Page last updated: 2024-10-15

ethylene chlorohydrin and Liver Dysfunction

ethylene chlorohydrin has been researched along with Liver Dysfunction in 3 studies

Ethylene Chlorohydrin: Used as a solvent, in the manufacture of insecticides, and for treating sweet potatoes before planting. May cause nausea, vomiting, pains in head and chest, stupefaction. Irritates mucous membranes and causes kidney and liver degeneration.
chloroethanol : An organochlorine compound that is ethanol substituted by at least one chloro group.

Research Excerpts

ExcerptRelevanceReference
" This pattern is consistent with formation of the toxic intermediate in the primary metabolic pathway of each compound."1.27Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study. ( Buben, JA; O'Flaherty, EJ, 1985)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lock, EA1
Reed, CJ1
McMillan, JM1
Oatis, JE1
Schnellmann, RG1
Buben, JA1
O'Flaherty, EJ1
Kawamoto, T1
Hobara, T1
Kobayashi, H1
Iwamoto, S1
Sakai, T1
Ogino, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514]2 participants (Actual)Interventional2011-08-31Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

3 other studies available for ethylene chlorohydrin and Liver Dysfunction

ArticleYear
Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid.
    Toxicology, 2007, Feb-12, Volume: 230, Issue:2-3

    Topics: Adolescent; Adult; Animals; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Chromatography,

2007
Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study.
    Toxicology and applied pharmacology, 1985, Mar-30, Volume: 78, Issue:1

    Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D

1985
Alteration of chloral hydrate metabolism in rats with carbon tetrachloride-induced liver damage.
    Toxicology letters, 1987, Volume: 37, Issue:3

    Topics: Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloral Hydra

1987