ethylnitrosourea has been researched along with Cell Transformation, Neoplastic in 89 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 56 (62.92) | 18.7374 |
1990's | 13 (14.61) | 18.2507 |
2000's | 12 (13.48) | 29.6817 |
2010's | 8 (8.99) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Chiba, M; Fujino, T; Kobayashi, Y; Koga, T; Mitsudomi, T; Nishino, M; Ohara, S; Shimoji, M; Suda, K; Takemoto, T; Tomizawa, K | 1 |
Bodakuntla, S; Lahiri, M; Libi, AV; Sural, S; Trivedi, P | 1 |
Fan, L; Harris, LC; Rehg, JE; Schuster, K; Volk, EL | 1 |
Basak, P; Chaklader, M; Chatterjee, S; Chaudhuri, S; Das, M; Das, P; Dutta, RK; Law, S; Pereira, JA | 1 |
Calaoagan, JM; Jang, T; Kwon, E; Laderoute, KR; Recht, L; Samuelsson, S | 1 |
Acharya, S; Begum, Z; Chatterjee, S; Chaudhuri, S; Dasgupta, S; Flora, SJ; Kumar, P | 1 |
Fischer, C; Kindler-Röhrborn, A; Koelsch, B; Kutritz, A; van den Berg, L; Winzen-Reichert, B | 1 |
Clipson, L; Dove, WF; Halberg, RB; Newton, MA; Plesh, L; Skinner, BL; Sullivan, R; Thliveris, AT; Waggoner, J; White, A; Zahm, CD | 1 |
Amasaki, Y; Fujimoto, S; Hino, O; Hirano, S; Imaoka, T; Kakinuma, S; Nishimura, M; Shimada, Y | 1 |
Dairkee, SH; Li, Z; Ljung, BM; Meng, ZH; Sayeed, A; Shalaby, R | 1 |
Bjerkvig, R; Eliasson, C; Pekny, M; Wilhelmsson, U | 1 |
Doi, K; Katayama, K; Nagata, T; Nakayama, H; Ueno, M; Yamauchi, H | 1 |
Fischer, C; Kindler-Röhrborn, A; Koelsch, BU; Neibecker, M; Rajewsky, MF; Schmidt, O; Schmitt, N | 1 |
Bonten, J; Carella, C; Grosveld, GC; Neale, G; Potter, M; Rehg, JE | 1 |
Casaccia-Bonnefil, P; Garcia-Verdugo, JM; Gil-Perotin, S; Li, J; Marin-Husstege, M; Roussel, MF; Soriano-Navarro, M; Zindy, F | 1 |
Baginskaia, NV; Il'nitskaia, SI; Kaledin, VI; Kholodar', AV; Obut, TA | 1 |
Fischer, C; Gering, KM; Kindler-Röhrborn, A; Lennartz, K; Marx, JA; Rajewsky, MF | 1 |
Fox, RR; Hard, GC | 2 |
Cravioto, H; Kageyama, N; Kida, Y; Kobayashi, T; Ransohoff, J; Shibuya, N; Yoshida, J | 1 |
De Ridder, L; Laerum, OD; Mørk, SJ | 1 |
Hayashi, K | 1 |
Alitalo, K; Hautanen, A; Keski-Oja, J; Rapp, UR | 1 |
Camp, RC; Capen, CC; Koestner, A; Vinores, SA | 1 |
Paoletti, P; Schiffer, D | 1 |
Kokunai, T; Matsumoto, S; Tamaki, N; Taomoto, K | 1 |
Singer, B | 3 |
Cervós-Navarro, J; Kroh, H | 1 |
Cravioto, H; Ransohoff, J; Yoshida, J | 1 |
de Ridder, L; Laerum, OD; Rajewsky, MF | 1 |
Rajewsky, MF | 1 |
Erickson, LC; Kohn, KW; Laurent, G; Sharkey, NA | 1 |
Cowing, D; Finkelstein, R; Padhy, LC; Shih, C; Weinberg, RA | 1 |
Owsianka, AM; Roscoe, JP | 1 |
Claisse, PJ; Hince, TA; Roscoe, JP; Winslow, DP | 1 |
Bressler, JP; Cole, R; de Vellis, J | 1 |
Bock, E; Haugen, A; Laerum, OD | 1 |
Claisse, PJ; Roscoe, JP | 1 |
Arita, N; Hayakawa, T; Higuchi, M; Hiraga, S; Izumoto, S; Ohnishi, T; Taki, T; Yamamoto, H | 1 |
Coca, S; Oya, S; Vaquero, J; Zurita, M | 1 |
Aguilar, F; Cerutti, P; Hussain, P; Pourzand, C | 1 |
Brüstle, O; Höll, T; Kleihues, P; Petersen, I; Plate, KH; Radner, H; Wiestler, OD | 1 |
Flesken-Nikitin, A; Jin, JJ; Nikitin, AY; Papewalis, J; Pozharisski, KM; Prokopenko, SN; Rajewsky, MF; Winterhager, E | 1 |
Bederson, JB; Germano, IM; Segal, DH | 1 |
Bilzer, T; Blass-Kampmann, S; Rajewsky, MF | 1 |
Geiger, M; Kindler-Röhrborn, A; Lennartz, K; Rajewsky, MF | 1 |
