Page last updated: 2024-08-21

ethyl pyruvate and Innate Inflammatory Response

ethyl pyruvate has been researched along with Innate Inflammatory Response in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (30.56)	29.6817
2010's	23 (63.89)	24.3611
2020's	2 (5.56)	2.80

Authors

Authors	Studies
Djedovic, N; Koprivica, I; Miljković, Đ; Stojanović, I	1
Bi, C; Dong, N; Li, X; Shan, A; Wang, C; Xu, X; Xue, C	1
Fujiwara, H; Imai, H; Kamada, Y; Kimura, A; Nishimori, R; Shimokawa, A; Stewart, NJ; Utsumi, S	1
Agriesti, F; Capitanio, N; Cela, O; Cinnella, G; Cotoia, A; De Gregorio, A; Gefter, JV; Menga, M; Pacelli, C; Piccoli, C; Scrima, R	1
Dieteren, S; Franz, N; Köhler, K; Marzi, I; Mörs, K; Nicin, L; Perl, M; Relja, B; Schmidt, J; Wagner, N	1
Bogojević, D; Grigorov, I; Ivanović-Matić, S; Jovanović Stojanov, S; Martinović, V; Petrović, A; Poznanović, G	1
Jin, H; Li, J; Li, X; Ling, B; Liu, P; Pan, X; Sun, J; Xiu, G; Zhou, X; Zhu, Y	1
Cheng, J; Li, C; Liao, N; Ma, C; Qin, L; Xu, M; Yi, K; Zhao, J	1
Cheng, C; Chvanov, M; Du, D; Han, C; Huang, W; Liu, T; Sutton, R; Windsor, J; Xia, Q; Yang, X; Yao, L	1
Bhat, SM; Charavaryamath, C; Kanthasamy, AG; Massey, N; Puttachary, S	1
Cho, IH; Jang, M; Lee, MJ	1
Juengel, E; Jurida, K; Kontradowitz, K; Marzi, I; Omid, N; Oppermann, E; Relja, B; Seebach, C; Störmann, P; Werner, I	1
Chen, J; Chen, S; Gong, G; Kong, W; Niu, Y; Wang, Y	1
Lei, C; Li, D; Liu, M; Wu, B; Zhang, S	1
Chen, R; Wang, S; Wang, Z; Zhang, X; Zhu, Z	1
Albadawi, H; Cambria, RP; Crawford, RS; Fink, MP; Nguyen, BN; Oklu, R; Watkins, MT	1
Chang, KC; Kim, HJ; Kim, JH; Kim, YM; Park, EJ; Park, SW	1
Bramanti, P; Caminiti, R; Cuzzocrea, S; Di Paola, R; Esposito, E; Fink, MP; Genovese, T; Mazzon, E; Meli, R	1
Bramanti, P; Caminiti, R; Crisafulli, C; Cuzzocrea, S; Di Paola, R; Esposito, E; Fink, MP; Genovese, T; Mazzon, E	1
Cai, B; Deitch, EA; Dong, W; Doucet, D; Lee, M; Lu, Q; Peña, G; Pisarenko, V; Ramos, L; Sharpe, S; Ulloa, L; Vida, G; Xu, DZ	1
Cai, B; Deitch, EA; Ulloa, L	1
Chung, YK; Jang, IS; Lee, HK; Park, MY; Shin, IW; Sohn, JT	1
Albadawi, H; Atkins, MD; Austen, WG; Conrad, MF; Crawford, RS; Fink, MP; Jones, JJ; Watkins, MT	1
Cook, VL; Corl, CM; Gandy, JC; Holcombe, SJ; Sordillo, LM	1
Barbul, A; Kavalukas, SL; O'Hearn, S; Zhang, Q	1
Cho, IH; Jang, M; Jung, HS; Kim, SH; Lee, MJ	1
Cook, VL; Gandy, JC; Hauptman, JG; Holcombe, SJ; Jacobs, CC; Sordillo, LM	1
Fink, MP	2
Fink, MP; Kaldas, H; Kellum, JA; Song, M	1
Delude, RL; Fink, ME; Fink, MP; Sappington, PL; Yang, R	1
Han, PL; Kim, JB; Kim, SY; Lee, JK; Lee, KW; Yu, YM	1
Kim, JB; Kim, SW; Lee, JK; Yu, YM	1
Fink, MP; Reade, MC	1
Choi, JE; Duong, HQ; Han, SI; Jeong, GA; Kang, HS; Kim, CH; Lim, SC	1
Johansson, AS; Johansson-Haque, K; Okret, S; Palmblad, J	1

