Rosoklija, G; Sherr, E; Stránecký, V; Traunbauer, AK; Tripathy, R; Zuber, J | 1 |
Do, HJ; Kim, KY; Ma, JY; Oh, TW; Park, KI | 1 |
Brown, FC; Burgio, G; Conway, AJ; Curtis, DJ; Foote, SJ; Hortle, EJ; Jane, SM; Morton, CJ | 1 |
Cleuren, AC; Ginsburg, D; Kotnik, EN; Saunders, TL; Siemieniak, DR; Tomberg, K; Westrick, RJ; Zhu, G | 1 |
Belz, GT; Bouillet, P; Goodnow, CC; Gray, DH; Horikawa, K; Kofler, J; Milla, L; O'Reilly, LA; Policheni, A; Strasser, A | 1 |
Abdelhamed, Z; Beier, DR; Bittermann, E; Liegel, RP; Menke, C; Stottmann, RW; Timms, A | 1 |
Abud, HE; Arkell, RM; Bagheri-Fam, S; Bertram, JF; Caruana, G; Cole, TJ; Dobbie, MS; Farlie, PG; Gordon, CT; Harley, VR; Hart, AH; Miller, KA; Smyth, IM; Wallace, MJ; Whittle, B | 1 |
Dahl, HH; Manji, SS; Miller, KA; Williams, LH | 1 |
Akiyama, T; Gondo, Y; Ikeda, A; Inoue, M; Kanda, H; Kaneda, H; Karashima, Y; Masuya, H; Matsui, J; Minowa, O; Miura, I; Motegi, H; Noda, T; Shiroishi, T; Suzuki, T; Toki, H; Wakana, S; Yamamoto, N; Yao, R | 1 |
Fischer, C; Grabellus, F; Kindler-Röhrborn, A; Koelsch, B; Kutritz, A; van den Berg, L | 1 |
Collins, D; Elbaz, B; Gomez, CM; Kidd, GJ; Millen, KJ; Popko, B; Traka, M | 1 |
Aizawa-Abe, M; Aotani, D; Ebihara, C; Ebihara, K; Hosoda, K; Kusakabe, T; Mashimo, T; Nakao, K; Sakai, T; Serikawa, T; Takizawa, A; Tomita, T; Yamamoto, Y; Yamamoto-Kataoka, S | 1 |
Ackerman, SL; Liu, Y; Orlowski, J; Zaun, HC | 1 |
Bouriez-Jones, T; Bull, KR; Chaudhry, S; Cornall, RJ; Crockford, TL; Goodnow, CC; Hough, TA; Mason, T; Rimmer, AJ; Roberts, IS; Silver, KL | 1 |
Bentley, L; Brown, MA; Brown, SD; Cox, RD; Croucher, PI; Esapa, CT; Evans, H; Fraser, WD; Hannan, FM; Head, RA; Hough, TA; Lath, D; Nesbit, MA; Podrini, C; Scudamore, CL; Thakker, RV | 1 |
Anderton, S; Chen, G; Devine, W; Francis, R; Kim, AJ; Kim, Y; Leatherbury, L; Liu, X; Lo, CW; Morgan, J; Pratt, HC; Ramirez, R; Reinholdt, L; Subramanian, R; Tobita, K; Wong, L | 1 |
Gondo, Y; Hida, A; Iwayama, Y; Mishima, K; Murata, T; Ohba, H; Ohnishi, T; Watanabe, A; Yoshikawa, T | 1 |
Kuramoro, T; Mashimo, T; Ohno, Y; Sasa, M; Serikawa, T; Voigt, B | 1 |
Cheng, CY; Fann, MJ; Hong, CJ; Kao, LS; Liou, YJ; Nian, FS; Tai, CY; Tsai, JW; Tsai, SJ; Wu, JC; Wu, PC | 1 |
Babinsky, VN; Brown, MA; Brown, SD; Cox, RD; Croucher, PI; Esapa, CT; Hannan, FM; Potter, P; Thakker, RV; Thomas, GP | 1 |
Abumrad, NN; Baek, JI; Choi, SY; Ess, KC; Flynn, CR; Gamse, JT; Hardiman, G; Kim, SH; Lipschutz, JH; Rockey, DC; Su, Y; Wu, SY | 1 |
Abe, K; Imai, K; Ishikawa, K; Lisse, T; Lisse, TS; Mashimo, T; Sakurai, Y; Serikawa, T; Takamatsu, N; Tanimoto, S; Tsurumi, T | 1 |
Beutler, B; Bull, KR; Kumar, S; Mallon, AM; Moresco, EM; Potter, PK; Simon, MM | 1 |
Dadras, SS; Dionne, LA; Fairfield, H; Potter, CS; Pratt, CH; Sundberg, JP | 1 |
Chen, B; Ouyang, HL; Wang, WH; Xue, ZF; Yan, LN; Yang, B; Yin, YH | 1 |
Cervantes-Ríos, E; Cortés-Barberena, E; Del Carmen García-Rodríguez, M; Ortiz-Muñiz, R; Pacheco-Martínez, MM; Rodríguez-Cruz, L | 1 |
Gratzinger, D; Johnson, C; Jonas, BA; Majeti, R | 1 |
Huang, YC; Lee, WH; Liu, SC; Liu, SJ; Su, CH; Tseng, YY; Wang, YC; Yang, ST | 1 |
Alexandrov, VA; Baranenko, DA; Bespalov, VG; Kostikova, VА; Vysochina, GI | 1 |
Brown, MA; Brown, SD; Cox, RD; Croucher, PI; Esapa, CT; Loh, NY; Nesbit, MA; Piret, SE; Thakker, RV; Thomas, G | 1 |
Cruz, CC; Hagiwara, MK; Maiorka, PC; Massironi, SM; Miyashiro, SI; Mori, CM | 1 |
Ahituv, N; Durgin, RS; Foreman, O; Magnani, PA; Paigen, B; Peters, LL; Savage, H; Svenson, KL | 1 |
Bachman, S; Breyer, MD; Davis, LS; Dikov, MM; Dunn, SR; Harris, RC; Ishibashi, K; Kadkina, V; Khuchua, Z; Rinchik, EM; Tchekneva, EE | 1 |
Gondo, Y | 2 |
Bahlo, M; Collinge, JE; de Graaf, CA; Ellis, S; Hacking, DF; Hilton, AA; Hilton, DJ; Kile, BT; Meikle, PJ; Mukhamedova, N; Satterley, K; Slattery, K; Smyth, I; Sviridov, D | 1 |
Beier, DR; Fernandez, L; Marchuk, DA; Moran, JL; Rockman, HA | 1 |
Bosman, EA; Fuchs, H; Hrabé de Angelis, M; Quint, E; Steel, KP | 1 |
Budde, B; Esposito, I; Fuchs, H; Graw, J; Hrabé de Angelis, M; Löster, J; Michel-Soewarto, D; Nürnberg, P; Puk, O; Söker, T; Wolf, E | 1 |
Fan, L; Harris, LC; Rehg, JE; Schuster, K; Volk, EL | 1 |
Kwiatkowski, D; Lane, H; Malinowska-Kolodziej, I; Pollizzi, K; Stumm, M | 1 |
Ahmad, N; Calzada-Wack, J; Dalke, C; de Angelis, MH; Graw, J; Klaften, M; Puk, O; Wagner, S | 1 |
Albertson, DG; Bacher, JW; Clipson, L; Dove, WF; Halberg, RB; Petrini, JH; Pitot, HC; Prunuske, AJ; Rasmussen, K; Sullivan, R; Waggoner, J; Washington, MK; White, A | 1 |
Argandoña, EG; Bengoetxea, H; Bulnes, S; Lafuente, JV; Leis, O; Ortuzar, N | 1 |
Chang, C; Chang, CP; Chen, YH; Chen, YT; Chern, Y; Hung, SI; Kuo, LT; Lee, MJ; Lee, YH; Stephenson, D; Tseng, HW; Tung, YY; Wu, JY; Wu, MT; Wu, YC | 1 |
Brown, SD; Hardisty-Hughes, RE; Parker, A | 1 |
Beier, DR; Bjork, BC; Hentges, KE; Justice, MJ; Kamp, A; Moran, J; Moskowitz, IP; Peterson, MA; Rajapaksha, TW; Seidman, CE; Seidman, JG; Svenson, KL | 1 |
Dasenbrock, C; Ernst, H; Hansen, V; Streckert, J; Taugner, F; Tillmann, T; Zhou, Y | 1 |
Barth, RF; Chou, TC; Elleaume, H; Grecula, JC; Gupta, N; Hoff, BA; Huo, T; Ross, BD; Rousseau, J; Weldon, M; Yang, W | 1 |
Damrau, C; Dean, CH; Ermakov, A; Formstone, C; Henderson, DJ; Lalanne, Z; Lu, X; Murdoch, JN; Norris, DP; Patterson, VL; Paudyal, A; Wells, S | 1 |
Becker, L; Calzada-Wack, J; Esposito, I; Fuchs, H; Hrabé de Angelis, M; Klein-Rodewald, T; Neff, F; Rosemann, M; Silva-Buttkus, P; Tost, M; Wagner, S | 1 |
Giraud, AS; Judd, LM; Kalantzis, A; Nguyen, N; van Driel, IR; Whittle, B | 1 |
Agoulnik, AI; Barrett, T; Bathgate, RA; Emge, D; Finlayson, C; Fisher, L; Harris, RM; Hurley, L; Jameson, JL; Weiss, J | 1 |
Beuschlein, F; Bidlingmaier, M; Gomez-Sanchez, C; Hrabé de Angelis, M; Manolopoulou, J; Rathkolb, B; Reincke, M; Spyroglou, A; Wagner, S; Wolf, E | 1 |
Cornall, RJ; Goodnow, CC; Lambe, T; Randall, KL | 1 |
Adamson, SL; Anderson, N; Barber, DL; Berberovic, Z; Birkenmeier, CS; Flenniken, A; Garcha, K; Haddon, DJ; Hughes, MR; Maltby, S; McNagny, KM; Minden, MD; Osborne, LR; Paulson, RF; Peters, LL; Rossant, J; Stanford, WL; Wang, C; Wong, J | 1 |
Ahmad, N; Graw, J; Hrabé de Angelis, M; Puk, O; Wagner, S | 1 |
Andreeva, V; Burt, J; Cardarelli, J; Connolly, MH; Fraher, D; Stewart-Swift, C; Yelick, PC | 1 |
Gao, X; Gu, X; Wang, Z; Xiong, X; Xu, L | 1 |
Hicks, WL; LaVail, MM; Maddox, DM; Naggert, JK; Nishina, PM; Vollrath, D | 1 |
Furuichi, T; Ikegawa, S; Imaizumi, K; Kudo, T; Masuya, H; Murakami, T; Nishida, K; Nishimura, G; Ohkawa, K; Suzuki, T; Wakana, S | 1 |
Aigner, B; Hrabé de Angelis, M; Klaften, M; Klempt, M; Laufs, J; Michel, D; Rathkolb, B; Schneider, B; Sedlmeier, R; Wagner, S; Wolf, E | 1 |
Ahmad, N; de Angelis, MH; Graw, J; Puk, O; Wagner, S | 1 |
Chen, TH; Chen, YT; Huang, CC; Kao, HJ; Lin, WD; Sabbagha, NG; Tarn, WY; Tsai, FJ; Wu, JY; Yang, CF | 1 |
Beutler, B; Du, X; Krebs, P; Krieg, L; Milstein, O; Xia, Y | 1 |
Douni, E; Eliopoulos, E; Kollias, G; Makrinou, E; Penninger, JM; Rinotas, V; Schett, G; Zwerina, J | 1 |
Furuse, T; Kaneda, H; Kobayashi, K; Kushida, T; Masuya, H; Miura, I; Wada, Y; Wakana, S; Yamada, I; Yuasa, S | 1 |
Hicks, W; Naggert, JK; Nishina, PM; Shi, LY; Wang, J; Won, J | 1 |
Baulac, S; Ishida, S; Kaneko, S; Kuwamura, M; Mashimo, T; Nishio, T; Ohno, Y; Sakamoto, Y; Serikawa, T; Takizawa, A | 1 |
Gondo, Y; Miyakawa, T; Shoji, H; Takamiya, Y; Toyama, K; Wakana, S | 1 |
Benet-Pagès, A; Calzada-Wack, J; Cohrs, CM; Eck, S; Esposito, I; Favor, J; Fuchs, H; Hans, W; Hrabě de Angelis, M; Klaften, M; Lorenz-Depiereux, B; Rathkolb, B; Rubio-Aliaga, I; Sabrautzki, S; Seedorf, H; Strom, TM; Wolf, E | 1 |
Adamson, SL; Aubin, JE; Chen, F; Flenniken, AM; Ichikawa, S; Osborne, LR; Owen, C; Rossant, J | 1 |
Chang, WP; Chen, TC; Hsieh, ST; Hsu, PN; Shyu, BC; Wu, JJ | 1 |
Cone, FE; Graw, J; Nguyen, C; Nguyen, TD; Oglesby, EN; Pease, ME; Puk, O; Quigley, HA; Steinhart, MR | 1 |
Andrews, TD; Balakishnan, B; Beutler, B; Cho, V; Enders, A; Field, MA; Goodnow, CC; Hager, J; Kirk, M; Shao, Y; Singh, M; Sjollema, G; Whittle, B; Winslade, S; Xia, Y; Zhang, Y | 1 |
Geghman, K; Li, C; Shenoy, S; Zheng, S | 1 |
Brown, MA; Brown, SD; Carr, AJ; Cheeseman, MT; Cox, RD; Croucher, PI; Esapa, CT; Evans, H; Head, RA; Hough, TA; Jeyabalan, J; McNally, EG; Thakker, RV; Thomas, GP | 1 |
Brown, FC; Collinge, JE; Curtis, DJ; Jane, SM; Kile, BT; Rank, G; Scott, N; Vadolas, J; Vickaryous, N; Whitelaw, E; Whitelaw, N | 1 |
Bosman, EA; Estabel, J; Ismail, O; Podrini, C; Steel, KP; White, JK | 1 |
Cohen, HJ; Jang, T; Lau, K; Merchant, M; Recht, B; Recht, L; Whitin, JC; Yu, TT | 1 |
Bertram, EM; Beutler, B; Brown, SD; Bull, KR; Cornall, RJ; Crockford, TL; Enders, A; Goodnow, CC; Lunter, G; Mallon, AM; Miosge, LA; Potter, PK; Rimmer, AJ; Roots, CM; Siggs, OM; Simon, MM; Whittle, B | 1 |