Anderson, LM; Buzard, GS; Devor, DE; Enomoto, T; Perantoni, AO; Rice, JM | 1 |
Cook, H; Kuraguchi, M; Thomas, GA; Williams, ED | 1 |
Stoica, G | 2 |
Thust, R | 1 |
Haglid, KG; Haugen, A; Laerum, OD; Rajewsky, MF; Schachner, M; Stavrou, D | 1 |
Haugen, A; Laerum, OD | 2 |
Asofsky, R; Kim, KJ; Mathieson, BJ; McKeever, PE; Weinbaum, FI | 1 |
Coutelle, R; Herrmann, V; Schreiber, D | 1 |
Haugen, A; Matre, R | 1 |
Taomoto, K | 1 |
Roscoe, JP; Rowles, PM; Winslow, DP | 1 |
Ostrovskaia, LA; Vermel', EM | 1 |
Laerum, OD; Rajewsky, MF | 1 |
Salamon, DP; Wani, AA; Yamasaki, EF | 1 |
Pitot, HC; Sattler, GL; Xu, YH; Zhang, JS | 1 |
Ballering, LA; Lyons, J; Rajewsky, MF | 1 |
Eberle, G; Huh, NH; Nehls, P; Rajewsky, MF; Thomale, J | 1 |
Chang, GT; de Kok, AJ; Sips, H; Verheijen, JH | 1 |
Chitale, AR; Deshpande, RB; Hasgekar, NN; Lalitha, VS | 1 |
Choudhury, S; Howett, MK; Kreider, JW; Mayo, DR; Pegg, AE | 1 |
Campanile, G; Capurro, G; Cipolla, M; Muratore, O; Rossi, L; Varnier, OE | 1 |
Aguzzi, A; Burger, PC; Kleihues, P; Shibata, T | 2 |
Ikeda, T; Iwasaki, K; Mashimoto, H; Matsuo, T; Shimokawa, I | 1 |
Bargmann, CI; Hung, MC; Weinberg, RA | 1 |
Cooper, CS; Newbold, RF; Shiner, AC | 1 |
Green, LJ; Roscoe, JP; Rumsby, PC | 1 |
Vinores, SA | 1 |
Guo, LP; Liu, YL; Lu, SZ; Luo, ZY; Su, ZZ | 1 |
de Kok, AJ; Den Engelse, L; Simons, JW; Sips, HM | 1 |
Kadlubar, FF; Kumari, L; Lehman, TA; Milo, GE; Noyes, I; Oldham, JW; West, RW | 1 |
O'Leary, M; Stoica, G | 1 |
Altena, B; Lens, PF; Nusse, R | 1 |
de Kok, AJ; den Engelse, L; Simons, JW; Sips, H | 1 |
Kokunai, T; Korosue, K; Matsumoto, S; Tamaki, N | 1 |
Bock, E; Haglid, K; Haugen, A; Laerum, OD; Mørk, SJ; Rosengren, L | 1 |
Koestner, A | 1 |
de Kok, AJ; Den Engelse, L; Simons, JW; Tates, AD | 1 |
de Kok, AJ; Den Engelse, L; Simons, JW; van Zeeland, AA | 1 |
4 review(s) available for ethylnitrosourea and Cell Transformation, Neoplastic
Article | Year |
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The transformation process.
Topics: Animals; Brain; Brain Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Humans; Hyperplasia; Karyotyping; Neoplasm Invasiveness; Neoplasm Staging; Nerve Tissue Proteins; Plasminogen Activators | 1984 |
Possible determinants for the differential susceptibility of mammalian cells and tissues to chemical carcinogens.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Phenotype; Rats | 1980 |
Mutagenesis of the H-ras protooncogene and the p53 tumor suppressor gene.
Topics: Aflatoxin B1; Base Sequence; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Codon; DNA Primers; Ethylnitrosourea; Genes, p53; Genes, ras; Humans; Liver Neoplasms; Molecular Sequence Data; Mutagenesis; Neoplasms; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proto-Oncogenes; Urinary Bladder Neoplasms | 1994 |
N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.
Topics: Alkylating Agents; Animals; Binding Sites; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA; DNA Repair; DNA, Single-Stranded; Ethylnitrosourea; Humans; Mutagens; Nitroso Compounds; Structure-Activity Relationship | 1979 |
85 other study(ies) available for ethylnitrosourea and Cell Transformation, Neoplastic
Article | Year |
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Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro.
