ethylisopropylamiloride has been researched along with EHS Tumor in 3 studies
ethylisopropylamiloride: structure in first source
ethylisopropylamiloride : A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When nigericin and EIPA were combined with administration of hydralazine, the surviving fraction of cells in both tumors was reduced by a factor of 0." | 1.29 | Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH. ( Hasuda, K; Lee, C; Tannock, IF, 1994) |
| " Weak acids that are normal cellular metabolites are not toxic in vivo, but weak acids carrying cytotoxic groups offer the potential for selective uptake and toxicity under the conditions of low pHe that exist in many solid tumours." | 1.29 | Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. ( Dobrowsky, E; Karuri, AR; Tannock, IF, 1993) |
| "Hydralazine, which may cause tumour hypoxia and lower pHi as well as pHe, caused cytotoxity when given alone by chronic infusion, and enhanced the cytotoxicity due to nigericin." | 1.29 | The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects. ( Tannock, IF; Yamagata, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hasuda, K | 1 |
| Lee, C | 1 |
| Tannock, IF | 3 |
| Karuri, AR | 1 |
| Dobrowsky, E | 1 |
| Yamagata, M | 1 |
3 other studies available for ethylisopropylamiloride and EHS Tumor
| Article | Year |
|---|---|
Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH.
Topics: Amiloride; Animals; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Drug Screening Assays, A | 1994 |
Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment.
Topics: Amiloride; Animals; Butyrates; Butyric Acid; Carboxylic Acids; Cell Hypoxia; Cell Survival; Female; | 1993 |
The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Antineoplastic Agents; Antipor | 1996 |