Brown, SD; Clements, S; Cox, RD; Fisher, EM; Glenister, PH; Goldsworthy, M; Gray, IC; Hough, TA; Hunter, AJ; Martin, JE; McCormack, SL; Moir, L; Nolan, PM; Peters, J; Rastan, S; Selley, RL; Spurr, N; Strivens, MA; Toye, AA; Tsipouri, V; Vizor, L; Wood, J | 1 |
Brown, SD; Hardisty, RE | 1 |
Bartleman, AP; Boyonoski, AC; Kirkland, JB; Spronck, JC | 1 |
Cordes, SP; Kim, DY; Pawson, CT; Weiss, KC | 1 |
Bjerkvig, R; Enger, PO; Ersland, L; Huszthy, PC; Lund-Johansen, M; Lundervold, A; Nordli, H; Standnes, T; Thorsen, F | 1 |
Grosse, J; Nehls, MC; Peters, T; Popp, A; Russ, A; Schlueter, V; Sedlmeier, R; Thaete, C; Wolf, S | 1 |
Chen, YT; Hillman, S; Kao, HJ; Li, SC; Millington, D; Stevens, R; Wu, JY | 1 |
Adachi, T; Fujimoto, N; Gondo, Y; Inoue, A; Inoue, M; Ishijima, J; Kadowaki, T; Kagami, T; Kaneda, H; Kasuga, M; Kubota, N; Masuya, H; Matsui, J; Matsumoto, R; Minowa, O; Miwa, I; Motegi, H; Noda, T; Sakuraba, Y; Shigeyama, Y; Shiroishi, T; Suzuki, T; Terauchi, Y; Toki, H; Toyoda, Y; Tsuchihashi, K; Wakana, S | 1 |
Chaudhuri, S; Duttagupta, AK; Ghosh, A; Mukherjee, J; Sarkar, S | 1 |
Zhang, YF; Zhang, ZY | 1 |
Bentley, L; Browne, M; Cox, RD; Goldsworthy, M; Haynes, A; Hough, T; Hugill, A; Hunter, AJ; Mijat, V; Moir, L; Quarterman, J; Spurr, N; Toye, AA | 1 |
Gu, MM; Kong, H; Lu, SY; Lu, ZY; Sun, YP; Tan, Y; Wang, L; Wang, Y; Wang, ZG | 1 |
Açil, Y; Albers, HK; Fuchs, H; Grundner-Culemann, E; Hrabe de Angelis, M; Reis, A; Seedorf, H; Springer, IN | 1 |
Aigner, B; de Angelis, MH; Klempt, M; Mohr, M; Rathkolb, B; Wolf, E | 1 |
Li, HD; Liu, J; Mao, HH; Shao, YX; Tang, D; Wu, BJ; Xue, ZF | 1 |
Chernik, IaI; Maksimiv, DV; Matiĭtsiv, NP; Shcherbata, GR | 1 |
Carlson, GA; Clark, AT; Frankel, WN; Goldowitz, D; Justice, MJ; Nadeau, JH; Peters, LL; Rossant, J; Siepka, SM; Takahashi, JS; Vitaterna, MH | 1 |
Behringer, RR; Conn, PM; Hess, DL; Janovick, JA; Justice, MJ; Kaiser, UB; Kanasaki, H; Pask, AJ; Stockton, DW | 1 |
Doi, K; Katayama, K; Nagata, T; Nakayama, H; Ueno, M; Yamauchi, H | 1 |
Fujimoto, N; Gondo, Y; Ishijima, J; Kaneda, H; Kawai, A; Kobayashi, K; Maeda, T; Masuya, H; Miura, I; Nagano, J; Noda, T; Sakuraba, Y; Sezutsu, H; Shimizu, A; Shimizu, K; Shiroishi, T; Wakana, S | 1 |
Gondo, Y; Sakuraba, Y | 1 |
Chaudhuri, S; Duttagupta, AK; Ghosh, A; Mazumdar, M; Mukherjee, J; Sarkar, P; Sarkar, S | 1 |
Aigner, B; Hrabé de Angelis, M; Klempt, M; Rathkolb, B; Tran, TV; Wanke, R; Wolf, E | 1 |
Brunt, EM; Di Bisceglie, AM; Osmack, P | 1 |
Beutler, B; Ding, L; Du, X; Gong, X; Horwitz, J; Huang, Q; Liu, H; McDonald, HW; Wang, M; Yates, JR | 1 |
Beynon, AJ; Croes, HJ; Cuppen, E; Fransen, JA; Guryev, V; Mul, JD; Peters, TA; Plasterk, RH; Smits, BM | 1 |
Dalke, C; Favor, J; Goldowitz, D; Graw, J; Jablonski, MM; Lu, L; Manly, KF; Pardue, MT; Pretsch, W; Rinchik, EM; Wang, X; Williams, RW | 1 |
Gekakis, N; Hall, FW; Lloyd, DJ; Tarantino, LM | 1 |
Cross, SH; Gautier, P; Hart, AW; Jackson, IJ; McKie, L; Morgan, JE; West, K | 1 |
Adamson, SL; Anderson, N; Aubin, JE; Bai, D; Bruneau, BG; Ciliberti, N; Fleming, C; Flenniken, AM; Gittens, JE; Gong, XQ; Grynpas, M; Henderson, JE; Henkelman, RM; Kelsey, LB; Kidder, GM; Laird, DW; Lounsbury, C; McKerlie, C; Moreno, L; Nieman, BJ; Osborne, LR; Peterson, K; Qu, D; Roscoe, W; Rossant, J; Shao, Q; Sled, JG; Stanford, WL; Tong, D; Veitch, GI; Voronina, I; Vukobradovic, I; Wood, GA; Zhu, Y; Zirngibl, RA | 1 |
Hioki, K; Hirose, M; Ishii, Y; Kanki, K; Kodama, Y; Kuroiwa, Y; Kurokawa, Y; Nishikawa, A; Nomura, T; Umemura, T | 1 |
Atsawasuwan, P; Ball, ST; Beason, DP; Birk, DE; Christner, PJ; Gentiletti, J; Peters, J; Soslowsky, LJ; Yamauchi, M | 1 |
Cools, AR; Cuppen, E; Ellenbroek, BA; Guryev, V; Homberg, J; Mudde, JB; Olivier, J; Plasterk, RH; Smits, BM; van de Belt, J; Verheul, M | 1 |
Cuppen, E; Smits, BM | 1 |
Duong, T; Jang, T; Kim, S; Lapointe, D; Litofsky, NS; Low, HP; Recht, L; Ross, AH; Savarese, T; Vogel, H; Weimann, JM | 1 |
Augustin, M; Biebermann, H; Grosse, J; Huffstadt, U; Korthaus, D; Nehls, M; Römpler, H; Schneider, B; Schöneberg, T; Sedlmeier, R; Tarnow, P; Wattler, S | 1 |
Handel, MA; Lessard, C; Lothrop, H; Schimenti, JC | 1 |
Babu, PP; Bhaskara, VK; Sundaram, C | 1 |
Goldowitz, D; Guo, YK; Kermany, MH; Miller, D; Parker, LL; Swanson, DJ; Yoo, TJ; Zuo, J | 1 |
Abe, K; Fuchs, H; Hans, W; Hrabé de Angelis, M; Lisse, T | 1 |
Breyer, MD; Davis, LS; Dunn, SR; Fogo, AB; Kadkina, V; Mohamed, Y; Polosukhina, D; Qi, Z; Rinchik, EM; Sharma, K; Tchekneva, EE | 1 |
Chiang, YJ; Huang, HW; Hung, SI; Li, CL; Yen, JJ | 1 |
Beutler, B; Chang, B; Cheung, D; Du, X; Gong, X; Liu, H; Park, A; Wang, M; Xia, CH; Yang, Y | 1 |
Avenarius, M; Bailey, JS; Banan, R; Federe, GC; Grabowski-Boase, L; Grillet, N; Hice, R; Housley, GD; Keithley, EM; Lagler, EA; Müller, U; Najmabadi, H; Ryan, AF; Schwander, M; Sczaniecka, A; Smith, RJ; Steffy, BM; Tarantino, LM; Wiltshire, T | 1 |
Beier, DR; Cockroft, JL; Goldowitz, D; Matera, I; Moran, JL; Pavan, WJ | 1 |
Aigner, B; Hrabé de Angelis, M; Klempt, M; Mohr, M; Rathkolb, B; Wolf, E | 1 |
Bergstrom, DE; Gagnon, LH; Johnson, KR; Longo-Guess, C | 1 |
Beutler, B; Chang, B; Cheng, C; Cheung, D; Du, X; Gong, X; Liu, H; Wang, M; Xia, CH | 1 |
Chang, C; Hsu, YH; Jang, T; Merchant, M; Recht, B; Recht, L; Sathy, B | 1 |
Abbasi, AR; Akiyama, K; Khalaj, M; Kunieda, T; Nishimura, R; Noguchi, J; Okuda, K; Tsuji, T | 1 |
Cuppen, E; de Bruin, A; Korving, J; Smits, BM; Toonen, PW; van Boxtel, R; van Roekel, HS; Verheul, M | 1 |
Hirabayashi, M; Kato, M; Kuramoto, T; Mashimo, T; Nakajima, R; Serikawa, T; Takizawa, A; Tokuda, S; Voigt, B; Yanagihara, K | 1 |
Douglas, DS; Popko, B | 1 |
Blasberg, RG; Groothuis, DR; Molnar, P | 1 |
Fox, RR; Hard, GC | 2 |
Raĭkhlin, NT; Timoshenko, IV; Turusov, VS | 1 |
Jänisch, W; Schmidt, T | 1 |
Deen, DF; Tofilon, PJ | 1 |
Paoletti, P; Schiffer, D | 1 |
Cravioto, H; Ransohoff, J; Yoshida, J | 1 |
Becci, PJ; Grubbs, CJ; Moon, RC; Thompson, HJ | 1 |
Fiebig, HH; Schmähl, D; Strobel, H | 1 |
McDonald, JD | 1 |
Shima, A; Shimada, A | 1 |
Shibutani, M | 1 |
de Wind, N; Dekker, M; te Riele, H; van der Valk, M; van Rossum, A | 1 |
Brown, SD | 1 |
Blain, F; Chang, TM; Heft, R; Peevers, R; Sarkissian, CN; Scriver, CR; Shao, Z; Su, H | 1 |
Adey, WR; Byus, CV; Cain, CD; Haggren, W; Higgins, RJ; Jones, RA; Kean, CJ; Kuster, N; MacMurray, A; Phillips, JL; Stagg, RB; Zimmerman, G | 1 |
Bradley, A; Justice, MJ; Noveroske, JK; Weber, JS; Zheng, B | 1 |
Al-Dhalimy, M; Finegold, M; Grompe, M; Manning, K | 1 |
Balling, R; Fella, C; Fuchs, H; Graw, J; Hrabé de Angelis, M; Jung, M; Klopp, N; Löster, J; Reis, A; Soewarto, D; Wolf, E | 1 |
Brown, SD; Hunter, AJ; Nolan, PM | 1 |
Balling, R; Fella, C; Heffner, S; Hrabé de Angelis, M; Marschall, S; Pargent, W; Rathkolb, B; Soewarto, D; Teubner, A; Wolf, E | 1 |
Knapik, EW | 1 |
Favor, J; Neuhäuser-Klaus, A | 1 |
Alessandrini, F; Balling, R; Behrendt, H; Decker, T; Fella, C; Flaswinkel, H; Hrabé de Angelis, M; Jakob, T; Kremmer, E; Marschall, S; Pfeffer, K; Rathkolb, B; Ring, J; Servatius, A; Soewarto, D; Wolf, E | 1 |
Balling, R; Fuchs, H; Hrabé de Angelis, M; Schughart, K; Wolf, E | 1 |
Fella, C; Gomolka, M; Hrabé de Angelis, M; Jung, T; Lobenwein, K; Pargent, W; Schindewolf, C; Singh, N; Soewarto, D; Trinczek, K | 1 |
Brown, SD; Hardisty, RE; Mburu, P | 1 |
Hrabé de Angelis, M; Strivens, M | 1 |
Blaivas, M; Kish, PE; McMahon, G; Muraszko, KM; Ross, BD; Ross, DA; Strawderman, M | 1 |
Boyonoski, AC; Gallacher, LM; Jacobs, RM; Kirkland, JB; Poirier, GG; Shah, GM; Spronck, JC | 1 |
Hardisty, R; Hough, T; Hunter, AJ; Nolan, PM; Thaung, C | 1 |
Arnold, K; Brown, SD; Clark, BJ; Cross, SH; Hunter, AJ; Jackson, IJ; McKie, L; Morgan, JE; Nolan, PM; Peters, J; Thaung, C; West, K | 1 |
Anisimov, VN; Beniashvili, DSh | 1 |
Falk, HL; Hudson, PM; Jurgelski, W; Kotin, P | 1 |
Swenberg, JA | 1 |
Cravioto, H; Yoshida, J | 1 |
Das, GD; Pfaffenroth, MJ | 1 |
Alexandrov, VA | 1 |
Fujiwara, K; Hirayama, A; Matsumoto, S; Shirataki, K; Yamasaki, S | 1 |
Aleksandrov, VA; Bespalov, VG; Petrov, AS; Troian, DN | 1 |
Kroh, H | 1 |
Hara, M; Kasuga, T; Nakamura, T | 2 |
Bode, VC; Dove, WF; McDonald, JD; Shedlovsky, A | 1 |
Giaccone, G; Giordana, MT; Mauro, A; Migheli, A; Pezzotta, S; Schiffer, D | 1 |
Cardesa, A; Mohr, U; Palacín, A; Ribalta, T; Von Schilling, B | 1 |
Hasgekar, NN; Lalitha, VS; Pendse, AM | 1 |
Hard, GC | 2 |
Barnett, LB; Erickson, RP; Lewis, SE; Tashian, RE; Venta, PJ | 1 |
Holzgraefe, M; Mennel, HD; Rama, B; Spoerri, O | 1 |
Koestner, A | 1 |
19 review(s) available for ethylnitrosourea and Disease Models, Animal
Article | Year |
---|---|
Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology.