Topics: Alkylating Agents; Cell Transformation, Neoplastic; Cells, Cultured; Drug Resistance, Neoplasm; Ethylnitrosourea; Exons; Humans; In Vitro Techniques; Interleukin-3; Leukemia; Lung Neoplasms; Mutation; Precursor Cells, B-Lymphoid; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met | 2019 |
N-nitroso-N-ethylurea activates DNA damage surveillance pathways and induces transformation in mammalian cells.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Checkpoints; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA Repair; Ethylnitrosourea; Humans; Phosphorylation; Protein Kinases; Signal Transduction | 2014 |
The MDM2-a splice variant of MDM2 alters transformation in vitro and the tumor spectrum in both Arf- and p53-null models of tumorigenesis.
Topics: Animals; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Ethylnitrosourea; Female; Fibroblasts; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Germ Cell and Embryonal; Protein Isoforms; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53 | 2009 |
Phenotypic alteration of bone marrow HSC and microenvironmental association in experimentally induced leukemia.
Topics: Animals; Antigens, Ly; Bone Marrow; Cell Transformation, Neoplastic; Cells, Cultured; Disease Progression; Ethylnitrosourea; Gene Expression Regulation, Neoplastic; Hematopoietic Stem Cells; Hyaluronan Receptors; Immunophenotyping; Leukemia; Membrane Proteins; Mice; Neoplastic Stem Cells; Proto-Oncogene Proteins c-kit; Receptors, CXCR4; Tumor Microenvironment | 2010 |
5'-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Blotting, Western; Brain Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Ethylnitrosourea; Fluorescent Antibody Technique; Glioma; Immunohistochemistry; Neoplasm Staging; Phosphorylation; Rats; Rats, Sprague-Dawley | 2011 |
Immunological profile of arsenic toxicity: a hint towards arsenic-induced carcinogenesis.
Topics: Alkylating Agents; Animals; Apoptosis; Arsenic; Caspases; Cell Transformation, Neoplastic; Cytokines; Ethylnitrosourea; Female; Humans; Male; Mice; Neoplasms, Experimental; Tissue Distribution | 2010 |
Sex-biased suppression of chemically induced neural carcinogenesis in congenic BDIX.BDIV-Mss4a rats.
Topics: Animals; Animals, Congenic; Cell Transformation, Neoplastic; Ethylnitrosourea; Female; Genetic Loci; Genome-Wide Association Study; Guanine Nucleotide Exchange Factors; Incidence; Male; Nerve Sheath Neoplasms; Rats; Rats, Transgenic; Sex Characteristics; Survival Analysis | 2011 |
Clonal structure of carcinogen-induced intestinal tumors in mice.
Topics: Adenomatous Polyposis Coli; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Chimerism; Clone Cells; Ethylnitrosourea; Female; Genes, APC; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Mutation; Proteins; RNA, Untranslated | 2011 |
Ikaros is a critical target during simultaneous exposure to X-rays and N-ethyl-N-nitrosourea in mouse T-cell lymphomagenesis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Cell Transformation, Neoplastic; DNA Mutational Analysis; Ethylnitrosourea; Female; Homeodomain Proteins; Ikaros Transcription Factor; Loss of Heterozygosity; Lymphoma, T-Cell; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Point Mutation; Proto-Oncogene Proteins p21(ras); Receptor, Notch1; Transcription Factor HES-1; Transcription, Genetic; Tumor Suppressor Protein p53; X-Rays | 2013 |
Genome-wide allelotyping of a new in vitro model system reveals early events in breast cancer progression.
Topics: Alleles; Breast; Breast Neoplasms; Cell Adhesion; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Disease Progression; Epithelial Cells; Ethylnitrosourea; Gene Deletion; Genes, p16; Genes, p53; Humans; Loss of Heterozygosity; Telomerase; Telomere | 2002 |
Loss of GFAP expression in high-grade astrocytomas does not contribute to tumor development or progression.
Topics: Animals; Astrocytoma; Brain Neoplasms; Cell Transformation, Neoplastic; Ethylnitrosourea; Glial Fibrillary Acidic Protein; Mice; Rats; Rats, Nude | 2003 |
Ethylnitrosourea induces neural progenitor cell apoptosis after S-phase accumulation in a p53-dependent manner.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Carcinogens; Cell Cycle; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Replication; Ethylnitrosourea; Female; G2 Phase; Male; Mice; Mice, Knockout; Neurons; Rats; Rats, Inbred F344; S Phase; Stem Cells; Tumor Suppressor Protein p53 | 2005 |
Gender-specific polygenic control of ethylnitrosourea-induced oncogenesis in the rat peripheral nervous system.
Topics: Alkylating Agents; Animals; Cell Transformation, Neoplastic; Chromosome Mapping; Ethylnitrosourea; Female; Genetic Predisposition to Disease; Male; Multifactorial Inheritance; Neurilemmoma; Peripheral Nervous System Neoplasms; Rats; Rats, Inbred Strains; Sex Factors | 2006 |
The ETS factor TEL2 is a hematopoietic oncoprotein.
