Page last updated: 2024-08-21

ethylnitrosourea and Disease Models, Animal

ethylnitrosourea has been researched along with Disease Models, Animal in 200 studies

Research

Studies (200)

TimeframeStudies, this research(%)All Research%
pre-199025 (12.50)18.7374
1990's15 (7.50)18.2507
2000's78 (39.00)29.6817
2010's77 (38.50)24.3611
2020's5 (2.50)2.80

Authors

AuthorsStudies
Debnath, M; Debnath, R; Maiti, D; Majumder, D; Nath, P; Singh Sekhawat, S1
Beutler, B; McAlpine, W; Murray, AR; Russell, J; Turer, E1
Gabriel, G; Lantz, B; Liu, X; Lo, CWY; Szabo-Rogers, HL; Wan, Y; White, C1
Fischer, C; Heupel, J; Kindler-Röhrborn, A; Koch, A; Koelsch, B; Kutritz, A; Mergener, S; Schmid, KW; Staniszewska, M; Theurer, S; Walk, F1
Carrera-González, MP; Martínez-Martos, JM; Ramírez-Expósito, MJ1
Bhattacharyya, S; Law, S1
Chatterjee, R; Gupta, S; Law, S1
Brown, FC; Conway, AJ; Curtis, DJ; Fullinfaw, RO; Jane, SM; Kile, BT1
Ball, G; Bhutta, MF; Brown, SDM; Burton, MJ; Crompton, M; Dean, CH; Gale, R; Hardisty-Hughes, RE; Mallon, AM; Parker, A; Purnell, T; Simon, MM; Tateossian, H; Tyrer, HE; Wells, S; Williams, D1
Amizuka, N; Arimatsu, K; Beutler, B; Crozat, K; Du, X; Hasegawa, T; Hoebe, K; Ida, T; Kaku, M; Maekawa, T; Matsuda, Y; Miyauchi, S; Moresco, EMY; Ohno, K; Tabeta, K; Takahashi, N; Yamazaki, K; Yokoji, M; Yoshie, H1
Cao, C; Hai, T; Hong, Q; Huang, J; Jia, Q; Li, Y; Liu, F; Liu, Z; Luo, A; Meng, A; Qin, G; Shi, G; Wang, H; Wang, X; Wang, Y; Wei, H; Xue, Y; Yao, J; Ying, H; Zhang, N; Zhang, R; Zhang, Y; Zhao, J; Zheng, Q; Zhou, Q1
Brown, SD; Cox, RD; Gorvin, CM; Hannan, FM; Hough, TA; Howles, SA; Nesbit, MA; Paudyal, A; Piret, SE; Stewart, M; Thakker, RV; Wells, S1
Cao, C; Chen, ZY; Guo, W; Hai, T; Hong, Q; Huang, J; Jia, Q; Jin, W; Li, Y; Luo, A; Meng, A; Qi, M; Qin, G; Shang, H; Wang, D; Wang, H; Wang, X; Wei, H; Yang, S; Yao, J; Zhang, H; Zhang, R; Zhang, T; Zhang, Y; Zhao, J; Zheng, Q; Zhou, Q1
Adams, DJ; Beltran, S; Breuss, M; Dürnberger, G; Edwards, A; Flint, J; Gstrein, T; Gut, I; Gut, M; Hansen, AH; Hochstoeger, T; Honzik, T; Keane, TM; Keays, DA; Kmoch, S; Landler, L; Leca, I; Mechtler, K; Pilat-Carotta, S; Přistoupilová, A; Repic, M; Rosoklija, G; Sherr, E; Stránecký, V; Traunbauer, AK; Tripathy, R; Zuber, J1
Do, HJ; Kim, KY; Ma, JY; Oh, TW; Park, KI1
Brown, FC; Burgio, G; Conway, AJ; Curtis, DJ; Foote, SJ; Hortle, EJ; Jane, SM; Morton, CJ1
Cleuren, AC; Ginsburg, D; Kotnik, EN; Saunders, TL; Siemieniak, DR; Tomberg, K; Westrick, RJ; Zhu, G1
Belz, GT; Bouillet, P; Goodnow, CC; Gray, DH; Horikawa, K; Kofler, J; Milla, L; O'Reilly, LA; Policheni, A; Strasser, A1
Abdelhamed, Z; Beier, DR; Bittermann, E; Liegel, RP; Menke, C; Stottmann, RW; Timms, A1
Abud, HE; Arkell, RM; Bagheri-Fam, S; Bertram, JF; Caruana, G; Cole, TJ; Dobbie, MS; Farlie, PG; Gordon, CT; Harley, VR; Hart, AH; Miller, KA; Smyth, IM; Wallace, MJ; Whittle, B1
Dahl, HH; Manji, SS; Miller, KA; Williams, LH1
Akiyama, T; Gondo, Y; Ikeda, A; Inoue, M; Kanda, H; Kaneda, H; Karashima, Y; Masuya, H; Matsui, J; Minowa, O; Miura, I; Motegi, H; Noda, T; Shiroishi, T; Suzuki, T; Toki, H; Wakana, S; Yamamoto, N; Yao, R1
Fischer, C; Grabellus, F; Kindler-Röhrborn, A; Koelsch, B; Kutritz, A; van den Berg, L1
Collins, D; Elbaz, B; Gomez, CM; Kidd, GJ; Millen, KJ; Popko, B; Traka, M1
Aizawa-Abe, M; Aotani, D; Ebihara, C; Ebihara, K; Hosoda, K; Kusakabe, T; Mashimo, T; Nakao, K; Sakai, T; Serikawa, T; Takizawa, A; Tomita, T; Yamamoto, Y; Yamamoto-Kataoka, S1
Ackerman, SL; Liu, Y; Orlowski, J; Zaun, HC1
Bouriez-Jones, T; Bull, KR; Chaudhry, S; Cornall, RJ; Crockford, TL; Goodnow, CC; Hough, TA; Mason, T; Rimmer, AJ; Roberts, IS; Silver, KL1
Bentley, L; Brown, MA; Brown, SD; Cox, RD; Croucher, PI; Esapa, CT; Evans, H; Fraser, WD; Hannan, FM; Head, RA; Hough, TA; Lath, D; Nesbit, MA; Podrini, C; Scudamore, CL; Thakker, RV1
Anderton, S; Chen, G; Devine, W; Francis, R; Kim, AJ; Kim, Y; Leatherbury, L; Liu, X; Lo, CW; Morgan, J; Pratt, HC; Ramirez, R; Reinholdt, L; Subramanian, R; Tobita, K; Wong, L1
Gondo, Y; Hida, A; Iwayama, Y; Mishima, K; Murata, T; Ohba, H; Ohnishi, T; Watanabe, A; Yoshikawa, T1
Kuramoro, T; Mashimo, T; Ohno, Y; Sasa, M; Serikawa, T; Voigt, B1
Cheng, CY; Fann, MJ; Hong, CJ; Kao, LS; Liou, YJ; Nian, FS; Tai, CY; Tsai, JW; Tsai, SJ; Wu, JC; Wu, PC1
Babinsky, VN; Brown, MA; Brown, SD; Cox, RD; Croucher, PI; Esapa, CT; Hannan, FM; Potter, P; Thakker, RV; Thomas, GP1
Abumrad, NN; Baek, JI; Choi, SY; Ess, KC; Flynn, CR; Gamse, JT; Hardiman, G; Kim, SH; Lipschutz, JH; Rockey, DC; Su, Y; Wu, SY1
Abe, K; Imai, K; Ishikawa, K; Lisse, T; Lisse, TS; Mashimo, T; Sakurai, Y; Serikawa, T; Takamatsu, N; Tanimoto, S; Tsurumi, T1
Beutler, B; Bull, KR; Kumar, S; Mallon, AM; Moresco, EM; Potter, PK; Simon, MM1
Dadras, SS; Dionne, LA; Fairfield, H; Potter, CS; Pratt, CH; Sundberg, JP1
Chen, B; Ouyang, HL; Wang, WH; Xue, ZF; Yan, LN; Yang, B; Yin, YH1
Cervantes-Ríos, E; Cortés-Barberena, E; Del Carmen García-Rodríguez, M; Ortiz-Muñiz, R; Pacheco-Martínez, MM; Rodríguez-Cruz, L1
Gratzinger, D; Johnson, C; Jonas, BA; Majeti, R1
Huang, YC; Lee, WH; Liu, SC; Liu, SJ; Su, CH; Tseng, YY; Wang, YC; Yang, ST1
Alexandrov, VA; Baranenko, DA; Bespalov, VG; Kostikova, VА; Vysochina, GI1
Brown, MA; Brown, SD; Cox, RD; Croucher, PI; Esapa, CT; Loh, NY; Nesbit, MA; Piret, SE; Thakker, RV; Thomas, G1
Cruz, CC; Hagiwara, MK; Maiorka, PC; Massironi, SM; Miyashiro, SI; Mori, CM1
Ahituv, N; Durgin, RS; Foreman, O; Magnani, PA; Paigen, B; Peters, LL; Savage, H; Svenson, KL1
Bachman, S; Breyer, MD; Davis, LS; Dikov, MM; Dunn, SR; Harris, RC; Ishibashi, K; Kadkina, V; Khuchua, Z; Rinchik, EM; Tchekneva, EE1
Gondo, Y2
Bahlo, M; Collinge, JE; de Graaf, CA; Ellis, S; Hacking, DF; Hilton, AA; Hilton, DJ; Kile, BT; Meikle, PJ; Mukhamedova, N; Satterley, K; Slattery, K; Smyth, I; Sviridov, D1
Beier, DR; Fernandez, L; Marchuk, DA; Moran, JL; Rockman, HA1
Bosman, EA; Fuchs, H; Hrabé de Angelis, M; Quint, E; Steel, KP1
Budde, B; Esposito, I; Fuchs, H; Graw, J; Hrabé de Angelis, M; Löster, J; Michel-Soewarto, D; Nürnberg, P; Puk, O; Söker, T; Wolf, E1
Fan, L; Harris, LC; Rehg, JE; Schuster, K; Volk, EL1
Kwiatkowski, D; Lane, H; Malinowska-Kolodziej, I; Pollizzi, K; Stumm, M1
Ahmad, N; Calzada-Wack, J; Dalke, C; de Angelis, MH; Graw, J; Klaften, M; Puk, O; Wagner, S1
Albertson, DG; Bacher, JW; Clipson, L; Dove, WF; Halberg, RB; Petrini, JH; Pitot, HC; Prunuske, AJ; Rasmussen, K; Sullivan, R; Waggoner, J; Washington, MK; White, A1
Argandoña, EG; Bengoetxea, H; Bulnes, S; Lafuente, JV; Leis, O; Ortuzar, N1
Chang, C; Chang, CP; Chen, YH; Chen, YT; Chern, Y; Hung, SI; Kuo, LT; Lee, MJ; Lee, YH; Stephenson, D; Tseng, HW; Tung, YY; Wu, JY; Wu, MT; Wu, YC1
Brown, SD; Hardisty-Hughes, RE; Parker, A1
Beier, DR; Bjork, BC; Hentges, KE; Justice, MJ; Kamp, A; Moran, J; Moskowitz, IP; Peterson, MA; Rajapaksha, TW; Seidman, CE; Seidman, JG; Svenson, KL1
Dasenbrock, C; Ernst, H; Hansen, V; Streckert, J; Taugner, F; Tillmann, T; Zhou, Y1
Barth, RF; Chou, TC; Elleaume, H; Grecula, JC; Gupta, N; Hoff, BA; Huo, T; Ross, BD; Rousseau, J; Weldon, M; Yang, W1
Damrau, C; Dean, CH; Ermakov, A; Formstone, C; Henderson, DJ; Lalanne, Z; Lu, X; Murdoch, JN; Norris, DP; Patterson, VL; Paudyal, A; Wells, S1
Becker, L; Calzada-Wack, J; Esposito, I; Fuchs, H; Hrabé de Angelis, M; Klein-Rodewald, T; Neff, F; Rosemann, M; Silva-Buttkus, P; Tost, M; Wagner, S1
Giraud, AS; Judd, LM; Kalantzis, A; Nguyen, N; van Driel, IR; Whittle, B1
Agoulnik, AI; Barrett, T; Bathgate, RA; Emge, D; Finlayson, C; Fisher, L; Harris, RM; Hurley, L; Jameson, JL; Weiss, J1
Beuschlein, F; Bidlingmaier, M; Gomez-Sanchez, C; Hrabé de Angelis, M; Manolopoulou, J; Rathkolb, B; Reincke, M; Spyroglou, A; Wagner, S; Wolf, E1
Cornall, RJ; Goodnow, CC; Lambe, T; Randall, KL1
Adamson, SL; Anderson, N; Barber, DL; Berberovic, Z; Birkenmeier, CS; Flenniken, A; Garcha, K; Haddon, DJ; Hughes, MR; Maltby, S; McNagny, KM; Minden, MD; Osborne, LR; Paulson, RF; Peters, LL; Rossant, J; Stanford, WL; Wang, C; Wong, J1
Ahmad, N; Graw, J; Hrabé de Angelis, M; Puk, O; Wagner, S1
Andreeva, V; Burt, J; Cardarelli, J; Connolly, MH; Fraher, D; Stewart-Swift, C; Yelick, PC1
Gao, X; Gu, X; Wang, Z; Xiong, X; Xu, L1
Hicks, WL; LaVail, MM; Maddox, DM; Naggert, JK; Nishina, PM; Vollrath, D1
Furuichi, T; Ikegawa, S; Imaizumi, K; Kudo, T; Masuya, H; Murakami, T; Nishida, K; Nishimura, G; Ohkawa, K; Suzuki, T; Wakana, S1
Aigner, B; Hrabé de Angelis, M; Klaften, M; Klempt, M; Laufs, J; Michel, D; Rathkolb, B; Schneider, B; Sedlmeier, R; Wagner, S; Wolf, E1
Ahmad, N; de Angelis, MH; Graw, J; Puk, O; Wagner, S1
Chen, TH; Chen, YT; Huang, CC; Kao, HJ; Lin, WD; Sabbagha, NG; Tarn, WY; Tsai, FJ; Wu, JY; Yang, CF1
Beutler, B; Du, X; Krebs, P; Krieg, L; Milstein, O; Xia, Y1
Douni, E; Eliopoulos, E; Kollias, G; Makrinou, E; Penninger, JM; Rinotas, V; Schett, G; Zwerina, J1
Furuse, T; Kaneda, H; Kobayashi, K; Kushida, T; Masuya, H; Miura, I; Wada, Y; Wakana, S; Yamada, I; Yuasa, S1
Hicks, W; Naggert, JK; Nishina, PM; Shi, LY; Wang, J; Won, J1
Baulac, S; Ishida, S; Kaneko, S; Kuwamura, M; Mashimo, T; Nishio, T; Ohno, Y; Sakamoto, Y; Serikawa, T; Takizawa, A1
Gondo, Y; Miyakawa, T; Shoji, H; Takamiya, Y; Toyama, K; Wakana, S1