Topics: Animals; Breeding; Disease Models, Animal; Ethylnitrosourea; Gene Expression Regulation; Genetic Testing; Humans; Mice; Mutagenesis; Mutagens; Mutation; Phenotype; Research Design; Signal Transduction; Skin; Skin Diseases | 2019 |
Advances on genetic rat models of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Ethylnitrosourea; Genetic Engineering; Genetic Predisposition to Disease; Genome; Intercellular Signaling Peptides and Proteins; Kv1.1 Potassium Channel; Models, Genetic; Mutagenesis; Mutation, Missense; NAV1.1 Voltage-Gated Sodium Channel; Phenotype; Proteins; Rats | 2015 |
Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing.
Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Genome; High-Throughput Nucleotide Sequencing; Mice; Mutagenesis; Mutation | 2015 |
Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Topics: Animals; Databases, Genetic; Disease Models, Animal; Ethylnitrosourea; Genomics; Mice; Mice, Transgenic; Models, Biological; Mutagenesis; Neoplasms | 2008 |
Now and future of mouse mutagenesis for human disease models.
Topics: Amino Acid Sequence; Animals; Base Sequence; Disease Models, Animal; Ethylnitrosourea; Gene Knockout Techniques; Genomics; Humans; Mice; Molecular Sequence Data; Mutagenesis; Phenotype | 2010 |
Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease.
Topics: Animals; Breeding; Disease Models, Animal; Ethylnitrosourea; Female; Genes; Genome; Genome-Wide Association Study; Inflammatory Bowel Diseases; Male; Mice; Mutagenesis; Phenotype | 2011 |
The essential role of DOCK8 in humoral immunity.
Topics: Animals; Antibodies; B-Lymphocytes; Disease Models, Animal; Ethylnitrosourea; Genome-Wide Association Study; Germinal Center; Guanine Nucleotide Exchange Factors; Immunity, Humoral; Immunologic Deficiency Syndromes; Immunologic Memory; Immunological Synapses; Male; Mice; Mice, Inbred C57BL; Mutation | 2010 |
Retake the center stage--new development of rat genetics.
Topics: Animals; Animals, Genetically Modified; Chromosomes, Artificial, Bacterial; Disease Models, Animal; DNA Transposable Elements; Embryonic Stem Cells; Ethylnitrosourea; Gene Targeting; Humans; Mutagenesis; Rats; Retroelements; Zinc Fingers | 2012 |
Mutagenesis strategies for identifying novel loci associated with disease phenotypes.
Topics: Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Genomics; Mice; Mutagenesis; Phenotype | 2003 |
Implementing large-scale ENU mutagenesis screens in North America.
Topics: Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Female; Male; Mice; Mutation; National Institutes of Health (U.S.); Nervous System Diseases; Phenotype; United States | 2004 |
[ENU mouse mutagenesis and advanced reverse genetics].
Topics: Animals; Base Sequence; Disease Models, Animal; Electrophoresis, Capillary; Ethylnitrosourea; Female; Gene Library; Genetic Techniques; Genetic Testing; Genetics; Genome; Heteroduplex Analysis; Humans; Male; Mice; Mice, Mutant Strains; Mutagenesis; Phenotype; Point Mutation; Semen Preservation; Sequence Analysis, DNA | 2004 |
Rat genetics: the next episode.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Ethylnitrosourea; Gene Silencing; Genetic Research; Genetic Techniques; Humans; Mutagenesis; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable; Rats; Recombination, Genetic; RNA, Small Interfering | 2006 |
Mouse forward genetics in the study of the peripheral nervous system and human peripheral neuropathy.
Topics: Alleles; Animals; Charcot-Marie-Tooth Disease; Disease Models, Animal; Ethylnitrosourea; Female; Forelimb; Humans; Immunogenetics; Leukodystrophy, Globoid Cell; Male; Mice; Mice, Mutant Strains; Mice, Neurologic Mutants; Muscular Dystrophies; Mutation; Peripheral Nervous System; Peripheral Nervous System Diseases; Phenotype | 2009 |
Using high-efficiency mouse germline mutagenesis to investigate complex biological phenomena: genetic diseases, behavior, and development.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Embryonic and Fetal Development; Ethylnitrosourea; Genes; Genetic Diseases, Inborn; Germ-Line Mutation; Humans; Mice; Mutagenesis | 1995 |
Mouse models of genetic disease: new approaches, new paradigms.
Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Genetic Diseases, Inborn; Humans; Mice; Mice, Mutant Strains; Mutagenesis; Mutagens; Phenotype | 1998 |
Mouse ENU mutagenesis.
Topics: Animals; Biological Specimen Banks; Databases, Factual; Disease Models, Animal; Ethylnitrosourea; Genetic Diseases, Inborn; Genetic Testing; Humans; Mice; Mutagenesis; Phenotype | 1999 |
Towards new models of disease and physiology in the neurosciences: the role of induced and naturally occurring mutations.
Topics: Animals; Behavior, Animal; Central Nervous System Diseases; Disease Models, Animal; Ethylnitrosourea; Mice; Mutagenesis; Mutation; Neurophysiology; Phenotype | 2000 |
ENU mutagenesis in zebrafish--from genes to complex diseases.
Topics: Alkylating Agents; Animals; Disease Models, Animal; Ethylnitrosourea; Genetic Diseases, Inborn; Genetic Testing; Mutagenesis; Mutagens; Zebrafish | 2000 |
Chemical- and virus-induced brain tumors.
Topics: Adenoviridae; Alkylation; Alpharetrovirus; Animals; Brain Neoplasms; Carcinogens; Disease Models, Animal; DNA, Neoplasm; Ethylnitrosourea; Humans; Methylnitrosourea; Neoplasms, Experimental; Oncogenic Viruses; Papillomaviridae; Polycyclic Compounds; Polyomaviridae; Retroviridae; Tumor Virus Infections | 1977 |
181 other study(ies) available for ethylnitrosourea and Disease Models, Animal
Article | Year |
---|---|
Immunotherapeutic potential of ethanolic olive leaves extract (EOLE) and IL-28B combination therapy in ENU induced animal model of leukemia.
Topics: Animals; Cytokines; Disease Models, Animal; Ethylnitrosourea; Immunotherapy; Interferon-gamma; Leukemia; Mice; Olea; Plant Extracts | 2022 |
Finding the
Topics: Aldehyde Oxidoreductases; Animals; Cleft Lip; Cleft Palate; Disease Models, Animal; Ethylnitrosourea; Mice; Mice, Mutant Strains; Mutagenesis; Mutation, Missense; Transcription Factors | 2020 |
An Animal Model Further Uncovers the Role of Mutant Braf
Topics: Alleles; Amino Acid Substitution; Animals; Carcinoma, Papillary; Disease Models, Animal; Ethylnitrosourea; Exons; Female; Humans; Immunohistochemistry; Male; Mutation; Prognosis; Proto-Oncogene Proteins B-raf; Rats; Sequence Analysis, DNA; Thyroid Cancer, Papillary; Thyroid Neoplasms | 2020 |
Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas.
Topics: Aminopeptidases; Animals; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Male; Rats, Wistar; Renin-Angiotensin System; Sex Characteristics | 2021 |
Environmental pollutant ENU induced leukemic NF-kB signaling amelioration by
Topics: Animals; Disease Models, Animal; Eclipta; Environmental Pollutants; Ethylnitrosourea; Leukemia; Mice; Neoplasms; NF-kappa B; Pesticides; Plant Extracts | 2022 |
Hematopathological alterations of major tumor suppressor cascade, vital cell cycle inhibitors and hematopoietic niche components in experimental myelodysplasia.
Topics: Animals; Cell Cycle; Disease Models, Animal; Ethylnitrosourea; Female; Glycogen Synthase Kinase 3 beta; Hematopoietic Stem Cells; Male; Membrane Potential, Mitochondrial; Mice; Myelodysplastic Syndromes; Stem Cell Niche; Tumor Suppressor Proteins | 2017 |
A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen.
Topics: Anemia, Hypochromic; Animals; Base Sequence; Biosynthetic Pathways; Coproporphyria, Hereditary; Coproporphyrinogen Oxidase; Disease Models, Animal; Ethylnitrosourea; Fasting; Feces; Female; Heme; Male; Mice, Mutant Strains; Mutagenesis; Mutation; Phenobarbital; Phenotype; Pregnancy | 2017 |
A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.
Topics: Alleles; Animals; Chromosome Mapping; Chronic Disease; Disease Models, Animal; Ear, Middle; Ethylnitrosourea; Female; Genotyping Techniques; Heterozygote; Homozygote; Humans; Imidazoline Receptors; Inflammation; Integrin alpha6; Intracellular Signaling Peptides and Proteins; Lim Kinases; Male; Mice; Mice, Knockout; Mutation, Missense; Neuropeptides; NF-kappa B; Otitis Media; p21-Activated Kinases; Penetrance; rac1 GTP-Binding Protein; Sequence Analysis, DNA; Up-Regulation; Vascular Endothelial Growth Factor A | 2017 |
An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue.