Topics: Alkylating Agents; Animals; Bone Marrow; Bone Marrow Transplantation; Carcinogens; Cell Transformation, Neoplastic; Ethylnitrosourea; ETS Translocation Variant 6 Protein; Female; Gene Expression; Hematopoiesis; HL-60 Cells; Humans; Lymphoma, T-Cell; Male; Mice; Proto-Oncogene Proteins c-ets; Repressor Proteins; Transcription Factors; Translocation, Genetic; U937 Cells | 2006 |
Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Cell Count; Cell Division; Cell Transformation, Neoplastic; Cerebral Ventricles; DNA Damage; Ethylnitrosourea; Female; Gene Expression Regulation; Genes, p53; Genetic Vectors; Glioblastoma; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Multipotent Stem Cells; Neoplasms, Radiation-Induced; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Time Factors; Tumor Suppressor Protein p53 | 2006 |
[Effect of phenobarbital and thyroxine on hepatocarcinogenesis initiated in mice by nitrosoethylurea and diethylnitrosamine].
Topics: Alkylating Agents; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Ethylnitrosourea; Female; Hypnotics and Sedatives; Leukemia; Lung Neoplasms; Male; Mice; Mice, Inbred CBA; Mice, Inbred ICR; Phenobarbital; Thyroxine | 2005 |
The interaction mode of premalignant Schwann and immune effector cells during chemically induced carcinogenesis in the rat peripheral nervous system is strongly influenced by genetic background.
Topics: Animals; Antibodies; CD18 Antigens; Cell Communication; Cell Transformation, Neoplastic; Cranial Nerve Neoplasms; Ethylnitrosourea; Immunohistochemistry; Leukocytes; Macrophages; Neurilemmoma; Precancerous Conditions; Rats; Rats, Inbred Strains; Schwann Cells; T-Lymphocytes, Cytotoxic; Trigeminal Nerve | 2006 |
Electron-microscopic analysis of nephroblastomas induced transplacentally in the IIIVO/J rabbit by a single dose of N-ethylnitrosourea.
Topics: Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Disease Models, Animal; Ethylnitrosourea; Female; Kidney Glomerulus; Kidney Neoplasms; Kidney Tubules; Mesenchymoma; Nitrosourea Compounds; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Wilms Tumor | 1984 |
[In vitro malignant transformation of fetal brain cells exposed in utero to ethylnitrosourea--serological analysis of cell surface antigens of transformed cells (author's transl)].
Topics: Animals; Antigens, Neoplasm; Antigens, Surface; Brain Neoplasms; Cell Transformation, Neoplastic; Epitopes; Ethylnitrosourea; Female; Fetus; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1981 |
Histologic characterization of renal tumors (nephroblastomas) induced transplacentally in IIIVO/J and WH/J rabbits by N-ethylnitrosourea.
Topics: Abdominal Neoplasms; Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Epithelium; Ethylnitrosourea; Female; Humans; Kidney Glomerulus; Kidney Neoplasms; Kidney Tubules; Lung Neoplasms; Maternal-Fetal Exchange; Neoplasms, Connective Tissue; Pregnancy; Rabbits; Wilms Tumor | 1983 |
Tissue culture of trigeminal nerves from rats administered transplacentally with ethylnitrosourea.
Topics: Aging; Animals; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cranial Nerve Neoplasms; Ethylnitrosourea; Female; Microscopy, Electron; Neoplasm Transplantation; Neurilemmoma; Nitrosourea Compounds; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Trigeminal Nerve | 1983 |
Transformation of cultured epithelial cells by ethylnitrosourea. Altered expression of type I procollagen chains.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Epithelium; Ethylnitrosourea; Kinetics; Macromolecular Substances; Molecular Weight; Nitrosourea Compounds; Peptides; Procollagen; Rats; Tetradecanoylphorbol Acetate | 1984 |
The effect of nerve growth factor and antibodies to nerve growth factor on ethylnitrosourea-induced neoplastic proliferation in rat trigeminal nerves.
Topics: Animals; Antibodies; Cell Transformation, Neoplastic; Cranial Nerve Neoplasms; Ethylnitrosourea; Female; Male; Mice; Nerve Growth Factors; Neurilemmoma; Nitrosourea Compounds; Pregnancy; Rats; Rats, Inbred Strains; Trigeminal Nerve | 1984 |
[Prospects in neuro-oncology].
Topics: Animals; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Cell Transformation, Neoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; Ependymoma; Ethylnitrosourea; Humans; Medical Oncology; Mice; Neoplasms, Experimental; Nerve Tissue; Nervous System Neoplasms; Neurology; Nitrosourea Compounds; Prognosis; Prospective Studies; Rats; Stem Cells | 1984 |
[Effect of tumor promoting agents on the in vitro malignant transformation of the fetal rat brain cells exposed in utero to ethylnitrosourea].