Reviews

6 review(s) available for ethyl pyruvate and Innate Inflammatory Response

Article	Year
Ethyl pyruvate, a versatile protector in inflammation and autoimmunity. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2022, Volume: 71, Issue:2 Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Humans; Inflammation; Myeloid Cells; Pyruvates; Reactive Oxygen Species; Signal Transduction; T-Lymphocytes	2022
Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of in vitro and in vivo studies. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2019, Volume: 19, Issue:2 Topics: Animals; Biomarkers; Humans; Inflammation; Pancreas; Pancreatitis; Pyruvates	2019
Novel insights for systemic inflammation in sepsis and hemorrhage. Mediators of inflammation, 2010, Volume: 2010 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Choline; Cytokines; Disease Models, Animal; Hemorrhage; HMGB1 Protein; Humans; Inflammation; Nicotinic Agonists; Nootropic Agents; Pyruvates; Receptors, Nicotinic; Sepsis	2010
Ethyl pyruvate: a novel anti-inflammatory agent. Critical care medicine, 2003, Volume: 31, Issue:1 Suppl Topics: Animals; Anti-Inflammatory Agents; Critical Care; Disease Models, Animal; Humans; Inflammation; Mice; Pyruvates; Rats	2003
Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate. Critical care (London, England), 2005, Volume: 9, Issue:6 Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Drug Administration Schedule; Humans; Inflammation; Oxidative Stress; Pyruvates; Treatment Outcome	2005
Ethyl pyruvate: a novel anti-inflammatory agent. Journal of internal medicine, 2007, Volume: 261, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Mice; Pyruvates; Rats	2007

Other Studies

30 other study(ies) available for ethyl pyruvate and Innate Inflammatory Response