Topics: Animals; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Ethylnitrosourea; Humans; Introns; Male; Mice; Mutation; Osteogenesis Imperfecta; RNA Splice Sites; RNA Splicing | 2017 |
Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis.
Topics: Animals; Congenital Hypothyroidism; Disease Models, Animal; Dual Oxidases; Ethylnitrosourea; Exome Sequencing; Gene Expression Regulation; Genes, Recessive; Hematopoiesis; Hydrogen Peroxide; Kruppel-Like Transcription Factors; Metabolic Networks and Pathways; Mutagenesis, Site-Directed; Mutation; Receptors, Thyroid Hormone; Swine; Thymus Gland; Thyroid Hormones; Zebrafish; Zebrafish Proteins | 2017 |
Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.
Topics: Administration, Oral; Animals; Calcium; Cinacalcet; Disease Models, Animal; Ethylnitrosourea; Female; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Hypercalcemia; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Models, Molecular; Mutation; Parathyroid Hormone; Receptors, Calcium-Sensing; Sequence Alignment; Sequence Analysis, DNA; Serum Albumin; Signal Transduction | 2017 |
Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Disease Models, Animal; Ethylnitrosourea; Female; Hearing Loss; Humans; Male; Microphthalmia-Associated Transcription Factor; Mutagenesis; Mutagens; Mutation; Sequence Homology; Swine; Swine, Miniature; Waardenburg Syndrome | 2017 |
Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Topics: Alkylating Agents; Animals; Animals, Newborn; Atrophy; Autophagy; Brain; Cell Movement; Disease Models, Animal; Embryo, Mammalian; Ethylnitrosourea; Female; Gene Expression Regulation, Developmental; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurodevelopmental Disorders; Neurons; Signal Transduction; Vacuolar Proton-Translocating ATPases | 2018 |
Leaves of Acer palmatum thumb. Rescues N-ethyl-N-nitrosourea (ENU)-Induced retinal degeneration in mice.
Topics: Acer; Administration, Oral; Animals; Disease Models, Animal; Ethylnitrosourea; Glial Fibrillary Acidic Protein; Injections, Intraperitoneal; Male; Mice, Inbred ICR; Nestin; Plant Extracts; Plant Leaves; Plants, Medicinal; Protective Agents; Retina; Retinal Degeneration; Rod Opsins | 2018 |
Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency.
Topics: Anemia, Hemolytic; Anemia, Hemolytic, Congenital Nonspherocytic; Animals; Bone Marrow Transplantation; Carbohydrate Metabolism, Inborn Errors; Disease Models, Animal; Erythrocytes; Ethylnitrosourea; Glycolysis; Homozygote; Mice; Mice, Mutant Strains; Mutagenesis; Mutation, Missense; Phenotype; Triose-Phosphate Isomerase | 2018 |
Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Ethylnitrosourea; Exome Sequencing; Factor V; Female; Genetic Predisposition to Disease; Heat-Shock Proteins; Humans; Kaplan-Meier Estimate; Lipoproteins; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis; Pedigree; Penetrance; Phospholipase C beta; Venous Thromboembolism | 2018 |
CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3
Topics: Animals; CARD Signaling Adaptor Proteins; Dermatitis, Atopic; Disease Models, Animal; Ethylnitrosourea; Forkhead Transcription Factors; Homeostasis; Humans; Introns; Loss of Function Mutation; Mice; Mice, Transgenic; Mutagenesis; Mutagens; Neuropilin-1; Polymorphism, Single Nucleotide; Signal Transduction; T-Lymphocytes, Regulatory | 2019 |
Differential requirements of tubulin genes in mammalian forebrain development.
Topics: Alleles; Animals; CRISPR-Cas Systems; Disease Models, Animal; Embryo, Mammalian; Ethylnitrosourea; Female; Gene Deletion; Gene Editing; Gene Expression Regulation, Developmental; Humans; Male; Malformations of Cortical Development; Mice; Mice, Transgenic; Microtubules; Models, Animal; Mutagenesis; Neurogenesis; Sensorimotor Cortex; Species Specificity; Tubulin | 2019 |
Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease.
Topics: Alleles; Animals; Congenital Abnormalities; Disease Models, Animal; DNA Ligase ATP; DNA Ligases; Ethylnitrosourea; Exome; Extracellular Matrix Proteins; Female; Genome-Wide Association Study; Genotype; Germ-Line Mutation; High-Throughput Nucleotide Sequencing; Homozygote; Left-Right Determination Factors; Male; Mice; Mice, Inbred C57BL; Mutagenesis; Mutagens; Phenotype; Polymorphism, Single Nucleotide | 2013 |
Characterization of a novel ENU-generated myosin VI mutant mouse strain with congenital deafness and vestibular dysfunction.
Topics: Amino Acid Sequence; Animals; Auditory Perception; Base Sequence; Cardiomyopathy, Hypertrophic; Cochlea; Deafness; Disease Models, Animal; Ethylnitrosourea; Genetic Predisposition to Disease; Hearing Tests; Homozygote; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Scanning; Molecular Sequence Data; Mutagens; Mutation; Myosin Heavy Chains; Phenotype; Vestibule, Labyrinth | 2013 |
Novel mouse model for Gardner syndrome generated by a large-scale N-ethyl-N-nitrosourea mutagenesis program.
Topics: Animals; Codon; Disease Models, Animal; Ethylnitrosourea; Female; Gardner Syndrome; Genes, APC; Genome; Heterozygote; Intestinal Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Mutagenesis; Mutagens; Mutation; Osteoma; Phenotype | 2013 |
Chemically induced rat Schwann cell neoplasia as a model for early-stage human peripheral nerve sheath tumors: phenotypic characteristics and dysregulated gene expression.
Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Staging; Nerve Sheath Neoplasms; Phenotype; Rats; Schwann Cells | 2013 |
WDR81 is necessary for purkinje and photoreceptor cell survival.
Topics: Actins; Alkylating Agents; Analysis of Variance; Animals; Animals, Newborn; Calbindins; Cell Line, Transformed; Cell Survival; Cerebellum; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Functional Laterality; Gait Apraxia; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Mitochondria; Mutagenesis; Mutation, Missense; Nerve Tissue Proteins; Nuclear Proteins; Photoreceptor Cells; Prostaglandin-Endoperoxide Synthases; Purkinje Cells; RNA, Messenger; S100 Calcium Binding Protein G; Sequence Analysis, DNA; Transfection | 2013 |
Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver.
Topics: Animals; Codon, Nonsense; Disease Models, Animal; Ethylnitrosourea; Fatty Liver; Gene Expression; Leptin; Lipid Metabolism; Liver; Male; Mice, Mutant Strains; Mutagenesis; Obesity; Rats, Mutant Strains; Real-Time Polymerase Chain Reaction | 2013 |
CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis.
Topics: Age Factors; Alkylating Agents; Animals; Ataxia; Axons; Calcium-Binding Proteins; Cation Transport Proteins; Cells, Cultured; Cerebellum; Cricetinae; Disease Models, Animal; Ethylnitrosourea; Female; Gene Expression Regulation, Developmental; Homeostasis; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Nerve Tissue Proteins; Point Mutation; Purkinje Cells; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers | 2013 |
Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome.
Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Eye Abnormalities; Genetic Association Studies; Genetic Predisposition to Disease; High-Throughput Nucleotide Sequencing; Kidney Tubules; Laminin; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Myasthenic Syndromes, Congenital; Nephrotic Syndrome; Pedigree; Phenotype; Proteinuria; Pupil Disorders | 2014 |
An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess.
Topics: Animals; Body Composition; Bone and Bones; Calcium; Cell Line; Chromosome Mapping; Corticosterone; Corticotropin-Releasing Hormone; Cushing Syndrome; Disease Models, Animal; Ethylnitrosourea; Female; Glucocorticoids; Lipid Metabolism; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mutation; Osteoblasts; Osteoporosis; Promoter Regions, Genetic | 2014 |
Interrogating congenital heart defects with noninvasive fetal echocardiography in a mouse forward genetic screen.
Topics: Animals; Disease Models, Animal; Echocardiography, Doppler; Echocardiography, Doppler, Color; Ethylnitrosourea; Female; Fetal Heart; Genetic Predisposition to Disease; Genetic Testing; Heart Defects, Congenital; Heredity; High-Throughput Screening Assays; Male; Mice; Mice, Inbred C57BL; Microscopy, Acoustic; Mutation; Pedigree; Phenotype; Ultrasonography, Prenatal | 2014 |
Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Bipolar Disorder; Brain; Brain Diseases; Circadian Rhythm; Disease Models, Animal; Ethylnitrosourea; Female; Gene Library; Genotype; Homozygote; Humans; Inositol; Lithium; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis; Mutation; Mutation, Missense; Phosphoric Monoester Hydrolases; Recombinant Proteins; Sequence Homology, Amino Acid; Time Factors | 2014 |
ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.
Topics: Abnormalities, Multiple; Age Factors; Animals; Axons; Cataract; Cornea; Disease Models, Animal; Endoplasmic Reticulum; Ethylnitrosourea; Eye; Hypogonadism; Intellectual Disability; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microcephaly; Microphthalmos; Mutagenesis; Nerve Degeneration; Optic Atrophy; Optic Nerve Diseases; Psychomotor Performance; rab GTP-Binding Proteins; Sequence Deletion; Testis; Touch Perception | 2015 |
N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.
Topics: Alleles; Amino Acid Sequence; Animals; Calcinosis; Chlorocebus aethiops; Codon, Nonsense; COS Cells; Disease Models, Animal; Endoplasmic Reticulum; Ethylnitrosourea; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Genetic Loci; Genotype; Glucuronidase; Humans; Kidney; Klotho Proteins; Longevity; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation, Missense; N-Acetylgalactosaminyltransferases; Phenotype; Phosphates; Polymorphism, Single Nucleotide; Polypeptide N-acetylgalactosaminyltransferase; Sequence Alignment; Vitamin D | 2015 |
A post-developmental genetic screen for zebrafish models of inherited liver disease.
Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Genetic Predisposition to Disease; Genetic Testing; Humans; Liver; Mutation; Non-alcoholic Fatty Liver Disease; Zebrafish | 2015 |
Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat.
Topics: Abnormalities, Multiple; Animals; Base Sequence; Chromosome Mapping; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Female; Gene Expression Regulation; Gene Order; Genes, Dominant; Genetic Loci; Genotype; Hernia, Diaphragmatic; Male; Mutation; Phenotype; Rats; Sequence Alignment; Spine | 2015 |
Gnaq(M1J): An ENU-Induced Mutant Allele Affecting Pigmentation in the Mouse.
Topics: Alleles; Animals; Biopsy, Needle; Disease Models, Animal; Ethylnitrosourea; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Hyperpigmentation; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mutation, Missense; Polymorphism, Single Nucleotide; Random Allocation; Sensitivity and Specificity | 2016 |
Hirschsprung disease is associated with an L286P mutation in the fifth transmembrane domain of the endothelin-B receptor in the N-ethyl-N-nitrosourea-induced mutant line.
Topics: Animals; Chromosomes, Human, Pair 14; Disease Models, Animal; Ethylnitrosourea; Female; Ganglia; Genetic Association Studies; Hirschsprung Disease; Humans; Intestinal Obstruction; Lysine; Male; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Mutation, Missense; Protein Domains; Receptor, Endothelin B; Receptors, G-Protein-Coupled | 2016 |
Moderate malnutrition in rats induces somatic gene mutations.
Topics: Animals; Animals, Newborn; Body Weight; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Erythrocytes; Ethylnitrosourea; Male; Malnutrition; Membrane Proteins; Mutation Rate; Rats, Wistar; Reticulocytes; Time Factors | 2016 |
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.
Topics: Alkylating Agents; Animals; Bone Marrow Cells; Disease Models, Animal; Ethylnitrosourea; Humans; Leukemia, Myeloid, Acute; Mice; Myelodysplastic Syndromes; Neoplasms, Second Primary; Neoplastic Stem Cells | 2016 |
Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bibenzyls; Brain; Brain Neoplasms; Camptothecin; Cisplatin; Disease Models, Animal; Drug Delivery Systems; Ethylnitrosourea; Glioblastoma; Glioma; Humans; Irinotecan; Lactic Acid; Male; Nanofibers; Neurosurgical Procedures; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Tumor Burden | 2016 |
The inhibiting activity of meadowsweet extract on neurocarcinogenesis induced transplacentally in rats by ethylnitrosourea.
Topics: Animals; Central Nervous System Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Filipendula; Kidney Neoplasms; Male; Maternal-Fetal Exchange; Plant Extracts; Pregnancy; Prenatal Exposure Delayed Effects | 2017 |
Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway.
