ethylene glycol has been researched along with Kidney Diseases in 25 studies
Ethylene Glycol: A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.
ethanediol : Any diol that is ethane or substituted ethane carrying two hydroxy groups.
ethylene glycol : A 1,2-glycol compound produced via reaction of ethylene oxide with water.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death." | 9.09 | Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. ( Brent, J; Burkhart, KK; Donovan, JW; Kulig, K; McMartin, K; Phillips, S; Wells, M, 1999) |
| "We administered intravenous fomepizole to 19 patients with ethylene glycol poisoning (plasma ethylene glycol concentration, > or =20 mg per deciliter [3." | 9.09 | Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. ( Brent, J; Burkhart, KK; Donovan, JW; Kulig, K; McMartin, K; Phillips, S; Wells, M, 1999) |
| "In patients with ethylene glycol poisoning, fomepizole administered early in the course of intoxication prevents renal injury by inhibiting the formation of toxic metabolites." | 9.09 | Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. ( Brent, J; Burkhart, KK; Donovan, JW; Kulig, K; McMartin, K; Phillips, S; Wells, M, 1999) |
| "Propolis extract has a potential protective effect against ethylene glycol induced hepatotoxicity and nephrotoxicity and has a potential to treat and prevent urinary calculus, crystaluria and proteinuria." | 7.83 | Protective Effect of Propolis in Proteinuria, Crystaluria, Nephrotoxicity and Hepatotoxicity Induced by Ethylene Glycol Ingestion. ( Al Waili, N; Al-Waili, H; Bakour, M; El Menyiy, N; Lyoussi, B, 2016) |
| "Ethylene glycol poisoning was diagnosed, and hyperlactatemia was ruled out on a blood sample sent to the biochemistry department." | 5.40 | False hyperlactatemia in life-threatening ethylene glycol poisoning. ( Bourgogne, E; Geri, G; Mongardon, N; Pène, F; Riquier, T, 2014) |
| "Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death." | 5.09 | Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. ( Brent, J; Burkhart, KK; Donovan, JW; Kulig, K; McMartin, K; Phillips, S; Wells, M, 1999) |
| "We administered intravenous fomepizole to 19 patients with ethylene glycol poisoning (plasma ethylene glycol concentration, > or =20 mg per deciliter [3." | 5.09 | Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. ( Brent, J; Burkhart, KK; Donovan, JW; Kulig, K; McMartin, K; Phillips, S; Wells, M, 1999) |
| "In patients with ethylene glycol poisoning, fomepizole administered early in the course of intoxication prevents renal injury by inhibiting the formation of toxic metabolites." | 5.09 | Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. ( Brent, J; Burkhart, KK; Donovan, JW; Kulig, K; McMartin, K; Phillips, S; Wells, M, 1999) |
| "Propolis extract has a potential protective effect against ethylene glycol induced hepatotoxicity and nephrotoxicity and has a potential to treat and prevent urinary calculus, crystaluria and proteinuria." | 3.83 | Protective Effect of Propolis in Proteinuria, Crystaluria, Nephrotoxicity and Hepatotoxicity Induced by Ethylene Glycol Ingestion. ( Al Waili, N; Al-Waili, H; Bakour, M; El Menyiy, N; Lyoussi, B, 2016) |
| "Nephrotoxicity can be grouped by the xenobiotics place of action, by the clinical presentation or by the generic toxic effect." | 2.39 | Nephrotoxicity of xenobiotics. ( Costa, MJ; Mitchell, LG; Nayar, R; Werner, M, 1995) |
| "Hyperoxaluria is well known to cause renal injury and end-stage kidney disease." | 1.56 | Alteration of the gut microbiota by vinegar is associated with amelioration of hyperoxaluria-induced kidney injury. ( Duan, X; He, Z; Lan, Y; Li, S; Liu, Y; Lu, S; Luo, L; Mai, X; Wu, C; Xiao, C; Yang, Z; Zeng, G; Zhang, X; Zhong, W; Zhu, W, 2020) |
