Page last updated: 2024-10-16

ethylene glycol and Urinary Calculi

ethylene glycol has been researched along with Urinary Calculi in 19 studies

Ethylene Glycol: A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.
ethanediol : Any diol that is ethane or substituted ethane carrying two hydroxy groups.
ethylene glycol : A 1,2-glycol compound produced via reaction of ethylene oxide with water.

Urinary Calculi: Low-density crystals or stones in any part of the URINARY TRACT. Their chemical compositions often include CALCIUM OXALATE, magnesium ammonium phosphate (struvite), CYSTINE, or URIC ACID.

Research Excerpts

ExcerptRelevanceReference
"Propolis extract has a potential protective effect against ethylene glycol induced hepatotoxicity and nephrotoxicity and has a potential to treat and prevent urinary calculus, crystaluria and proteinuria."7.83Protective Effect of Propolis in Proteinuria, Crystaluria, Nephrotoxicity and Hepatotoxicity Induced by Ethylene Glycol Ingestion. ( Al Waili, N; Al-Waili, H; Bakour, M; El Menyiy, N; Lyoussi, B, 2016)
"Propolis extract has a potential protective effect against ethylene glycol induced hepatotoxicity and nephrotoxicity and has a potential to treat and prevent urinary calculus, crystaluria and proteinuria."3.83Protective Effect of Propolis in Proteinuria, Crystaluria, Nephrotoxicity and Hepatotoxicity Induced by Ethylene Glycol Ingestion. ( Al Waili, N; Al-Waili, H; Bakour, M; El Menyiy, N; Lyoussi, B, 2016)
"We investigated the effects of a traditional Chinese herbal formula, Wulingsan (WLS), on renal stone prevention using an ethylene glycol-induced nephrocalcinosis rat model."3.74A traditional Chinese herbal antilithic formula, Wulingsan, effectively prevents the renal deposition of calcium oxalate crystal in ethylene glycol-fed rats. ( Chen, LD; Chen, WC; Chen, YC; Ho, CY; Lai, MT; Pan, TC; Tsai, CH; Tsai, FJ, 2008)
"Hyperoxaluria was induced using 0."1.33Counteraction of oxalate induced nitrosative stress by supplementation of l-arginine, a potent antilithic agent. ( Kalaiselvi, P; Pragasam, V; Srinivasan, S; Sumitra, K; Varalakshmi, P, 2005)
"The results showed that there were no urinary stones or calcium oxalate crystal deposits in the intact or uNX rats fed a normal diet."1.28Uninephrectomy enhances urolithiasis in ethylene glycol treated rats. ( Chang, LS; Chen, MT; Huang, JK; Huang, WC; Lee, YH, 1992)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.53)18.7374
1990's10 (52.63)18.2507
2000's4 (21.05)29.6817
2010's3 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zharikova, GV1
Bryukhanov, VM1
Neymark, AI1
Zharikov, AY1
Bobrov, IP1
Yakushev, NN1
Zhang, H1
Li, N1
Li, K1
Li, P1
El Menyiy, N1
Al Waili, N1
Bakour, M1
Al-Waili, H1
Lyoussi, B1
TANRET, P1
THOMAS, J1
COTTENOT, F1
Pragasam, V1
Kalaiselvi, P1
Sumitra, K1
Srinivasan, S1
Varalakshmi, P1
Tsai, CH1
Chen, YC1
Chen, LD1
Pan, TC1
Ho, CY1
Lai, MT1
Tsai, FJ1
Chen, WC1
de Bruijn, WC2
Boevé, ER2
van Run, PR2
van Miert, PP2
de Water, R2
Romijn, JC2
Verkoelen, CF2
Cao, LC2
Schröder, FH1
van 't Noordende, JM1
Schrder, FH1
Lee, YH3
Huang, WC3
Huang, JK3
Chang, LS3
Angayarkanni, N1
Selvam, R1
Fan, J1
Glass, MA1
Chandhoke, PS1
Yasui, T2
Fujita, K2
Sasaki, S1
Sato, M2
Sugimoto, M1
Hirota, S1
Kitamura, Y1
Nomura, S2
Kohri, K2
Tozawa, K1
Yagisawa, T1
Ito, F1
Osaka, Y1
Amano, H1
Kobayashi, C1
Toma, H1
Chen, MT2
Chiang, H1
Cifuentes Delatte, L1
Khera, KS1
Khan, SR1
Shevock, PN1
Hackett, RL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Renal Protective Effect of ACEI and ARB in Primary Hyperoxaluria[NCT00280215]Phase 30 participants (Actual)Interventional2007-12-31Withdrawn (stopped due to Inadequate number of patients, lack of funding)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

19 other studies available for ethylene glycol and Urinary Calculi

ArticleYear
[The features of the pathologic changes in chronic oxalate stone disease after 16 week of experimental phase].
    Urologiia (Moscow, Russia : 1999), 2018, Issue:5

    Topics: Animals; Calcium Oxalate; Ethylene Glycol; Kidney; Kidney Calculi; Rats; Time Factors; Urinary Calcu

2018
Protective effect of Urtica dioica methanol extract against experimentally induced urinary calculi in rats.
    Molecular medicine reports, 2014, Volume: 10, Issue:6

    Topics: Ammonium Chloride; Animals; Calcium; Calcium Oxalate; Chlorogenic Acid; Creatinine; Ethylene Glycol;

