ethylmaleimide has been researched along with Pregnancy in 67 studies
Ethylmaleimide: A sulfhydryl reagent that is widely used in experimental biochemical studies.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Excerpt | Relevance | Reference |
---|---|---|
"The effects of cadmium (Cd) exposure during the preimplantation period of pregnancy on the subsequent development and implantation of mouse embryos were examined." | 3.68 | Stage-specific effects of cadmium on preimplantation embryo development and implantation in the mouse. ( Andrews, GK; De, SK; Dey, SK; Paria, BC, 1993) |
"Diamide was found to produce a differential effect on the enzymatic activities determined in this study, with greater degrees of inhibition seen in the tissue supernatants from the visceral yolk sac (VYS) compared to those from the embryo." | 1.29 | Diamide-induced alterations of intracellular thiol status and the regulation of glucose metabolism in the developing rat conceptus in vitro. ( Harris, C; Hiranruengchok, R, 1995) |
"L-histidine is an essential amino acid." | 1.28 | Characteristics of histidine uptake by human placental microvillous membrane vesicles. ( Fisher, SE; Karl, PI; Tkaczevski, H, 1989) |
"125I-fibrinogen was hardly recognized by the beads even in presence of the fibronectin fragment." | 1.27 | N-terminal fibronectin 30-kDa fragment mediates the immobilization of soluble fibrin by factor XIIIa-coated polystyrene beads. ( Hörmann, H; Jelinić, V; Richter, H; Wendt, C, 1987) |
"N-Ethylmaleimide was less effective as an inhibitor of binding when applied after hepatocytes had been exposed to 125I-prl, binding being decreased by about 15%." | 1.27 | Evidence that non-covalent forces, thiol and disulphide groups affect the structure and binding properties of the prolactin receptor on hepatocytes from pregnant rats. ( Donner, DB; Yamada, K, 1985) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 40 (59.70) | 18.7374 |
1990's | 22 (32.84) | 18.2507 |
2000's | 4 (5.97) | 29.6817 |
2010's | 1 (1.49) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kalf, GF | 3 |
Metrione, RM | 2 |
Kerlavage, BL | 1 |
Koszalka, TR | 2 |
González, M | 1 |
Gallardo, V | 1 |
Rodríguez, N | 1 |
Salomón, C | 1 |
Westermeier, F | 1 |
Guzmán-Gutiérrez, E | 1 |
Abarzúa, F | 1 |
Leiva, A | 1 |
Casanello, P | 2 |
Sobrevia, L | 2 |
Taira, N | 1 |
Marshall, JM | 1 |
Newburger, PE | 1 |
Maturo, JM | 2 |
Hollenberg, MD | 2 |
Aglio, LS | 2 |
Pike, LJ | 1 |
Kuenzel, EA | 1 |
Casnellie, JE | 1 |
Krebs, EG | 1 |
Walker, TS | 1 |
Das, SK | 1 |
Kakkad, PB | 1 |
McCullough, MS | 1 |
Shia, MA | 1 |
Rubin, JB | 1 |
Pilch, PF | 1 |
Rauvala, H | 1 |
Prieels, JP | 1 |
Finne, J | 1 |
Ito, A | 1 |
Kobayashi, J | 1 |
Mori, Y | 1 |
Hirakawa, S | 1 |
Siegel, RL | 1 |
Heller, C | 1 |
Coirini, H | 1 |
De Nicola, AF | 1 |
Kleczkowska, D | 2 |
Kurył, T | 1 |
Niedbalski, W | 2 |
Zwierzchowski, L | 3 |
Eichler, DC | 1 |
Tatar, TF | 1 |
Lasater, LS | 1 |
Jahn, GA | 1 |
Kalbermann, LE | 1 |
Machiavelli, G | 1 |