| "Nephrolithiasis is a complex disease that results from a combination of factors related to both urine composition and kidney morphoanatomy." | 1.42 | Effects of polyphenols from grape seeds on renal lithiasis. ( Costa-Bauzá, A; Fernandez-Cabot, RA; Grases, F; Prieto, RM; Torres, JJ; Tur, F, 2015) |
| "Ethylene glycol poisoning was diagnosed, and hyperlactatemia was ruled out on a blood sample sent to the biochemistry department." | 1.40 | False hyperlactatemia in life-threatening ethylene glycol poisoning. ( Bourgogne, E; Geri, G; Mongardon, N; Pène, F; Riquier, T, 2014) |
| "Ethylene glycol poisoning is a medical emergency that presents challenges for clinicians and clinical laboratories." | 1.39 | The 'gap' in the 'plasma osmolar gap'. ( Arora, A, 2013) |
| " The development and evaluation of the PBPK model was based upon previously published pharmacokinetic studies coupled with measured blood and tissue partition coefficients and rates of in vitro metabolism of glyoxylic acid to oxalic acid, glycine and other metabolites using primary hepatocytes isolated from male Wistar rats and humans." | 1.37 | Extension of a PBPK model for ethylene glycol and glycolic acid to include the competitive formation and clearance of metabolites associated with kidney toxicity in rats and humans. ( Bartels, MJ; Corley, RA; Creim, J; Hansen, SC; McMartin, KE; Saghir, SA; Snellings, WM, 2011) |
| "Treatment for ethylene glycol poisoning typically includes basic supportive care, alcohol dehydrogenase inhibition, and hemodialysis." | 1.34 | Ethylene glycol ingestion treated only with fomepizole. ( Keyes, DC; Lee, YC; Shepherd, G; Velez, LI, 2007) |
| "Ethylene glycol is a widely used chemical that is capable of causing significant injury if ingested." | 1.34 | Ethylene glycol ingestion treated only with fomepizole. ( Keyes, DC; Lee, YC; Shepherd, G; Velez, LI, 2007) |
| "Fomepizole therapy was initiated and initial laboratory studies later revealed an osmol gap of 157 mOsm and an ethylene glycol concentration of 706 mg/dL." | 1.34 | Ethylene glycol ingestion treated only with fomepizole. ( Keyes, DC; Lee, YC; Shepherd, G; Velez, LI, 2007) |
| "Ethylene glycol was mixed in the diet at concentrations to deliver constant target dosage levels of 0, 50, 150, 500, or 1000 mg/kg/day for 16 weeks to groups of 10 male Wistar and 10 male F-344 rats based on weekly group mean body weights and feed consumption." | 1.32 | Subchronic toxicity of ethylene glycol in Wistar and F-344 rats related to metabolism and clearance of metabolites. ( Corley, RA; Cruzan, G; Deyo, JA; Gingell, R; Hard, GC; McMartin, KE; Mertens, JJ; Snellings, WM, 2004) |
| " Ethylene glycol was mixed in the diet at concentrations to deliver constant target dosage levels of 0, 50, 150, 500, or 1000 mg/kg/day for 16 weeks to groups of 10 male Wistar and 10 male F-344 rats based on weekly group mean body weights and feed consumption." | 1.32 | Subchronic toxicity of ethylene glycol in Wistar and F-344 rats related to metabolism and clearance of metabolites. ( Corley, RA; Cruzan, G; Deyo, JA; Gingell, R; Hard, GC; McMartin, KE; Mertens, JJ; Snellings, WM, 2004) |
| "Ethylene glycol levels were measured in 154 breathing zone air samples and in 117 urine samples of 33 aviation workers exposed to de-icing fluid (basket operators, de-icing truck drivers, leads and coordinators) studied during 42 worker-days over a winter period of 2 months at a Montreal airport." | 1.30 | A study of ethylene glycol exposure and kidney function of aircraft de-icing workers. ( Adib, G; Bégin, D; Drolet, D; Gérin, M; Goldberg, MS; Patrice, S; Viau, C; Vyskocil, A, 1997) |
