Page last updated: 2024-08-21

ethyl pyruvate and Disease Models, Animal

ethyl pyruvate has been researched along with Disease Models, Animal in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	27 (32.93)	29.6817
2010's	47 (57.32)	24.3611
2020's	8 (9.76)	2.80

Authors

Authors	Studies
Despotović, S; Gajić, D; Koprivica, I; Miljković, Đ; Saksida, T	1
Djedovic, N; Koprivica, I; Miljković, Đ; Stojanović, I	1
Ayral, M; Dedeoğlu, S	1
An, J; Ding, ZB; Han, QX; He, Y; Ma, CG; Miao, Q; Sui, RX; Wang, Q; Xiao, BG; Yin, JJ	1
Akkaya, E; Armutak, EI; Baran, O; Calis, F; Cevik, S; Evran, S; Gurevin, EG; Hanimoglu, H; Hatiboglu, MA; Karatas, E; Katar, S; Kaynar, MY; Kocyigit, A	1
Cheng, X; Qiu, X; Yang, X; Yuan, C; Zhang, J; Zhao, M	1
Liang, F; Tang, Y; Tong, J; Xie, L; Yang, X; Yang, Y; Yuan, C; Zhao, K; Zhong, X; Zhong, Y	1
An, J; Ding, ZB; Han, QX; He, Y; Huang, JJ; Ma, CG; Miao, Q; Sui, RX; Xiao, BG; Yin, JJ	1
He, G; Liang, X; Shen, Y; Tan, G; Zhang, X	1
Chen, G; Dou, Y; Feng, D; Li, H; Liu, C; Shen, H; Sun, L; Sun, Q; Tian, X; Wang, Z; Zhou, F	1
Chen, LW; Chen, W; Hong, GL; Lian, J; Lu, ZQ; Mo, QF; Qin, J; Ye, JJ; Zhao, GJ; Zhi, SC	1
Baek, SY; Cho, ML; Hong, SM; Jang, SG; Jung, SM; Kwok, SK; Lee, J; Park, JS; Park, SH	1
Dieteren, S; Franz, N; Marzi, I; Mörs, K; Perl, M; Relja, B; Schmidt, J; Wagner, N	1
Choi, N; Jun, JH; Kwak, YL; Shim, JK; Shin, EJ; Song, JW	1
He, Y; Li, M; Lv, C; Ma, X; Song, J; Sun, L; Zhang, L	1
Gajić, D; Koprivica, I; Saksida, T; Stojanović, I; Vujičić, M	1
Gong, ZJ; Han, XQ; Li, X; Wang, LK; Wang, LW	1
Apodaca-Torrez, FR; Goldenberg, A; Matone, J; Moretti, AI	1
Jo, K; Kim, CS; Kim, J; Kim, JS; Kim, SG; Lee, YM; Shin, SD; Sohn, EJ	1
Cao, G; Fang, C; Li, S; Liu, C; Liu, K; Wan, Z; Wang, B; Wu, S	1
Antoine, DJ; Ashby, CR; Entezari, M; Gorasiya, S; Javdan, M; Li, J; Mantell, LL; Morrow, DM; Patel, V; Sharma, L; Sitapara, RA; Thomas, D; Wang, H; Wang, M; Wu, W; Yang, H; Zur, M	1
Altun, G; Civelek, A; Hemşinli, D; Menteşe, A; Pulathan, Z; Yuluğ, E	1
Cai, S; Dong, H; Liang, Z; LV, Y; Song, J; Tang, H; Yao, L; Zhao, H; Zou, F	1
Caglayan, EK; Caglayan, K; Cinar, H; Göcmen, AY; Güngör, B; Polat, MF; Seckin, L; Seckin, S	1
Aslani, F; Bhushan, S; Fijak, M; Guazzone, VA; Lochnit, G; Lustig, L; Meinhardt, A; Schuppe, HC; Wahle, E	1
Chen, J; Gao, YQ; Hu, XM; Leak, RK; Pu, HJ; Shi, H; Shi, YJ; Wang, GH; Wang, HL; Zhang, J; Zhang, WT	1
Blaževski, J; Djedović, N; Jevtić, B; Miljković, D; Momčilović, M; Mostarica Stojković, M; Petković, F; Spasojević, I; Stanisavljević, S	1
Chen, J; Chen, S; Gong, G; Kong, W; Niu, Y; Wang, Y	1
Cao, T; Lei, C; Liu, M; Tao, W; Wu, B; Zhang, S	1
Chang, L; Lee, W; Pan, R; Rong, Z	1
Breithaupt-Faloppa, AC; Correia, CJ; Ferreira, SG; Guarda, IF; Martinez, MB; Moreno, AC; Rocha-e-Silva, M; Sannomiya, P	1
Chen, J; Chen, M; Guan, X; Jiang, Z; Li, X; Lin, Z	1
Akay, A; Arslan, E; Artis, AS; Artis, T; Deniz, K; Mutlu, F	1
Ahmet, M; Ari, NS; Asli, M; Aynur, S; Esin, Y; Ozgur, T; Selim, D; Suha, T; Süleyman, T; Yunus, K	1
Cao, G; Liu, C; Liu, K; Liu, Y; Pang, X; Sun, H; Zhang, X	1
Albadawi, H; Cambria, RP; Crawford, RS; Fink, MP; Nguyen, BN; Oklu, R; Watkins, MT	1
Han, JY; Kim, JS; Kim, YA; Lee, WG; Park, M; Shim, HS; Shin, IW; Song, YG	1
Du, Q; Fei, A; Luo, Y; Pan, S; Wang, H; Yu, Y; Zhu, Q	1
Ding, X; Jiang, J; Liu, Y; Su, Q; Zhou, C	1
Alleva, LM; Budd, AC; Clark, IA	1
Ling, Y; Tao, J; Wang, CY; Wu, HS; Xiong, JX; Yang, ZY; Yin, T	1