Szijan, I | 1 |
Burdman, JA | 1 |
Whalley, T | 1 |
Sokoloff, A | 1 |
Brunette, MG | 1 |
Bastani, B | 1 |
Leclerc, M | 1 |
Narbaitz, R | 1 |
Ijlst, L | 1 |
Wanders, RJ | 1 |
Tang, LH | 1 |
Aizenman, E | 1 |
Saraf, HA | 1 |
Dombrowski, MP | 1 |
Leach, KC | 1 |
Hurd, WW | 1 |
Satlin, LM | 1 |
Yasoshima, K | 1 |
Schwartz, GJ | 1 |
Frank, P | 1 |
Albert, S | 1 |
Cazenave, C | 1 |
Toulmé, JJ | 1 |
Johanson, CE | 1 |
Preston, JE | 1 |
De, SK | 1 |
Paria, BC | 1 |
Dey, SK | 1 |
Andrews, GK | 1 |
Hiranruengchok, R | 2 |
Harris, C | 2 |
Furesz, TC | 2 |
Smith, CH | 2 |
Way, BA | 1 |
Schwarz, JK | 1 |
Moe, AJ | 1 |
Corchs, JL | 1 |
Taborda, D | 1 |
Serrani, RE | 1 |
Kudo, Y | 2 |
Boyd, CA | 2 |
Gibson, JS | 1 |
Speake, PF | 1 |
Muzyamba, MC | 1 |
Husain, F | 1 |
Luckas, MC | 1 |
Ellory, JC | 1 |
Roskoski, R | 1 |
Lim, CT | 1 |
Roskoski, LM | 1 |
Watanabe, A | 1 |
Taketa, K | 1 |
Kosaka, K | 1 |
Artal, R | 1 |
Burgeson, RE | 1 |
Hobel, CJ | 1 |
Hollister, D | 1 |
Feldman, D | 1 |
Dziak, R | 1 |
Koehler, R | 1 |
Stern, P | 1 |
Felix, JM | 1 |
Sutter-Dub, MT | 1 |
Legrele, C | 1 |
Birch-Machin, MA | 1 |
Farnsworth, L | 1 |
Ackrell, BA | 1 |
Cochran, B | 1 |
Jackson, S | 1 |
Bindoff, LA | 1 |
Aitken, A | 1 |
Diamond, AG | 1 |
Turnbull, DM | 1 |
Barszczewska, I | 1 |
Barańczyk-Kuźma, A | 1 |
Simon, BJ | 1 |
Kulanthaivel, P | 1 |
Burckhardt, G | 1 |
Ramamoorthy, S | 1 |
Leibach, FH | 2 |
Ganapathy, V | 2 |
Mas, A | 1 |
Sarkar, B | 1 |
Chiacchia, KB | 1 |
van Dijk, JP | 1 |
Bierings, MB | 1 |
van der Zande, FG | 1 |
Finn, FM | 1 |
Ridge, KD | 1 |
Hofmann, K | 1 |
Van Winkle, LJ | 1 |
Mann, DF | 1 |
Campione, AL | 1 |
Farrington, BH | 1 |
Baker, ME | 1 |
Liu, SQ | 1 |
Bhatnagar, A | 1 |
Das, B | 1 |
Srivastava, SK | 1 |
Hörmann, H | 1 |
Richter, H | 1 |
Jelinić, V | 1 |
Wendt, C | 1 |
Karl, PI | 1 |
Tkaczevski, H | 1 |
Fisher, SE | 1 |
Yu, KT | 1 |
Werth, DK | 1 |
Pastan, IH | 1 |
Czech, MP | 1 |
Yamada, K | 1 |
Donner, DB | 1 |
Wasilewska, LD | 1 |
Weber, S | 1 |
Dölz, R | 1 |
Timpl, R | 1 |
Fessler, JH | 1 |
Engel, J | 1 |
Mena, F | 1 |
Clapp, C | 1 |
Aguayo, D | 1 |
Lorenson, MY | 1 |
Martinez-Escalera, G | 1 |
Ogle, TF | 1 |
Ganapathy, ME | 1 |
Mahesh, VB | 1 |
Howard, JC | 1 |
Devoe, LD | 1 |
Sweiry, JH | 1 |
Yudilevich, DL | 1 |
Young, PC | 1 |
Cleary, RE | 1 |
Nicolas, JC | 1 |
Harris, JI | 1 |
Thomas, DM | 1 |
Moss, DW | 1 |
Srivastiva, SK | 1 |
Blume, KG | 1 |
Van Loon, C | 1 |
Beutler, E | 1 |
Terenius, L | 1 |
1 trial available for ethylmaleimide and Pregnancy
Article | Year |
---|---|
A simple, straightforward assay for long-chain 3-hydroxyacyl-CoA dehydrogenase based on the use of N-ethylmaleimide: potential for pre- and postnatal diagnosis.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Ethylmaleimide; Female; Fibroblasts; Humans; Infant, Newborn; Leuk | 1993 |
66 other studies available for ethylmaleimide and Pregnancy
Article | Year |
---|---|
Variation of DNA polymerase activities of rat giant trophoblast cells in mid-gestation.