| "Clinical signs consisted of ataxia, polydipsia, decreased rumen motility, and constipation." | 1.27 | Ethylene glycol toxicosis in a pygmy goat. ( Boermans, HJ; Leach, M; Ruegg, PL, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 7 (28.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tafer, N | 1 |
| de Seigneux, S | 1 |
| Saudan, P | 1 |
| Martin, PY | 1 |
| Zhu, W | 1 |
| Liu, Y | 2 |
| Duan, X | 1 |
| Xiao, C | 1 |
| Lan, Y | 1 |
| Luo, L | 1 |
| Wu, C | 1 |
| Yang, Z | 1 |
| Mai, X | 1 |
| Lu, S | 1 |
| Zhong, W | 1 |
| Li, S | 1 |
| He, Z | 1 |
| Zhang, X | 1 |
| Zeng, G | 1 |
| Sommerfeld-Klatta, K | 1 |
| Przystanowicz, J | 1 |
| Kowalówka-Zawieja, J | 1 |
| Zielińska-Psuja, B | 1 |
| Arora, A | 1 |
| Riquier, T | 1 |
| Geri, G | 1 |
| Mongardon, N | 1 |
| Bourgogne, E | 1 |
| Pène, F | 1 |
| Grases, F | 1 |
| Prieto, RM | 1 |
| Fernandez-Cabot, RA | 1 |
| Costa-Bauzá, A | 1 |
| Tur, F | 1 |
| Torres, JJ | 1 |
| El Menyiy, N | 1 |
| Al Waili, N | 1 |
| Bakour, M | 1 |
| Al-Waili, H | 1 |
| Lyoussi, B | 1 |
| Ting, SM | 1 |
| Ching, I | 1 |
| Nair, H | 1 |
| Langman, G | 1 |
| Suresh, V | 1 |
| Temple, RM | 1 |
| Bacchetta, J | 1 |
| Dubourg, L | 1 |
| Juillard, L | 1 |
| Cochat, P | 1 |
| Corley, RA | 3 |
| Saghir, SA | 1 |
| Bartels, MJ | 1 |
| Hansen, SC | 1 |
| Creim, J | 1 |
| McMartin, KE | 3 |
| Snellings, WM | 3 |
| Kirman, CR | 1 |
| Bobst, SM | 1 |
| BERMAN, LB | 1 |
| SCHREINER, GE | 1 |
| FEYS, J | 1 |
| Cruzan, G | 1 |
| Hard, GC | 1 |
| Mertens, JJ | 1 |
| Gingell, R | 1 |
| Deyo, JA | 1 |
| Mohanasundari, M | 1 |
| Sabesan, M | 1 |
| Sethupathy, S | 1 |
| Ozcan, K | 1 |
| Ozen, H | 1 |
| Karaman, M | 1 |
| Velez, LI | 1 |
| Shepherd, G | 1 |
| Lee, YC | 1 |
| Keyes, DC | 1 |
| Werner, M | 1 |
| Costa, MJ | 1 |
| Mitchell, LG | 1 |
| Nayar, R | 1 |
| Gérin, M | 1 |
| Patrice, S | 1 |
| Bégin, D | 1 |
| Goldberg, MS | 1 |
| Vyskocil, A | 1 |
| Adib, G | 1 |
| Drolet, D | 1 |
| Viau, C | 1 |
| Miyazaki, K | 1 |
| Ozono, Y | 1 |
| Kohno, S | 1 |
| Harada, T | 1 |
| Yamaguchi, K | 1 |
| Tadokoro, M | 1 |
| Muraya, Y | 1 |
| Brent, J | 1 |
| McMartin, K | 1 |
| Phillips, S | 1 |
| Burkhart, KK | 1 |
| Donovan, JW | 1 |
| Wells, M | 1 |
| Kulig, K | 1 |
| LaKind, JS | 1 |
| McKenna, EA | 1 |
| Hubner, RP | 1 |
| Tardiff, RG | 1 |
| Tobé, TJ | 1 |
| Braam, GB | 1 |
| Meulenbelt, J | 1 |
| van Dijk, GW | 1 |
| Litovitz, T | 1 |
| Boermans, HJ | 1 |
| Ruegg, PL | 1 |
| Leach, M | 1 |
| Sondheimer, JH | 1 |
| Migdal, SD | 1 |
7 reviews available for ethylene glycol and Kidney Diseases
| Article | Year |
|---|---|
[Ethylene glycol intoxication requires a multidisciplinary approach].
Topics: Ethylene Glycol; Humans; Kidney Diseases | 2020 |
Non-drug-induced nephrotoxicity.
Topics: Child; Child, Preschool; China; Disease Outbreaks; Environmental Exposure; Ethylene Glycol; Food Con | 2009 |
Nephrotoxicity of xenobiotics.
Topics: Aminoglycosides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclosporine; Ethylene Glycol; Et | 1995 |
[Nephropathy induced by non-drug chemical agents].
Topics: Ethylene Glycol; Ethylene Glycols; Humans; Insecticides; Kidney Diseases; Mercuric Chloride; Metals; | 1997 |
A review of the comparative mammalian toxicity of ethylene glycol and propylene glycol.
Topics: Animals; Environmental Exposure; Ethylene Glycol; Humans; Kidney Diseases; Mammals; Oxidation-Reduct | 1999 |
The alcohols: ethanol, methanol, isopropanol, ethylene glycol.