Bramanti, P; Caminiti, R; Cuzzocrea, S; Di Paola, R; Esposito, E; Fink, MP; Genovese, T; Mazzon, E; Meli, R	1
Li, M; Meng, M; Qin, C; Zhang, Y	1
Cai, B; Deitch, EA; Grande, D; Ulloa, L	1
Barochia, A; Cui, X; Eichacker, PQ; Li, X; Li, Y; Su, J	1
Gong, G; Li, Y; Wang, P; Wei, Z	1
Han, PL; Jeong, JY; Kim, HJ; Kim, SW; Lee, JK; Seo, JS; Yoon, SH	1
Deng, ZH; Lin, J; Ti, DD; Wang, LH; Xue, H; Yan, GT	1
Guo, RX; Luan, ZG; Ma, XC; Zhang, C; Zhang, H	1
Dong, L; Jia, CQ; Li, Y; Lin, DJ; Shang, GH; Wang, AH; Xiao, W	1
Cruz, RJ; Fink, MP; Harada, T; Sasatomi, E	1
Chen, J; Gao, H; Gao, Y; Hu, X; Liu, C; Shen, H; Stetler, RA; Wang, S; Zhang, W	1
Fink, MP; Kao, KK	1
Choi, JS; Jeong, JW; Lee, MS	1
Cai, B; Deitch, EA; Ulloa, L	1
Albadawi, H; Atkins, MD; Austen, WG; Conrad, MF; Crawford, RS; Fink, MP; Jones, JJ; Watkins, MT	1
Cheng, PY; Kung, CW; Lee, YM; Peng, YJ; Yen, MH	1
Ansari, NH; Kalariya, NM; Ramana, KV; Reddy, AB; VanKuijk, FJ	1
Chung, YC; Hong, JK; Hong, JY; Huh, SH; Hwang, O; Jin, BK; Jin, MY; Kim, YS; Pak, YK; Piao, Y; Son, HJ; Yoon, NS	1
Hai, CX; Li, WL; Pauluhn, J	1
Akalin, B; Altun, H; Aydin, MT; Ekci, B; Karip, AB; Memisoglu, K; Onur, E	1
Abbott, A; Buela, KA; Du, Y; Gupta, D; Jakub, AM; Piluek, J; Schuman, JS; SundarRaj, N	1
Chen, H; Fan, C; Gong, ZJ; He, CM; Li, X; Wang, LK; Wang, LW	1
Fink, MP	3
Delude, RL; Fink, MP; Uchiyama, T	1
Hewitt, SM; Hu, X; Iyer, S; Miyaji, T; Muramatsu, Y; Star, RA; Yuen, PS	1
Dong, N; Dong, YQ; Liu, H; Sheng, ZY; Wei, P; Yao, YM; Yu, Y	2
Albicini, M; Asfar, P; Bracht, H; Brückner, UB; Ehrmann, U; Fink, MP; Hauser, B; Kick, J; Radermacher, P; Vogt, J; Wachter, U	1
Cruz, RJ; Delude, RL; Fink, MP; Harada, T; Moore, BA; Yang, R	1
Berry, MF; Cohen, JE; Gardner, TJ; Grand, TJ; Hsu, V; Liao, GP; Taylor, MD; Woo, YJ; Zentko, S	1
Hegde, KR; Kovtun, S; Varma, SD	1
Dong, N; Wang, WJ; Xian, LM; Yao, YM; Yu, Y	1
Li, K; Qiu, XH; Wu, CT	1
Das, UN	1
Cai, Y; Remmelink, M; Su, F; Vincent, JL; Wang, Z	1
Crisostomo, PR; Lahm, T; Meldrum, DR; Morrell, ED; Poynter, J; Tsai, BM; Wang, M	1
Dou, KF; Sheng, ZY; Wang, Q; Wang, WJ; Wang, YB; Xian, LM; Yao, YM	1
Guan, XD; Kou, QY	1
Tenhunen, JJ	1

Reviews

8 review(s) available for ethyl pyruvate and Disease Models, Animal

Article	Year
Ethyl pyruvate, a versatile protector in inflammation and autoimmunity. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2022, Volume: 71, Issue:2 Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Humans; Inflammation; Myeloid Cells; Pyruvates; Reactive Oxygen Species; Signal Transduction; T-Lymphocytes	2022
Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate. Expert opinion on investigational drugs, 2009, Volume: 18, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Humans; Mice; NF-kappa B; Pyruvates; Sepsis; Sesquiterpenes	2009
The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds. Biochemical pharmacology, 2010, Jul-15, Volume: 80, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytoprotection; Disease Models, Animal; Free Radical Scavengers; Humans; Oxidative Stress; Pyruvates; Randomized Controlled Trials as Topic	2010
Novel insights for systemic inflammation in sepsis and hemorrhage. Mediators of inflammation, 2010, Volume: 2010 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Choline; Cytokines; Disease Models, Animal; Hemorrhage; HMGB1 Protein; Humans; Inflammation; Nicotinic Agonists; Nootropic Agents; Pyruvates; Receptors, Nicotinic; Sepsis	2010
