ethylmethylhydroxypyridine-succinate and Ventricular-Fibrillation

The effects of mexicor (ethylmethylhydroxypyridine succinate) at doses of 50 and 100 mg/kg on myocardial infarct size, serum levels of myocardial markers, and severity of ischemia- and reperfusion-induced arrhythmias were studied in the rat model of myocardial ischemia-reperfusion injury. It was shown that pre-ischemic intravenous infusion of mexicor at a dose of 50 mg/kg resulted in significant reduction of myocardial infarct size and troponin I level. When the dose of mexicor was increased up to 100 mg/kg the infarct-limiting effect was reversed. Both doses of mexicor tested in this study failed to protect the heart from ischemic tachyarrhythmias but decreased the occurrence of persistent reperfusion-induced ventricular fibrillation.

Topics: Animals; Biomarkers; Dose-Response Relationship, Drug; Male; Myocardial Reperfusion Injury; Pyridines; Rats; Rats, Wistar; Troponin I; Ventricular Fibrillation