ethylisopropylamiloride has been researched along with Brain Ischemia in 4 studies
ethylisopropylamiloride: structure in first source
ethylisopropylamiloride : A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of the selective Na(+)/H(+) antiporter inhibitor 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) on cerebral ischemia/reperfusion injury was evaluated in the Mongolian gerbil." | 3.70 | 5-(N-Ethyl-N-isopropyl)-amiloride, an Na(+)-H(+) exchange inhibitor, protects gerbil hippocampal neurons from ischemic injury. ( Estevez, AY; Guyot, LL; O'Regan, MH; Phillis, JW, 1999) |
| "In a rat transient middle cerebral artery occlusion model, intravenous infusion of SM-20220 reduced cerebral infarction when the serum concentration of SM- 20220 was maintained at about 10(-7) mol/l." | 1.31 | The Na(+)/H(+) exchanger SM-20220 attenuates ischemic injury in in vitro and in vivo models. ( Horikawa, N; Itoh, N; Kuribayashi, Y; Matsui, K; Nishioka, M; Ohashi, N, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Phillis, JW | 3 |
| O'Regan, MH | 3 |
| Song, D | 1 |
| Estevez, AY | 1 |
| Guyot, LL | 1 |
| Ren, J | 1 |
| Horikawa, N | 1 |
| Nishioka, M | 1 |
| Itoh, N | 1 |
| Kuribayashi, Y | 1 |
| Matsui, K | 1 |
| Ohashi, N | 1 |
4 other studies available for ethylisopropylamiloride and Brain Ischemia
| Article | Year |
|---|---|
5-(N-Ethyl-N-isopropyl)-amiloride inhibits amino acid release from the ischemic rat cerebral cortex: role of Na+-H+ exchange.
Topics: Amiloride; Amino Acids; Animals; Brain Ischemia; Male; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen E | 1998 |
5-(N-Ethyl-N-isopropyl)-amiloride, an Na(+)-H(+) exchange inhibitor, protects gerbil hippocampal neurons from ischemic injury.
Topics: Amiloride; Animals; Brain Ischemia; Gerbillinae; Hippocampus; Male; Neurons; Neuroprotective Agents; | 1999 |
Inhibition of Na(+)/H(+) exchange by 5-(N-ethyl-N-isopropyl)-amiloride reduces free fatty acid efflux from the ischemic reperfused rat cerebral cortex.
Topics: Acidosis; Amiloride; Animals; Brain Ischemia; Cardiovascular Physiological Phenomena; Cerebral Corte | 2000 |
The Na(+)/H(+) exchanger SM-20220 attenuates ischemic injury in in vitro and in vivo models.
Topics: Amides; Amiloride; Animals; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Dose-Res | 2001 |