Benet-Pagès, A; Calzada-Wack, J; Cohrs, CM; Eck, S; Esposito, I; Favor, J; Fuchs, H; Hans, W; Hrabě de Angelis, M; Klaften, M; Lorenz-Depiereux, B; Rathkolb, B; Rubio-Aliaga, I; Sabrautzki, S; Seedorf, H; Strom, TM; Wolf, E1
Adamson, SL; Aubin, JE; Chen, F; Flenniken, AM; Ichikawa, S; Osborne, LR; Owen, C; Rossant, J1
Chang, WP; Chen, TC; Hsieh, ST; Hsu, PN; Shyu, BC; Wu, JJ1
Cone, FE; Graw, J; Nguyen, C; Nguyen, TD; Oglesby, EN; Pease, ME; Puk, O; Quigley, HA; Steinhart, MR1
Andrews, TD; Balakishnan, B; Beutler, B; Cho, V; Enders, A; Field, MA; Goodnow, CC; Hager, J; Kirk, M; Shao, Y; Singh, M; Sjollema, G; Whittle, B; Winslade, S; Xia, Y; Zhang, Y1
Geghman, K; Li, C; Shenoy, S; Zheng, S1
Brown, MA; Brown, SD; Carr, AJ; Cheeseman, MT; Cox, RD; Croucher, PI; Esapa, CT; Evans, H; Head, RA; Hough, TA; Jeyabalan, J; McNally, EG; Thakker, RV; Thomas, GP1
Brown, FC; Collinge, JE; Curtis, DJ; Jane, SM; Kile, BT; Rank, G; Scott, N; Vadolas, J; Vickaryous, N; Whitelaw, E; Whitelaw, N1
Bosman, EA; Estabel, J; Ismail, O; Podrini, C; Steel, KP; White, JK1
Cohen, HJ; Jang, T; Lau, K; Merchant, M; Recht, B; Recht, L; Whitin, JC; Yu, TT1
Bertram, EM; Beutler, B; Brown, SD; Bull, KR; Cornall, RJ; Crockford, TL; Enders, A; Goodnow, CC; Lunter, G; Mallon, AM; Miosge, LA; Potter, PK; Rimmer, AJ; Roots, CM; Siggs, OM; Simon, MM; Whittle, B1
Brown, SD; Clements, S; Cox, RD; Fisher, EM; Glenister, PH; Goldsworthy, M; Gray, IC; Hough, TA; Hunter, AJ; Martin, JE; McCormack, SL; Moir, L; Nolan, PM; Peters, J; Rastan, S; Selley, RL; Spurr, N; Strivens, MA; Toye, AA; Tsipouri, V; Vizor, L; Wood, J1
Brown, SD; Hardisty, RE1
Bartleman, AP; Boyonoski, AC; Kirkland, JB; Spronck, JC1
Cordes, SP; Kim, DY; Pawson, CT; Weiss, KC1
Bjerkvig, R; Enger, PO; Ersland, L; Huszthy, PC; Lund-Johansen, M; Lundervold, A; Nordli, H; Standnes, T; Thorsen, F1
Grosse, J; Nehls, MC; Peters, T; Popp, A; Russ, A; Schlueter, V; Sedlmeier, R; Thaete, C; Wolf, S1
Chen, YT; Hillman, S; Kao, HJ; Li, SC; Millington, D; Stevens, R; Wu, JY1
Adachi, T; Fujimoto, N; Gondo, Y; Inoue, A; Inoue, M; Ishijima, J; Kadowaki, T; Kagami, T; Kaneda, H; Kasuga, M; Kubota, N; Masuya, H; Matsui, J; Matsumoto, R; Minowa, O; Miwa, I; Motegi, H; Noda, T; Sakuraba, Y; Shigeyama, Y; Shiroishi, T; Suzuki, T; Terauchi, Y; Toki, H; Toyoda, Y; Tsuchihashi, K; Wakana, S1
Chaudhuri, S; Duttagupta, AK; Ghosh, A; Mukherjee, J; Sarkar, S1
Zhang, YF; Zhang, ZY1
Bentley, L; Browne, M; Cox, RD; Goldsworthy, M; Haynes, A; Hough, T; Hugill, A; Hunter, AJ; Mijat, V; Moir, L; Quarterman, J; Spurr, N; Toye, AA1
Gu, MM; Kong, H; Lu, SY; Lu, ZY; Sun, YP; Tan, Y; Wang, L; Wang, Y; Wang, ZG1
Açil, Y; Albers, HK; Fuchs, H; Grundner-Culemann, E; Hrabe de Angelis, M; Reis, A; Seedorf, H; Springer, IN1
Aigner, B; de Angelis, MH; Klempt, M; Mohr, M; Rathkolb, B; Wolf, E1
Li, HD; Liu, J; Mao, HH; Shao, YX; Tang, D; Wu, BJ; Xue, ZF1
Chernik, IaI; Maksimiv, DV; Matiĭtsiv, NP; Shcherbata, GR1
Carlson, GA; Clark, AT; Frankel, WN; Goldowitz, D; Justice, MJ; Nadeau, JH; Peters, LL; Rossant, J; Siepka, SM; Takahashi, JS; Vitaterna, MH1
Behringer, RR; Conn, PM; Hess, DL; Janovick, JA; Justice, MJ; Kaiser, UB; Kanasaki, H; Pask, AJ; Stockton, DW1
Doi, K; Katayama, K; Nagata, T; Nakayama, H; Ueno, M; Yamauchi, H1
Fujimoto, N; Gondo, Y; Ishijima, J; Kaneda, H; Kawai, A; Kobayashi, K; Maeda, T; Masuya, H; Miura, I; Nagano, J; Noda, T; Sakuraba, Y; Sezutsu, H; Shimizu, A; Shimizu, K; Shiroishi, T; Wakana, S1
Gondo, Y; Sakuraba, Y1
Chaudhuri, S; Duttagupta, AK; Ghosh, A; Mazumdar, M; Mukherjee, J; Sarkar, P; Sarkar, S1
Aigner, B; Hrabé de Angelis, M; Klempt, M; Rathkolb, B; Tran, TV; Wanke, R; Wolf, E1
Brunt, EM; Di Bisceglie, AM; Osmack, P1
Beutler, B; Ding, L; Du, X; Gong, X; Horwitz, J; Huang, Q; Liu, H; McDonald, HW; Wang, M; Yates, JR1
Beynon, AJ; Croes, HJ; Cuppen, E; Fransen, JA; Guryev, V; Mul, JD; Peters, TA; Plasterk, RH; Smits, BM1
Dalke, C; Favor, J; Goldowitz, D; Graw, J; Jablonski, MM; Lu, L; Manly, KF; Pardue, MT; Pretsch, W; Rinchik, EM; Wang, X; Williams, RW1
Gekakis, N; Hall, FW; Lloyd, DJ; Tarantino, LM1
Cross, SH; Gautier, P; Hart, AW; Jackson, IJ; McKie, L; Morgan, JE; West, K1
Adamson, SL; Anderson, N; Aubin, JE; Bai, D; Bruneau, BG; Ciliberti, N; Fleming, C; Flenniken, AM; Gittens, JE; Gong, XQ; Grynpas, M; Henderson, JE; Henkelman, RM; Kelsey, LB; Kidder, GM; Laird, DW; Lounsbury, C; McKerlie, C; Moreno, L; Nieman, BJ; Osborne, LR; Peterson, K; Qu, D; Roscoe, W; Rossant, J; Shao, Q; Sled, JG; Stanford, WL; Tong, D; Veitch, GI; Voronina, I; Vukobradovic, I; Wood, GA; Zhu, Y; Zirngibl, RA1
Hioki, K; Hirose, M; Ishii, Y; Kanki, K; Kodama, Y; Kuroiwa, Y; Kurokawa, Y; Nishikawa, A; Nomura, T; Umemura, T1
Atsawasuwan, P; Ball, ST; Beason, DP; Birk, DE; Christner, PJ; Gentiletti, J; Peters, J; Soslowsky, LJ; Yamauchi, M1
Cools, AR; Cuppen, E; Ellenbroek, BA; Guryev, V; Homberg, J; Mudde, JB; Olivier, J; Plasterk, RH; Smits, BM; van de Belt, J; Verheul, M1
Cuppen, E; Smits, BM1
Duong, T; Jang, T; Kim, S; Lapointe, D; Litofsky, NS; Low, HP; Recht, L; Ross, AH; Savarese, T; Vogel, H; Weimann, JM1
Augustin, M; Biebermann, H; Grosse, J; Huffstadt, U; Korthaus, D; Nehls, M; Römpler, H; Schneider, B; Schöneberg, T; Sedlmeier, R; Tarnow, P; Wattler, S1
Handel, MA; Lessard, C; Lothrop, H; Schimenti, JC1
Babu, PP; Bhaskara, VK; Sundaram, C1
Goldowitz, D; Guo, YK; Kermany, MH; Miller, D; Parker, LL; Swanson, DJ; Yoo, TJ; Zuo, J1
Abe, K; Fuchs, H; Hans, W; Hrabé de Angelis, M; Lisse, T1
Breyer, MD; Davis, LS; Dunn, SR; Fogo, AB; Kadkina, V; Mohamed, Y; Polosukhina, D; Qi, Z; Rinchik, EM; Sharma, K; Tchekneva, EE1
Chiang, YJ; Huang, HW; Hung, SI; Li, CL; Yen, JJ1
Beutler, B; Chang, B; Cheung, D; Du, X; Gong, X; Liu, H; Park, A; Wang, M; Xia, CH; Yang, Y1
Avenarius, M; Bailey, JS; Banan, R; Federe, GC; Grabowski-Boase, L; Grillet, N; Hice, R; Housley, GD; Keithley, EM; Lagler, EA; Müller, U; Najmabadi, H; Ryan, AF; Schwander, M; Sczaniecka, A; Smith, RJ; Steffy, BM; Tarantino, LM; Wiltshire, T1
Beier, DR; Cockroft, JL; Goldowitz, D; Matera, I; Moran, JL; Pavan, WJ1
Aigner, B; Hrabé de Angelis, M; Klempt, M; Mohr, M; Rathkolb, B; Wolf, E1
Bergstrom, DE; Gagnon, LH; Johnson, KR; Longo-Guess, C1
Beutler, B; Chang, B; Cheng, C; Cheung, D; Du, X; Gong, X; Liu, H; Wang, M; Xia, CH1
Chang, C; Hsu, YH; Jang, T; Merchant, M; Recht, B; Recht, L; Sathy, B1
Abbasi, AR; Akiyama, K; Khalaj, M; Kunieda, T; Nishimura, R; Noguchi, J; Okuda, K; Tsuji, T1
Cuppen, E; de Bruin, A; Korving, J; Smits, BM; Toonen, PW; van Boxtel, R; van Roekel, HS; Verheul, M1
Hirabayashi, M; Kato, M; Kuramoto, T; Mashimo, T; Nakajima, R; Serikawa, T; Takizawa, A; Tokuda, S; Voigt, B; Yanagihara, K1
Douglas, DS; Popko, B1
Blasberg, RG; Groothuis, DR; Molnar, P1
Fox, RR; Hard, GC2
Raĭkhlin, NT; Timoshenko, IV; Turusov, VS1
Jänisch, W; Schmidt, T1
Deen, DF; Tofilon, PJ1
Paoletti, P; Schiffer, D1
Cravioto, H; Ransohoff, J; Yoshida, J1
Becci, PJ; Grubbs, CJ; Moon, RC; Thompson, HJ1
Fiebig, HH; Schmähl, D; Strobel, H1
McDonald, JD1
Shima, A; Shimada, A1
Shibutani, M1
de Wind, N; Dekker, M; te Riele, H; van der Valk, M; van Rossum, A1
Brown, SD1
Blain, F; Chang, TM; Heft, R; Peevers, R; Sarkissian, CN; Scriver, CR; Shao, Z; Su, H1
Adey, WR; Byus, CV; Cain, CD; Haggren, W; Higgins, RJ; Jones, RA; Kean, CJ; Kuster, N; MacMurray, A; Phillips, JL; Stagg, RB; Zimmerman, G1
Bradley, A; Justice, MJ; Noveroske, JK; Weber, JS; Zheng, B1
Al-Dhalimy, M; Finegold, M; Grompe, M; Manning, K1
Balling, R; Fella, C; Fuchs, H; Graw, J; Hrabé de Angelis, M; Jung, M; Klopp, N; Löster, J; Reis, A; Soewarto, D; Wolf, E1
Brown, SD; Hunter, AJ; Nolan, PM1
Balling, R; Fella, C; Heffner, S; Hrabé de Angelis, M; Marschall, S; Pargent, W; Rathkolb, B; Soewarto, D; Teubner, A; Wolf, E1
Knapik, EW1
Favor, J; Neuhäuser-Klaus, A1
Alessandrini, F; Balling, R; Behrendt, H; Decker, T; Fella, C; Flaswinkel, H; Hrabé de Angelis, M; Jakob, T; Kremmer, E; Marschall, S; Pfeffer, K; Rathkolb, B; Ring, J; Servatius, A; Soewarto, D; Wolf, E1
Balling, R; Fuchs, H; Hrabé de Angelis, M; Schughart, K; Wolf, E1
Fella, C; Gomolka, M; Hrabé de Angelis, M; Jung, T; Lobenwein, K; Pargent, W; Schindewolf, C; Singh, N; Soewarto, D; Trinczek, K1
Brown, SD; Hardisty, RE; Mburu, P1
Hrabé de Angelis, M; Strivens, M1
Blaivas, M; Kish, PE; McMahon, G; Muraszko, KM; Ross, BD; Ross, DA; Strawderman, M1
Boyonoski, AC; Gallacher, LM; Jacobs, RM; Kirkland, JB; Poirier, GG; Shah, GM; Spronck, JC1
Hardisty, R; Hough, T; Hunter, AJ; Nolan, PM; Thaung, C1
Arnold, K; Brown, SD; Clark, BJ; Cross, SH; Hunter, AJ; Jackson, IJ; McKie, L; Morgan, JE; Nolan, PM; Peters, J; Thaung, C; West, K1
Anisimov, VN; Beniashvili, DSh1
Falk, HL; Hudson, PM; Jurgelski, W; Kotin, P1
Swenberg, JA1
Cravioto, H; Yoshida, J1
Das, GD; Pfaffenroth, MJ1
Alexandrov, VA1
Fujiwara, K; Hirayama, A; Matsumoto, S; Shirataki, K; Yamasaki, S1
Aleksandrov, VA; Bespalov, VG; Petrov, AS; Troian, DN1
Kroh, H1
Hara, M; Kasuga, T; Nakamura, T2
Bode, VC; Dove, WF; McDonald, JD; Shedlovsky, A1
Giaccone, G; Giordana, MT; Mauro, A; Migheli, A; Pezzotta, S; Schiffer, D1
Cardesa, A; Mohr, U; Palacín, A; Ribalta, T; Von Schilling, B1
Hasgekar, NN; Lalitha, VS; Pendse, AM1
Hard, GC2
Barnett, LB; Erickson, RP; Lewis, SE; Tashian, RE; Venta, PJ1
Holzgraefe, M; Mennel, HD; Rama, B; Spoerri, O1
Koestner, A1

