ethylene chlorohydrin has been researched along with Acute Liver Injury, Drug-Induced in 5 studies
Ethylene Chlorohydrin: Used as a solvent, in the manufacture of insecticides, and for treating sweet potatoes before planting. May cause nausea, vomiting, pains in head and chest, stupefaction. Irritates mucous membranes and causes kidney and liver degeneration.
chloroethanol : An organochlorine compound that is ethanol substituted by at least one chloro group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Occupational exposure to trichloroethylene (TCE) induces trichloroethylene hypersensitivity syndrome (TCEHS), which causes hypersensitivity dermatitis and hepatitis." | 7.96 | Trichloroethylene and trichloroethanol induce skin sensitization with focal hepatic necrosis in guinea pigs. ( Cai, T; Huang, H; Huang, Y; Ito, Y; Kamijima, M; Li, H; Liu, L; Lu, F; Naito, H; Nakajima, T; Song, X; Wang, H; Zhao, N, 2020) |
| "TCE is the main cause of allergy and TCEOH is a secondary factor for allergy in guinea pigs." | 5.56 | Trichloroethylene and trichloroethanol induce skin sensitization with focal hepatic necrosis in guinea pigs. ( Cai, T; Huang, H; Huang, Y; Ito, Y; Kamijima, M; Li, H; Liu, L; Lu, F; Naito, H; Nakajima, T; Song, X; Wang, H; Zhao, N, 2020) |
| "Occupational exposure to trichloroethylene (TCE) induces trichloroethylene hypersensitivity syndrome (TCEHS), which causes hypersensitivity dermatitis and hepatitis." | 3.96 | Trichloroethylene and trichloroethanol induce skin sensitization with focal hepatic necrosis in guinea pigs. ( Cai, T; Huang, H; Huang, Y; Ito, Y; Kamijima, M; Li, H; Liu, L; Lu, F; Naito, H; Nakajima, T; Song, X; Wang, H; Zhao, N, 2020) |
| "TCE is the main cause of allergy and TCEOH is a secondary factor for allergy in guinea pigs." | 1.56 | Trichloroethylene and trichloroethanol induce skin sensitization with focal hepatic necrosis in guinea pigs. ( Cai, T; Huang, H; Huang, Y; Ito, Y; Kamijima, M; Li, H; Liu, L; Lu, F; Naito, H; Nakajima, T; Song, X; Wang, H; Zhao, N, 2020) |
| " This pattern is consistent with formation of the toxic intermediate in the primary metabolic pathway of each compound." | 1.27 | Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study. ( Buben, JA; O'Flaherty, EJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, N | 1 |
| Song, X | 1 |
| Naito, H | 1 |
| Li, H | 1 |
| Huang, Y | 1 |
| Liu, L | 1 |
| Lu, F | 1 |
| Cai, T | 1 |
| Ito, Y | 1 |
| Kamijima, M | 1 |
| Huang, H | 1 |
| Nakajima, T | 1 |
| Wang, H | 1 |
| Lock, EA | 1 |
| Reed, CJ | 1 |
| McMillan, JM | 1 |
| Oatis, JE | 1 |
| Schnellmann, RG | 1 |
| Nakayama, H | 1 |
| Kobayashi, M | 1 |
| Takahashi, M | 1 |
| Ageishi, Y | 1 |
| Takano, T | 1 |
| Buben, JA | 1 |
| O'Flaherty, EJ | 1 |
| Kawamoto, T | 1 |
| Hobara, T | 1 |
| Kobayashi, H | 1 |
| Iwamoto, S | 1 |
| Sakai, T | 1 |
| Ogino, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for ethylene chlorohydrin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Trichloroethylene and trichloroethanol induce skin sensitization with focal hepatic necrosis in guinea pigs.
Topics: Animals; Chemical and Drug Induced Liver Injury; Ethylene Chlorohydrin; Female; Guinea Pigs; Hyperse | 2020 |
Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid.
Topics: Adolescent; Adult; Animals; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Chromatography, | 2007 |
Generalized eruption with severe liver dysfunction associated with occupational exposure to trichloroethylene.
Topics: Adult; Chemical and Drug Induced Liver Injury; Dermatitis, Occupational; Ethylene Chlorohydrin; Huma | 1988 |
Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 1985 |
Alteration of chloral hydrate metabolism in rats with carbon tetrachloride-induced liver damage.
Topics: Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloral Hydra | 1987 |