Topics: Animals; Bone Density; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Ethylnitrosourea; Female; Glycosylation; Kyphosis; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mutation, Missense; Protein Processing, Post-Translational; Receptors, Atrial Natriuretic Factor; Spine; Tibia | 2016 |
A Mouse Model for Human Unstable Hemoglobin Santa Ana.
Topics: Anemia, Hemolytic, Congenital; Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Female; Genotype; Hemoglobins, Abnormal; Humans; Male; Mice; Mice, Inbred BALB C; Mutation | 2016 |
A new mouse mutant for the LDL receptor identified using ENU mutagenesis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Disease Models, Animal; Ethylnitrosourea; Female; Hyperlipoproteinemia Type II; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Mutagens; Mutation, Missense; Receptors, LDL | 2008 |
Single amino acid substitution in aquaporin 11 causes renal failure.
Topics: Amino Acid Substitution; Animals; Aquaporins; Disease Models, Animal; Ethylnitrosourea; Female; Male; Mice; Mice, Mutant Strains; Point Mutation; Polymorphism, Single Nucleotide; Renal Insufficiency; Syndrome | 2008 |
A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis.
Topics: Animals; ATP-Binding Cassette Transporters; Biological Transport; Cell Differentiation; Disease Models, Animal; Epidermis; Ethylnitrosourea; Female; Homeostasis; Humans; Ichthyosis, Lamellar; Keratinocytes; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mutagenesis; Skin | 2008 |
An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15.
Topics: Animals; Cardiomyopathies; Chromosome Mapping; Chromosomes, Mammalian; Disease Models, Animal; Ethylnitrosourea; Female; Genes, Recessive; Genetic Testing; Heart; Heart Failure; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mutagenesis; Mutagens | 2009 |
Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Bone Morphogenetic Protein 4; Branchio-Oto-Renal Syndrome; Calcium-Binding Proteins; Disease Models, Animal; Ear, Inner; Embryo, Mammalian; Ethylnitrosourea; Hair Cells, Auditory; Homeodomain Proteins; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Kidney; Membrane Proteins; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagens; Point Mutation; Serrate-Jagged Proteins; SOXB1 Transcription Factors | 2009 |
A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease?
Topics: Amino Acid Sequence; Animals; Atrophy; Base Sequence; Chromosomes, Mammalian; Disease Models, Animal; Dry Eye Syndromes; Ethylnitrosourea; Eye Abnormalities; Female; Fibroblast Growth Factor 10; Genome-Wide Association Study; Harderian Gland; Heterozygote; In Situ Hybridization; Lens, Crystalline; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Phenotype; Polymerase Chain Reaction; Retina | 2009 |
The MDM2-a splice variant of MDM2 alters transformation in vitro and the tumor spectrum in both Arf- and p53-null models of tumorigenesis.
Topics: Animals; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Ethylnitrosourea; Female; Fibroblasts; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Germ Cell and Embryonal; Protein Isoforms; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53 | 2009 |
Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Disease Models, Animal; Ethylnitrosourea; Everolimus; Imidazoles; Kidney Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Neoplasm Recurrence, Local; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Proteins; Quinolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors; Tuberous Sclerosis | 2009 |
Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2G257D mutant mouse.
Topics: Alkylating Agents; Animals; Anterior Chamber; Collagen Type VIII; Cornea; Disease Models, Animal; Ethylnitrosourea; Eye Abnormalities; Female; Genetic Linkage; Immunoenzyme Techniques; In Situ Hybridization; Interferometry; Light; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Microsatellite Repeats; Mutagenesis, Site-Directed; Ophthalmoscopy; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Visual Acuity | 2009 |
Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.
Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Alkylating Agents; Animals; Cell Cycle Proteins; Disease Models, Animal; Disease Progression; DNA-Binding Proteins; Ethylnitrosourea; Feces; Female; Helicobacter Infections; Helicobacter pylori; Humans; Intestinal Neoplasms; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mutation; Nuclear Proteins; Signal Transduction; Survival Analysis; Time Factors | 2009 |
The role of eNOS in vascular permeability in ENU-induced gliomas.
Topics: Animals; Autoantigens; Brain Neoplasms; Capillary Permeability; Disease Models, Animal; Ethylnitrosourea; Gadolinium; Glioma; Glucose Transporter Type 1; Nitric Oxide Synthase Type III; Pentetic Acid; Plant Lectins; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2010 |
Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus.
Topics: Animals; Brain; Cognition Disorders; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Hydrocephalus, Normal Pressure; Intracranial Pressure; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Motor Skills; Mutagenesis; Polymorphism, Single Nucleotide | 2009 |
A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.
Topics: Animals; Behavior, Animal; Breeding; Disease Models, Animal; Ear, Inner; Ethylnitrosourea; Genetic Testing; Hearing Loss; Mice; Mutation | 2010 |
Genome-wide identification of mouse congenital heart disease loci.
Topics: Animals; Animals, Newborn; Chromosome Mapping; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Female; Genetic Predisposition to Disease; Genetic Testing; Genome-Wide Association Study; Heart Defects, Congenital; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardium | 2010 |
Indication of cocarcinogenic potential of chronic UMTS-modulated radiofrequency exposure in an ethylnitrosourea mouse model.
Topics: Animals; Body Weight; Cell Phone; Disease Models, Animal; Electromagnetic Fields; Ethylnitrosourea; Female; Lung; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasms, Radiation-Induced; Pregnancy; Prenatal Exposure Delayed Effects; Time Factors | 2010 |
Convection enhanced delivery of carboplatin in combination with radiotherapy for the treatment of brain tumors.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Brain Neoplasms; Carboplatin; Combined Modality Therapy; Convection; Disease Models, Animal; Drug Delivery Systems; Ethylnitrosourea; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Radiation Dosage; Rats; Rats, Inbred F344; Survival Rate; Tissue Distribution; X-Ray Therapy | 2011 |
The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.
Topics: Animals; Cell Polarity; Disease Models, Animal; Ear, Inner; Ethylnitrosourea; Heart Defects, Congenital; Humans; Lung; Mice; Mutagenesis, Insertional; Nerve Tissue Proteins; Neural Crest; Neural Tube Defects; Receptor Protein-Tyrosine Kinases; Receptors, G-Protein-Coupled; Signal Transduction | 2010 |
[Characterization of ENU-mutant mice. Animal models for human diseases using morphological and molecular methods].
Topics: Alkylating Agents; Alleles; Animals; Base Pairing; Disease Models, Animal; Ethylnitrosourea; Genetic Diseases, Inborn; Genome-Wide Association Study; Genome, Human; Humans; Mice; Mice, Mutant Strains; Mutagenesis; Phenotype; Point Mutation | 2010 |
A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism.
Topics: Animals; Chromosome Mapping; Cryptorchidism; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Gene Knockout Techniques; Genetic Complementation Test; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutation, Missense; Polymerase Chain Reaction; Protein Conformation; Protein Folding; Receptors, G-Protein-Coupled; Signal Transduction; Testis | 2010 |
Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism.
Topics: Animals; Breeding; Disease Models, Animal; Ethylnitrosourea; Female; Hyperaldosteronism; Male; Mice; Mice, Inbred Strains; Mutagenesis; Pedigree | 2011 |
A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.
Topics: Alkylating Agents; Amino Acid Sequence; Animals; Ankyrins; Codon, Nonsense; Disease Models, Animal; Erythrocytes; Ethylnitrosourea; Female; Humans; Male; Mice; Mice, Mutant Strains; Protein Binding; Sequence Deletion; Spherocytosis, Hereditary | 2011 |
First mutation in the βA2-crystallin encoding gene is associated with small lenses and age-related cataracts.
Topics: Aging; Animals; beta-Crystallin A Chain; Biomarkers; Cataract; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Genetic Linkage; Genotype; In Situ Hybridization; Lens, Crystalline; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Polymorphism, Single Nucleotide; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
Identification of adult mineralized tissue zebrafish mutants.
Topics: Alcian Blue; Animals; Anthraquinones; Cartilage; Craniofacial Abnormalities; Disease Models, Animal; Ethylnitrosourea; Genes, Recessive; Mutagenesis; Phenotype; Zebrafish | 2011 |
Identification of a novel point mutation of mouse Atp2b2 induced by N-ethyl-N-nitrosourea mutagenesis.
Topics: Animals; Disease Models, Animal; Ear, Inner; Ethylnitrosourea; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Humans; Mice; Mice, Mutant Strains; Mutagenesis; Plasma Membrane Calcium-Transporting ATPases; Point Mutation | 2011 |
An ENU-induced mutation in the Mertk gene (Mertknmf12) leads to a slow form of retinal degeneration.
Topics: Animals; Blotting, Western; c-Mer Tyrosine Kinase; Cell Death; Disease Models, Animal; Disease Progression; DNA; Electroretinography; Ethylnitrosourea; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mutation; Ophthalmoscopy; Phenotype; Photoreceptor Cells, Vertebrate; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Retina; Retinal Degeneration; Tumor Necrosis Factor-alpha | 2011 |
ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type.
Topics: Alcian Blue; Animals; Anthraquinones; Bone and Bones; Chromosome Mapping; Collagen Type II; Disease Models, Animal; DNA Primers; Ethylnitrosourea; Genotype; Immunohistochemistry; Mice; Mice, Mutant Strains; Microscopy, Electron, Transmission; Mutagenesis; Mutation, Missense; Osteochondrodysplasias; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters.
Topics: Animals; Base Sequence; Disease Models, Animal; Ethylnitrosourea; Female; Genetic Linkage; Genotype; Hematologic Diseases; Hematologic Tests; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mutagenesis; Mutagens; Mutation; Phenotype; Receptors, Transferrin; Reference Values | 2011 |
Microphakia and congenital cataract formation in a novel Lim2(C51R) mutant mouse.
Topics: Animals; Base Sequence; Cataract; Disease Models, Animal; Ethylnitrosourea; Eye; Eye Proteins; Female; Founder Effect; Genetic Linkage; Heterozygote; Homozygote; Lens, Crystalline; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microphthalmos; Molecular Sequence Data; Mutation; Polymorphism, Single Nucleotide | 2011 |
Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice.
Topics: Acyl-CoA Dehydrogenase; Alternative Splicing; Amino Acid Metabolism, Inborn Errors; Animals; Base Sequence; Cold Temperature; Disease Models, Animal; Disease Progression; DNA Mutational Analysis; Ethylnitrosourea; Fatty Liver; Gene Expression Regulation, Enzymologic; Genetic Predisposition to Disease; Liver X Receptors; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Transmission; Mitochondria, Liver; Mitochondrial Swelling; Molecular Sequence Data; Mutagens; Mutation; Orphan Nuclear Receptors; Oxidoreductases Acting on CH-CH Group Donors; Phenotype; PPAR alpha; PPAR gamma; RNA, Messenger; Thermogenesis; Thermosensing | 2011 |
Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice.
Topics: Achlorhydria; Amino Acid Substitution; Anemia, Iron-Deficiency; Animals; Disease Models, Animal; Ethylnitrosourea; Female; H(+)-K(+)-Exchanging ATPase; Intestinal Absorption; Iron, Dietary; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mutagens; Osmotic Fragility; Point Mutation; Protein Subunits; Stomach | 2011 |
A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF.
Topics: Amino Acid Substitution; Animals; Disease Models, Animal; Ethylnitrosourea; Genes, Dominant; Mice; Mutation, Missense; Osteoclasts; Osteopetrosis; Point Mutation; Protein Binding; Protein Multimerization; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Tumor Necrosis Factor-alpha | 2012 |
Behavioral and neuromorphological characterization of a novel Tuba1 mutant mouse.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Attention; Behavior, Animal; Bromodeoxyuridine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Stimulants; Chromosome Mapping; Dark Adaptation; Developmental Disabilities; Disease Models, Animal; DNA Mutational Analysis; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethylnitrosourea; Exploratory Behavior; Female; Gene Expression Regulation; Glycine; Homing Behavior; Male; Methylphenidate; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Transmission; Mutagenesis; Mutagens; Neocortex; Neurons; Phenotype; Time Factors; Tubulin | 2012 |
Translational vision research models program.
