ethylisopropylamiloride has been researched along with Experimental Mammary Neoplasms in 4 studies
ethylisopropylamiloride: structure in first source
ethylisopropylamiloride : A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using two human (MCF7, MDA-MB231) and one murine (EMT6) breast cancer cell lines, we evaluated the influence of two new agents, cariporide (an inhibitor of the Na(+)/H(+) antiport) and S3705 (an inhibitor of the Na(+)-dependent Cl(-)/HCO(3)(-) exchanger) on the regulation of intracellular pH (pHi)." | 3.71 | Cytostatic potential of novel agents that inhibit the regulation of intracellular pH. ( Kleemann, HW; Tannock, IF; Wong, P, 2002) |
| " Weak acids that are normal cellular metabolites are not toxic in vivo, but weak acids carrying cytotoxic groups offer the potential for selective uptake and toxicity under the conditions of low pHe that exist in many solid tumours." | 1.29 | Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. ( Dobrowsky, E; Karuri, AR; Tannock, IF, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, CW | 2 |
| Kim, GE | 1 |
| Lyons, JC | 2 |
| Makepeace, CM | 2 |
| Griffin, RJ | 2 |
| Rao, GH | 1 |
| Cragoe, EJ | 2 |
| Karuri, AR | 1 |
| Dobrowsky, E | 1 |
| Tannock, IF | 2 |
| Wong, P | 1 |
| Kleemann, HW | 1 |
4 other studies available for ethylisopropylamiloride and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Thermosensitization by increasing intracellular acidity with amiloride and its analogs.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Cell Division; Cell Line; Dose | 1994 |
Effects of HMA, an analog of amiloride, on the thermosensitivity of tumors in vivo.
Topics: Amiloride; Animals; Cell Death; Cell Division; Hydrogen-Ion Concentration; Hyperthermia, Induced; Ma | 1994 |
Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment.
Topics: Amiloride; Animals; Butyrates; Butyric Acid; Carboxylic Acids; Cell Hypoxia; Cell Survival; Female; | 1993 |
Cytostatic potential of novel agents that inhibit the regulation of intracellular pH.
Topics: Adenocarcinoma; Amiloride; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Chloride | 2002 |