Reviews

19 review(s) available for ethylnitrosourea and Disease Models, Animal

ArticleYear
Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:9

    Topics: Animals; Breeding; Disease Models, Animal; Ethylnitrosourea; Gene Expression Regulation; Genetic Testing; Humans; Mice; Mutagenesis; Mutagens; Mutation; Phenotype; Research Design; Signal Transduction; Skin; Skin Diseases

2019
Advances on genetic rat models of epilepsy.
    Experimental animals, 2015, Volume: 64, Issue:1

    Topics: Animals; Disease Models, Animal; Epilepsy; Ethylnitrosourea; Genetic Engineering; Genetic Predisposition to Disease; Genome; Intercellular Signaling Peptides and Proteins; Kv1.1 Potassium Channel; Models, Genetic; Mutagenesis; Mutation, Missense; NAV1.1 Voltage-Gated Sodium Channel; Phenotype; Proteins; Rats

2015
Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2015, Volume: 26, Issue:9-10

    Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Genome; High-Throughput Nucleotide Sequencing; Mice; Mutagenesis; Mutation

2015
Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
    Nature reviews. Genetics, 2008, Volume: 9, Issue:10

    Topics: Animals; Databases, Genetic; Disease Models, Animal; Ethylnitrosourea; Genomics; Mice; Mice, Transgenic; Models, Biological; Mutagenesis; Neoplasms

2008
Now and future of mouse mutagenesis for human disease models.
    Journal of genetics and genomics = Yi chuan xue bao, 2010, Volume: 37, Issue:9

    Topics: Amino Acid Sequence; Animals; Base Sequence; Disease Models, Animal; Ethylnitrosourea; Gene Knockout Techniques; Genomics; Humans; Mice; Molecular Sequence Data; Mutagenesis; Phenotype

2010
Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease.
    American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 300, Issue:1

    Topics: Animals; Breeding; Disease Models, Animal; Ethylnitrosourea; Female; Genes; Genome; Genome-Wide Association Study; Inflammatory Bowel Diseases; Male; Mice; Mutagenesis; Phenotype

2011
The essential role of DOCK8 in humoral immunity.
    Disease markers, 2010, Volume: 29, Issue:3-4

    Topics: Animals; Antibodies; B-Lymphocytes; Disease Models, Animal; Ethylnitrosourea; Genome-Wide Association Study; Germinal Center; Guanine Nucleotide Exchange Factors; Immunity, Humoral; Immunologic Deficiency Syndromes; Immunologic Memory; Immunological Synapses; Male; Mice; Mice, Inbred C57BL; Mutation

2010
Retake the center stage--new development of rat genetics.
    Journal of genetics and genomics = Yi chuan xue bao, 2012, Jun-20, Volume: 39, Issue:6

    Topics: Animals; Animals, Genetically Modified; Chromosomes, Artificial, Bacterial; Disease Models, Animal; DNA Transposable Elements; Embryonic Stem Cells; Ethylnitrosourea; Gene Targeting; Humans; Mutagenesis; Rats; Retroelements; Zinc Fingers

2012
Mutagenesis strategies for identifying novel loci associated with disease phenotypes.
    Seminars in cell & developmental biology, 2003, Volume: 14, Issue:1

    Topics: Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Genomics; Mice; Mutagenesis; Phenotype

2003
Implementing large-scale ENU mutagenesis screens in North America.
    Genetica, 2004, Volume: 122, Issue:1

    Topics: Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Female; Male; Mice; Mutation; National Institutes of Health (U.S.); Nervous System Diseases; Phenotype; United States

2004
[ENU mouse mutagenesis and advanced reverse genetics].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2004, Volume: 49, Issue:17 Suppl

    Topics: Animals; Base Sequence; Disease Models, Animal; Electrophoresis, Capillary; Ethylnitrosourea; Female; Gene Library; Genetic Techniques; Genetic Testing; Genetics; Genome; Heteroduplex Analysis; Humans; Male; Mice; Mice, Mutant Strains; Mutagenesis; Phenotype; Point Mutation; Semen Preservation; Sequence Analysis, DNA

2004
Rat genetics: the next episode.
    Trends in genetics : TIG, 2006, Volume: 22, Issue:4

    Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Ethylnitrosourea; Gene Silencing; Genetic Research; Genetic Techniques; Humans; Mutagenesis; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable; Rats; Recombination, Genetic; RNA, Small Interfering

2006
Mouse forward genetics in the study of the peripheral nervous system and human peripheral neuropathy.
    Neurochemical research, 2009, Volume: 34, Issue:1

    Topics: Alleles; Animals; Charcot-Marie-Tooth Disease; Disease Models, Animal; Ethylnitrosourea; Female; Forelimb; Humans; Immunogenetics; Leukodystrophy, Globoid Cell; Male; Mice; Mice, Mutant Strains; Mice, Neurologic Mutants; Muscular Dystrophies; Mutation; Peripheral Nervous System; Peripheral Nervous System Diseases; Phenotype

2009
Using high-efficiency mouse germline mutagenesis to investigate complex biological phenomena: genetic diseases, behavior, and development.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1995, Volume: 209, Issue:4

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Embryonic and Fetal Development; Ethylnitrosourea; Genes; Genetic Diseases, Inborn; Germ-Line Mutation; Humans; Mice; Mutagenesis

1995
Mouse models of genetic disease: new approaches, new paradigms.
    Journal of inherited metabolic disease, 1998, Volume: 21, Issue:5

    Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Genetic Diseases, Inborn; Humans; Mice; Mice, Mutant Strains; Mutagenesis; Mutagens; Phenotype

1998
Mouse ENU mutagenesis.
    Human molecular genetics, 1999, Volume: 8, Issue:10

    Topics: Animals; Biological Specimen Banks; Databases, Factual; Disease Models, Animal; Ethylnitrosourea; Genetic Diseases, Inborn; Genetic Testing; Humans; Mice; Mutagenesis; Phenotype

1999
Towards new models of disease and physiology in the neurosciences: the role of induced and naturally occurring mutations.
    Human molecular genetics, 2000, Apr-12, Volume: 9, Issue:6

    Topics: Animals; Behavior, Animal; Central Nervous System Diseases; Disease Models, Animal; Ethylnitrosourea; Mice; Mutagenesis; Mutation; Neurophysiology; Phenotype

2000
ENU mutagenesis in zebrafish--from genes to complex diseases.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2000, Volume: 11, Issue:7

    Topics: Alkylating Agents; Animals; Disease Models, Animal; Ethylnitrosourea; Genetic Diseases, Inborn; Genetic Testing; Mutagenesis; Mutagens; Zebrafish

2000
Chemical- and virus-induced brain tumors.
    National Cancer Institute monograph, 1977, Volume: 46

    Topics: Adenoviridae; Alkylation; Alpharetrovirus; Animals; Brain Neoplasms; Carcinogens; Disease Models, Animal; DNA, Neoplasm; Ethylnitrosourea; Humans; Methylnitrosourea; Neoplasms, Experimental; Oncogenic Viruses; Papillomaviridae; Polycyclic Compounds; Polyomaviridae; Retroviridae; Tumor Virus Infections

1977

Other Studies

181 other study(ies) available for ethylnitrosourea and Disease Models, Animal

ArticleYear
Immunotherapeutic potential of ethanolic olive leaves extract (EOLE) and IL-28B combination therapy in ENU induced animal model of leukemia.
    Cytokine, 2022, Volume: 156

    Topics: Animals; Cytokines; Disease Models, Animal; Ethylnitrosourea; Immunotherapy; Interferon-gamma; Leukemia; Mice; Olea; Plant Extracts

2022
Finding the
    Genes, 2020, 01-11, Volume: 11, Issue:1

    Topics: Aldehyde Oxidoreductases; Animals; Cleft Lip; Cleft Palate; Disease Models, Animal; Ethylnitrosourea; Mice; Mice, Mutant Strains; Mutagenesis; Mutation, Missense; Transcription Factors

2020
An Animal Model Further Uncovers the Role of Mutant Braf
    The American journal of pathology, 2020, Volume: 190, Issue:3

    Topics: Alleles; Amino Acid Substitution; Animals; Carcinoma, Papillary; Disease Models, Animal; Ethylnitrosourea; Exons; Female; Humans; Immunohistochemistry; Male; Mutation; Prognosis; Proto-Oncogene Proteins B-raf; Rats; Sequence Analysis, DNA; Thyroid Cancer, Papillary; Thyroid Neoplasms

2020
Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas.
    Brain research bulletin, 2021, Volume: 168

    Topics: Aminopeptidases; Animals; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Male; Rats, Wistar; Renin-Angiotensin System; Sex Characteristics

2021
Environmental pollutant ENU induced leukemic NF-kB signaling amelioration by
    International journal of environmental health research, 2022, Volume: 32, Issue:11

    Topics: Animals; Disease Models, Animal; Eclipta; Environmental Pollutants; Ethylnitrosourea; Leukemia; Mice; Neoplasms; NF-kappa B; Pesticides; Plant Extracts

2022
Hematopathological alterations of major tumor suppressor cascade, vital cell cycle inhibitors and hematopoietic niche components in experimental myelodysplasia.
    Chemico-biological interactions, 2017, Aug-01, Volume: 273

    Topics: Animals; Cell Cycle; Disease Models, Animal; Ethylnitrosourea; Female; Glycogen Synthase Kinase 3 beta; Hematopoietic Stem Cells; Male; Membrane Potential, Mitochondrial; Mice; Myelodysplastic Syndromes; Stem Cell Niche; Tumor Suppressor Proteins

2017
A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen.
    Disease models & mechanisms, 2017, 08-01, Volume: 10, Issue:8

    Topics: Anemia, Hypochromic; Animals; Base Sequence; Biosynthetic Pathways; Coproporphyria, Hereditary; Coproporphyrinogen Oxidase; Disease Models, Animal; Ethylnitrosourea; Fasting; Feces; Female; Heme; Male; Mice, Mutant Strains; Mutagenesis; Mutation; Phenobarbital; Phenotype; Pregnancy

2017
A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.
    PLoS genetics, 2017, Volume: 13, Issue:8

    Topics: Alleles; Animals; Chromosome Mapping; Chronic Disease; Disease Models, Animal; Ear, Middle; Ethylnitrosourea; Female; Genotyping Techniques; Heterozygote; Homozygote; Humans; Imidazoline Receptors; Inflammation; Integrin alpha6; Intracellular Signaling Peptides and Proteins; Lim Kinases; Male; Mice; Mice, Knockout; Mutation, Missense; Neuropeptides; NF-kappa B; Otitis Media; p21-Activated Kinases; Penetrance; rac1 GTP-Binding Protein; Sequence Analysis, DNA; Up-Regulation; Vascular Endothelial Growth Factor A

2017
An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue.
    Scientific reports, 2017, 09-15, Volume: 7, Issue:1

    Topics: Animals; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Ethylnitrosourea; Humans; Introns; Male; Mice; Mutation; Osteogenesis Imperfecta; RNA Splice Sites; RNA Splicing

2017
Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis.
    Blood, 2017, 11-16, Volume: 130, Issue:20

    Topics: Animals; Congenital Hypothyroidism; Disease Models, Animal; Dual Oxidases; Ethylnitrosourea; Exome Sequencing; Gene Expression Regulation; Genes, Recessive; Hematopoiesis; Hydrogen Peroxide; Kruppel-Like Transcription Factors; Metabolic Networks and Pathways; Mutagenesis, Site-Directed; Mutation; Receptors, Thyroid Hormone; Swine; Thymus Gland; Thyroid Hormones; Zebrafish; Zebrafish Proteins

2017
Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.
    JCI insight, 2017, 10-19, Volume: 2, Issue:20

    Topics: Administration, Oral; Animals; Calcium; Cinacalcet; Disease Models, Animal; Ethylnitrosourea; Female; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Hypercalcemia; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Models, Molecular; Mutation; Parathyroid Hormone; Receptors, Calcium-Sensing; Sequence Alignment; Sequence Analysis, DNA; Serum Albumin; Signal Transduction

2017
Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis.
    Human genetics, 2017, Volume: 136, Issue:11-12

    Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Disease Models, Animal; Ethylnitrosourea; Female; Hearing Loss; Humans; Male; Microphthalmia-Associated Transcription Factor; Mutagenesis; Mutagens; Mutation; Sequence Homology; Swine; Swine, Miniature; Waardenburg Syndrome

2017
Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
    Nature neuroscience, 2018, Volume: 21, Issue:2