Article	Year
Ethyl pyruvate inhibits LPS induced IPEC-J2 inflammation and apoptosis through p38 and ERK1/2 pathways. Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:20 Topics: Animals; Apoptosis; Cell Line; Cytokines; Down-Regulation; Enterocytes; Inflammation; Lipopolysaccharides; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pyruvates; RNA-Seq; RNA, Messenger; Signal Transduction; Swine; Up-Regulation	2019
Inflammation during Lung Cancer Progression and Ethyl Pyruvate Treatment Observed by Pulmonary Functional Hyperpolarized Contrast media & molecular imaging, 2021, Volume: 2021 Topics: Animals; Carcinogens; Inflammation; Lung Neoplasms; Magnetic Resonance Imaging; Male; Mice; Pyruvates; Urethane; Xenon	2021
Para-hydroxyphenylpyruvate inhibits the pro-inflammatory stimulation of macrophage preventing LPS-mediated nitro-oxidative unbalance and immunometabolic shift. PloS one, 2017, Volume: 12, Issue:11 Topics: Animals; Anti-Inflammatory Agents; Cell Respiration; Fibroblasts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Interleukin-6; Lipopolysaccharides; Macrophages; Metabolic Flux Analysis; Mice; Mitochondria; Models, Biological; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Nitrosation; Oxidation-Reduction; Peroxides; Phenylpyruvic Acids; Pyruvates; RAW 264.7 Cells	2017
Ethyl pyruvate ameliorates hepatic injury following blunt chest trauma and hemorrhagic shock by reducing local inflammation, NF-kappaB activation and HMGB1 release. PloS one, 2018, Volume: 13, Issue:2 Topics: Animals; Female; HMGB1 Protein; Inflammation; Liver; NF-kappa B; Pyruvates; Rats; Rats, Inbred Lew; Shock, Hemorrhagic; Thoracic Injuries; Wounds, Nonpenetrating	2018
Modulation of diabetes-related liver injury by the HMGB1/TLR4 inflammatory pathway. Journal of physiology and biochemistry, 2018, Volume: 74, Issue:2 Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Haptoglobins; Heme Oxygenase (Decyclizing); HMGB1 Protein; Humans; Inflammation; Interleukin-6; Liver Diseases; Male; MAP Kinase Signaling System; NF-E2-Related Factor 2; Protein Kinases; Pyruvates; Rats, Wistar; Streptozocin; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha	2018
The role of HMGB1 in BMSC transplantation for treating MODS in rats. Cell and tissue research, 2018, Volume: 373, Issue:2 Topics: Animals; HMGB1 Protein; Inflammation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Multiple Organ Failure; Phosphorylation; Protective Agents; Pyruvates; Rats, Sprague-Dawley; Transcription Factor RelA	2018
Ethyl Pyruvate Attenuates CaCl2-Induced Tubular Epithelial Cell Injury by Inhibiting Autophagy and Inflammatory Responses. Kidney & blood pressure research, 2018, Volume: 43, Issue:5 Topics: Autophagy; Calcium Chloride; Cell Line; Epithelial Cells; HMGB1 Protein; Humans; Inflammation; Kidney Tubules; NF-kappa B; Pyruvates; Toll-Like Receptor 4	2018
HMGB1-RAGE Signaling Plays a Role in Organic Dust-Induced Microglial Activation and Neuroinflammation. Toxicological sciences : an official journal of the Society of Toxicology, 2019, 06-01, Volume: 169, Issue:2 Topics: Active Transport, Cell Nucleus; Animals; Brain; Cells, Cultured; Dust; HMGB1 Protein; Inflammation; Mice; Mice, Inbred C57BL; Microglia; Pyruvates; Reactive Nitrogen Species; Receptor for Advanced Glycation End Products; Signal Transduction	2019
Ethyl pyruvate ameliorates 3-nitropropionic acid-induced striatal toxicity through anti-neuronal cell death and anti-inflammatory mechanisms. Brain, behavior, and immunity, 2014, Volume: 38 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Behavior, Animal; Corpus Striatum; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Nitro Compounds; Propionates; Pyruvates; Signal Transduction	2014
Decreased inflammatory responses of human lung epithelial cells after ethanol exposure are mimicked by ethyl pyruvate. Mediators of inflammation, 2014, Volume: 2014 Topics: Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Ethanol; HSP70 Heat-Shock Proteins; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Interleukin-8; Lipopolysaccharides; Neutrophils; Pyruvates; RNA; Transforming Growth Factor beta	2014
Ethyl pyruvate attenuates murine allergic rhinitis partly by decreasing high mobility group box 1 release. Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:11 Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Immunoglobulin E; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Pyruvates; Rhinitis, Allergic; Toll-Like Receptor 4; Up-Regulation	2015
Blockade of high mobility group box-1 signaling via the receptor for advanced glycation end-products ameliorates inflammatory damage after acute intracerebral hemorrhage. Neuroscience letters, 2015, Nov-16, Volume: 609 Topics: Acute Disease; Animals; Apoptosis; Benzamides; Brain; Brain Edema; Cerebral Hemorrhage; HMGB1 Protein; Inflammation; Interleukin-1beta; Male; Matrix Metalloproteinase 9; Pyruvates; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4	2015
Effects of insulin combined with ethyl pyruvate on inflammatory response and oxidative stress in multiple-organ dysfunction syndrome rats with severe burns. The American journal of emergency medicine, 2016, Volume: 34, Issue:11 Topics: Alanine Transaminase; Animals; Antioxidants; Blood Glucose; Burns; Creatine; Creatine Kinase; Drug Therapy, Combination; HMGB1 Protein; Hypoglycemic Agents; Inflammation; Insulin; Malondialdehyde; Multiple Organ Failure; Oxidative Stress; Pyruvates; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha	2016
Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice. Journal of vascular surgery, 2016, Volume: 64, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Aorta, Thoracic; Apoptosis; Apoptosis Regulatory Proteins; Constriction; Disease Models, Animal; Inflammation; Inflammation Mediators; Male; Mice, Inbred C57BL; Neuroprotective Agents; Paralysis; Pyruvates; Regional Blood Flow; Reperfusion Injury; Signal Transduction; Spinal Cord; Spinal Cord Ischemia; Time Factors	2016
Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1/STAT signaling in LPS-activated RAW264.7 cells and peritoneal macrophages. International immunopharmacology, 2016, Volume: 41 Topics: Acetylation; Animals; Cells, Cultured; HMGB1 Protein; Inflammation; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Phosphorylation; Pyruvates; RAW 264.7 Cells; Signal Transduction; Sirtuin 1; STAT1 Transcription Factor; Up-Regulation	2016
Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury. Shock (Augusta, Ga.), 2009, Volume: 32, Issue:2 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Fas Ligand Protein; Gene Expression Regulation; Humans; Inflammation; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Peroxidase; Phosphorylation; Pyruvates; Spinal Cord Injuries; Time Factors; Tyrosine	2009
Ethyl pyruvate reduces the development of zymosan-induced generalized inflammation in mice. Critical care medicine, 2009, Volume: 37, Issue:1 Topics: Animals; Cytokines; Inflammation; Male; Mice; Pyruvates; Zymosan	2009
Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage. Shock (Augusta, Ga.), 2010, Volume: 34, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Blood Coagulation; Hemorrhage; Hyperglycemia; Inflammation; Intestinal Mucosa; Male; NF-kappa B; Pyruvates; Resuscitation; Swine; Tumor Necrosis Factor-alpha	2010
Ethyl pyruvate has anti-inflammatory and delayed myocardial protective effects after regional ischemia/reperfusion injury. Yonsei medical journal, 2010, Volume: 51, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Cell Nucleus; Cytoplasm; Heart; Inflammation; Male; Myocardial Infarction; Myocardium; NF-kappa B; Peroxidase; Pyruvates; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2010
Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion. The Journal of trauma, 2011, Volume: 70, Issue:1 Topics: Adenosine Triphosphate; Animals; Antithrombin III; Disease Models, Animal; Inflammation; Interleukin-1; Lactates; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Peptide Hydrolases; Peroxidase; Pyruvates; Reperfusion Injury; Thrombosis	2011
Ethyl pyruvate decreases proinflammatory gene expression in lipopolysaccharide-stimulated equine monocytes. Veterinary immunology and immunopathology, 2011, May-15, Volume: 141, Issue:1-2 Topics: Animals; Caspase 3; Caspase 7; Cell Survival; Cells, Cultured; Flow Cytometry; Gene Expression Regulation; Horses; Inflammation; Lipopolysaccharides; Monocytes; Pyruvates	2011
Role of high mobility group box 1 (HMGB1) in wound healing. The Journal of surgical research, 2012, Volume: 176, Issue:1 Topics: Animals; Cell Proliferation; Cells, Cultured; Collagen; Fibroblasts; Glycation End Products, Advanced; HMGB1 Protein; Inflammation; Male; Models, Animal; Pyruvates; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Recombinant Proteins; Wound Healing	2012
Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation. Molecular pain, 2012, May-28, Volume: 8 Topics: Animals; CD11 Antigens; Cell Shape; Edema; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Formaldehyde; Inflammation; Injections, Spinal; Male; Microglia; Neurons; Nociception; Phosphorylation; Proto-Oncogene Proteins c-fos; Pyruvates; Rats; Rats, Sprague-Dawley; Spinal Cord	2012
Ethyl pyruvate diminishes the inflammatory response to lipopolysaccharide infusion in horses. Equine veterinary journal, 2013, Volume: 45, Issue:3 Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Clonixin; Female; Gene Expression Regulation; Horse Diseases; Horses; Inflammation; Interleukin-6; Interleukin-8; Lipopolysaccharides; Male; Pyruvates; Tumor Necrosis Factor-alpha	2013
Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; DNA; Glutathione; In Vitro Techniques; Inflammation; Interleukin-10; Interleukin-6; Lipid Peroxidation; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pyruvates; RNA, Messenger	2004
Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction. Shock (Augusta, Ga.), 2003, Volume: 20, Issue:6 Topics: Animals; Biological Transport; Caco-2 Cells; Cell Line, Tumor; Cytokines; Down-Regulation; Epithelial Cells; Epithelium; Humans; Inflammation; Interferon-gamma; Interleukin-1; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pyruvates; Pyruvic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha	2003
Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke, 2005, Volume: 36, Issue:10 Topics: Animals; Brain; Brain Injuries; Brain Ischemia; Coloring Agents; Cytokines; Dose-Response Relationship, Drug; Immunoblotting; Immunohistochemistry; Infarction, Middle Cerebral Artery; Inflammation; Ischemia; Lipopolysaccharides; Male; Microglia; Neuroprotective Agents; Neuropsychological Tests; Nitric Oxide; Pyruvates; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sepsis; Tetrazolium Salts; Time Factors	2005
Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain research, 2005, Oct-26, Volume: 1060, Issue:1-2 Topics: Animals; Apoptosis; Brain; Cells, Cultured; Glucose; Hydrogen Peroxide; Hypoxia; Infarction, Middle Cerebral Artery; Inflammation; Male; Microglia; Neurons; Neuroprotective Agents; NF-kappa B; Oxidants; Pyruvates; Rats	2005
Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells. International journal of molecular medicine, 2007, Volume: 20, Issue:2 Topics: Adenocarcinoma; Apoptosis; Glucose; HMGB1 Protein; Humans; Inflammation; Lung Neoplasms; Necrosis; Pyruvates; Reactive Oxygen Species; Superoxide Dismutase; Tumor Cells, Cultured	2007
Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-kappaB pathway. British journal of pharmacology, 2008, Volume: 154, Issue:6 Topics: Animals; Biomarkers; Cell Adhesion; Cell Survival; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cytokines; E-Selectin; Endothelial Cells; Granulocyte Colony-Stimulating Factor; Humans; Inflammation; Interleukin-1 Receptor-Associated Kinases; Interleukin-1beta; Lipopolysaccharides; Neutrophils; NF-kappa B; Plasmids; Pyruvates; Signal Transduction; Transfection; Tumor Necrosis Factor-alpha	2008