Ethyl pyruvate: a novel anti-inflammatory agent. Critical care medicine, 2003, Volume: 31, Issue:1 Suppl Topics: Animals; Anti-Inflammatory Agents; Critical Care; Disease Models, Animal; Humans; Inflammation; Mice; Pyruvates; Rats	2003
Is pyruvate an endogenous anti-inflammatory molecule? Nutrition (Burbank, Los Angeles County, Calif.), 2006, Volume: 22, Issue:9 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Critical Illness; Cytokines; Disease Models, Animal; Free Radical Scavengers; Humans; Insulin; Macrophage Migration-Inhibitory Factors; Myocardial Infarction; NF-kappa B; Pyruvates; Pyruvic Acid; Sepsis; Signal Transduction	2006
Ethyl pyruvate: a novel treatment for sepsis. Current drug targets, 2007, Volume: 8, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Humans; Mice; Pyruvates; Sepsis	2007
Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution. Current opinion in clinical nutrition and metabolic care, 2002, Volume: 5, Issue:2 Topics: Adult; Animals; Critical Care; Disease Models, Animal; Humans; Isotonic Solutions; Multiple Organ Failure; NF-kappa B; Pyruvates; Reactive Oxygen Species; Respiratory Distress Syndrome; Resuscitation; Sepsis; Shock, Hemorrhagic	2002

Other Studies

74 other study(ies) available for ethyl pyruvate and Disease Models, Animal

Article	Year
Ethyl Pyruvate Ameliorates Experimental Autoimmune Myocarditis. Biomolecules, 2021, 11-25, Volume: 11, Issue:12 Topics: Animals; Antigen Presentation; Autoimmune Diseases; Cells, Cultured; Culture Media; Cytokines; Disease Models, Animal; Lymph Nodes; Male; Mice; Myocarditis; Phenotype; Pyruvates; Th1 Cells; Th17 Cells	2021
Protective effect of ethyl pyruvate on amikacin-induced ototoxicity in rats. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:7 Topics: Amikacin; Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Otoacoustic Emissions, Spontaneous; Ototoxicity; Pyruvates; Rats; Rats, Wistar	2022
Ethyl pyruvate enhances spontaneous remyelination by targeting microglia phagocytosis. International immunopharmacology, 2019, Volume: 77 Topics: Animals; Behavior, Animal; Cell Line; Cell Movement; Cell Survival; Cuprizone; Cytokines; Demyelinating Diseases; Disease Models, Animal; Male; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Phagocytosis; Pyruvates; Remyelination	2019
The effect of high mobility group box-1 protein on cerebral edema, blood-brain barrier, oxidative stress and apoptosis in an experimental traumatic brain injury model. Brain research bulletin, 2020, Volume: 154 Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Brain Injuries, Traumatic; Claudin-5; Disease Models, Animal; High Mobility Group Proteins; HMG-Box Domains; HMGB1 Protein; Male; Occludin; Oxidative Stress; Pyruvates; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Toll-Like Receptor 4; Zonula Occludens-1 Protein	2020
Ethyl pyruvate confers protection against endotoxemia and sepsis by inhibiting caspase-11-dependent cell pyroptosis. International immunopharmacology, 2020, Volume: 78 Topics: Animals; Caspase Inhibitors; Caspases, Initiator; Cells, Cultured; Disease Models, Animal; Endotoxemia; Humans; Inflammasomes; Interleukin-1alpha; Interleukin-1beta; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Phosphate-Binding Proteins; Primary Cell Culture; Pyroptosis; Pyruvates	2020
Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome. Molecular medicine (Cambridge, Mass.), 2020, 06-09, Volume: 26, Issue:1 Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Inflammasomes; Injections, Spinal; Male; Mice; Microglia; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Protective Agents; Pyruvates; Sepsis-Associated Encephalopathy	2020
Ethyl Pyruvate-Derived Transdifferentiation of Astrocytes to Oligodendrogenesis in Cuprizone-Induced Demyelinating Model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, Volume: 18, Issue:1 Topics: Animals; Astrocytes; Cell Transdifferentiation; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Oligodendroglia; Phagocytosis; Pyruvates; Receptors, Interleukin-1	2021
Ethyl pyruvate ameliorate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in rats with acute rhinosinusitis. Scientific reports, 2021, 03-18, Volume: 11, Issue:1 Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Formaldehyde; Gene Expression Regulation; HMGB1 Protein; Interleukin-6; Male; Nasal Mucosa; Polyvinyl Alcohol; Pyruvates; Rats; Rats, Sprague-Dawley; Rhinitis; Sinusitis; Treatment Outcome; Tumor Necrosis Factor-alpha	2021
HMGB1 promotes neurovascular remodeling via Rage in the late phase of subarachnoid hemorrhage. Brain research, 2017, Sep-01, Volume: 1670 Topics: Animals; Benzamides; Brain; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Doublecortin Protein; Glycyrrhizic Acid; HMGB1 Protein; Male; Neurons; Pyruvates; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Recombinant Proteins; Signal Transduction; Subarachnoid Hemorrhage; Vascular Remodeling	2017
Ethyl pyruvate reverses development of Pseudomonas aeruginosa pneumonia during sepsis-induced immunosuppression. International immunopharmacology, 2017, Volume: 52 Topics: Animals; Apoptosis; Bacterial Load; Cecum; Cytokines; Disease Models, Animal; HMGB1 Protein; Immunity, Innate; Immunosuppression Therapy; Interleukin-10; Lung; Male; Mice; Mice, Inbred BALB C; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Pyruvates; Sepsis; Spleen	2017
Ethyl pyruvate ameliorates inflammatory arthritis in mice. International immunopharmacology, 2017, Volume: 52 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Differentiation; Cells, Cultured; Disease Models, Animal; HMGB1 Protein; Humans; Lymphocyte Activation; Male; Mice; Mice, Inbred DBA; Monocytes; Nuclear Receptor Subfamily 1, Group F, Member 3; Osteogenesis; Pyruvates; Synovial Membrane; Th17 Cells	2017
Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-κB and HMGB1. Immunobiology, 2018, Volume: 223, Issue:3 Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Gene Expression Regulation; HMGB1 Protein; Humans; Lung; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Pyruvates; Rats; Rats, Inbred Lew; Shock, Hemorrhagic; Signal Transduction; Thoracic Injuries; Tumor Necrosis Factor-alpha	2018
Ethyl pyruvate is renoprotective against ischemia-reperfusion injury under hyperglycemia. The Journal of thoracic and cardiovascular surgery, 2018, Volume: 155, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; bcl-2-Associated X Protein; Blood Glucose; Cytoprotection; Disease Models, Animal; HMGB1 Protein; Hyperglycemia; Interleukin-1beta; Kidney; Kidney Diseases; Male; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Pyruvates; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptors; Tumor Necrosis Factor-alpha	2018
Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma, 2019, 02-01, Volume: 36, Issue:3 Topics: Animals; Aquaporin 4; Astrocytes; Disease Models, Animal; Edema; Female; Glial Fibrillary Acidic Protein; Glycyrrhizic Acid; HMGB1 Protein; Laminectomy; NF-kappa B; Pyruvates; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries	2019
Ethyl Pyruvate Stimulates Regulatory T Cells and Ameliorates Type 1 Diabetes Development in Mice. Frontiers in immunology, 2018, Volume: 9 Topics: Adaptive Immunity; Animals; Antigen-Presenting Cells; Biomarkers; Cell Differentiation; Cell Movement; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Immunity, Innate; Insulin-Secreting Cells; Lymphocyte Activation; Mice; Nitric Oxide; Pyruvates; Reactive Oxygen Species; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory	2018
Ethyl pyruvate prevents inflammatory factors release and decreases intestinal permeability in rats with D-galactosamine-induced acute liver failure. Hepatobiliary & pancreatic diseases international : HBPD INT, 2013, Volume: 12, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Bacterial Translocation; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Endotoxins; Galactosamine; Inflammation Mediators; Intestinal Mucosa; Liver; Liver Failure, Acute; Male; Permeability; Pyruvates; Rats; Rats, Wistar; Time Factors	2013
Ethyl-pyruvate reduces lung injury matrix metalloproteinases and cytokines and improves survival in experimental model of severe acute pancreatitis. Acta cirurgica brasileira, 2013, Volume: 28, Issue:8 Topics: Acute Lung Injury; Animals; Cytokines; Disease Models, Animal; Immunoblotting; Isotonic Solutions; Kaplan-Meier Estimate; Male; Matrix Metalloproteinases; Pancreatitis, Acute Necrotizing; Pyruvates; Random Allocation; Rats; Rats, Wistar; Reference Values; Reproducibility of Results; Time Factors; Treatment Outcome	2013
Ethyl pyruvate inhibits retinal pathogenic neovascularization by downregulating HMGB1 expression. Journal of diabetes research, 2013, Volume: 2013 Topics: Animals; Animals, Newborn; Disease Models, Animal; Down-Regulation; Drug Evaluation, Preclinical; HMGB1 Protein; Mice; Mice, Inbred C57BL; Oxygen; Pyruvates; Retina; Retinal Neovascularization	2013
Ethyl pyruvate ameliorates monocrotaline-induced pulmonary arterial hypertension in rats. Journal of cardiovascular pharmacology, 2014, Volume: 64, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Administration Schedule; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Hypertension, Pulmonary; Injections, Intraperitoneal; Interleukin-6; Male; Monocrotaline; Pyruvates; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha	2014
Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury. Redox biology, 2014, Volume: 2 Topics: Acetylation; Acute Lung Injury; Animals; Antibodies; Bronchoalveolar Lavage Fluid; Cell Hypoxia; Cell Line; Disease Models, Animal; HMGB1 Protein; Injections, Spinal; Lung; Male; Mice; Mice, Inbred C57BL; Neutrophils; Pyruvates	2014
Role of ethyl pyruvate in systemic inflammatory response and lung injury in an experimental model of ruptured abdominal aortic aneurysm. BioMed research international, 2014, Volume: 2014 Topics: Aneurysm, Ruptured; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Humans; Lung Injury; Male; Pyruvates; Rats; Reperfusion Injury; Systemic Inflammatory Response Syndrome	2014