Topics: Alkylating Agents; Animals; Chromosome Mapping; Cyclic Nucleotide Phosphodiesterases, Type 6; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Eye Proteins; Humans; Mice; Mice, Inbred C57BL; Mutagenesis; Retinal Degeneration; Rhodopsin; Translational Research, Biomedical | 2012 |
Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
Topics: Animals; Antiemetics; Biophysical Phenomena; Biotinylation; Body Weight; Carbamazepine; Cells, Cultured; Chromosome Mapping; Disease Models, Animal; DNA Mutational Analysis; Electric Stimulation; Electroencephalography; Electromyography; Epilepsy; Ethylnitrosourea; Gene Transfer Techniques; Humans; Isaacs Syndrome; Kv1.1 Potassium Channel; Male; Membrane Potentials; Mice; Models, Molecular; Mutagenesis; Mutagens; Mutation, Missense; Myokymia; Oocytes; Patch-Clamp Techniques; Protein Transport; Psychomotor Performance; Rats; Rats, Inbred F344; Rats, Mutant Strains; Sequence Analysis; Serine; Survival Analysis; Swimming; Threonine; Time Factors; Xenopus | 2012 |
Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice.
Topics: Alkylating Agents; Amino Acid Substitution; Analysis of Variance; Animals; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Motor Activity; Mutation; Nerve Tissue Proteins; Reflex, Startle; Schizophrenia; Social Behavior | 2012 |
New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Base Sequence; Bone Diseases, Metabolic; Calcium; Chromosomes, Mammalian; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Female; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mutagenesis; Mutagens; Mutation; Phenotype; PHEX Phosphate Regulating Neutral Endopeptidase; Phosphates; Polymorphism, Single Nucleotide; Receptors, Calcium-Sensing; Statistics, Nonparametric; X Chromosome | 2012 |
A novel Phex mutation in a new mouse model of hypophosphatemic rickets.
Topics: Adaptor Proteins, Signal Transducing; Animals; Base Sequence; Bone and Bones; Bone Marrow Cells; Calcification, Physiologic; Cells, Cultured; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Extracellular Matrix Proteins; Familial Hypophosphatemic Rickets; Female; Fibroblast Growth Factor-23; Genetic Diseases, X-Linked; Glycoproteins; Integrin-Binding Sialoprotein; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mutagens; Osteoblasts; Osteocalcin; PHEX Phosphate Regulating Neutral Endopeptidase; Phosphoproteins; Point Mutation; RNA, Messenger; Sequence Analysis, DNA; Stromal Cells | 2012 |
Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cytoskeletal Proteins; Disease Models, Animal; Ethylnitrosourea; Inflammation; Mice; Mice, Inbred C57BL; Mutagenesis; Mutation; Pain; Polymorphism, Single Nucleotide | 2012 |
Mice with an induced mutation in collagen 8A2 develop larger eyes and are resistant to retinal ganglion cell damage in an experimental glaucoma model.
Topics: Animals; Axial Length, Eye; Axons; Cell Count; Collagen Type VIII; Disease Models, Animal; Ethylnitrosourea; Glaucoma; Homozygote; Intraocular Pressure; Mice; Mice, Inbred C57BL; Microspheres; Mutation, Missense; Ocular Hypertension; Optic Nerve; Organ Size; Polystyrenes; Protein Isoforms; Retinal Ganglion Cells; Sclera | 2012 |
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.
Topics: Animals; Crosses, Genetic; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Exome; Female; Genes, Recessive; Heterozygote; Homozygote; Inbreeding; Leukocyte Common Antigens; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagenesis; Polymorphism, Single Nucleotide; Sequence Analysis, DNA | 2012 |
A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis.
Topics: Animals; Apoptosis; Blotting, Western; Bone and Bones; Calcinosis; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Ethylnitrosourea; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Genes, Recessive; Green Fluorescent Proteins; Hyperostosis, Cortical, Congenital; Hyperphosphatemia; Male; Mice; Mutation, Missense; N-Acetylgalactosaminyltransferases; Polypeptide N-acetylgalactosaminyltransferase; Reverse Transcriptase Polymerase Chain Reaction; Sertoli Cells; Spermatozoa; Testis | 2012 |
ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level.
Topics: Animals; beta-Globins; beta-Thalassemia; Codon; Codon, Nonsense; Disease Models, Animal; Erythrocyte Indices; Ethylnitrosourea; Exons; Female; Fetal Death; Genes, Dominant; Genes, Lethal; Genetic Complementation Test; Genotype; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutagenesis; Mutagens; Polyadenylation; Pregnancy; Spleen | 2013 |
Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1.
Topics: Alleles; Animals; Chromosome Mapping; Chromosomes; Disease Models, Animal; Ethylnitrosourea; Female; Gene Expression Regulation; Genes, Lethal; Genes, Recessive; Male; Membrane Proteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Mutation; Osteopetrosis; Phenotype | 2013 |
Alterations in cerebrospinal fluid proteins in a presymptomatic primary glioma model.
Topics: Animals; Biomarkers; Brain; Brain Neoplasms; Cerebrospinal Fluid Proteins; Disease Models, Animal; Ethylnitrosourea; Gene Expression Regulation, Neoplastic; Glioma; Glutathione; Intermediate Filament Proteins; Nerve Tissue Proteins; Nestin; Proteome; Proteomics; Rats; Rats, Sprague-Dawley; Time Factors | 2012 |
Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.
Topics: Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Genes, Dominant; Genes, Recessive; Genome; Humans; Mice; Mutagenesis; Mutation; Phenotype; Sequence Analysis, DNA | 2013 |
Novel phenotypes identified by plasma biochemical screening in the mouse.
Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagenesis; Phenotype; Plasma | 2002 |
Chronic DNA damage and niacin deficiency enhance cell injury and cause unusual interactions in NAD and poly(ADP-ribose) metabolism in rat bone marrow.
Topics: Alkylating Agents; Animals; Bone Marrow Cells; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Erythrocytes; Ethylnitrosourea; Male; NAD; Neoplasms, Experimental; Niacin; Poly Adenosine Diphosphate Ribose; Random Allocation; Rats; Rats, Long-Evans | 2003 |
A genetic screen for mouse mutations with defects in serotonin responsiveness.
Topics: Alkylating Agents; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylnitrosourea; Female; Genetic Testing; Head Movements; Indophenol; Male; Mice; Mice, Inbred Strains; Motor Activity; Mutagenesis; Mutation; Psychotic Disorders; Serotonin; Serotonin Receptor Agonists; Species Specificity; Statistics, Nonparametric; Time Factors | 2003 |
Imaging of experimental rat gliomas using a clinical MR scanner.
Topics: Animals; Brain Neoplasms; Collagen; Disease Models, Animal; Endostatins; Ethylnitrosourea; Female; Glioma; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Neoplasms, Experimental; Peptide Fragments; Rats; Transfection; Tumor Cells, Cultured | 2003 |
A mouse model for cystinuria type I.
Topics: Amino Acid Sequence; Amino Acid Transport Systems, Basic; Amino Acids; Animals; Arginine; Carrier Proteins; Chromosome Mapping; Cystine; Cystinuria; Disease Models, Animal; Ethylnitrosourea; Female; Genotype; Lysine; Male; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Mutation; Ornithine; Phenotype; Sequence Homology, Amino Acid; Urinary Bladder Calculi; Urinary Calculi | 2003 |
ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.
Topics: Amino Acid Sequence; Amino Acids, Branched-Chain; Animals; Base Sequence; Disease Models, Animal; Ethylnitrosourea; Humans; Maple Syrup Urine Disease; Mass Spectrometry; Mice; Mitochondria; Molecular Sequence Data; Mutagens; Mutation; Transaminases | 2004 |
A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Ethylnitrosourea; Female; Gene Expression; Glucokinase; Glucose Tolerance Test; Homozygote; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagenesis; Phenotype; Point Mutation; RNA, Messenger | 2004 |
Immunotherapeutic effects of T11TS/S-LFA3 against nitrosocompound mediated neural genotoxicity.
Topics: Adjuvants, Immunologic; Age Factors; Animals; Apoptosis; Brain; Brain Neoplasms; CD2 Antigens; CD58 Antigens; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Ethylnitrosourea; Female; Lymphocytes; Male; Mutagens; Phagocytosis; Rats; Rosette Formation; Sheep; Spleen | 2004 |
[p16 protein expression in the transplacental induced brain tumor in rat].
Topics: Animals; Brain; Brain Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Immunohistochemistry; Male; Placenta; Pregnancy; Rats; Rats, Sprague-Dawley | 2004 |
A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.
Topics: Adenine; Amino Acid Sequence; Amino Acid Substitution; Animals; Chromosome Mapping; Diabetes Mellitus, Type 2; Disease Models, Animal; Ethylnitrosourea; Glucokinase; Glucose; Glucose Intolerance; Heterozygote; Homozygote; Isoleucine; Male; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagens; Mutation, Missense; Phenylalanine; Phosphorylation; Thymine | 2004 |
[HUP98-HOXA9 transgenic mice are susceptible to N-ethyl-N-nitrosourea stimulation in leukemogenesis].
Topics: Animals; Bone Marrow Cells; Disease Models, Animal; Ethylnitrosourea; Female; Gene Expression Regulation, Leukemic; Genotype; Homeodomain Proteins; Humans; Leukemia, Myeloid; Male; Mice; Mice, Transgenic; Nuclear Pore Complex Proteins; Oncogene Proteins, Fusion; Phenotype; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2004 |
Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21).
Topics: Amelogenesis Imperfecta; Animals; Chromosome Mapping; Chromosomes, Human, Pair 4; Chromosomes, Human, Pair 5; Dental Enamel; Dental Enamel Proteins; Dentin; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Female; Genetic Testing; Humans; Male; Mice; Mice, Inbred C3H; Mice, Mutant Strains; Mutagenesis; Mutagens | 2004 |
Hypercholesterolemia in ENU-induced mouse mutants.
Topics: Alleles; Animals; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Ethylnitrosourea; Genes, Dominant; Genes, Recessive; Genetic Predisposition to Disease; Hypercholesterolemia; Mice; Mice, Inbred C3H; Mutagenesis; Mutagens; Mutation; Phenotype | 2004 |
Two kinds of ENU-induced scant hair mice and mapping of the mutant genes.
Topics: Alkylating Agents; Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Female; Genes, Dominant; Genes, Recessive; Genomics; Genotype; Hair Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Mutagenesis; Phenotype; Pregnancy | 2004 |
[Chemically induced Drosophila melanogaster mutants with changes in brain structure].
Topics: Animals; Brain; Disease Models, Animal; Drosophila melanogaster; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Genes, Insect; Male; Mutagens; Mutation; Nerve Degeneration | 2004 |
A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation.
Topics: Animals; Disease Models, Animal; Disorders of Sex Development; Ethylnitrosourea; Female; Follicle Stimulating Hormone; Hypogonadism; Luteinizing Hormone; Male; Mice; Ovary; Pituitary Gland; Point Mutation; Receptors, LHRH; Sex Differentiation; Testis; Transcription, Genetic | 2005 |
Ethylnitrosourea induces neural progenitor cell apoptosis after S-phase accumulation in a p53-dependent manner.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Carcinogens; Cell Cycle; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Replication; Ethylnitrosourea; Female; G2 Phase; Male; Mice; Mice, Knockout; Neurons; Rats; Rats, Inbred F344; S Phase; Stem Cells; Tumor Suppressor Protein p53 | 2005 |
Enamelin (Enam) is essential for amelogenesis: ENU-induced mouse mutants as models for different clinical subtypes of human amelogenesis imperfecta (AI).
Topics: Amelogenesis; Amelogenesis Imperfecta; Amino Acid Sequence; Animals; Chromosome Mapping; Dental Enamel Proteins; Disease Models, Animal; Ethylnitrosourea; Humans; Mice; Molecular Sequence Data; Mutation; Phenotype; RNA, Messenger; Sequence Analysis, DNA | 2005 |
T11TS/S-LFA3 induces apoptosis of the brain tumor cells: a new approach to characterise the apoptosis associated genetic changes by arbitrarily primed-PCR.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; CD2 Antigens; CD58 Antigens; Disease Models, Animal; DNA Fragmentation; DNA, Neoplasm; Ethylnitrosourea; Female; In Situ Nick-End Labeling; Male; Phosphatidylserines; Polymerase Chain Reaction; Rats; Rats, Inbred Strains | 2005 |
Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants.
Topics: Albuminuria; Alkylating Agents; Animals; Disease Models, Animal; Ethylnitrosourea; Female; Male; Mice; Mice, Inbred C3H; Mutagenesis; Pedigree; Phenotype; Proteinuria | 2005 |
Chemoprevention of hepatocellular carcinoma: use of tamoxifen in an animal model of hepatocarcinogenesis.
Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Chemoprevention; Disease Models, Animal; Ethylnitrosourea; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Precancerous Conditions; Tamoxifen; Tretinoin | 2005 |
Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency.