    Topics: Alkylating Agents; Animals; Animals, Newborn; Atrophy; Autophagy; Brain; Cell Movement; Disease Models, Animal; Embryo, Mammalian; Ethylnitrosourea; Female; Gene Expression Regulation, Developmental; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurodevelopmental Disorders; Neurons; Signal Transduction; Vacuolar Proton-Translocating ATPases

2018
Leaves of Acer palmatum thumb. Rescues N-ethyl-N-nitrosourea (ENU)-Induced retinal degeneration in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Mar-15, Volume: 42

    Topics: Acer; Administration, Oral; Animals; Disease Models, Animal; Ethylnitrosourea; Glial Fibrillary Acidic Protein; Injections, Intraperitoneal; Male; Mice, Inbred ICR; Nestin; Plant Extracts; Plant Leaves; Plants, Medicinal; Protective Agents; Retina; Retinal Degeneration; Rod Opsins

2018
Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency.
    Disease models & mechanisms, 2018, 05-21, Volume: 11, Issue:5

    Topics: Anemia, Hemolytic; Anemia, Hemolytic, Congenital Nonspherocytic; Animals; Bone Marrow Transplantation; Carbohydrate Metabolism, Inborn Errors; Disease Models, Animal; Erythrocytes; Ethylnitrosourea; Glycolysis; Homozygote; Mice; Mice, Mutant Strains; Mutagenesis; Mutation, Missense; Phenotype; Triose-Phosphate Isomerase

2018
Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.
    PLoS genetics, 2018, Volume: 14, Issue:9

    Topics: Animals; Carrier Proteins; Disease Models, Animal; Ethylnitrosourea; Exome Sequencing; Factor V; Female; Genetic Predisposition to Disease; Heat-Shock Proteins; Humans; Kaplan-Meier Estimate; Lipoproteins; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis; Pedigree; Penetrance; Phospholipase C beta; Venous Thromboembolism

2018
CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3
    Immunology and cell biology, 2019, Volume: 97, Issue:8

    Topics: Animals; CARD Signaling Adaptor Proteins; Dermatitis, Atopic; Disease Models, Animal; Ethylnitrosourea; Forkhead Transcription Factors; Homeostasis; Humans; Introns; Loss of Function Mutation; Mice; Mice, Transgenic; Mutagenesis; Mutagens; Neuropilin-1; Polymorphism, Single Nucleotide; Signal Transduction; T-Lymphocytes, Regulatory

2019
Differential requirements of tubulin genes in mammalian forebrain development.
    PLoS genetics, 2019, Volume: 15, Issue:8

    Topics: Alleles; Animals; CRISPR-Cas Systems; Disease Models, Animal; Embryo, Mammalian; Ethylnitrosourea; Female; Gene Deletion; Gene Editing; Gene Expression Regulation, Developmental; Humans; Male; Malformations of Cortical Development; Mice; Mice, Transgenic; Microtubules; Models, Animal; Mutagenesis; Neurogenesis; Sensorimotor Cortex; Species Specificity; Tubulin

2019
Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Alleles; Animals; Congenital Abnormalities; Disease Models, Animal; DNA Ligase ATP; DNA Ligases; Ethylnitrosourea; Exome; Extracellular Matrix Proteins; Female; Genome-Wide Association Study; Genotype; Germ-Line Mutation; High-Throughput Nucleotide Sequencing; Homozygote; Left-Right Determination Factors; Male; Mice; Mice, Inbred C57BL; Mutagenesis; Mutagens; Phenotype; Polymorphism, Single Nucleotide

2013
Characterization of a novel ENU-generated myosin VI mutant mouse strain with congenital deafness and vestibular dysfunction.
    Hearing research, 2013, Volume: 299

    Topics: Amino Acid Sequence; Animals; Auditory Perception; Base Sequence; Cardiomyopathy, Hypertrophic; Cochlea; Deafness; Disease Models, Animal; Ethylnitrosourea; Genetic Predisposition to Disease; Hearing Tests; Homozygote; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Scanning; Molecular Sequence Data; Mutagens; Mutation; Myosin Heavy Chains; Phenotype; Vestibule, Labyrinth

2013
Novel mouse model for Gardner syndrome generated by a large-scale N-ethyl-N-nitrosourea mutagenesis program.
    Cancer science, 2013, Volume: 104, Issue:7

    Topics: Animals; Codon; Disease Models, Animal; Ethylnitrosourea; Female; Gardner Syndrome; Genes, APC; Genome; Heterozygote; Intestinal Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Mutagenesis; Mutagens; Mutation; Osteoma; Phenotype

2013
Chemically induced rat Schwann cell neoplasia as a model for early-stage human peripheral nerve sheath tumors: phenotypic characteristics and dysregulated gene expression.
    Journal of neuropathology and experimental neurology, 2013, Volume: 72, Issue:5

    Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Staging; Nerve Sheath Neoplasms; Phenotype; Rats; Schwann Cells

2013
WDR81 is necessary for purkinje and photoreceptor cell survival.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Apr-17, Volume: 33, Issue:16

    Topics: Actins; Alkylating Agents; Analysis of Variance; Animals; Animals, Newborn; Calbindins; Cell Line, Transformed; Cell Survival; Cerebellum; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Functional Laterality; Gait Apraxia; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Mitochondria; Mutagenesis; Mutation, Missense; Nerve Tissue Proteins; Nuclear Proteins; Photoreceptor Cells; Prostaglandin-Endoperoxide Synthases; Purkinje Cells; RNA, Messenger; S100 Calcium Binding Protein G; Sequence Analysis, DNA; Transfection

2013
Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver.
    Physiological genomics, 2013, Sep-03, Volume: 45, Issue:17

    Topics: Animals; Codon, Nonsense; Disease Models, Animal; Ethylnitrosourea; Fatty Liver; Gene Expression; Leptin; Lipid Metabolism; Liver; Male; Mice, Mutant Strains; Mutagenesis; Obesity; Rats, Mutant Strains; Real-Time Polymerase Chain Reaction

2013
CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jul-31, Volume: 33, Issue:31

    Topics: Age Factors; Alkylating Agents; Animals; Ataxia; Axons; Calcium-Binding Proteins; Cation Transport Proteins; Cells, Cultured; Cerebellum; Cricetinae; Disease Models, Animal; Ethylnitrosourea; Female; Gene Expression Regulation, Developmental; Homeostasis; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Nerve Tissue Proteins; Point Mutation; Purkinje Cells; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers

2013
Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome.
    The Journal of pathology, 2014, Volume: 233, Issue:1

    Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Eye Abnormalities; Genetic Association Studies; Genetic Predisposition to Disease; High-Throughput Nucleotide Sequencing; Kidney Tubules; Laminin; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Myasthenic Syndromes, Congenital; Nephrotic Syndrome; Pedigree; Phenotype; Proteinuria; Pupil Disorders

2014
An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess.
    Endocrinology, 2014, Volume: 155, Issue:3

    Topics: Animals; Body Composition; Bone and Bones; Calcium; Cell Line; Chromosome Mapping; Corticosterone; Corticotropin-Releasing Hormone; Cushing Syndrome; Disease Models, Animal; Ethylnitrosourea; Female; Glucocorticoids; Lipid Metabolism; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mutation; Osteoblasts; Osteoporosis; Promoter Regions, Genetic

2014
Interrogating congenital heart defects with noninvasive fetal echocardiography in a mouse forward genetic screen.
    Circulation. Cardiovascular imaging, 2014, Volume: 7, Issue:1

    Topics: Animals; Disease Models, Animal; Echocardiography, Doppler; Echocardiography, Doppler, Color; Ethylnitrosourea; Female; Fetal Heart; Genetic Predisposition to Disease; Genetic Testing; Heart Defects, Congenital; Heredity; High-Throughput Screening Assays; Male; Mice; Mice, Inbred C57BL; Microscopy, Acoustic; Mutation; Pedigree; Phenotype; Ultrasonography, Prenatal

2014
Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.
    The Journal of biological chemistry, 2014, Apr-11, Volume: 289, Issue:15

    Topics: Amino Acid Sequence; Animals; Behavior, Animal; Bipolar Disorder; Brain; Brain Diseases; Circadian Rhythm; Disease Models, Animal; Ethylnitrosourea; Female; Gene Library; Genotype; Homozygote; Humans; Inositol; Lithium; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis; Mutation; Mutation, Missense; Phosphoric Monoester Hydrolases; Recombinant Proteins; Sequence Homology, Amino Acid; Time Factors

2014
ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.
    Experimental neurology, 2015, Volume: 267

    Topics: Abnormalities, Multiple; Age Factors; Animals; Axons; Cataract; Cornea; Disease Models, Animal; Endoplasmic Reticulum; Ethylnitrosourea; Eye; Hypogonadism; Intellectual Disability; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microcephaly; Microphthalmos; Mutagenesis; Nerve Degeneration; Optic Atrophy; Optic Nerve Diseases; Psychomotor Performance; rab GTP-Binding Proteins; Sequence Deletion; Testis; Touch Perception

2015
N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Alleles; Amino Acid Sequence; Animals; Calcinosis; Chlorocebus aethiops; Codon, Nonsense; COS Cells; Disease Models, Animal; Endoplasmic Reticulum; Ethylnitrosourea; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Genetic Loci; Genotype; Glucuronidase; Humans; Kidney; Klotho Proteins; Longevity; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation, Missense; N-Acetylgalactosaminyltransferases; Phenotype; Phosphates; Polymorphism, Single Nucleotide; Polypeptide N-acetylgalactosaminyltransferase; Sequence Alignment; Vitamin D

2015
A post-developmental genetic screen for zebrafish models of inherited liver disease.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Genetic Predisposition to Disease; Genetic Testing; Humans; Liver; Mutation; Non-alcoholic Fatty Liver Disease; Zebrafish

2015
Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Abnormalities, Multiple; Animals; Base Sequence; Chromosome Mapping; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Female; Gene Expression Regulation; Gene Order; Genes, Dominant; Genetic Loci; Genotype; Hernia, Diaphragmatic; Male; Mutation; Phenotype; Rats; Sequence Alignment; Spine

2015
Gnaq(M1J): An ENU-Induced Mutant Allele Affecting Pigmentation in the Mouse.
    The Journal of investigative dermatology, 2016, Volume: 136, Issue:1

    Topics: Alleles; Animals; Biopsy, Needle; Disease Models, Animal; Ethylnitrosourea; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Hyperpigmentation; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mutation, Missense; Polymorphism, Single Nucleotide; Random Allocation; Sensitivity and Specificity

2016
Hirschsprung disease is associated with an L286P mutation in the fifth transmembrane domain of the endothelin-B receptor in the N-ethyl-N-nitrosourea-induced mutant line.
    Experimental animals, 2016, Jul-29, Volume: 65, Issue:3

    Topics: Animals; Chromosomes, Human, Pair 14; Disease Models, Animal; Ethylnitrosourea; Female; Ganglia; Genetic Association Studies; Hirschsprung Disease; Humans; Intestinal Obstruction; Lysine; Male; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Mutation, Missense; Protein Domains; Receptor, Endothelin B; Receptors, G-Protein-Coupled

2016
Moderate malnutrition in rats induces somatic gene mutations.
    Mutation research, 2016, Volume: 789

    Topics: Animals; Animals, Newborn; Body Weight; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Erythrocytes; Ethylnitrosourea; Male; Malnutrition; Membrane Proteins; Mutation Rate; Rats, Wistar; Reticulocytes; Time Factors

2016
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Alkylating Agents; Animals; Bone Marrow Cells; Disease Models, Animal; Ethylnitrosourea; Humans; Leukemia, Myeloid, Acute; Mice; Myelodysplastic Syndromes; Neoplasms, Second Primary; Neoplastic Stem Cells

2016
Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes.
    Oncotarget, 2016, Sep-13, Volume: 7, Issue:37

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bibenzyls; Brain; Brain Neoplasms; Camptothecin; Cisplatin; Disease Models, Animal; Drug Delivery Systems; Ethylnitrosourea; Glioblastoma; Glioma; Humans; Irinotecan; Lactic Acid; Male; Nanofibers; Neurosurgical Procedures; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Tumor Burden

2016
The inhibiting activity of meadowsweet extract on neurocarcinogenesis induced transplacentally in rats by ethylnitrosourea.
    Journal of neuro-oncology, 2017, Volume: 131, Issue:3

    Topics: Animals; Central Nervous System Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Filipendula; Kidney Neoplasms; Male; Maternal-Fetal Exchange; Plant Extracts; Pregnancy; Prenatal Exposure Delayed Effects

2017
Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Animals; Bone Density; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Ethylnitrosourea; Female; Glycosylation; Kyphosis; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mutation, Missense; Protein Processing, Post-Translational; Receptors, Atrial Natriuretic Factor; Spine; Tibia

2016
A Mouse Model for Human Unstable Hemoglobin Santa Ana.
    Comparative medicine, 2016, 12-01, Volume: 66, Issue:6

    Topics: Anemia, Hemolytic, Congenital; Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Female; Genotype; Hemoglobins, Abnormal; Humans; Male; Mice; Mice, Inbred BALB C; Mutation

2016
A new mouse mutant for the LDL receptor identified using ENU mutagenesis.
    Journal of lipid research, 2008, Volume: 49, Issue:11

    Topics: Amino Acid Sequence; Animals; Base Sequence; Disease Models, Animal; Ethylnitrosourea; Female; Hyperlipoproteinemia Type II; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Mutagens; Mutation, Missense; Receptors, LDL

2008
Single amino acid substitution in aquaporin 11 causes renal failure.
    Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:10

    Topics: Amino Acid Substitution; Animals; Aquaporins; Disease Models, Animal; Ethylnitrosourea; Female; Male; Mice; Mice, Mutant Strains; Point Mutation; Polymorphism, Single Nucleotide; Renal Insufficiency; Syndrome

2008
A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis.
    PLoS genetics, 2008, Sep-19, Volume: 4, Issue:9

    Topics: Animals; ATP-Binding Cassette Transporters; Biological Transport; Cell Differentiation; Disease Models, Animal; Epidermis; Ethylnitrosourea; Female; Homeostasis; Humans; Ichthyosis, Lamellar; Keratinocytes; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mutagenesis; Skin

2008
An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2009, Volume: 20, Issue:5

    Topics: Animals; Cardiomyopathies; Chromosome Mapping; Chromosomes, Mammalian; Disease Models, Animal; Ethylnitrosourea; Female; Genes, Recessive; Genetic Testing; Heart; Heart Failure; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mutagenesis; Mutagens