2014
Protective Effect of Propolis in Proteinuria, Crystaluria, Nephrotoxicity and Hepatotoxicity Induced by Ethylene Glycol Ingestion.
    Archives of medical research, 2016, Volume: 47, Issue:7

    Topics: Animals; Chemical and Drug Induced Liver Injury; Ethylene Glycol; Kidney; Kidney Diseases; Male; Pla

2016
[Evolution of oxalic and lipid deposits in experimental renal lithiasis by ethylene glycol and oxalic acid].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1961, Volume: 155

    Topics: Ethylene Glycol; Glycols; Humans; Lipid Metabolism; Lipids; Lithiasis; Nephrolithiasis; Oxalates; Ox

1961
Counteraction of oxalate induced nitrosative stress by supplementation of l-arginine, a potent antilithic agent.
    Clinica chimica acta; international journal of clinical chemistry, 2005, Volume: 354, Issue:1-2

    Topics: Animals; Antioxidants; Arginine; Body Weight; Dietary Supplements; Disease Models, Animal; Ethylene

2005
A traditional Chinese herbal antilithic formula, Wulingsan, effectively prevents the renal deposition of calcium oxalate crystal in ethylene glycol-fed rats.
    Urological research, 2008, Volume: 36, Issue:1

    Topics: Animals; Calcium Oxalate; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ethylene Glycol;

2008
Etiology of calcium oxalate nephrolithiasis in rats. I. Can this be a model for human stone formation?
    Scanning microscopy, 1995, Volume: 9, Issue:1

    Topics: Ammonium Chloride; Animals; Calcium Oxalate; Crystallization; Disease Models, Animal; Ethylene Glyco

1995
Etiology of calcium oxalate nephrolithiasis in rats. II. The role of the papilla in stone formation.
    Scanning microscopy, 1995, Volume: 9, Issue:1

    Topics: Ammonium Chloride; Animals; Calcium Oxalate; Crystallization; Disease Models, Animal; Electron Probe

1995
Testosterone enhances whereas estrogen inhibits calcium oxalate stone formation in ethylene glycol treated rats.
    The Journal of urology, 1996, Volume: 156, Issue:2 Pt 1

    Topics: Animals; Calcium Oxalate; Castration; Crystallization; Drug Interactions; Estrogens; Ethylene Glycol

1996
Enhanced renal vitamin-K-dependent gamma-glutamyl carboxylase activity in experimental rat urolithiasis.
    European urology, 1998, Volume: 33, Issue:1

    Topics: Animals; Carbon-Carbon Ligases; Dicumarol; Disease Models, Animal; Enzyme Activation; Ethylene Glyco

1998
Effect of castration and finasteride on urinary oxalate excretion in male rats.
    Urological research, 1998, Volume: 26, Issue:1

    Topics: Animals; Calcium Oxalate; Crystallization; Enzyme Inhibitors; Ethylene Glycol; Finasteride; Kidney;

1998
Expression of bone matrix proteins in urolithiasis model rats.
    Urological research, 1999, Volume: 27, Issue:4

    Topics: Animals; Blood Urea Nitrogen; Blotting, Northern; Calcium Oxalate; Calcium-Binding Proteins; Choleca

1999
Effects of citrate on renal stone formation and osteopontin expression in a rat urolithiasis model.
    Urological research, 2001, Volume: 29, Issue:1

    Topics: Animals; Blotting, Northern; Chelating Agents; Cholecalciferol; Citric Acid; Disease Models, Animal;

2001
The influence of sex hormones on renal osteopontin expression and urinary constituents in experimental urolithiasis.
    The Journal of urology, 2001, Volume: 166, Issue:3

    Topics: Animals; Ethylene Glycol; Gonadal Steroid Hormones; Kidney; Male; Orchiectomy; Osteopontin; Phosphop

2001
Uninephrectomy enhances urolithiasis in ethylene glycol treated rats.
    Kidney international, 1992, Volume: 42, Issue:2

    Topics: Animals; Calcium; Calcium Oxalate; Ethylene Glycol; Ethylene Glycols; Kidney; Male; Microscopy, Elec

1992
Determinant role of testosterone in the pathogenesis of urolithiasis in rats.
    The Journal of urology, 1992, Volume: 147, Issue:4

    Topics: Animals; Body Weight; Castration; Ethylene Glycol; Ethylene Glycols; Female; Kidney; Male; Rats; Rat

1992
[Alkalinizing treatment as a preventative of recurrent calcium oxalate lithiasis].
    Archivos espanoles de urologia, 1991, Volume: 44, Issue:8

    Topics: Animals; Calcium Oxalate; Chemical Precipitation; Citrates; Crystallization; Ethylene Glycol; Ethyle

1991
Chemically induced alterations in maternal homeostasis and histology of conceptus: their etiologic significance in rat fetal anomalies.
    Teratology, 1991, Volume: 44, Issue:3

    Topics: Abnormalities, Drug-Induced; Acid-Base Equilibrium; Animals; Cadmium; Cadmium Chloride; Catheterizat

1991
Urinary enzymes and calcium oxalate urolithiasis.
    The Journal of urology, 1989, Volume: 142, Issue:3

    Topics: Acetylglucosaminidase; Alkaline Phosphatase; Animals; Calcium Oxalate; Crystallization; Enzymes; Eth

1989