ethylenethiourea has been researched along with Fetal-Death* in 4 studies
1 review(s) available for ethylenethiourea and Fetal-Death
Article | Year |
---|---|
The electrocardiogram of fetal and newborn rats and dysrhythmias induced by toxic exposure.
Topics: Animals; Animals, Newborn; Arrhythmias, Cardiac; Aspirin; Dose-Response Relationship, Drug; Electrocardiography; Ethylenethiourea; Female; Fetal Death; Fetal Heart; Gestational Age; Heart Block; Insecticides; Lithium; Maternal-Fetal Exchange; Mirex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Trichlorfon; Trypan Blue | 1983 |
3 other study(ies) available for ethylenethiourea and Fetal-Death
Article | Year |
---|---|
Developmental toxicity of nine selected compounds following prenatal exposure in the mouse: naphthalene, p-nitrophenol, sodium selenite, dimethyl phthalate, ethylenethiourea, and four glycol ether derivatives.
Ethylene glycol dimethyl ether (EGdiME), diethylene glycol dimethyl ether (diEGdiME), triethylene glycol dimethyl ether (triEGdiME), diethylene glycol diethyl ether (diEGdiEE), ethylenethiourea (ETU), sodium selenite (SS), dimethyl phthalate (DMP), naphthalene (NAP), or p-nitrophenol (PNP) were administered by gavage for eight consecutive days to female CD-1 mice. Weight loss was insensitive as an index of sublethal adult toxicity and was inadequate for determining a maximum tolerated dose. LD50 values indicate that SS, NAP, and PNP were more toxic (8.4, 353.6, and 625.7 mg/kg, respectively) than the polyglycol ethers, ETU, and DMP (LD50 values ranged from 2525.8 to 6281.9 mg/kg). Each of the compounds was administered on d 7 through 14 to pregnant animals at a single dose estimated to be at or just below the threshold of adult lethality. In such a reproductive study, each of the compounds could be categorized on the basis of the pattern of maternal lethality and fetotoxicity which it produced. The number of dams with complete resorptions was significantly increased after administration of ETU, and no mice in the EGdiME-, diEGdiME-, or triEGdiME-treated groups delivered any viable offspring. Maternal lethality was significant in the EGdiME, triEGdiME, PNP, and NAP groups. There was a slight reduction in the average number of live pups per litter in the diEGdiEE- and PNP-treated groups and a significant reduction in the NAP group. The number dead per litter was increased with diEGdiEE. SS and DMP had no effect on maternal or fetal survival at the doses administered. Individual pup weight at d 1 postpartum was only significantly reduced by diEGdiEE, and no gross congenital abnormalities were detected in neonates from any treatment group. These results provide guidelines for the subsequent toxicity testing of these chemicals. Topics: Administration, Oral; Analysis of Variance; Animals; Birth Weight; Body Weight; Drug Evaluation, Preclinical; Ethylene Glycols; Ethylenethiourea; Female; Fetal Death; Fetus; Imidazoles; Lethal Dose 50; Maternal-Fetal Exchange; Mice; Naphthalenes; Nitrophenols; Phthalic Acids; Pregnancy; Reproduction; Selenious Acid; Selenium | 1985 |
Postnatal effects of oral administration of ethylenethiourea to rats during late pregnancy.
Ethylenethiourea (ETU), a manufacturing, processing, and metabolic product of the ethylenebisdithiocarbamate fungicides, was evaluated for its effects on postnatal performance of rats. ETU was given to pregnant rats as a single oral dose of 1-50 mg/kg on day 17, 18, 19, or 20 of gestation. The number of stillborn rats was significantly increased at dose levels of 30 and 50 mg/kg. Treatment of dams with 50 mg/kg on day 20 of gestation caused reduction in the birth weight of the offspring. Progeny survival was impaired after maternal treatment with doses of 10 mg/kg and more. The high mortality was attributable to the development of hydrocephalus in the pups. At 6 months of age, 16 and 26% of the surviving offspring from dams treated with 10 or 20 mg/kg had hydrocephalus. Topics: Administration, Oral; Animals; Ethylenethiourea; Female; Fetal Death; Gestational Age; Growth; Hydrocephalus; Imidazoles; Male; Pregnancy; Rats | 1980 |
Teratogenic effects of combined administration of ethylenethiourea and nitrite in mice.
Teratogenic potential of ethylenethiourea (ETU) was investigated in SLC-ICR mice after its reaction with sodium nitrite. ETU was given orally in doses of 400 mg/kg on various days of pregnancy in combination with 200 mg/kg NaNO2 at varied intervals. When NaNO2 was given to females immediately after their treatment with ETU on day 6 or 8 of pregnancy, fetal survival was significantly decreased. Various types of malformations were observed in the living fetuses from mothers treated on day 6, 8, or 10 of pregnancy, but not on day 12. The teratogenicity disappeared when NaNO2 was given 2 h after the treatment with ETU. Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Drug Synergism; Ethylenethiourea; Female; Fetal Death; Fetus; Gestational Age; Imidazoles; Lung; Mice; Nitrites; Pregnancy; Sodium Nitrite; Time Factors | 1980 |