2009
Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome.
    Developmental biology, 2009, Apr-15, Volume: 328, Issue:2

    Topics: Amino Acid Sequence; Animals; Behavior, Animal; Bone Morphogenetic Protein 4; Branchio-Oto-Renal Syndrome; Calcium-Binding Proteins; Disease Models, Animal; Ear, Inner; Embryo, Mammalian; Ethylnitrosourea; Hair Cells, Auditory; Homeodomain Proteins; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Kidney; Membrane Proteins; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagens; Point Mutation; Serrate-Jagged Proteins; SOXB1 Transcription Factors

2009
A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease?
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:9

    Topics: Amino Acid Sequence; Animals; Atrophy; Base Sequence; Chromosomes, Mammalian; Disease Models, Animal; Dry Eye Syndromes; Ethylnitrosourea; Eye Abnormalities; Female; Fibroblast Growth Factor 10; Genome-Wide Association Study; Harderian Gland; Heterozygote; In Situ Hybridization; Lens, Crystalline; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Phenotype; Polymerase Chain Reaction; Retina

2009
The MDM2-a splice variant of MDM2 alters transformation in vitro and the tumor spectrum in both Arf- and p53-null models of tumorigenesis.
    Molecular cancer research : MCR, 2009, Volume: 7, Issue:6

    Topics: Animals; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Ethylnitrosourea; Female; Fibroblasts; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Germ Cell and Embryonal; Protein Isoforms; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53

2009
Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis.
    Molecular cancer, 2009, Jun-15, Volume: 8

    Topics: Animals; Antineoplastic Agents; Carrier Proteins; Disease Models, Animal; Ethylnitrosourea; Everolimus; Imidazoles; Kidney Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Neoplasm Recurrence, Local; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Proteins; Quinolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors; Tuberous Sclerosis

2009
Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2G257D mutant mouse.
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:12

    Topics: Alkylating Agents; Animals; Anterior Chamber; Collagen Type VIII; Cornea; Disease Models, Animal; Ethylnitrosourea; Eye Abnormalities; Female; Genetic Linkage; Immunoenzyme Techniques; In Situ Hybridization; Interferometry; Light; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Microsatellite Repeats; Mutagenesis, Site-Directed; Ophthalmoscopy; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Visual Acuity

2009
Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.
    Cancer research, 2009, Jul-15, Volume: 69, Issue:14

    Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Alkylating Agents; Animals; Cell Cycle Proteins; Disease Models, Animal; Disease Progression; DNA-Binding Proteins; Ethylnitrosourea; Feces; Female; Helicobacter Infections; Helicobacter pylori; Humans; Intestinal Neoplasms; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mutation; Nuclear Proteins; Signal Transduction; Survival Analysis; Time Factors

2009
The role of eNOS in vascular permeability in ENU-induced gliomas.
    Acta neurochirurgica. Supplement, 2010, Volume: 106

    Topics: Animals; Autoantigens; Brain Neoplasms; Capillary Permeability; Disease Models, Animal; Ethylnitrosourea; Gadolinium; Glioma; Glucose Transporter Type 1; Nitric Oxide Synthase Type III; Pentetic Acid; Plant Lectins; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A

2010
Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus.
    PloS one, 2009, Nov-17, Volume: 4, Issue:11

    Topics: Animals; Brain; Cognition Disorders; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Hydrocephalus, Normal Pressure; Intracranial Pressure; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Motor Skills; Mutagenesis; Polymorphism, Single Nucleotide

2009
A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.
    Nature protocols, 2010, Volume: 5, Issue:1

    Topics: Animals; Behavior, Animal; Breeding; Disease Models, Animal; Ear, Inner; Ethylnitrosourea; Genetic Testing; Hearing Loss; Mice; Mutation

2010
Genome-wide identification of mouse congenital heart disease loci.
    Human molecular genetics, 2010, Aug-15, Volume: 19, Issue:16

    Topics: Animals; Animals, Newborn; Chromosome Mapping; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Female; Genetic Predisposition to Disease; Genetic Testing; Genome-Wide Association Study; Heart Defects, Congenital; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardium

2010
Indication of cocarcinogenic potential of chronic UMTS-modulated radiofrequency exposure in an ethylnitrosourea mouse model.
    International journal of radiation biology, 2010, Volume: 86, Issue:7

    Topics: Animals; Body Weight; Cell Phone; Disease Models, Animal; Electromagnetic Fields; Ethylnitrosourea; Female; Lung; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasms, Radiation-Induced; Pregnancy; Prenatal Exposure Delayed Effects; Time Factors

2010
Convection enhanced delivery of carboplatin in combination with radiotherapy for the treatment of brain tumors.
    Journal of neuro-oncology, 2011, Volume: 101, Issue:3

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Brain Neoplasms; Carboplatin; Combined Modality Therapy; Convection; Disease Models, Animal; Drug Delivery Systems; Ethylnitrosourea; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Radiation Dosage; Rats; Rats, Inbred F344; Survival Rate; Tissue Distribution; X-Ray Therapy

2011
The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.
    BMC developmental biology, 2010, Aug-12, Volume: 10

    Topics: Animals; Cell Polarity; Disease Models, Animal; Ear, Inner; Ethylnitrosourea; Heart Defects, Congenital; Humans; Lung; Mice; Mutagenesis, Insertional; Nerve Tissue Proteins; Neural Crest; Neural Tube Defects; Receptor Protein-Tyrosine Kinases; Receptors, G-Protein-Coupled; Signal Transduction

2010
[Characterization of ENU-mutant mice. Animal models for human diseases using morphological and molecular methods].
    Der Pathologe, 2010, Volume: 31 Suppl 2

    Topics: Alkylating Agents; Alleles; Animals; Base Pairing; Disease Models, Animal; Ethylnitrosourea; Genetic Diseases, Inborn; Genome-Wide Association Study; Genome, Human; Humans; Mice; Mice, Mutant Strains; Mutagenesis; Phenotype; Point Mutation

2010
A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2010, Volume: 21, Issue:9-10

    Topics: Animals; Chromosome Mapping; Cryptorchidism; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Gene Knockout Techniques; Genetic Complementation Test; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutation, Missense; Polymerase Chain Reaction; Protein Conformation; Protein Folding; Receptors, G-Protein-Coupled; Signal Transduction; Testis

2010
Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism.
    Endocrinology, 2011, Volume: 152, Issue:1

    Topics: Animals; Breeding; Disease Models, Animal; Ethylnitrosourea; Female; Hyperaldosteronism; Male; Mice; Mice, Inbred Strains; Mutagenesis; Pedigree

2011
A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.
    Experimental hematology, 2011, Volume: 39, Issue:3

    Topics: Alkylating Agents; Amino Acid Sequence; Animals; Ankyrins; Codon, Nonsense; Disease Models, Animal; Erythrocytes; Ethylnitrosourea; Female; Humans; Male; Mice; Mice, Mutant Strains; Protein Binding; Sequence Deletion; Spherocytosis, Hereditary

2011
First mutation in the βA2-crystallin encoding gene is associated with small lenses and age-related cataracts.
    Investigative ophthalmology & visual science, 2011, Apr-20, Volume: 52, Issue:5

    Topics: Aging; Animals; beta-Crystallin A Chain; Biomarkers; Cataract; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Genetic Linkage; Genotype; In Situ Hybridization; Lens, Crystalline; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Polymorphism, Single Nucleotide; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2011
Identification of adult mineralized tissue zebrafish mutants.
    Genesis (New York, N.Y. : 2000), 2011, Volume: 49, Issue:4

    Topics: Alcian Blue; Animals; Anthraquinones; Cartilage; Craniofacial Abnormalities; Disease Models, Animal; Ethylnitrosourea; Genes, Recessive; Mutagenesis; Phenotype; Zebrafish

2011
Identification of a novel point mutation of mouse Atp2b2 induced by N-ethyl-N-nitrosourea mutagenesis.
    Experimental animals, 2011, Volume: 60, Issue:1

    Topics: Animals; Disease Models, Animal; Ear, Inner; Ethylnitrosourea; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Humans; Mice; Mice, Mutant Strains; Mutagenesis; Plasma Membrane Calcium-Transporting ATPases; Point Mutation

2011
An ENU-induced mutation in the Mertk gene (Mertknmf12) leads to a slow form of retinal degeneration.
    Investigative ophthalmology & visual science, 2011, Jul-01, Volume: 52, Issue:7

    Topics: Animals; Blotting, Western; c-Mer Tyrosine Kinase; Cell Death; Disease Models, Animal; Disease Progression; DNA; Electroretinography; Ethylnitrosourea; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mutation; Ophthalmoscopy; Phenotype; Photoreceptor Cells, Vertebrate; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Retina; Retinal Degeneration; Tumor Necrosis Factor-alpha

2011
ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2011, Volume: 22, Issue:5-6

    Topics: Alcian Blue; Animals; Anthraquinones; Bone and Bones; Chromosome Mapping; Collagen Type II; Disease Models, Animal; DNA Primers; Ethylnitrosourea; Genotype; Immunohistochemistry; Mice; Mice, Mutant Strains; Microscopy, Electron, Transmission; Mutagenesis; Mutation, Missense; Osteochondrodysplasias; Reverse Transcriptase Polymerase Chain Reaction

2011
Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2011, Volume: 22, Issue:9-10

    Topics: Animals; Base Sequence; Disease Models, Animal; Ethylnitrosourea; Female; Genetic Linkage; Genotype; Hematologic Diseases; Hematologic Tests; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mutagenesis; Mutagens; Mutation; Phenotype; Receptors, Transferrin; Reference Values

2011
Microphakia and congenital cataract formation in a novel Lim2(C51R) mutant mouse.
    Molecular vision, 2011, Volume: 17

    Topics: Animals; Base Sequence; Cataract; Disease Models, Animal; Ethylnitrosourea; Eye; Eye Proteins; Female; Founder Effect; Genetic Linkage; Heterozygote; Homozygote; Lens, Crystalline; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microphthalmos; Molecular Sequence Data; Mutation; Polymorphism, Single Nucleotide

2011
Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice.
    Pediatric research, 2011, Volume: 70, Issue:1

    Topics: Acyl-CoA Dehydrogenase; Alternative Splicing; Amino Acid Metabolism, Inborn Errors; Animals; Base Sequence; Cold Temperature; Disease Models, Animal; Disease Progression; DNA Mutational Analysis; Ethylnitrosourea; Fatty Liver; Gene Expression Regulation, Enzymologic; Genetic Predisposition to Disease; Liver X Receptors; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Transmission; Mitochondria, Liver; Mitochondrial Swelling; Molecular Sequence Data; Mutagens; Mutation; Orphan Nuclear Receptors; Oxidoreductases Acting on CH-CH Group Donors; Phenotype; PPAR alpha; PPAR gamma; RNA, Messenger; Thermogenesis; Thermosensing

2011
Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice.
    Blood, 2011, Dec-08, Volume: 118, Issue:24

    Topics: Achlorhydria; Amino Acid Substitution; Anemia, Iron-Deficiency; Animals; Disease Models, Animal; Ethylnitrosourea; Female; H(+)-K(+)-Exchanging ATPase; Intestinal Absorption; Iron, Dietary; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mutagens; Osmotic Fragility; Point Mutation; Protein Subunits; Stomach

2011
A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF.
    Human molecular genetics, 2012, Feb-15, Volume: 21, Issue:4

    Topics: Amino Acid Substitution; Animals; Disease Models, Animal; Ethylnitrosourea; Genes, Dominant; Mice; Mutation, Missense; Osteoclasts; Osteopetrosis; Point Mutation; Protein Binding; Protein Multimerization; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Tumor Necrosis Factor-alpha

2012
Behavioral and neuromorphological characterization of a novel Tuba1 mutant mouse.
    Behavioural brain research, 2012, Feb-01, Volume: 227, Issue:1

    Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Attention; Behavior, Animal; Bromodeoxyuridine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Stimulants; Chromosome Mapping; Dark Adaptation; Developmental Disabilities; Disease Models, Animal; DNA Mutational Analysis; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethylnitrosourea; Exploratory Behavior; Female; Gene Expression Regulation; Glycine; Homing Behavior; Male; Methylphenidate; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Transmission; Mutagenesis; Mutagens; Neocortex; Neurons; Phenotype; Time Factors; Tubulin

2012
Translational vision research models program.
    Advances in experimental medicine and biology, 2012, Volume: 723

    Topics: Alkylating Agents; Animals; Chromosome Mapping; Cyclic Nucleotide Phosphodiesterases, Type 6; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Eye Proteins; Humans; Mice; Mice, Inbred C57BL; Mutagenesis; Retinal Degeneration; Rhodopsin; Translational Research, Biomedical

2012
Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
    Brain research, 2012, Jan-30, Volume: 1435

    Topics: Animals; Antiemetics; Biophysical Phenomena; Biotinylation; Body Weight; Carbamazepine; Cells, Cultured; Chromosome Mapping; Disease Models, Animal; DNA Mutational Analysis; Electric Stimulation; Electroencephalography; Electromyography; Epilepsy; Ethylnitrosourea; Gene Transfer Techniques; Humans; Isaacs Syndrome; Kv1.1 Potassium Channel; Male; Membrane Potentials; Mice; Models, Molecular; Mutagenesis; Mutagens; Mutation, Missense; Myokymia; Oocytes; Patch-Clamp Techniques; Protein Transport; Psychomotor Performance; Rats; Rats, Inbred F344; Rats, Mutant Strains; Sequence Analysis; Serine; Survival Analysis; Swimming; Threonine; Time Factors; Xenopus

2012
Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice.
    BMC research notes, 2012, Feb-20, Volume: 5

    Topics: Alkylating Agents; Amino Acid Substitution; Analysis of Variance; Animals; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Motor Activity; Mutation; Nerve Tissue Proteins; Reflex, Startle; Schizophrenia; Social Behavior

2012
New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2012, Volume: 23, Issue:7-8

    Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Base Sequence; Bone Diseases, Metabolic; Calcium; Chromosomes, Mammalian; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Female; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mutagenesis; Mutagens; Mutation; Phenotype; PHEX Phosphate Regulating Neutral Endopeptidase; Phosphates; Polymorphism, Single Nucleotide; Receptors, Calcium-Sensing; Statistics, Nonparametric; X Chromosome