Topics: alpha-Crystallins; Angiography; Animals; Chromatography, Gel; Circular Dichroism; Cloning, Molecular; Crystallins; Disease Models, Animal; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Ethylnitrosourea; Fluorescein; gamma-Crystallins; Genetic Linkage; Homozygote; Immunohistochemistry; Isoleucine; Lens, Crystalline; Mice; Mice, Mutant Strains; Mutagenesis; Mutagens; Mutation; Mutation, Missense; Phenotype; Phenylalanine; Protein Binding; Recombinant Proteins; Retinal Vessels; Sequence Analysis, DNA; Ultraviolet Rays | 2005 |
Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics.
Topics: Animals; Chromosome Disorders; Codon, Terminator; Disease Models, Animal; Dyneins; Ethylnitrosourea; Genes, Recessive; Genetic Linkage; Humans; Male; Mutagenesis; Mutagens; Myosin VIIa; Myosins; Point Mutation; Polymorphism, Single Nucleotide; Rats; Rats, Wistar; Usher Syndromes | 2005 |
An ENU-induced mutation in Rs1h causes disruption of retinal structure and function.
Topics: Alkylating Agents; Animals; Base Sequence; Cell Adhesion Molecules; Chromosome Mapping; Disease Models, Animal; DNA Mutational Analysis; Electroretinography; Ethylnitrosourea; Eye Proteins; Female; Immunoenzyme Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Molecular Sequence Data; Mutagenesis; Mutation; Retina; Retinoschisis | 2005 |
Diabetes insipidus in mice with a mutation in aquaporin-2.
Topics: Animals; Aquaporin 2; Diabetes Insipidus; Disease Models, Animal; Endoplasmic Reticulum; Ethylnitrosourea; Mice; Mice, Mutant Strains; Mutation, Missense; Protein Transport | 2005 |
Genotype-phenotype correlation of mouse pde6b mutations.
Topics: Alkylating Agents; Alleles; Animals; Cyclic Nucleotide Phosphodiesterases, Type 6; Disease Models, Animal; Disease Progression; DNA Mutational Analysis; Electrophoresis, Capillary; Ethylnitrosourea; Female; Genotype; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mutation; Phenotype; Phosphoric Diester Hydrolases; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Visual Acuity | 2005 |
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia.
Topics: Abnormalities, Multiple; Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Connexin 43; Craniofacial Abnormalities; Dental Enamel Hypoplasia; Disease Models, Animal; Ethylnitrosourea; Eye Abnormalities; Gap Junctions; Heart Defects, Congenital; Humans; Mice; Penetrance; Point Mutation; Stem Cells; Syndactyly | 2005 |
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Antioxidants; Benzo(a)pyrene; Butylated Hydroxytoluene; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Incidence; Lung Neoplasms; Male; Methylcholanthrene; Mice; Mice, Transgenic; Oncogene Protein p21(ras) | 2006 |
Collagen dysregulation in the dermis of the Sagg/+ mouse: a loose skin model.
Topics: Animals; Chromosome Mapping; Collagen; Cutis Laxa; Disease Models, Animal; Ehlers-Danlos Syndrome; Ethylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mutation; RNA, Messenger; Skin; Tensile Strength | 2006 |
Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Female; Genetic Techniques; Genome; Male; Mutagenesis, Site-Directed; Pharmacogenetics; Rats; Rats, Inbred F344 | 2006 |
Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea.
Topics: Animals; Astrocytes; Biomarkers, Tumor; Cerebral Cortex; Disease Models, Animal; Disease Progression; Ethylnitrosourea; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Immunohistochemistry; Intermediate Filament Proteins; Nerve Tissue Proteins; Nestin; Osteopontin; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Sialoglycoproteins; Time Factors; Transfection | 2006 |
N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.
Topics: Alkylating Agents; Animals; Chlorocebus aethiops; COS Cells; Disease Models, Animal; DNA Mutational Analysis; Enzyme-Linked Immunosorbent Assay; Ethylnitrosourea; Female; Green Fluorescent Proteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagenesis; Mutation; Phylogeny; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Receptors, G-Protein-Coupled; Signal Transduction; Transfection | 2006 |
Mutagenesis-generated mouse models of human infertility with abnormal sperm.
Topics: Animals; Bacterial Proteins; Calcium-Binding Proteins; Disease Models, Animal; Ethylnitrosourea; Humans; Immunohistochemistry; Infertility, Male; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mutagenesis; Phenotype; Spermatozoa | 2007 |
pERK, pAkt and pBad: a possible role in cell proliferation and sustained cellular survival during tumorigenesis and tumor progression in ENU induced transplacental glioma rat model.
Topics: Alkylating Agents; Animals; bcl-Associated Death Protein; Brain; Cell Proliferation; Cell Survival; Disease Models, Animal; Enzyme Activation; Ethylnitrosourea; Extracellular Signal-Regulated MAP Kinases; Female; Glioma; Male; Phosphorylation; Placenta; Pregnancy; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction | 2006 |
Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen.
Topics: Animals; Cochlea; Disease Models, Animal; Ethylnitrosourea; Evoked Potentials, Auditory, Brain Stem; Genetic Testing; Hearing Loss, Noise-Induced; Mice; Mice, Inbred C57BL; Mutagenesis; Mutagens; Noise; Pedigree; Phenotype; Presbycusis; Sex Factors | 2006 |
New ENU-induced semidominant mutation, Ali18, causes inflammatory arthritis, dermatitis, and osteoporosis in the mouse.
Topics: Absorptiometry, Photon; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Dermatitis; Disease Models, Animal; Ethylnitrosourea; Extremities; Female; Humans; Male; Mice; Mutation; Osteoporosis; Phenotype | 2006 |
A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.
Topics: Albuminuria; Animals; Diabetic Nephropathies; Disease Models, Animal; Ethylnitrosourea; Female; Genes, Dominant; Genetic Predisposition to Disease; Genetic Testing; Humans; Insulin; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagens; Mutation; Phenotype; Sensitivity and Specificity | 2007 |
An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis.
Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Cell Line; Cell Lineage; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Genome; Interleukin-7; Lymphopenia; Lymphopoiesis; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis; RNA Splicing; RNA, Messenger; Sequence Deletion; T-Lymphocytes | 2007 |
Characterization of mouse mutants with abnormal RPE cells.
Topics: Animals; Cell Line; Disease Models, Animal; Ethylnitrosourea; Female; Heterozygote; Homozygote; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Mutation; Pigment Epithelium of Eye; Retinal Degeneration; Time Factors | 2006 |
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.
Topics: Animals; Base Sequence; Chromosome Mapping; Deafness; Disease Models, Animal; Ethylnitrosourea; Female; Genes, Recessive; Genetic Testing; Hair Cells, Auditory, Outer; Humans; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutagens; Neoplasm Proteins; Pedigree; Point Mutation; Psychomotor Agitation; Sequence Alignment | 2007 |
A mouse model of Waardenburg syndrome type IV resulting from an ENU-induced mutation in endothelin 3.
Topics: Animals; Arginine; Chromosome Mapping; Disease Models, Animal; Endothelin-3; Ethylnitrosourea; Gene Expression Regulation; Genetic Linkage; Histidine; Humans; Mice; Mutation; Pigmentation; Point Mutation; Waardenburg Syndrome | 2007 |
Generation of ENU-induced mouse mutants with hypocholesterolemia: novel tools for dissecting plasma lipoprotein homeostasis.
Topics: Animals; Cholesterol; Disease Models, Animal; Dyslipidemias; Ethylnitrosourea; Female; Homeostasis; Lipoproteins; Male; Mice; Mice, Inbred C3H; Mice, Mutant Strains; Mutagenesis; Mutagens; Mutation; Phenotype | 2007 |
A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9.
Topics: Acoustic Stimulation; Amino Acid Motifs; Amino Acid Sequence; Animals; Behavior, Animal; Conserved Sequence; Deafness; Disease Models, Animal; Ethylnitrosourea; Evoked Potentials, Auditory, Brain Stem; Genotype; Hair Cells, Auditory; Heterozygote; Homozygote; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Molecular Sequence Data; Mutagens; Mutation, Missense; Phenotype; Protein Denaturation; Protein Structure, Tertiary | 2007 |
A model for familial exudative vitreoretinopathy caused by LPR5 mutations.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Capillaries; Disease Models, Animal; Ethylnitrosourea; Exons; Frameshift Mutation; Homozygote; LDL-Receptor Related Proteins; Low Density Lipoprotein Receptor-Related Protein-5; Male; Mice; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Mutagenesis, Insertional; Protein Structure, Tertiary; Retinal Diseases; Retinal Vessels | 2008 |
A distinct phenotypic change in gliomas at the time of magnetic resonance imaging detection.
Topics: Alkylating Agents; Animals; Brain Neoplasms; Disease Models, Animal; Disease Progression; Ethylnitrosourea; Glial Fibrillary Acidic Protein; Glioma; Intermediate Filament Proteins; Magnetic Resonance Imaging; Male; Nerve Tissue Proteins; Nestin; Osteopontin; Phenotype; Rats; Rats, Sprague-Dawley | 2008 |
Leydig cell hyperplasia in an ENU-induced mutant mouse with germ cell depletion.
Topics: Alkylating Agents; Animals; Cell Count; Disease Models, Animal; Ethylnitrosourea; Homozygote; Hyperplasia; Infertility, Male; Leydig Cells; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Phenotype; Sertoli Cells; Spermatogenesis; Spermatozoa; Testosterone | 2008 |
Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Blotting, Western; Colorectal Neoplasms, Hereditary Nonpolyposis; Disease Models, Animal; DNA-Binding Proteins; Ethylnitrosourea; Genotype; Microsatellite Instability; Microsatellite Repeats; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Rats | 2008 |
An ENU-induced mutant archive for gene targeting in rats.
Topics: Animals; Bacteriophage mu; Cryopreservation; Disease Models, Animal; DNA Transposable Elements; Ethylnitrosourea; Gene Targeting; Genetic Diseases, Inborn; Genetic Testing; Humans; Male; Mutagenesis, Insertional; Mutation; Rats; Sperm Injections, Intracytoplasmic; Spermatozoa | 2008 |
Regional blood flow and blood-to-tissue transport in five brain tumor models. Implications for chemotherapy.
Topics: Aminoisobutyric Acids; Animals; Astrocytoma; Biological Transport; Brain Neoplasms; Capillary Permeability; Carcinoma 256, Walker; Disease Models, Animal; Ethylnitrosourea; Glioma; Oligodendroglioma; Rats; Regional Blood Flow; Sarcoma, Avian | 1984 |
Electron-microscopic analysis of nephroblastomas induced transplacentally in the IIIVO/J rabbit by a single dose of N-ethylnitrosourea.
Topics: Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Disease Models, Animal; Ethylnitrosourea; Female; Kidney Glomerulus; Kidney Neoplasms; Kidney Tubules; Mesenchymoma; Nitrosourea Compounds; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Wilms Tumor | 1984 |
[Experimental models of embryonic nephroblastomas (Wilms' tumor)].
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Enzyme Activation; Ethylnitrosourea; Female; Kidney Neoplasms; Neoplasms, Experimental; Pregnancy; Rats; Time Factors; Wilms Tumor | 1980 |
[Tumour induction with alkyl-nitrosoureas in ribbed newts (Pleurodeles waltlii) (author's transl)].
Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Female; Fibrosarcoma; Hemangioma; Hemangiosarcoma; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pleurodeles; Salamandridae; Sarcoma, Experimental; Wilms Tumor | 1980 |
Histologic characterization of renal tumors (nephroblastomas) induced transplacentally in IIIVO/J and WH/J rabbits by N-ethylnitrosourea.
Topics: Abdominal Neoplasms; Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Epithelium; Ethylnitrosourea; Female; Humans; Kidney Glomerulus; Kidney Neoplasms; Kidney Tubules; Lung Neoplasms; Maternal-Fetal Exchange; Neoplasms, Connective Tissue; Pregnancy; Rabbits; Wilms Tumor | 1983 |
Combined effects of drugs and radiation against tumor cells.
Topics: Animals; Brain Neoplasms; Cell Survival; Cells, Cultured; Combined Modality Therapy; Disease Models, Animal; Ethylnitrosourea; Humans; Nitrosourea Compounds; Rats; X-Rays | 1984 |
[Prospects in neuro-oncology].
Topics: Animals; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Cell Transformation, Neoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; Ependymoma; Ethylnitrosourea; Humans; Medical Oncology; Mice; Neoplasms, Experimental; Nerve Tissue; Nervous System Neoplasms; Neurology; Nitrosourea Compounds; Prognosis; Prospective Studies; Rats; Stem Cells | 1984 |
In vitro transformation of fetal brain cells from CDF rats exposed in utero to N-ethyl-N-nitrosourea: morphologic and immunologic studies.