Topics: 1-Propanol; Absorption; Acidosis; Adult; Alcoholic Intoxication; Bicarbonates; Blindness; Child; Chi | 1986 |
Toxic nephropathies.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Contrast Medi | 1987 |
1 trial available for ethylene glycol and Kidney Diseases
| Article | Year |
|---|---|
Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group.
Topics: Adult; Aged; Antidotes; Ethylene Glycol; Female; Fomepizole; Glycolates; Humans; Keratolytic Agents; | 1999 |
17 other studies available for ethylene glycol and Kidney Diseases
| Article | Year |
|---|---|
Alteration of the gut microbiota by vinegar is associated with amelioration of hyperoxaluria-induced kidney injury.
Topics: Acetic Acid; Administration, Oral; Animals; Ethylene Glycol; Gastrointestinal Microbiome; Hyperoxalu | 2020 |
Effect of repeated administration of 4-methylpyrazole on renal function and lipid peroxidation products in rat kidney after ethylene glycol poisoning.
Topics: Animals; Antidotes; Biotransformation; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Dr | 2017 |
The 'gap' in the 'plasma osmolar gap'.
Topics: Acidosis; Adult; Alcohol Dehydrogenase; Alcohols; Biomarkers; Ethylene Glycol; Glycolates; Humans; K | 2013 |
False hyperlactatemia in life-threatening ethylene glycol poisoning.
Topics: Acidosis, Lactic; Coma; Ethylene Glycol; Humans; Hyperlactatemia; Ill-Housed Persons; Kidney Disease | 2014 |
Effects of polyphenols from grape seeds on renal lithiasis.
Topics: Ammonium Chloride; Animals; Body Weight; Calcium; Catechin; Ethylene Glycol; Grape Seed Extract; Kid | 2015 |
Protective Effect of Propolis in Proteinuria, Crystaluria, Nephrotoxicity and Hepatotoxicity Induced by Ethylene Glycol Ingestion.
Topics: Animals; Chemical and Drug Induced Liver Injury; Ethylene Glycol; Kidney; Kidney Diseases; Male; Pla | 2016 |
Early and late presentations of ethylene glycol poisoning.
Topics: Acidosis; Acute Disease; Diagnosis, Differential; Ethylene Glycol; Hemofiltration; Humans; Kidney Di | 2009 |
Extension of a PBPK model for ethylene glycol and glycolic acid to include the competitive formation and clearance of metabolites associated with kidney toxicity in rats and humans.
Topics: Animals; Calcium Oxalate; Dose-Response Relationship, Drug; Drug Administration Routes; Ethylene Gly | 2011 |
Oral Reference Dose for ethylene glycol based on oxalate crystal-induced renal tubule degeneration as the critical effect.
Topics: Administration, Oral; Animals; Benchmarking; Calcium Oxalate; Crystallization; Dose-Response Relatio | 2013 |
The nephrotoxic lesion of ethylene glycol.
Topics: Ethylene Glycol; Glycols; Humans; Kidney; Kidney Diseases | 1957 |
Subchronic toxicity of ethylene glycol in Wistar and F-344 rats related to metabolism and clearance of metabolites.
Topics: Animals; Biotransformation; Body Weight; Diet; Drinking; Ethylene Glycol; Glycolates; Kidney; Kidney | 2004 |
Renoprotective effect of grape seeds extract in ethylene glycol induced nephrotoxic mice.
Topics: Animals; Antioxidants; Disease Models, Animal; Ethylene Glycol; Kidney; Kidney Diseases; Lipid Perox | 2005 |
Nitrosative tissue damage and apoptotic cell death in kidneys and livers of naturally ethylene glycol (antifreeze)-poisoned geese.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Ethylene Glycol; Geese; Kidney; Kidney D | 2007 |
Ethylene glycol ingestion treated only with fomepizole.
Topics: Acid-Base Imbalance; Adult; Antidotes; Ethylene Glycol; Fomepizole; Humans; Injections, Intravenous; | 2007 |
A study of ethylene glycol exposure and kidney function of aircraft de-icing workers.
Topics: Acetylglucosaminidase; Aircraft; Albuminuria; beta 2-Microglobulin; Ethylene Glycol; Ethylene Glycol | 1997 |
Ethylene glycol poisoning mimicking Snow White.
Topics: Adult; Alcoholic Neuropathy; Ethylene Glycol; Humans; Kidney Diseases; Male | 2002 |
Ethylene glycol toxicosis in a pygmy goat.
Topics: Animals; Ataxia; Ethylene Glycol; Ethylene Glycols; Female; Goats; Kidney Diseases | 1988 |