2012
A novel Phex mutation in a new mouse model of hypophosphatemic rickets.
    Journal of cellular biochemistry, 2012, Volume: 113, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Animals; Base Sequence; Bone and Bones; Bone Marrow Cells; Calcification, Physiologic; Cells, Cultured; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Extracellular Matrix Proteins; Familial Hypophosphatemic Rickets; Female; Fibroblast Growth Factor-23; Genetic Diseases, X-Linked; Glycoproteins; Integrin-Binding Sialoprotein; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mutagens; Osteoblasts; Osteocalcin; PHEX Phosphate Regulating Neutral Endopeptidase; Phosphoproteins; Point Mutation; RNA, Messenger; Sequence Analysis, DNA; Stromal Cells

2012
Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis.
    Journal of biomedical science, 2012, May-30, Volume: 19

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cytoskeletal Proteins; Disease Models, Animal; Ethylnitrosourea; Inflammation; Mice; Mice, Inbred C57BL; Mutagenesis; Mutation; Pain; Polymorphism, Single Nucleotide

2012
Mice with an induced mutation in collagen 8A2 develop larger eyes and are resistant to retinal ganglion cell damage in an experimental glaucoma model.
    Molecular vision, 2012, Volume: 18

    Topics: Animals; Axial Length, Eye; Axons; Cell Count; Collagen Type VIII; Disease Models, Animal; Ethylnitrosourea; Glaucoma; Homozygote; Intraocular Pressure; Mice; Mice, Inbred C57BL; Microspheres; Mutation, Missense; Ocular Hypertension; Optic Nerve; Organ Size; Polystyrenes; Protein Isoforms; Retinal Ganglion Cells; Sclera

2012
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.
    Open biology, 2012, Volume: 2, Issue:5

    Topics: Animals; Crosses, Genetic; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Exome; Female; Genes, Recessive; Heterozygote; Homozygote; Inbreeding; Leukocyte Common Antigens; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagenesis; Polymorphism, Single Nucleotide; Sequence Analysis, DNA

2012
A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Animals; Apoptosis; Blotting, Western; Bone and Bones; Calcinosis; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Ethylnitrosourea; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Genes, Recessive; Green Fluorescent Proteins; Hyperostosis, Cortical, Congenital; Hyperphosphatemia; Male; Mice; Mutation, Missense; N-Acetylgalactosaminyltransferases; Polypeptide N-acetylgalactosaminyltransferase; Reverse Transcriptase Polymerase Chain Reaction; Sertoli Cells; Spermatozoa; Testis

2012
ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level.
    Blood cells, molecules & diseases, 2013, Volume: 50, Issue:2

    Topics: Animals; beta-Globins; beta-Thalassemia; Codon; Codon, Nonsense; Disease Models, Animal; Erythrocyte Indices; Ethylnitrosourea; Exons; Female; Fetal Death; Genes, Dominant; Genes, Lethal; Genetic Complementation Test; Genotype; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutagenesis; Mutagens; Polyadenylation; Pregnancy; Spleen

2013
Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2013, Volume: 24, Issue:1-2

    Topics: Alleles; Animals; Chromosome Mapping; Chromosomes; Disease Models, Animal; Ethylnitrosourea; Female; Gene Expression Regulation; Genes, Lethal; Genes, Recessive; Male; Membrane Proteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Mutation; Osteopetrosis; Phenotype

2013
Alterations in cerebrospinal fluid proteins in a presymptomatic primary glioma model.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Animals; Biomarkers; Brain; Brain Neoplasms; Cerebrospinal Fluid Proteins; Disease Models, Animal; Ethylnitrosourea; Gene Expression Regulation, Neoplastic; Glioma; Glutathione; Intermediate Filament Proteins; Nerve Tissue Proteins; Nestin; Proteome; Proteomics; Rats; Rats, Sprague-Dawley; Time Factors

2012
Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.
    PLoS genetics, 2013, Volume: 9, Issue:1

    Topics: Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Genes, Dominant; Genes, Recessive; Genome; Humans; Mice; Mutagenesis; Mutation; Phenotype; Sequence Analysis, DNA

2013
Novel phenotypes identified by plasma biochemical screening in the mouse.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2002, Volume: 13, Issue:10

    Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagenesis; Phenotype; Plasma

2002
Chronic DNA damage and niacin deficiency enhance cell injury and cause unusual interactions in NAD and poly(ADP-ribose) metabolism in rat bone marrow.
    Nutrition and cancer, 2003, Volume: 45, Issue:1

    Topics: Alkylating Agents; Animals; Bone Marrow Cells; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Erythrocytes; Ethylnitrosourea; Male; NAD; Neoplasms, Experimental; Niacin; Poly Adenosine Diphosphate Ribose; Random Allocation; Rats; Rats, Long-Evans

2003
A genetic screen for mouse mutations with defects in serotonin responsiveness.
    Brain research. Molecular brain research, 2003, Jul-23, Volume: 115, Issue:2

    Topics: Alkylating Agents; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylnitrosourea; Female; Genetic Testing; Head Movements; Indophenol; Male; Mice; Mice, Inbred Strains; Motor Activity; Mutagenesis; Mutation; Psychotic Disorders; Serotonin; Serotonin Receptor Agonists; Species Specificity; Statistics, Nonparametric; Time Factors

2003
Imaging of experimental rat gliomas using a clinical MR scanner.
    Journal of neuro-oncology, 2003, Volume: 63, Issue:3

    Topics: Animals; Brain Neoplasms; Collagen; Disease Models, Animal; Endostatins; Ethylnitrosourea; Female; Glioma; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Neoplasms, Experimental; Peptide Fragments; Rats; Transfection; Tumor Cells, Cultured

2003
A mouse model for cystinuria type I.
    Human molecular genetics, 2003, Sep-01, Volume: 12, Issue:17

    Topics: Amino Acid Sequence; Amino Acid Transport Systems, Basic; Amino Acids; Animals; Arginine; Carrier Proteins; Chromosome Mapping; Cystine; Cystinuria; Disease Models, Animal; Ethylnitrosourea; Female; Genotype; Lysine; Male; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Mutation; Ornithine; Phenotype; Sequence Homology, Amino Acid; Urinary Bladder Calculi; Urinary Calculi

2003
ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.
    The Journal of clinical investigation, 2004, Volume: 113, Issue:3

    Topics: Amino Acid Sequence; Amino Acids, Branched-Chain; Animals; Base Sequence; Disease Models, Animal; Ethylnitrosourea; Humans; Maple Syrup Urine Disease; Mass Spectrometry; Mice; Mitochondria; Molecular Sequence Data; Mutagens; Mutation; Transaminases

2004
A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.
    Human molecular genetics, 2004, Jun-01, Volume: 13, Issue:11

    Topics: Amino Acid Sequence; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Ethylnitrosourea; Female; Gene Expression; Glucokinase; Glucose Tolerance Test; Homozygote; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagenesis; Phenotype; Point Mutation; RNA, Messenger

2004
Immunotherapeutic effects of T11TS/S-LFA3 against nitrosocompound mediated neural genotoxicity.
    Toxicology letters, 2004, May-02, Volume: 150, Issue:3

    Topics: Adjuvants, Immunologic; Age Factors; Animals; Apoptosis; Brain; Brain Neoplasms; CD2 Antigens; CD58 Antigens; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Ethylnitrosourea; Female; Lymphocytes; Male; Mutagens; Phagocytosis; Rats; Rosette Formation; Sheep; Spleen

2004
[p16 protein expression in the transplacental induced brain tumor in rat].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 2004, Mar-22, Volume: 42, Issue:6

    Topics: Animals; Brain; Brain Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Immunohistochemistry; Male; Placenta; Pregnancy; Rats; Rats, Sprague-Dawley

2004
A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.
    Diabetes, 2004, Volume: 53, Issue:6

    Topics: Adenine; Amino Acid Sequence; Amino Acid Substitution; Animals; Chromosome Mapping; Diabetes Mellitus, Type 2; Disease Models, Animal; Ethylnitrosourea; Glucokinase; Glucose; Glucose Intolerance; Heterozygote; Homozygote; Isoleucine; Male; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagens; Mutation, Missense; Phenylalanine; Phosphorylation; Thymine

2004
[HUP98-HOXA9 transgenic mice are susceptible to N-ethyl-N-nitrosourea stimulation in leukemogenesis].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2004, Volume: 25, Issue:5

    Topics: Animals; Bone Marrow Cells; Disease Models, Animal; Ethylnitrosourea; Female; Gene Expression Regulation, Leukemic; Genotype; Homeodomain Proteins; Humans; Leukemia, Myeloid; Male; Mice; Mice, Transgenic; Nuclear Pore Complex Proteins; Oncogene Proteins, Fusion; Phenotype; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Transfection

2004
Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21).
    Journal of dental research, 2004, Volume: 83, Issue:8

    Topics: Amelogenesis Imperfecta; Animals; Chromosome Mapping; Chromosomes, Human, Pair 4; Chromosomes, Human, Pair 5; Dental Enamel; Dental Enamel Proteins; Dentin; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Female; Genetic Testing; Humans; Male; Mice; Mice, Inbred C3H; Mice, Mutant Strains; Mutagenesis; Mutagens

2004
Hypercholesterolemia in ENU-induced mouse mutants.
    Journal of lipid research, 2004, Volume: 45, Issue:11

    Topics: Alleles; Animals; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Ethylnitrosourea; Genes, Dominant; Genes, Recessive; Genetic Predisposition to Disease; Hypercholesterolemia; Mice; Mice, Inbred C3H; Mutagenesis; Mutagens; Mutation; Phenotype

2004
Two kinds of ENU-induced scant hair mice and mapping of the mutant genes.
    Journal of dermatological science, 2004, Volume: 36, Issue:3

    Topics: Alkylating Agents; Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Female; Genes, Dominant; Genes, Recessive; Genomics; Genotype; Hair Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Mutagenesis; Phenotype; Pregnancy

2004
[Chemically induced Drosophila melanogaster mutants with changes in brain structure].
    Genetika, 2004, Volume: 40, Issue:9

    Topics: Animals; Brain; Disease Models, Animal; Drosophila melanogaster; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Genes, Insect; Male; Mutagens; Mutation; Nerve Degeneration

2004
A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation.
    Molecular endocrinology (Baltimore, Md.), 2005, Volume: 19, Issue:4

    Topics: Animals; Disease Models, Animal; Disorders of Sex Development; Ethylnitrosourea; Female; Follicle Stimulating Hormone; Hypogonadism; Luteinizing Hormone; Male; Mice; Ovary; Pituitary Gland; Point Mutation; Receptors, LHRH; Sex Differentiation; Testis; Transcription, Genetic

2005
Ethylnitrosourea induces neural progenitor cell apoptosis after S-phase accumulation in a p53-dependent manner.
    Neurobiology of disease, 2005, Volume: 18, Issue:1

    Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Carcinogens; Cell Cycle; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Replication; Ethylnitrosourea; Female; G2 Phase; Male; Mice; Mice, Knockout; Neurons; Rats; Rats, Inbred F344; S Phase; Stem Cells; Tumor Suppressor Protein p53

2005
Enamelin (Enam) is essential for amelogenesis: ENU-induced mouse mutants as models for different clinical subtypes of human amelogenesis imperfecta (AI).
    Human molecular genetics, 2005, Mar-01, Volume: 14, Issue:5

    Topics: Amelogenesis; Amelogenesis Imperfecta; Amino Acid Sequence; Animals; Chromosome Mapping; Dental Enamel Proteins; Disease Models, Animal; Ethylnitrosourea; Humans; Mice; Molecular Sequence Data; Mutation; Phenotype; RNA, Messenger; Sequence Analysis, DNA

2005
T11TS/S-LFA3 induces apoptosis of the brain tumor cells: a new approach to characterise the apoptosis associated genetic changes by arbitrarily primed-PCR.
    Cancer letters, 2005, May-10, Volume: 222, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; CD2 Antigens; CD58 Antigens; Disease Models, Animal; DNA Fragmentation; DNA, Neoplasm; Ethylnitrosourea; Female; In Situ Nick-End Labeling; Male; Phosphatidylserines; Polymerase Chain Reaction; Rats; Rats, Inbred Strains

2005
Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants.
    Nephron. Experimental nephrology, 2005, Volume: 100, Issue:4

    Topics: Albuminuria; Alkylating Agents; Animals; Disease Models, Animal; Ethylnitrosourea; Female; Male; Mice; Mice, Inbred C3H; Mutagenesis; Pedigree; Phenotype; Proteinuria

2005
Chemoprevention of hepatocellular carcinoma: use of tamoxifen in an animal model of hepatocarcinogenesis.
    The Journal of laboratory and clinical medicine, 2005, Volume: 145, Issue:3

    Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Chemoprevention; Disease Models, Animal; Ethylnitrosourea; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Precancerous Conditions; Tamoxifen; Tretinoin

2005
Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency.
    The Journal of biological chemistry, 2005, Jul-01, Volume: 280, Issue:26

    Topics: alpha-Crystallins; Angiography; Animals; Chromatography, Gel; Circular Dichroism; Cloning, Molecular; Crystallins; Disease Models, Animal; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Ethylnitrosourea; Fluorescein; gamma-Crystallins; Genetic Linkage; Homozygote; Immunohistochemistry; Isoleucine; Lens, Crystalline; Mice; Mice, Mutant Strains; Mutagenesis; Mutagens; Mutation; Mutation, Missense; Phenotype; Phenylalanine; Protein Binding; Recombinant Proteins; Retinal Vessels; Sequence Analysis, DNA; Ultraviolet Rays

2005
Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics.
    Genetics, 2005, Volume: 170, Issue:4

    Topics: Animals; Chromosome Disorders; Codon, Terminator; Disease Models, Animal; Dyneins; Ethylnitrosourea; Genes, Recessive; Genetic Linkage; Humans; Male; Mutagenesis; Mutagens; Myosin VIIa; Myosins; Point Mutation; Polymorphism, Single Nucleotide; Rats; Rats, Wistar; Usher Syndromes

2005
An ENU-induced mutation in Rs1h causes disruption of retinal structure and function.
    Molecular vision, 2005, Jul-27, Volume: 11