Topics: Animals; Brain Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Drug Interactions; Ethylnitrosourea; Female; Fetus; In Vitro Techniques; Maternal-Fetal Exchange; Nitrosourea Compounds; Phenobarbital; Phorbols; Pregnancy; Rats; Tetradecanoylphorbol Acetate | 1984 |
Alkylation of the O6 of guanine is only one of many chemical events that may initiate carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Guanine; Methylnitrosourea; Neoplasms, Experimental | 1984 |
Transformation of oligodendroglia: a para- or preneoplastic effect of ethylnitrosourea on mouse brain.
Topics: Animals; Cell Transformation, Neoplastic; Demyelinating Diseases; Ethylnitrosourea; Female; Maternal-Fetal Exchange; Mice; Microscopy, Electron; Neuroglia; Nitrosourea Compounds; Oligodendroglia; Pregnancy | 1983 |
In vitro transformation of fetal brain cells from CDF rats exposed in utero to N-ethyl-N-nitrosourea: morphologic and immunologic studies.
Topics: Animals; Animals, Newborn; Antibody Formation; Brain; Brain Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats; Rats, Inbred Strains; Thymectomy; Transplantation, Isogeneic | 1980 |
Malignant transformation of rat neural cells in culture.
Topics: Animals; Brain; Brain Neoplasms; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Microscopy, Electron, Scanning; Rats | 1982 |
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.
Topics: Cell Line; Cell Transformation, Neoplastic; Cross-Linking Reagents; DNA Repair; DNA, Neoplasm; Ethylnitrosourea; Humans; Methylation; Mutation; Nitrosourea Compounds; Peptide Hydrolases | 1980 |
Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; DNA, Neoplasm; Ethylnitrosourea; Fibroblasts; Fibrosarcoma; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Neuroblastoma; Phosphoproteins; Rats; Transfection | 1982 |
Alginate: a reversible semi-solid medium for investigating cell transformation.
Topics: Alginates; Animals; Brain; Cell Line; Cell Separation; Cell Survival; Cell Transformation, Neoplastic; Clone Cells; Culture Media; Ethylnitrosourea; Rats | 1982 |
Correlations between sites of chemical modification of DNA, repair, and carcinogenesis.
Topics: Alkylating Agents; Alkylation; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; DNA Repair; Ethylnitrosourea; Humans; Neoplasms; Nucleic Acid Conformation; Transcription, Genetic | 1982 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on two charateristics of transformation acquired sequentially by ENU-exposed rat brain cells.
Topics: Agar; Animals; Brain; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Phorbols; Plasminogen Activators; Rats; Tetradecanoylphorbol Acetate | 1980 |
Cell culture systems to study glial transformation.
Topics: Animals; Astrocytes; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media; Ethylnitrosourea; Female; Glioma; Humans; Maternal-Fetal Exchange; Neoplasms, Experimental; Neuroglia; Nitrosourea Compounds; Oligodendroglia; Pregnancy; Rats | 1980 |
Responsiveness of fetal rat brain cells to glia maturation factor during neoplastic transformation in cell culture.
Topics: Animals; Brain; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Female; Glia Maturation Factor; Microscopy, Electron, Scanning; Nerve Tissue Proteins; Neuroglia; Pregnancy; Rats; Swine | 1981 |
Different response of ENU-exposed and unexposed rat brain cells to cholera toxin at early passages in culture.
Topics: Animals; Brain; Cell Transformation, Neoplastic; Cells, Cultured; Cholera Toxin; Clone Cells; Ethylnitrosourea; Female; Nitrosourea Compounds; Rats; Rats, Inbred Strains | 1981 |
Transformation of type 1 astrocytes with N-ethyl-N-nitrosourea: establishment of an in vitro system and the role of the p53 gene.
Topics: Animals; Astrocytes; Brain; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA Damage; Ethylnitrosourea; Gene Expression Regulation, Neoplastic; Genes, p53; Glioma; Mice; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Rats; Rats, Wistar; RNA, Neoplasm; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 1995 |
Experimental induction of primitive neuro-ectodermal tumours in rats: a re-appraisement of the ENU-model of neurocarcinogenesis.
Topics: Animals; Biomarkers, Tumor; Brain; Brain Neoplasms; Cell Line; Cell Transformation, Neoplastic; Ethylnitrosourea; Female; Immunoenzyme Techniques; Male; Microscopy, Electron; Neoplasm Transplantation; Neuroectodermal Tumors, Primitive; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 1994 |
Complementary tumor induction in neural grafts exposed to N-ethyl-N-nitrosourea and an activated myc gene.
Topics: Animals; Base Sequence; Brain; Brain Neoplasms; Brain Tissue Transplantation; Cell Transformation, Neoplastic; Cocarcinogenesis; Ethylnitrosourea; Female; Gene Expression Regulation, Neoplastic; Genes, myc; Male; Maternal-Fetal Exchange; Molecular Sequence Data; Pregnancy; Rats; Rats, Inbred F344; Transfection | 1993 |
Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells.