Topics: Animals; DNA; DNA-Directed DNA Polymerase; Ethylmaleimide; Female; Gestational Age; Pregnancy; Rats; | 1981 |
Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arginine; Biological Transport; | 2011 |
Intrauterine growth retardation is associated with reduced activity and expression of the cationic amino acid transport systems y+/hCAT-1 and y+/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cells.
Topics: Amino Acid Transport Systems, Basic; Arginine; Biological Transport; Cationic Amino Acid Transporter | 2002 |
Action of oxytocin antagonists on electrical and mechanical activity of the uterus.
Topics: Acetylcholine; Action Potentials; Animals; Bradykinin; Drug Antagonism; Electric Stimulation; Enzyme | 1967 |
Superoxide generation by human fetal granulocytes.
Topics: Deoxyglucose; Ethylmaleimide; Female; Fetal Blood; Granulocytes; Humans; Lymphocyte Activation; Oxyg | 1982 |
Insulin receptor: insulin-modulated interconversion between distinct molecular forms involving disulfide-sulfhydryl exchange.
Topics: Cell Line; Disulfides; Ethylmaleimide; Female; Humans; Insulin; Placenta; Pregnancy; Protein Conform | 1983 |
A comparison of the insulin- and epidermal growth factor-stimulated protein kinases from human placenta.
Topics: Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Ethylmaleimide; Female; H | 1984 |
Rickettsial interactions with human endothelial cells in vitro: adherence and entry.
Topics: Cell Adhesion; Cells, Cultured; Cytochalasin D; Cytochalasins; Endothelium; Ethylmaleimide; Female; | 1984 |
Development of glycerophosphate acyltransferase in guinea pig lung mitochondria and microsomes.
Topics: Acyltransferases; Animals; Ethylmaleimide; Female; Gestational Age; Glycerol-3-Phosphate O-Acyltrans | 1984 |
The insulin receptor protein kinase. Physicochemical requirements for activity.
Topics: Dithiothreitol; Ethylmaleimide; Female; Histones; Humans; Macromolecular Substances; Microsomes; Pan | 1983 |
Cell adhesion mediated by a purified fucosyltransferase.
Topics: Cell Adhesion; Embryo, Mammalian; Ethylmaleimide; Female; Fibroblasts; Fibronectins; Fucosyltransfer | 1983 |
Two kinds of succinyl-trialanine-p-nitroanilide hydrolases in rabbit myometrium.
Topics: Animals; Chlorides; Chloromercuribenzoates; Chromatography, Gel; Edetic Acid; Ethylmaleimide; Female | 1980 |
DNA polymerase beta involvement in DNA endoreduplication in rat giant trophoblast cells.
Topics: Animals; Cell Nucleus; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; DNA Replication; DNA | 1982 |
Binding of [3H]dexamethasone by rat placenta.
Topics: Animals; Binding, Competitive; Cell Nucleus; Cytosol; Dexamethasone; Ethylmaleimide; Female; Kinetic | 1981 |
A protein stimulatory factor for DNA polymerase alpha in rat giant trophoblast cells.