    Topics: Alkylating Agents; Animals; Base Sequence; Cell Adhesion Molecules; Chromosome Mapping; Disease Models, Animal; DNA Mutational Analysis; Electroretinography; Ethylnitrosourea; Eye Proteins; Female; Immunoenzyme Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Molecular Sequence Data; Mutagenesis; Mutation; Retina; Retinoschisis

2005
Diabetes insipidus in mice with a mutation in aquaporin-2.
    PLoS genetics, 2005, Volume: 1, Issue:2

    Topics: Animals; Aquaporin 2; Diabetes Insipidus; Disease Models, Animal; Endoplasmic Reticulum; Ethylnitrosourea; Mice; Mice, Mutant Strains; Mutation, Missense; Protein Transport

2005
Genotype-phenotype correlation of mouse pde6b mutations.
    Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:9

    Topics: Alkylating Agents; Alleles; Animals; Cyclic Nucleotide Phosphodiesterases, Type 6; Disease Models, Animal; Disease Progression; DNA Mutational Analysis; Electrophoresis, Capillary; Ethylnitrosourea; Female; Genotype; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mutation; Phenotype; Phosphoric Diester Hydrolases; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Visual Acuity

2005
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia.
    Development (Cambridge, England), 2005, Volume: 132, Issue:19

    Topics: Abnormalities, Multiple; Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Connexin 43; Craniofacial Abnormalities; Dental Enamel Hypoplasia; Disease Models, Animal; Ethylnitrosourea; Eye Abnormalities; Gap Junctions; Heart Defects, Congenital; Humans; Mice; Penetrance; Point Mutation; Stem Cells; Syndactyly

2005
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
    Cancer letters, 2006, Jan-18, Volume: 231, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Antioxidants; Benzo(a)pyrene; Butylated Hydroxytoluene; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Incidence; Lung Neoplasms; Male; Methylcholanthrene; Mice; Mice, Transgenic; Oncogene Protein p21(ras)

2006
Collagen dysregulation in the dermis of the Sagg/+ mouse: a loose skin model.
    The Journal of investigative dermatology, 2006, Volume: 126, Issue:3

    Topics: Animals; Chromosome Mapping; Collagen; Cutis Laxa; Disease Models, Animal; Ehlers-Danlos Syndrome; Ethylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mutation; RNA, Messenger; Skin; Tensile Strength

2006
Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis.
    Pharmacogenetics and genomics, 2006, Volume: 16, Issue:3

    Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Female; Genetic Techniques; Genome; Male; Mutagenesis, Site-Directed; Pharmacogenetics; Rats; Rats, Inbred F344

2006
Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea.
    The American journal of pathology, 2006, Volume: 168, Issue:5

    Topics: Animals; Astrocytes; Biomarkers, Tumor; Cerebral Cortex; Disease Models, Animal; Disease Progression; Ethylnitrosourea; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Immunohistochemistry; Intermediate Filament Proteins; Nerve Tissue Proteins; Nestin; Osteopontin; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Sialoglycoproteins; Time Factors; Transfection

2006
N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.
    Physiological genomics, 2006, Aug-16, Volume: 26, Issue:3

    Topics: Alkylating Agents; Animals; Chlorocebus aethiops; COS Cells; Disease Models, Animal; DNA Mutational Analysis; Enzyme-Linked Immunosorbent Assay; Ethylnitrosourea; Female; Green Fluorescent Proteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagenesis; Mutation; Phylogeny; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Receptors, G-Protein-Coupled; Signal Transduction; Transfection

2006
Mutagenesis-generated mouse models of human infertility with abnormal sperm.
    Human reproduction (Oxford, England), 2007, Volume: 22, Issue:1

    Topics: Animals; Bacterial Proteins; Calcium-Binding Proteins; Disease Models, Animal; Ethylnitrosourea; Humans; Immunohistochemistry; Infertility, Male; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mutagenesis; Phenotype; Spermatozoa

2007
pERK, pAkt and pBad: a possible role in cell proliferation and sustained cellular survival during tumorigenesis and tumor progression in ENU induced transplacental glioma rat model.
    Neurochemical research, 2006, Volume: 31, Issue:9

    Topics: Alkylating Agents; Animals; bcl-Associated Death Protein; Brain; Cell Proliferation; Cell Survival; Disease Models, Animal; Enzyme Activation; Ethylnitrosourea; Extracellular Signal-Regulated MAP Kinases; Female; Glioma; Male; Phosphorylation; Placenta; Pregnancy; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction

2006
Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen.
    Hearing research, 2006, Volume: 220, Issue:1-2

    Topics: Animals; Cochlea; Disease Models, Animal; Ethylnitrosourea; Evoked Potentials, Auditory, Brain Stem; Genetic Testing; Hearing Loss, Noise-Induced; Mice; Mice, Inbred C57BL; Mutagenesis; Mutagens; Noise; Pedigree; Phenotype; Presbycusis; Sex Factors

2006
New ENU-induced semidominant mutation, Ali18, causes inflammatory arthritis, dermatitis, and osteoporosis in the mouse.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2006, Volume: 17, Issue:9

    Topics: Absorptiometry, Photon; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Dermatitis; Disease Models, Animal; Ethylnitrosourea; Extremities; Female; Humans; Male; Mice; Mutation; Osteoporosis; Phenotype

2006
A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:1

    Topics: Albuminuria; Animals; Diabetic Nephropathies; Disease Models, Animal; Ethylnitrosourea; Female; Genes, Dominant; Genetic Predisposition to Disease; Genetic Testing; Humans; Insulin; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagens; Mutation; Phenotype; Sensitivity and Specificity

2007
An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis.
    Journal of biomedical science, 2007, Volume: 14, Issue:2

    Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Cell Line; Cell Lineage; Disease Models, Animal; DNA Mutational Analysis; Ethylnitrosourea; Genome; Interleukin-7; Lymphopenia; Lymphopoiesis; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis; RNA Splicing; RNA, Messenger; Sequence Deletion; T-Lymphocytes

2007
Characterization of mouse mutants with abnormal RPE cells.
    Advances in experimental medicine and biology, 2006, Volume: 572

    Topics: Animals; Cell Line; Disease Models, Animal; Ethylnitrosourea; Female; Heterozygote; Homozygote; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Mutation; Pigment Epithelium of Eye; Retinal Degeneration; Time Factors

2006
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Feb-28, Volume: 27, Issue:9

    Topics: Animals; Base Sequence; Chromosome Mapping; Deafness; Disease Models, Animal; Ethylnitrosourea; Female; Genes, Recessive; Genetic Testing; Hair Cells, Auditory, Outer; Humans; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutagens; Neoplasm Proteins; Pedigree; Point Mutation; Psychomotor Agitation; Sequence Alignment

2007
A mouse model of Waardenburg syndrome type IV resulting from an ENU-induced mutation in endothelin 3.
    Pigment cell research, 2007, Volume: 20, Issue:3

    Topics: Animals; Arginine; Chromosome Mapping; Disease Models, Animal; Endothelin-3; Ethylnitrosourea; Gene Expression Regulation; Genetic Linkage; Histidine; Humans; Mice; Mutation; Pigmentation; Point Mutation; Waardenburg Syndrome

2007
Generation of ENU-induced mouse mutants with hypocholesterolemia: novel tools for dissecting plasma lipoprotein homeostasis.
    Lipids, 2007, Volume: 42, Issue:8

    Topics: Animals; Cholesterol; Disease Models, Animal; Dyslipidemias; Ethylnitrosourea; Female; Homeostasis; Lipoproteins; Male; Mice; Mice, Inbred C3H; Mice, Mutant Strains; Mutagenesis; Mutagens; Mutation; Phenotype

2007
A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9.
    Hearing research, 2007, Volume: 234, Issue:1-2

    Topics: Acoustic Stimulation; Amino Acid Motifs; Amino Acid Sequence; Animals; Behavior, Animal; Conserved Sequence; Deafness; Disease Models, Animal; Ethylnitrosourea; Evoked Potentials, Auditory, Brain Stem; Genotype; Hair Cells, Auditory; Heterozygote; Homozygote; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Molecular Sequence Data; Mutagens; Mutation, Missense; Phenotype; Protein Denaturation; Protein Structure, Tertiary

2007
A model for familial exudative vitreoretinopathy caused by LPR5 mutations.
    Human molecular genetics, 2008, Jun-01, Volume: 17, Issue:11

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Capillaries; Disease Models, Animal; Ethylnitrosourea; Exons; Frameshift Mutation; Homozygote; LDL-Receptor Related Proteins; Low Density Lipoprotein Receptor-Related Protein-5; Male; Mice; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Mutagenesis, Insertional; Protein Structure, Tertiary; Retinal Diseases; Retinal Vessels

2008
A distinct phenotypic change in gliomas at the time of magnetic resonance imaging detection.
    Journal of neurosurgery, 2008, Volume: 108, Issue:4

    Topics: Alkylating Agents; Animals; Brain Neoplasms; Disease Models, Animal; Disease Progression; Ethylnitrosourea; Glial Fibrillary Acidic Protein; Glioma; Intermediate Filament Proteins; Magnetic Resonance Imaging; Male; Nerve Tissue Proteins; Nestin; Osteopontin; Phenotype; Rats; Rats, Sprague-Dawley

2008
Leydig cell hyperplasia in an ENU-induced mutant mouse with germ cell depletion.
    The Journal of reproduction and development, 2008, Volume: 54, Issue:3

    Topics: Alkylating Agents; Animals; Cell Count; Disease Models, Animal; Ethylnitrosourea; Homozygote; Hyperplasia; Infertility, Male; Leydig Cells; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Phenotype; Sertoli Cells; Spermatogenesis; Spermatozoa; Testosterone

2008
Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.
    Carcinogenesis, 2008, Volume: 29, Issue:6

    Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Blotting, Western; Colorectal Neoplasms, Hereditary Nonpolyposis; Disease Models, Animal; DNA-Binding Proteins; Ethylnitrosourea; Genotype; Microsatellite Instability; Microsatellite Repeats; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Rats

2008
An ENU-induced mutant archive for gene targeting in rats.
    Nature genetics, 2008, Volume: 40, Issue:5

    Topics: Animals; Bacteriophage mu; Cryopreservation; Disease Models, Animal; DNA Transposable Elements; Ethylnitrosourea; Gene Targeting; Genetic Diseases, Inborn; Genetic Testing; Humans; Male; Mutagenesis, Insertional; Mutation; Rats; Sperm Injections, Intracytoplasmic; Spermatozoa

2008
Regional blood flow and blood-to-tissue transport in five brain tumor models. Implications for chemotherapy.
    Progress in experimental tumor research, 1984, Volume: 27

    Topics: Aminoisobutyric Acids; Animals; Astrocytoma; Biological Transport; Brain Neoplasms; Capillary Permeability; Carcinoma 256, Walker; Disease Models, Animal; Ethylnitrosourea; Glioma; Oligodendroglioma; Rats; Regional Blood Flow; Sarcoma, Avian

1984
Electron-microscopic analysis of nephroblastomas induced transplacentally in the IIIVO/J rabbit by a single dose of N-ethylnitrosourea.
    The American journal of pathology, 1984, Volume: 117, Issue:2

    Topics: Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Disease Models, Animal; Ethylnitrosourea; Female; Kidney Glomerulus; Kidney Neoplasms; Kidney Tubules; Mesenchymoma; Nitrosourea Compounds; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Wilms Tumor

1984
[Experimental models of embryonic nephroblastomas (Wilms' tumor)].
    Arkhiv patologii, 1980, Volume: 42, Issue:2

    Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Enzyme Activation; Ethylnitrosourea; Female; Kidney Neoplasms; Neoplasms, Experimental; Pregnancy; Rats; Time Factors; Wilms Tumor

1980
[Tumour induction with alkyl-nitrosoureas in ribbed newts (Pleurodeles waltlii) (author's transl)].
    Archiv fur Geschwulstforschung, 1980, Volume: 50, Issue:3

    Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Female; Fibrosarcoma; Hemangioma; Hemangiosarcoma; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pleurodeles; Salamandridae; Sarcoma, Experimental; Wilms Tumor

1980
Histologic characterization of renal tumors (nephroblastomas) induced transplacentally in IIIVO/J and WH/J rabbits by N-ethylnitrosourea.
    The American journal of pathology, 1983, Volume: 113, Issue:1

    Topics: Abdominal Neoplasms; Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Epithelium; Ethylnitrosourea; Female; Humans; Kidney Glomerulus; Kidney Neoplasms; Kidney Tubules; Lung Neoplasms; Maternal-Fetal Exchange; Neoplasms, Connective Tissue; Pregnancy; Rabbits; Wilms Tumor

1983
Combined effects of drugs and radiation against tumor cells.
    Progress in experimental tumor research, 1984, Volume: 28

    Topics: Animals; Brain Neoplasms; Cell Survival; Cells, Cultured; Combined Modality Therapy; Disease Models, Animal; Ethylnitrosourea; Humans; Nitrosourea Compounds; Rats; X-Rays

1984
[Prospects in neuro-oncology].
    Minerva medica, 1984, May-19, Volume: 75, Issue:21

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Cell Transformation, Neoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; Ependymoma; Ethylnitrosourea; Humans; Medical Oncology; Mice; Neoplasms, Experimental; Nerve Tissue; Nervous System Neoplasms; Neurology; Nitrosourea Compounds; Prognosis; Prospective Studies; Rats; Stem Cells

1984
In vitro transformation of fetal brain cells from CDF rats exposed in utero to N-ethyl-N-nitrosourea: morphologic and immunologic studies.
    Journal of the National Cancer Institute, 1980, Volume: 64, Issue:5

    Topics: Animals; Animals, Newborn; Antibody Formation; Brain; Brain Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats; Rats, Inbred Strains; Thymectomy; Transplantation, Isogeneic

1980
Carcinogenicity of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea when applied to a localized area of the hamster trachea.
    Journal of the National Cancer Institute, 1981, Volume: 66, Issue:5

    Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylnitrosourea; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Papilloma; Trachea; Tracheal Neoplasms

1981
Experimental chemotherapy with N'N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) in autochthonous neurogenic tumors of the rat transplacentally induced by ethylnitrosourea.
    Journal of cancer research and clinical oncology, 1982, Volume: 104, Issue:1-2

