ethylisopropylamiloride has been researched along with Fibrosarcoma in 3 studies
ethylisopropylamiloride: structure in first source
ethylisopropylamiloride : A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "When nigericin and EIPA were combined with administration of hydralazine, the surviving fraction of cells in both tumors was reduced by a factor of 0." | 1.29 | Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH. ( Hasuda, K; Lee, C; Tannock, IF, 1994) |
| "Hydralazine, which may cause tumour hypoxia and lower pHi as well as pHe, caused cytotoxity when given alone by chronic infusion, and enhanced the cytotoxicity due to nigericin." | 1.29 | The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects. ( Tannock, IF; Yamagata, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Babsky, A | 1 |
| Hekmatyar, SK | 1 |
| Gorski, T | 1 |
| Nelson, DS | 1 |
| Bansal, N | 1 |
| Hasuda, K | 1 |
| Lee, C | 1 |
| Tannock, IF | 2 |
| Yamagata, M | 1 |
3 other studies available for ethylisopropylamiloride and Fibrosarcoma
| Article | Year |
|---|---|
Heat-induced changes in intracellular Na+, pH and bioenergetic status in superfused RIF-1 tumour cells determined by 23Na and 31P magnetic resonance spectroscopy.
Topics: Amiloride; Cell Line, Tumor; Fibrosarcoma; Humans; Hydrogen-Ion Concentration; Hyperthermia, Induced | 2005 |
Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH.
Topics: Amiloride; Animals; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Drug Screening Assays, A | 1994 |
The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Antineoplastic Agents; Antipor | 1996 |