Topics: Animals; Cattle; DNA; DNA Polymerase II; DNA-Directed DNA Polymerase; Ethylmaleimide; Female; In Vit | 1981 |
Characterization of DNA polymerases from the mammary gland of pregnant rabbit.
Topics: Animals; Cattle; Cell Extracts; Cell Nucleus; Cells, Cultured; Centrifugation, Density Gradient; Cyt | 1981 |
Effect of human placental ribonuclease inhibitor in cell-free ribosomal RNA synthesis.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Nucleolus; Cell-Free System; Ethylmaleimide; Female; Humans; | 1981 |
DNA polymerases in the rat pituitary gland. Effect of oestrogens and sulpiride.
Topics: Animals; DNA-Directed DNA Polymerase; Estrogens; Ethylmaleimide; Female; Male; Pituitary Gland, Ante | 1980 |
The N-ethylmaleimide-sensitive protein thiol groups necessary for sea-urchin egg cortical-granule exocytosis are highly exposed to the medium and are required for triggering by Ca2+.
Topics: Animals; Calcium; Cytoplasmic Granules; Dextrans; Ethylmaleimide; Exocytosis; Female; Membrane Prote | 1994 |
Detection of different adenosine triphosphatases in human placental brush border membranes.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alkaline Phosphatase; Animals; Anti-Bacterial Age | 1995 |
The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro.
Topics: Alkylating Agents; Animals; Cerebral Cortex; Culture Techniques; Dithionitrobenzoic Acid; Dithiothre | 1993 |
Characterization of the effect of cocaine on catecholamine uptake by pregnant myometrium.
Topics: Analysis of Variance; Cocaine; Corticosterone; Desipramine; Ethylmaleimide; Female; Humans; In Vitro | 1995 |
H+ secretion in rabbit mesonephric collecting tubule.
Topics: Absorption; Animals; Anti-Bacterial Agents; Bicarbonates; Biological Transport; Calorimetry; Cell Co | 1994 |
Purification and characterization of human ribonuclease HII.
Topics: Base Sequence; Cations, Divalent; Ethylmaleimide; Female; Humans; Hydrogen-Ion Concentration; Kineti | 1994 |
Potassium efflux from infant and adult rat choroid plexuses: effects of CSF anion substitution, N-ethylmaleimide and Cl transport inhibitors.
Topics: Aging; Animals; Anions; Benzoates; Bumetanide; Chlorides; Choroid Plexus; Ethylmaleimide; Female; Fu | 1994 |
Stage-specific effects of cadmium on preimplantation embryo development and implantation in the mouse.
Topics: Animals; Blastomeres; Cadmium; Cells, Cultured; Embryo Transfer; Embryo, Mammalian; Ethylmaleimide; | 1993 |
Formation of protein-glutathione mixed disulfides in the developing rat conceptus following diamide treatment in vitro.
Topics: Animals; Cysteine; Diamide; Dithiothreitol; Dose-Response Relationship, Drug; Embryo, Mammalian; Emb | 1995 |
Diamide-induced alterations of intracellular thiol status and the regulation of glucose metabolism in the developing rat conceptus in vitro.
Topics: Animals; Buthionine Sulfoximine; Diamide; Embryo, Mammalian; Embryonic and Fetal Development; Ethylm | 1995 |
Identification of two leucine-sensitive lysine transport activities in human placental basal membrane.
Topics: Amino Acid Transport Systems, Basic; Basement Membrane; Carrier Proteins; Chorionic Villi; Ethylmale | 1997 |
Sodium-independent lysine uptake by the BeWo choriocarcinoma cell line.
Topics: Biological Transport, Active; Choriocarcinoma; DNA, Neoplasm; Ethylmaleimide; Female; Humans; Kineti | 1998 |
Human red blood cells from prenatal hemopoiesis. Lithium flux (sodium dependent) asymmetry.
Topics: Amiloride; Cell Membrane; Culture Media; Erythrocytes; Ethylmaleimide; Female; Fetal Blood; Hematopo | 2000 |
Characterisation of L-tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles.
Topics: Amino Acids; Anions; Biological Transport; Carrier Proteins; Cations; Ethylmaleimide; Female; Humans | 2001 |
K(+) transport in red blood cells from human umbilical cord.
