ethylenethiourea and Multiple-Myeloma

ethylenethiourea has been researched along with Multiple-Myeloma* in 1 studies

Other Studies

1 other study(ies) available for ethylenethiourea and Multiple-Myeloma

Article	Year
Topoisomerase II-dependent novel antitumor compounds merocil and merodantoin induce apoptosis in Daudi cells. Anti-cancer drugs, 1994, Volume: 5, Issue:5 Three photoproducts of merocyanine 540 have been isolated, chemically characterized and synthesized. Two of these photoproducts, merocil and merodantoin, show significant antitumor activity in vitro and in vivo while demonstrating minimal toxicity to normal cells and tissues. Treatment of lymphoma cells with these compounds resulted in a rapid decline in macromolecular synthesis, DNA fragmentation inhibitable by actinomycin D and cycloheximide, and a marked rise in intracellular calcium. In vitro analysis revealed that activity of these compounds is dependent on topoisomerase II. These results are discussed in terms of the novel class of topoisomerase II-dependent compounds for potential use in chemotherapy. Topics: Antineoplastic Agents; Apoptosis; Benzoxazoles; Calcium; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Electrophoresis, Agar Gel; Ethylenethiourea; Humans; Multiple Myeloma; Neoplasm Proteins; RNA, Neoplasm; Thiobarbiturates; Topoisomerase II Inhibitors; Tumor Cells, Cultured	1994

Article

Year

Topoisomerase II-dependent novel antitumor compounds merocil and merodantoin induce apoptosis in Daudi cells.

Anti-cancer drugs, 1994, Volume: 5, Issue:5

Three photoproducts of merocyanine 540 have been isolated, chemically characterized and synthesized. Two of these photoproducts, merocil and merodantoin, show significant antitumor activity in vitro and in vivo while demonstrating minimal toxicity to normal cells and tissues. Treatment of lymphoma cells with these compounds resulted in a rapid decline in macromolecular synthesis, DNA fragmentation inhibitable by actinomycin D and cycloheximide, and a marked rise in intracellular calcium. In vitro analysis revealed that activity of these compounds is dependent on topoisomerase II. These results are discussed in terms of the novel class of topoisomerase II-dependent compounds for potential use in chemotherapy.

Topics: Antineoplastic Agents; Apoptosis; Benzoxazoles; Calcium; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Electrophoresis, Agar Gel; Ethylenethiourea; Humans; Multiple Myeloma; Neoplasm Proteins; RNA, Neoplasm; Thiobarbiturates; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1994