ethylmorphine and Opioid-Related-Disorders

A fatal opiates overdose, where ethylmorphine, hydrocodone, dihydrocodeine and codeine were consumed concomitantly, is reported. This case report may contribute to data on fatal blood concentrations of drugs with rare incidence. The relative retention times in capillary gas chromatography and full mass spectra of various opiates in their silylated forms, detected together in one sample, may serve as a helpful analytical reference for clinical and forensic toxicologists.

Topics: Adult; Codeine; Drug Overdose; Ethylmorphine; Fatal Outcome; Gas Chromatography-Mass Spectrometry; Humans; Hydrocodone; Male; Opioid-Related Disorders; Toxicology

The authors report on some laboratory indicators in opiate abusers dependent for prolonged periods on opiates. The objective of the study is a proposal for an examination pattern in adepts during oral substitution therapy and emphasis on the necessity of systematic follow up of the health status.. In 27 opiate abusers with a varying period of dependence on opiates the hematology laboratory tests was assessed, plasma levels of some minerals, renal and hepatic functions, some enzymes and metabolic indicators and vitamin D metabolites. For statistical evaluation Student's t-test was used and simultaneous testing.. Long-term opiate abuse damages in 30 and 35% resp. liver functions. Therefore vitamin D deficiency develops. The authors recommend to follow up the health status of opiate abusers during oral substitution treatment (tertiary prevention).

Topics: Adult; Ethylmorphine; Female; Humans; Male; Narcotics; Opioid-Related Disorders