Topics: Acetates; Biological Transport; Bumetanide; Carrier Proteins; Chlorides; Erythrocyte Membrane; Eryth | 2001 |
Human brain and placental choline acetyltransferase: purification and properties.
Topics: Acetyltransferases; Caudate Nucleus; Choline O-Acetyltransferase; Ethylmaleimide; Female; Humans; Hy | 1975 |
Microheterogeneity of rat alpha-fetoprotein.
Topics: alpha-Fetoproteins; Animals; Binding Sites; Electrophoresis, Cellulose Acetate; Electrophoresis, Dis | 1975 |
An in vitro model for the study of enzymatically mediated biomechanical changes in the chorioamniotic membranes.
Topics: Amnion; Chorion; Collagen; Connective Tissue; Culture Media; Edetic Acid; Elasticity; Endopeptidases | 1979 |
Cytoplasmic glucocorticoid binding proteins in bone cells.
Topics: 17-Hydroxycorticosteroids; Aldosterone; Animals; Binding Sites; Binding, Competitive; Bone and Bones | 1975 |
Studies on the different forms of material reacting with antiinsulin antibodies in the fetal and adult rat.
Topics: Animals; Antigen-Antibody Reactions; Binding Sites; Ethylmaleimide; Female; Fetus; Insulin; Insulin | 1975 |
The sequence of the flavoprotein subunit of bovine heart succinate dehydrogenase.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Cattle; DNA; Ethylma | 1992 |
Placenta as a protecting barrier--some properties of glutathione-S-transferase.
Topics: Amnion; Catecholamines; Chorion; Enzyme Stability; Ethylmaleimide; Female; Glutathione Transferase; | 1992 |
Characterization of an ATP-driven H+ pump in human placental brush-border membrane vesicles.
Topics: Acridine Orange; Adenosine Triphosphatases; Adenosine Triphosphate; Anti-Bacterial Agents; Biologica | 1992 |
Binding, uptake and efflux of 65Zn by isolated human trophoblast cells.
Topics: Acetates; Acetic Acid; Biological Transport; Cells, Cultured; Culture Media; Ethylmaleimide; Female; | 1991 |
Quantitation of the class I disulfides of the insulin receptor.
Topics: Cell Membrane; Disulfides; Electrophoresis, Polyacrylamide Gel; Ethylmaleimide; Female; Humans; Macr | 1991 |
An investigation of placental transferrin processing: influence of N-ethylmaleimide.
Topics: Animals; Ethylmaleimide; Female; Guinea Pigs; Iron; Organ Culture Techniques; Placenta; Pregnancy; T | 1990 |
Labile disulfide bonds in human placental insulin receptor.
Topics: Adenosine Triphosphate; Alkylation; Chlorides; Disulfides; Electrophoresis, Polyacrylamide Gel; Ethy | 1990 |
Human placental L-tyrosine transport: a comparison of brush-border and basal membrane vesicles.
Topics: Amino Acids; Basement Membrane; Biological Transport, Active; Ethylmaleimide; Female; Humans; Hydrog | 1990 |
Transport of benzenoid amino acids by system T and four broad scope systems in preimplantation mouse conceptuses.
Topics: Amino Acids; Animals; Benzene Derivatives; Biological Transport; Blastocyst; Drug Resistance; Embryo | 1990 |
A surprising increase in the affinity of estrogen for rat alpha-fetoprotein after it is treated with N-ethylmaleimide.
Topics: alpha-Fetoproteins; Amniotic Fluid; Animals; Estradiol; Estrone; Ethylmaleimide; Female; Hydrogen-Io | 1986 |
Functional cysteinyl residues in human placental aldose reductase.
Topics: Aldehyde Reductase; Cysteine; Dithionitrobenzoic Acid; Dithiothreitol; Ethylmaleimide; Female; Human | 1989 |
N-terminal fibronectin 30-kDa fragment mediates the immobilization of soluble fibrin by factor XIIIa-coated polystyrene beads.