Topics: Alleles; Animals; Base Sequence; Cell Transformation, Neoplastic; Ethylnitrosourea; Gene Expression Regulation, Developmental; Genes, erbB-2; Homozygote; Molecular Sequence Data; Mutation; Neurilemmoma; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Schwann Cells; Transfection; Transgenes; Trigeminal Nerve | 1996 |
Effects of basic fibroblast growth factor on in vivo cerebral tumorigenesis in rats.
Topics: Animals; Brain Neoplasms; Cell Transformation, Neoplastic; Ethylnitrosourea; Female; Fibroblast Growth Factor 2; Glioma; Humans; Male; Neovascularization, Pathologic; Pregnancy; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 1997 |
gp130RB13-6-positive neural progenitor cells are susceptible to the oncogenic effect of ethylnitrosourea in pre-natal rat brain.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Ethylnitrosourea; Fetus; Humans; Lysosomal Membrane Proteins; Membrane Glycoproteins; Neoplasms, Nerve Tissue; Neurons; Rats; Rats, Inbred Strains; Stem Cells; Tumor Cells, Cultured | 1998 |
Determinants of carcinogen-induced malignant conversion in rat brain: proliferative properties of neural precursor cell subpopulations analyzed by multi-parameter flow cytometry.
Topics: Animals; Antibodies, Monoclonal; Brain Neoplasms; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Ethylnitrosourea; Flow Cytometry; In Vitro Techniques; Rats; Rats, Inbred Strains; Stem Cells | 1998 |
Activation of neu by missense point mutation in the transmembrane domain in schwannomas induced in C3H/HeNCr mice by transplacental exposure to N-nitrosoethylurea.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Transformation, Neoplastic; CHO Cells; Cricetinae; DNA Mutational Analysis; DNA, Neoplasm; Ethylnitrosourea; Female; Gene Expression Regulation; Maternal-Fetal Exchange; Membrane Proteins; Mice; Mice, Inbred C3H; Molecular Sequence Data; Neurilemmoma; Placenta; Point Mutation; Polymorphism, Restriction Fragment Length; Pregnancy; Protein Structure, Tertiary; Receptor, ErbB-2; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Transfection; Tumor Cells, Cultured | 1999 |
Differences in susceptibility to colonic stem cell somatic mutation in three strains of mice.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colon; Ethylnitrosourea; Female; Genetic Predisposition to Disease; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mutagens; Mutation; Species Specificity; Stem Cells | 2001 |
ENU mutagenesis of rat mammary epithelial cells.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Epithelial Cells; Ethylnitrosourea; Female; Flow Cytometry; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mutagens; Rats | 2002 |
ENU-induced ovarian cancer.
Topics: Animals; Carcinogens; Cell Culture Techniques; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Female; Humans; Karyotyping; Ovarian Neoplasms; Ovary; Rats; Sertoli Cell Tumor | 2002 |
[Long-term cultures of experimental CNS tumours as models in neurooncological research (author's transl)].
Topics: Animals; Brain Neoplasms; Bucladesine; Cell Division; Cell Transformation, Neoplastic; Culture Techniques; Ethylnitrosourea; Glioma; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Rats; Rats, Inbred Strains; Time Factors | 1976 |
Phenotypic properties of neoplastic cell lines developed from fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo.
Topics: Animals; Brain; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Ectoderm; Ethylnitrosourea; Fetus; In Vitro Techniques; Neoplasm Transplantation; Neoplasms, Experimental; Neoplasms, Nerve Tissue; Nitrosourea Compounds; Phenotype; Rats | 1977 |
Surface structure of fetal rat brain cells during neoplastic transformation in cell culture.
Topics: Animals; Brain Neoplasms; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Female; Maternal-Fetal Exchange; Microscopy, Electron, Scanning; Neoplasms, Experimental; Precancerous Conditions; Pregnancy; Rats; Time Factors | 1978 |
Transmission electron microscopy of fetal rat brain cells during neoplastic transformation in cell culture.
Topics: Animals; Brain Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Microscopy, Electron; Neoplasms, Experimental; Pregnancy; Rats; Time Factors | 1979 |
Characteristics of BALB/C T cell lymphomas grown as continuous in vitro lines.
Topics: Animals; Antigens; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Chromosomes; Ethylnitrosourea; Karyotyping; Lymphoma; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; T-Lymphocytes | 1978 |
[Electronmicroscopic investigations of N. trigeminus of rats during the phase of tumour induction by ethylnitrosourea (author's transl)].
Topics: Animals; Cell Transformation, Neoplastic; Ethylnitrosourea; Mitosis; Myelin Sheath; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Schwann Cells; Trigeminal Nerve | 1979 |
Fc gamma receptors receptors on fetal rat brain cells during neoplastic transformation in culture after exposure to ethylnitrosourea in vivo.