    Topics: Animals; Carmustine; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Neoplasms, Experimental; Nervous System Neoplasms; Pregnancy; Rats

1982
The Japanese medaka, Oryzias latipes, as a new model organism for studying environmental germ-cell mutagenesis.
    Environmental health perspectives, 1994, Volume: 102 Suppl 12

    Topics: Animals; Disease Models, Animal; Environmental Pollutants; Ethylnitrosourea; Female; Gamma Rays; Germ-Line Mutation; Male; Mutagenesis; Mutagens; Oryzias; Pregnancy; Spermatogenesis

1994
Neuronal lineage in ethyl-nitrosourea-induced brain tumors.
    Acta neuropathologica, 1994, Volume: 88, Issue:5

    Topics: Animals; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Rats

1994
Mouse models for hereditary nonpolyposis colorectal cancer.
    Cancer research, 1998, Jan-15, Volume: 58, Issue:2

    Topics: Adenomatous Polyposis Coli Protein; Animals; Clone Cells; Colorectal Neoplasms, Hereditary Nonpolyposis; Cytoskeletal Proteins; Disease Models, Animal; DNA-Binding Proteins; Ethylnitrosourea; Female; Gene Deletion; Immunocompromised Host; Loss of Heterozygosity; Lymphoma; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Survival Rate

1998
A different approach to treatment of phenylketonuria: phenylalanine degradation with recombinant phenylalanine ammonia lyase.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Mar-02, Volume: 96, Issue:5

    Topics: Animals; Basidiomycota; Cloning, Molecular; Disease Models, Animal; Escherichia coli; Ethylnitrosourea; Humans; Injections, Intraperitoneal; Mice; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylketonurias; Recombinant Proteins

1999
Spontaneous and nitrosourea-induced primary tumors of the central nervous system in Fischer 344 rats chronically exposed to 836 MHz modulated microwaves.
    Radiation research, 1999, Volume: 152, Issue:3

    Topics: Animals; Brain Neoplasms; Carcinogens; Central Nervous System Neoplasms; Cocarcinogenesis; Disease Models, Animal; Ethylnitrosourea; Female; Incidence; Male; Microwaves; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Spinal Cord Neoplasms

1999
In vivo suppressor mutations correct a murine model of hereditary tyrosinemia type I.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Oct-12, Volume: 96, Issue:21

    Topics: Acetoacetates; Alanine Transaminase; Animals; Cloning, Molecular; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Gene Conversion; Gene Deletion; Genotype; Heterozygote; Liver; Loss of Heterozygosity; Mice; Mice, Knockout; Models, Genetic; Mutagenesis; Precancerous Conditions; Reverse Transcriptase Polymerase Chain Reaction; Suppression, Genetic; Tyrosine; Tyrosinemias

1999
Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse.
    Genomics, 1999, Nov-15, Volume: 62, Issue:1

    Topics: Amino Acid Sequence; Animals; Base Sequence; beta-Crystallin A Chain; Cataract; Crystallins; Disease Models, Animal; Ethylnitrosourea; Female; Genes; Genes, Dominant; Genotype; Humans; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Microsatellite Repeats; Molecular Sequence Data; Mutagenesis; Mutagens; Polymerase Chain Reaction; RNA Splicing; RNA, Messenger; Specific Pathogen-Free Organisms

1999
The large-scale Munich ENU-mouse-mutagenesis screen.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2000, Volume: 11, Issue:7

    Topics: Animals; Chromosome Mapping; Congenital Abnormalities; Databases, Factual; Disease Models, Animal; Ethylnitrosourea; Genetic Diseases, Inborn; Genetic Testing; Human Genome Project; Internet; Mice; Mice, Mutant Strains; Mutagenesis; Mutagens

2000
Saturation mutagenesis for dominant eye morphological defects in the mouse Mus musculus.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2000, Volume: 11, Issue:7

    Topics: Animals; Chromosome Mapping; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Eye Diseases, Hereditary; Genes, Dominant; Genetic Testing; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Phenotype; Radiation Genetics

2000
Identification of immunological relevant phenotypes in ENU mutagenized mice.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2000, Volume: 11, Issue:7

    Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Ethylnitrosourea; Flow Cytometry; Immune System Diseases; Immunity; Immunoglobulins; Internet; Mice; Mutagenesis; Mutagens; Phenotype; Polymerase Chain Reaction; Reproducibility of Results

2000
Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2000, Volume: 11, Issue:7

    Topics: Animals; Congenital Abnormalities; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Female; Genetic Testing; Internet; Male; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Mutation; Phenotype

2000
Comet assay as a tool to screen for mouse models with inherited radiation sensitivity.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2000, Volume: 11, Issue:7

    Topics: Animals; Comet Assay; Disease Models, Animal; DNA Damage; Ethylnitrosourea; Genetic Testing; In Vitro Techniques; Lymphocytes; Mice; Mutagenesis; Mutagens; Radiation Tolerance; Radiation, Ionizing

2000
ENU mutagenesis and the search for deafness genes.
    British journal of audiology, 1999, Volume: 33, Issue:5

    Topics: Animals; Deafness; Disease Models, Animal; Ethylnitrosourea; Mice; Mutagenesis; Point Mutation

1999
Large-scale production of mouse phenotypes: the search for animal models for inherited diseases in humans.
    Briefings in bioinformatics, 2001, Volume: 2, Issue:2

    Topics: Animals; Computational Biology; Data Interpretation, Statistical; Databases, Factual; Disease Models, Animal; Ethylnitrosourea; Female; Genetic Diseases, Inborn; Humans; Male; Mice; Mutagenesis; Mutagens; Phenotype; Semen Preservation

2001
Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas.
    Journal of neuro-oncology, 2001, Volume: 53, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Brain Neoplasms; Carcinogens; Diet; Disease Models, Animal; Diterpenes; Ethylnitrosourea; Glioma; Indoles; Magnetic Resonance Imaging; Neoplasms, Multiple Primary; Neoplasms, Second Primary; Pyrroles; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Retinyl Esters; Survival Analysis; Time Factors; Vitamin A

2001
Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats.
    The Journal of nutrition, 2002, Volume: 132, Issue:1

    Topics: Alkylating Agents; Animals; Bone Marrow; Disease Models, Animal; Ethylnitrosourea; Male; Morbidity; Neoplasms, Experimental; Niacin; Nutritional Status; Poly Adenosine Diphosphate Ribose; Rats; Rats, Long-Evans; Time Factors

2002
In search of new disease models in the mouse using ENU mutagenesis.
    Ernst Schering Research Foundation workshop, 2002, Issue:36

    Topics: Alkylating Agents; Animals; Disease Models, Animal; Ethylnitrosourea; Genetic Techniques; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mutagenesis, Site-Directed; Mutation; Phenotype; Retina

2002
Novel ENU-induced eye mutations in the mouse: models for human eye disease.
    Human molecular genetics, 2002, Apr-01, Volume: 11, Issue:7

    Topics: Alkylating Agents; Animals; Chromosome Mapping; Disease Models, Animal; Ethylnitrosourea; Eye Diseases; Female; Humans; Male; Mice; Mutation

2002
[Induction of tumors of the sympathetic nervous system in rats].
    Voprosy onkologii, 2002, Volume: 48, Issue:1

    Topics: Animals; Carcinogens; Disease Models, Animal; Ethylnitrosourea; Ganglioneuroblastoma; Ganglioneuroma; Light; Neuroblastoma; Rats

2002
Embryonal neoplasms in the opossum: a new model for solid tumors of infancy and childhood.
    Science (New York, N.Y.), 1976, Jul-23, Volume: 193, Issue:4250

    Topics: Animals; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Jaw Neoplasms; Kidney Neoplasms; Liver Neoplasms; Neoplasms, Experimental; Neoplasms, Germ Cell and Embryonal; Opossums

1976
Nitrosourea-induced brain tumors: an in vivo and in vitro tumor model system.
    Journal of the National Cancer Institute, 1978, Volume: 61, Issue:2

    Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Immunosuppression Therapy; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Neurilemmoma; Nitrosourea Compounds; Pregnancy; Rats; Rats, Inbred Strains; Thymus Gland; Time Factors; Transplantation, Isogeneic

1978
N-ethyl-N-nitrosourea-induced spinal tumors in an inbred strain of W albino rats.
    Journal of the National Cancer Institute, 1979, Volume: 63, Issue:3

    Topics: Animals; Animals, Newborn; Astrocytoma; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Male; Maternal-Fetal Exchange; Neoplasms, Experimental; Nitrosourea Compounds; Oligodendroglioma; Pregnancy; Rats; Rats, Inbred Strains; Spinal Cord Neoplasms

1979
Some results and prospects of transplacental carcinogenesis studies.
    Neoplasma, 1976, Volume: 23, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Animals; Brain; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nervous System Diseases; Nitrosourea Compounds; Organ Specificity; Placenta; Pregnancy; Rats

1976
Comparative study of various models of experimental hydrocephalus.
    Child's brain, 1975, Volume: 1, Issue:4

    Topics: Animals; Cats; Disease Models, Animal; Dogs; Ethylnitrosourea; Hydrocephalus; Kaolin; Methods; Mice; Rabbits; Rats; Silicones

1975
[The anticarcinogenic effects of fumaric acid on models of carcinogenesis in the esophagus, nervous system and kidney].
    Voprosy onkologii, 1992, Volume: 38, Issue:8

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Chi-Square Distribution; Dimethylnitrosamine; Disease Models, Animal; Drug Screening Assays, Antitumor; Esophageal Neoplasms; Ethylnitrosourea; Female; Fumarates; Kidney Neoplasms; Male; Nervous System Neoplasms; Pregnancy; Prenatal Exposure Delayed Effects; Rats

1992
Ganglion cells and their satellites in experimental trigeminal schwannomas in the rat.
    Neuropatologia polska, 1991, Volume: 29, Issue:1-2

    Topics: Animals; Astrocytes; Cranial Nerve Neoplasms; Disease Models, Animal; Ethylnitrosourea; Glial Fibrillary Acidic Protein; Neurilemmoma; Rats; Schwann Cells; Trigeminal Ganglion

1991
Early lesion of N-nitroso-N-ethylurea-induced hamster neurofibromatosis model.
    Cancer research, 1991, Jan-01, Volume: 51, Issue:1

    Topics: Animals; Bromodeoxyuridine; Cell Division; Disease Models, Animal; Ethylnitrosourea; Neurofibromatosis 1; Rats; S100 Proteins; Schwann Cells; Time Factors

1991
The use of N-ethyl-N-nitrosourea to produce mouse models for human phenylketonuria and hyperphenylalaninemia.
    Progress in clinical and biological research, 1990, Volume: 340C

    Topics: Amino Acid Metabolism, Inborn Errors; Animals; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Male; Mice; Mice, Mutant Strains; Mutation; Phenotype; Phenylalanine; Phenylketonurias

1990
Glial fibrillary acidic protein and vimentin in the experimental glial reaction of the rat brain.
    Brain research, 1986, May-21, Volume: 374, Issue:1

    Topics: Animals; Astrocytes; Brain; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Glial Fibrillary Acidic Protein; Lasers; Nerve Crush; Pregnancy; Rats; Rats, Inbred F344; Staining and Labeling; Vimentin

1986
Experimental model of tumors associated with neurofibromatosis.
    Cancer, 1989, May-01, Volume: 63, Issue:9

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Ethylnitrosourea; Female; Kidney Neoplasms; Neoplasms, Multiple Primary; Nervous System Neoplasms; Neurofibromatosis 1; Peripheral Nervous System Neoplasms; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Spinal Nerves; Trigeminal Nerve; Wilms Tumor

1989
Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: I. Induction.
    Pediatric pathology, 1989, Volume: 9, Issue:2

    Topics: Animals; Cobalt Radioisotopes; Disease Models, Animal; Ethylnitrosourea; Kidney Neoplasms; Radiation Dosage; Rats; Rats, Inbred Strains; Time Factors; Whole-Body Irradiation; Wilms Tumor

1989
Transplacental induction of peripheral nervous tumor in the Syrian golden hamster by N-nitroso-N-ethylurea. A new animal model for von Recklinghausen's neurofibromatosis.
    The American journal of pathology, 1989, Volume: 135, Issue:2

    Topics: Animals; Cricetinae; Disease Models, Animal; Ethylnitrosourea; Female; Fluorescent Antibody Technique; Immunohistochemistry; Maternal-Fetal Exchange; Melanoma; Mesocricetus; Microscopy, Electron; Neural Crest; Neurofibroma; Neurofibromatosis 1; Peripheral Nervous System Neoplasms; Pheochromocytoma; Pregnancy; S100 Proteins; Wilms Tumor

1989
Differential renal tumor response to N-ethylnitrosourea and dimethylnitrosamine in the Nb rat: basis for a new rodent model of nephroblastoma.
    Carcinogenesis, 1985, Volume: 6, Issue:11

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Female; Kidney Neoplasms; Male; Ovariectomy; Placenta; Pregnancy; Rats; Wilms Tumor

1985
Experimental models for the sequential analysis of chemically-induced renal carcinogenesis.
    Toxicologic pathology, 1986, Volume: 14, Issue:1

    Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Animals; Carcinoma, Renal Cell; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Kidney Neoplasms; Mesenchymoma; Rabbits; Rats; Rats, Inbred Strains; Wilms Tumor

1986
N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:6

    Topics: Alleles; Animals; Carbonic Anhydrases; Chromosomes, Human, Pair 3; Disease Models, Animal; Ethylnitrosourea; Female; Genes; Humans; Immunodiffusion; Isoelectric Focusing; Male; Metabolism, Inborn Errors; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mutation; Osteopetrosis

1988
Current brain tumour models with particular consideration of the transplantation techniques. Outline of literature and personal preliminary results.
    Acta neurochirurgica, 1986, Volume: 79, Issue:1

    Topics: Animals; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Glioma; Graft Survival; Intracranial Pressure; Male; Neoplasm Transplantation; Rats; Rats, Inbred Strains

1986
The brain-tumour issue in long-term toxicity studies in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1986, Volume: 24, Issue:2

    Topics: Age Factors; Animal Diseases; Animals; Brain; Brain Neoplasms; Carcinogens; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylnitrosourea; Rats; Research Design; Time Factors

1986