Topics: Animals; Animals, Newborn; Antibody Formation; Brain; Brain Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats; Rats, Inbred Strains; Thymectomy; Transplantation, Isogeneic | 1980 |
Carcinogenicity of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea when applied to a localized area of the hamster trachea.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylnitrosourea; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Papilloma; Trachea; Tracheal Neoplasms | 1981 |
Experimental chemotherapy with N'N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) in autochthonous neurogenic tumors of the rat transplacentally induced by ethylnitrosourea.
Topics: Animals; Carmustine; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Neoplasms, Experimental; Nervous System Neoplasms; Pregnancy; Rats | 1982 |
The Japanese medaka, Oryzias latipes, as a new model organism for studying environmental germ-cell mutagenesis.
Topics: Animals; Disease Models, Animal; Environmental Pollutants; Ethylnitrosourea; Female; Gamma Rays; Germ-Line Mutation; Male; Mutagenesis; Mutagens; Oryzias; Pregnancy; Spermatogenesis | 1994 |
Neuronal lineage in ethyl-nitrosourea-induced brain tumors.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Rats | 1994 |
Mouse models for hereditary nonpolyposis colorectal cancer.
Topics: Adenomatous Polyposis Coli Protein; Animals; Clone Cells; Colorectal Neoplasms, Hereditary Nonpolyposis; Cytoskeletal Proteins; Disease Models, Animal; DNA-Binding Proteins; Ethylnitrosourea; Female; Gene Deletion; Immunocompromised Host; Loss of Heterozygosity; Lymphoma; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Survival Rate | 1998 |
A different approach to treatment of phenylketonuria: phenylalanine degradation with recombinant phenylalanine ammonia lyase.
Topics: Animals; Basidiomycota; Cloning, Molecular; Disease Models, Animal; Escherichia coli; Ethylnitrosourea; Humans; Injections, Intraperitoneal; Mice; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylketonurias; Recombinant Proteins | 1999 |
Spontaneous and nitrosourea-induced primary tumors of the central nervous system in Fischer 344 rats chronically exposed to 836 MHz modulated microwaves.
Topics: Animals; Brain Neoplasms; Carcinogens; Central Nervous System Neoplasms; Cocarcinogenesis; Disease Models, Animal; Ethylnitrosourea; Female; Incidence; Male; Microwaves; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Spinal Cord Neoplasms | 1999 |
In vivo suppressor mutations correct a murine model of hereditary tyrosinemia type I.
Topics: Acetoacetates; Alanine Transaminase; Animals; Cloning, Molecular; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Gene Conversion; Gene Deletion; Genotype; Heterozygote; Liver; Loss of Heterozygosity; Mice; Mice, Knockout; Models, Genetic; Mutagenesis; Precancerous Conditions; Reverse Transcriptase Polymerase Chain Reaction; Suppression, Genetic; Tyrosine; Tyrosinemias | 1999 |
Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse.
Topics: Amino Acid Sequence; Animals; Base Sequence; beta-Crystallin A Chain; Cataract; Crystallins; Disease Models, Animal; Ethylnitrosourea; Female; Genes; Genes, Dominant; Genotype; Humans; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Microsatellite Repeats; Molecular Sequence Data; Mutagenesis; Mutagens; Polymerase Chain Reaction; RNA Splicing; RNA, Messenger; Specific Pathogen-Free Organisms | 1999 |
The large-scale Munich ENU-mouse-mutagenesis screen.
Topics: Animals; Chromosome Mapping; Congenital Abnormalities; Databases, Factual; Disease Models, Animal; Ethylnitrosourea; Genetic Diseases, Inborn; Genetic Testing; Human Genome Project; Internet; Mice; Mice, Mutant Strains; Mutagenesis; Mutagens | 2000 |
Saturation mutagenesis for dominant eye morphological defects in the mouse Mus musculus.
Topics: Animals; Chromosome Mapping; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Eye Diseases, Hereditary; Genes, Dominant; Genetic Testing; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Phenotype; Radiation Genetics | 2000 |
Identification of immunological relevant phenotypes in ENU mutagenized mice.
Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Ethylnitrosourea; Flow Cytometry; Immune System Diseases; Immunity; Immunoglobulins; Internet; Mice; Mutagenesis; Mutagens; Phenotype; Polymerase Chain Reaction; Reproducibility of Results | 2000 |
Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.
Topics: Animals; Congenital Abnormalities; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Female; Genetic Testing; Internet; Male; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Mutation; Phenotype | 2000 |
Comet assay as a tool to screen for mouse models with inherited radiation sensitivity.
Topics: Animals; Comet Assay; Disease Models, Animal; DNA Damage; Ethylnitrosourea; Genetic Testing; In Vitro Techniques; Lymphocytes; Mice; Mutagenesis; Mutagens; Radiation Tolerance; Radiation, Ionizing | 2000 |
ENU mutagenesis and the search for deafness genes.
Topics: Animals; Deafness; Disease Models, Animal; Ethylnitrosourea; Mice; Mutagenesis; Point Mutation | 1999 |
Large-scale production of mouse phenotypes: the search for animal models for inherited diseases in humans.
Topics: Animals; Computational Biology; Data Interpretation, Statistical; Databases, Factual; Disease Models, Animal; Ethylnitrosourea; Female; Genetic Diseases, Inborn; Humans; Male; Mice; Mutagenesis; Mutagens; Phenotype; Semen Preservation | 2001 |
Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas.
Topics: Angiogenesis Inhibitors; Animals; Brain Neoplasms; Carcinogens; Diet; Disease Models, Animal; Diterpenes; Ethylnitrosourea; Glioma; Indoles; Magnetic Resonance Imaging; Neoplasms, Multiple Primary; Neoplasms, Second Primary; Pyrroles; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Retinyl Esters; Survival Analysis; Time Factors; Vitamin A | 2001 |
Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats.
Topics: Alkylating Agents; Animals; Bone Marrow; Disease Models, Animal; Ethylnitrosourea; Male; Morbidity; Neoplasms, Experimental; Niacin; Nutritional Status; Poly Adenosine Diphosphate Ribose; Rats; Rats, Long-Evans; Time Factors | 2002 |
In search of new disease models in the mouse using ENU mutagenesis.
Topics: Alkylating Agents; Animals; Disease Models, Animal; Ethylnitrosourea; Genetic Techniques; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mutagenesis, Site-Directed; Mutation; Phenotype; Retina | 2002 |
Novel ENU-induced eye mutations in the mouse: models for human eye disease.
Topics: Alkylating Agents; Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Eye Diseases; Female; Humans; Male; Mice; Mutation | 2002 |
[Induction of tumors of the sympathetic nervous system in rats].
Topics: Animals; Carcinogens; Disease Models, Animal; Ethylnitrosourea; Ganglioneuroblastoma; Ganglioneuroma; Light; Neuroblastoma; Rats | 2002 |
Embryonal neoplasms in the opossum: a new model for solid tumors of infancy and childhood.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Jaw Neoplasms; Kidney Neoplasms; Liver Neoplasms; Neoplasms, Experimental; Neoplasms, Germ Cell and Embryonal; Opossums | 1976 |
Nitrosourea-induced brain tumors: an in vivo and in vitro tumor model system.
Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Immunosuppression Therapy; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Neurilemmoma; Nitrosourea Compounds; Pregnancy; Rats; Rats, Inbred Strains; Thymus Gland; Time Factors; Transplantation, Isogeneic | 1978 |
N-ethyl-N-nitrosourea-induced spinal tumors in an inbred strain of W albino rats.
Topics: Animals; Animals, Newborn; Astrocytoma; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Male; Maternal-Fetal Exchange; Neoplasms, Experimental; Nitrosourea Compounds; Oligodendroglioma; Pregnancy; Rats; Rats, Inbred Strains; Spinal Cord Neoplasms | 1979 |
Some results and prospects of transplacental carcinogenesis studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Animals; Brain; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nervous System Diseases; Nitrosourea Compounds; Organ Specificity; Placenta; Pregnancy; Rats | 1976 |
Comparative study of various models of experimental hydrocephalus.
Topics: Animals; Cats; Disease Models, Animal; Dogs; Ethylnitrosourea; Hydrocephalus; Kaolin; Methods; Mice; Rabbits; Rats; Silicones | 1975 |
[The anticarcinogenic effects of fumaric acid on models of carcinogenesis in the esophagus, nervous system and kidney].
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Chi-Square Distribution; Dimethylnitrosamine; Disease Models, Animal; Drug Screening Assays, Antitumor; Esophageal Neoplasms; Ethylnitrosourea; Female; Fumarates; Kidney Neoplasms; Male; Nervous System Neoplasms; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1992 |
Ganglion cells and their satellites in experimental trigeminal schwannomas in the rat.
Topics: Animals; Astrocytes; Cranial Nerve Neoplasms; Disease Models, Animal; Ethylnitrosourea; Glial Fibrillary Acidic Protein; Neurilemmoma; Rats; Schwann Cells; Trigeminal Ganglion | 1991 |
Early lesion of N-nitroso-N-ethylurea-induced hamster neurofibromatosis model.
Topics: Animals; Bromodeoxyuridine; Cell Division; Disease Models, Animal; Ethylnitrosourea; Neurofibromatosis 1; Rats; S100 Proteins; Schwann Cells; Time Factors | 1991 |
The use of N-ethyl-N-nitrosourea to produce mouse models for human phenylketonuria and hyperphenylalaninemia.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Male; Mice; Mice, Mutant Strains; Mutation; Phenotype; Phenylalanine; Phenylketonurias | 1990 |
Glial fibrillary acidic protein and vimentin in the experimental glial reaction of the rat brain.
Topics: Animals; Astrocytes; Brain; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Glial Fibrillary Acidic Protein; Lasers; Nerve Crush; Pregnancy; Rats; Rats, Inbred F344; Staining and Labeling; Vimentin | 1986 |
Experimental model of tumors associated with neurofibromatosis.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Ethylnitrosourea; Female; Kidney Neoplasms; Neoplasms, Multiple Primary; Nervous System Neoplasms; Neurofibromatosis 1; Peripheral Nervous System Neoplasms; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Spinal Nerves; Trigeminal Nerve; Wilms Tumor | 1989 |
Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: I. Induction.
Topics: Animals; Cobalt Radioisotopes; Disease Models, Animal; Ethylnitrosourea; Kidney Neoplasms; Radiation Dosage; Rats; Rats, Inbred Strains; Time Factors; Whole-Body Irradiation; Wilms Tumor | 1989 |
Transplacental induction of peripheral nervous tumor in the Syrian golden hamster by N-nitroso-N-ethylurea. A new animal model for von Recklinghausen's neurofibromatosis.
Topics: Animals; Cricetinae; Disease Models, Animal; Ethylnitrosourea; Female; Fluorescent Antibody Technique; Immunohistochemistry; Maternal-Fetal Exchange; Melanoma; Mesocricetus; Microscopy, Electron; Neural Crest; Neurofibroma; Neurofibromatosis 1; Peripheral Nervous System Neoplasms; Pheochromocytoma; Pregnancy; S100 Proteins; Wilms Tumor | 1989 |
Differential renal tumor response to N-ethylnitrosourea and dimethylnitrosamine in the Nb rat: basis for a new rodent model of nephroblastoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Female; Kidney Neoplasms; Male; Ovariectomy; Placenta; Pregnancy; Rats; Wilms Tumor | 1985 |
Experimental models for the sequential analysis of chemically-induced renal carcinogenesis.
Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Animals; Carcinoma, Renal Cell; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Kidney Neoplasms; Mesenchymoma; Rabbits; Rats; Rats, Inbred Strains; Wilms Tumor | 1986 |
N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome.
Topics: Alleles; Animals; Carbonic Anhydrases; Chromosomes, Human, Pair 3; Disease Models, Animal; Ethylnitrosourea; Female; Genes; Humans; Immunodiffusion; Isoelectric Focusing; Male; Metabolism, Inborn Errors; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mutation; Osteopetrosis | 1988 |
Current brain tumour models with particular consideration of the transplantation techniques. Outline of literature and personal preliminary results.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Glioma; Graft Survival; Intracranial Pressure; Male; Neoplasm Transplantation; Rats; Rats, Inbred Strains | 1986 |
The brain-tumour issue in long-term toxicity studies in rats.
Topics: Age Factors; Animal Diseases; Animals; Brain; Brain Neoplasms; Carcinogens; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylnitrosourea; Rats; Research Design; Time Factors | 1986 |