Topics: Edetic Acid; Ethylmaleimide; Factor XIII; Female; Fibrin; Fibronectins; Humans; Peptide Fragments; P | 1987 |
Characteristics of histidine uptake by human placental microvillous membrane vesicles.
Topics: Aminoisobutyric Acids; Anions; Biological Transport, Active; Cations; Cysteine; Ethylmaleimide; Fema | 1989 |
src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase.
Topics: Amino Acids; Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chromatography, High P | 1985 |
Evidence that non-covalent forces, thiol and disulphide groups affect the structure and binding properties of the prolactin receptor on hepatocytes from pregnant rats.
Topics: Animals; Binding Sites; Chromatography, Gel; Dithiothreitol; Ethylmaleimide; Female; Growth Hormone; | 1985 |
Receptors for insulin and epidermal growth factor: interaction with organomercurial agarose.
Topics: Chromatography, Affinity; Dithiothreitol; ErbB Receptors; Ethylmaleimide; Female; Humans; In Vitro T | 1985 |
DNA polymerases of rabbit mammary gland: partial purification, characterization and changes in DNA polymerase activities as a function of physiological state.
Topics: Animals; Aphidicolin; Arabinofuranosylcytosine Triphosphate; Diterpenes; DNA Polymerase I; DNA Polym | 1986 |
Reductive cleavage and reformation of the interchain and intrachain disulfide bonds in the globular hexameric domain NC1 involved in network assembly of basement membrane collagen (type IV).
Topics: Animals; Basement Membrane; Collagen; Disulfides; Ethylmaleimide; Female; Humans; Kidney; Kinetics; | 1988 |
Thiol regulation of depletion-transformation and release of prolactin by the pituitary of the lactating rat.
Topics: Animals; Cysteamine; Disulfides; Dithionitrobenzoic Acid; Ethylmaleimide; Female; Glutathione; Hydro | 1986 |
Characterization of progesterone binding to nuclear receptors in rat placenta.
Topics: Animals; Cell Nucleus; Dithiothreitol; Ethylmaleimide; Female; Placenta; Potassium Chloride; Pregnan | 1986 |
Characterization of tryptophan transport in human placental brush-border membrane vesicles.
Topics: Amino Acids; Azides; Biological Transport; Ethylmaleimide; Female; Humans; In Vitro Techniques; Kine | 1986 |
Effect of cytosol on DNA synthesis in isolated mammary gland nuclei from rabbits during pregnancy and early lactation.
Topics: Animals; Cell Nucleus; Cytosol; DNA; Ethylmaleimide; Female; Hot Temperature; Lactation; Mammary Gla | 1985 |
Characterization of choline transport at maternal and fetal interfaces of the perfused guinea-pig placenta.
Topics: Animals; Biological Transport; Choline; Ethylmaleimide; Female; Guinea Pigs; Hemicholinium 3; In Vit | 1985 |
Characterization and properties of progesterone-binding components in human endometrium.
Topics: Adenocarcinoma; Adolescent; Adult; Benzamides; Binding Sites; Binding, Competitive; Centrifugation, | 1974 |
Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine.
Topics: Alkylation; Amino Acids; Carbon Isotopes; Chromatography, Gel; Chromatography, Paper; Cysteine; Elec | 1973 |
Chemical modification of alkaline phosphatases. The effects of several treatments on human placental alkaline phosphatase isoenzymes.
Topics: Acetates; Acylation; Alkaline Phosphatase; Anhydrides; Chemical Phenomena; Chemistry; Electrophoresi | 1972 |
Purification and kinetic properties of galactokinase from human placenta.
Topics: Ammonium Sulfate; Chemical Phenomena; Chemical Precipitation; Chemistry, Physical; Chloromercuribenz | 1972 |
Selective retention of estrogen isomers in estrogen-dependent breast tumors of rats demonstrated by in vitro methods.
Topics: Adipose Tissue; Animals; Benz(a)Anthracenes; Chromatography, Thin Layer; Diaphragm; Estradiol; Estro | 1968 |