Topics: Animals; Brain Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Female; Fetus; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats; Receptors, Fc | 1979 |
[Experimental brain tumor produced transplacentally by ethylnitrosourea (3). Autoradiographic studies on tumor cell proliferation].
Topics: Animals; Autoradiography; Brain Neoplasms; Cell Division; Cell Transformation, Neoplastic; DNA, Neoplasm; Ethylnitrosourea; Female; Maternal-Fetal Exchange; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats | 1977 |
Changes in surface morphology associated with ethylnitrosourea-induced malignant transformation of cultured rat brain cells studied by scanning electron microscopy.
Topics: Brain; Cell Line; Cell Membrane; Cell Nucleus; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Ethylnitrosourea; Microvilli; Pseudopodia | 1978 |
[Growth kinetics of transplantable mammary gland tumors in mice].
Topics: Adenocarcinoma; Animals; Cell Transformation, Neoplastic; Ethylnitrosourea; Kinetics; Male; Mammary Neoplasms, Experimental; Mathematics; Methylnitrosourea; Mice; Mice, Inbred A; Mice, Inbred C3H; Neoplasm Transplantation; Nitrosourea Compounds; Time Factors | 1975 |
Neoplastic transformation of fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo.
Topics: Animals; Brain; Brain Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Female; Models, Biological; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats; Time Factors | 1975 |
Mutational activation of H-ras oncogene transformability by alkylnitrosourea-induced DNA damage.
Topics: 3T3 Cells; Alkylation; Animals; Base Sequence; Cell Transformation, Neoplastic; DNA; DNA Damage; Ethylnitrosourea; Gene Expression Regulation; Genes, ras; Methylnitrosourea; Mice; Molecular Sequence Data; Mutation | 1992 |
DNA damage and repair in gamma-glutamyltranspeptidase-positive and negative hepatocytes in primary culture from carcinogen-treated rats.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Rats; Rats, Inbred F344 | 1991 |
Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage.
Topics: Alleles; Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; DNA, Neoplasm; Ethylnitrosourea; Molecular Sequence Data; Mutagenesis; Neurilemmoma; Polymorphism, Restriction Fragment Length; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Rats; Rats, Inbred Strains; Receptor, ErbB-2; Schwann Cells | 1991 |
Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea.
Topics: Animals; Carmustine; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Clone Cells; DNA; DNA Repair; Ethylnitrosourea; Guanine; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1990 |
Enhanced plasminogen activator production of Syrian hamster embryo cells transformed by chemicals or the c-Ha-ras oncogene: type of plasminogen activators involved and their contribution to the transformed phenotype.
Topics: Animals; Antibodies; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Embryo, Mammalian; Enzyme Precursors; Ethylnitrosourea; Genes, ras; Humans; Insulin; Isoflurophate; Mesocricetus; Phenotype; Plasminogen Activators; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 1989 |
Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: II. Comparative pathology.
Topics: Adult; Animals; Cell Transformation, Neoplastic; Ethylnitrosourea; Humans; Kidney Neoplasms; Rats; Rats, Inbred Strains; Wilms Tumor | 1989 |
Administration of ethylnitrosourea to neonate hamsters increases growth and frequency of SV40-induced fibrosarcomas.
Topics: Animals; Animals, Newborn; Antigens, Polyomavirus Transforming; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cricetinae; Ethylnitrosourea; Fibrosarcoma; Mesocricetus; Neoplasm Metastasis; Neoplasm Transplantation; Simian virus 40; Tumor Virus Infections | 1989 |
Acutely transforming retroviruses as carcinogens in mouse embryos.
Topics: Animals; Animals, Newborn; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cocarcinogenesis; Embryo, Mammalian; Ethylnitrosourea; Female; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Sarcoma Viruses, Murine | 1989 |
Cell-specific brain tumour induction in neural transplants: evidence for multistep carcinogenesis in the nervous system.
Topics: Animals; Brain; Brain Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Ethylnitrosourea; Female; Nerve Tissue; Oligodendroglioma; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344 | 1989 |
A sequential ultrastructural and histoautoradiographic study of early neoplastic lesions in ethylnitrosourea-induced rat glioma.
Topics: Animals; Autoradiography; Brain Neoplasms; Cell Transformation, Neoplastic; Ethylnitrosourea; Female; Glioma; Hyperplasia; Male; Microscopy, Electron; Neurons; Rats; Rats, Inbred Strains | 1989 |
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.
Topics: Alleles; Animals; Cell Line; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Gene Expression Regulation; Mice; Mutation; Oncogenes; Protein Conformation; Proto-Oncogene Proteins; Rats; Rats, Inbred Strains; Receptor, ErbB-2; Receptors, Cell Surface | 1986 |
Morphological transformation of immortalized hamster dermal fibroblasts following treatment with simple alkylating carcinogens.
Topics: Alkylating Agents; Animals; Cell Division; Cell Transformation, Neoplastic; Cricetinae; DNA; DNA Damage; Ethylnitrosourea; Genes, ras; Methylnitrosourea; Mice; Mice, Nude; Neoplasms, Experimental; Sulfuric Acid Esters | 1988 |
An increase in plasminogen activator mRNA occurs at an early stage in ethylnitrosourea-induced transformation of rat brain cells.
Topics: Animals; Brain; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Gene Expression Regulation; Rats; RNA, Messenger; Time Factors; Tissue Plasminogen Activator | 1986 |
Nerve growth factor modification of the ethylnitrosourea model for multiple schwannomas.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Cranial Nerve Neoplasms; Ethylnitrosourea; Neoplasm Transplantation; Neoplasms, Multiple Primary; Nerve Growth Factors; Nervous System Neoplasms; Neurilemmoma; Neurofibromatosis 1; Rats; Trigeminal Nerve | 1986 |
Transformation of cultured human fetal gastric fibroblasts with physico-chemical agents.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Ethylnitrosourea; Fetus; Fibroblasts; Mice; Neoplasm Transplantation; Rats; Stomach; Ultraviolet Rays | 1988 |
Epidermal growth factor enhances N-ethyl-N-nitrosourea-induced morphological transformation of Syrian hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Embryo, Mammalian; Epidermal Growth Factor; Ethylnitrosourea; Mesocricetus | 1988 |
Cocarcinogenicity of saccharin and N-alkylnitrosoureas in cultured human diploid fibroblasts.
Topics: Antigens, Neoplasm; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Ethylnitrosourea; Fibroblasts; Humans; Insulin; Interphase; Methylnitrosourea; Saccharin | 1988 |
In vitro malignant transformation of in vivo ENU-induced rat ovarian Sertoli cell tumor (adenoma).
Topics: Adenoma; Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; DNA; Ethylnitrosourea; Female; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Rats; Sertoli Cell Tumor; Species Specificity; Tumor Cells, Cultured | 1988 |
Selective induction by N-nitrosoethylurea of oligodendrogliomas in fetal forebrain transplants.
Topics: Animals; Brain; Brain Neoplasms; Cell Differentiation; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Female; Fetus; Nerve Tissue; Oligodendroglioma; Rats; Rats, Inbred F344 | 1988 |
Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea.
Topics: Animals; Brain; Brain Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Female; Genes; Glioma; Maternal-Fetal Exchange; Oncogenes; Platelet-Derived Growth Factor; Pregnancy; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-sis; Rats | 1986 |
Transformation of C3H10T1/2 cells by N-ethyl-N-nitrosourea occurs as a single, low frequency, mutation-like event.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Ethylnitrosourea; Mice; Mutation; Proto-Oncogenes | 1986 |
Promoting effect of 12-O-tetradecanoylphorbol-13-acetate on the in vitro malignant transformation of fetal rat brain cells exposed in utero to ethylnitrosourea.
Topics: Animals; Brain Neoplasms; Cell Aggregation; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Concanavalin A; Ethylnitrosourea; Female; Glial Fibrillary Acidic Protein; Maternal-Fetal Exchange; Neoplasm Transplantation; Neoplastic Stem Cells; Phorbols; Pregnancy; Rats; Tetradecanoylphorbol Acetate | 1986 |
Differentiation markers (S-100, GFAP, NSE and D2) in fetal rat brain cells during malignant transformation in cell culture.
Topics: Animals; Antigens, Surface; Brain; Brain Chemistry; Brain Neoplasms; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Female; Fetus; Glial Fibrillary Acidic Protein; Nerve Tissue Proteins; Phosphopyruvate Hydratase; Pregnancy; Rats; Rats, Inbred Strains; S100 Proteins | 1985 |
Prognostic role of cell morphology of animal tumors.
Topics: Anaplasia; Animals; Cell Cycle; Cell Transformation, Neoplastic; Dog Diseases; Dogs; Ethylnitrosourea; Glioma; Neoplasms; Nerve Growth Factors; Prognosis; Trigeminal Nerve | 1985 |
Genetic and molecular mechanisms of the in vitro transformation of Syrian hamster embryo cells by the carcinogen N-ethyl-N-nitrosourea. I. Correlation of morphological transformation and enhanced fibrinolytic activity to gene mutation, chromosomal alterat
Topics: Animals; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Cricetinae; Embryo, Mammalian; Ethylnitrosourea; Female; Fibrinolysis; Mesocricetus; Mutation; Sister Chromatid Exchange | 1985 |
Genetic and molecular mechanisms of the in vitro transformation of Syrian hamster embryo cells by the carcinogen N-ethyl-N-nitrosourea II. Correlation of morphological transformation, enhanced fibrinolytic activity, gene mutations, chromosomal alterations
Topics: Alkylation; Animals; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Cricetinae; DNA; DNA Repair; Ethylnitrosourea; Female; Fibrinolysis; Mesocricetus; Mutation; Sister Chromatid Exchange | 1985 |