Ethyl pyruvate decreases airway neutrophil infiltration partly through a high mobility group box 1-dependent mechanism in a chemical-induced murine asthma model. International immunopharmacology, 2014, Volume: 21, Issue:1 Topics: Animals; Asthma; Cell Count; Cell Movement; Cells, Cultured; Chemokine CXCL2; Disease Models, Animal; HMGB1 Protein; Lung; Male; Mice; Neutrophils; Pyruvates; Receptors, Interleukin-8B; Toluene 2,4-Diisocyanate; Tumor Necrosis Factor-alpha	2014
Protective effect of ethyl pyruvate on ischemia-reperfusion injury in rat ovary: biochemical and histopathological evaluation. European journal of obstetrics, gynecology, and reproductive biology, 2014, Volume: 182 Topics: Animals; Antioxidants; Arginine; Disease Models, Animal; Female; Malondialdehyde; Ovary; Pyruvates; Rats; Rats, Wistar; Reperfusion Injury; Torsion Abnormality	2014
Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. Human reproduction (Oxford, England), 2015, Volume: 30, Issue:2 Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Biopsy; Cell Nucleus; Cells, Cultured; Disease Models, Animal; HMGB1 Protein; Humans; Infertility, Male; Lymphocytes; Macrophage Activation; Male; Molecular Targeted Therapy; Orchitis; Protein Transport; Pyruvates; Rats, Wistar; Recombinant Proteins; Testis	2015
Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury. CNS neuroscience & therapeutics, 2015, Volume: 21, Issue:4 Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Cells, Cultured; Disease Models, Animal; Male; Matrix Metalloproteinase 9; Maze Learning; Microglia; Neuroimmunomodulation; Neuroprotective Agents; Neutrophils; Pyruvates; Random Allocation; Rats, Sprague-Dawley; Recovery of Function; Time Factors; Treatment Outcome	2015
A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate. Journal of immunology (Baltimore, Md. : 1950), 2015, Mar-15, Volume: 194, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Cell Survival; Cells, Cultured; Cytokines; Dimethyl Fumarate; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Female; Flow Cytometry; Fumarates; Humans; Immunoblotting; Leukocytes, Mononuclear; Lipopolysaccharides; Lymph Nodes; Macrophages; Microglia; Multiple Sclerosis; NF-kappa B; Pyruvates; Rats; Reactive Oxygen Species; Spinal Cord	2015
Ethyl pyruvate attenuates murine allergic rhinitis partly by decreasing high mobility group box 1 release. Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:11 Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Immunoglobulin E; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Pyruvates; Rhinitis, Allergic; Toll-Like Receptor 4; Up-Regulation	2015
HMGB1 may act via RAGE to promote angiogenesis in the later phase after intracerebral hemorrhage. Neuroscience, 2015, Jun-04, Volume: 295 Topics: Animals; Benzamides; Cerebral Hemorrhage; Collagenases; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Functional Laterality; Gene Expression Regulation; Glial Fibrillary Acidic Protein; HMGB1 Protein; Male; Neovascularization, Physiologic; Pyruvates; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Up-Regulation; Vascular Endothelial Growth Factor A	2015
Combination treatment with ethyl pyruvate and IGF-I exerts neuroprotective effects against brain injury in a rat model of neonatal hypoxic-ischemic encephalopathy. International journal of molecular medicine, 2015, Volume: 36, Issue:1 Topics: Animals; Animals, Newborn; Brain Injuries; Carotid Arteries; Cell Survival; Cells, Cultured; Disease Models, Animal; Doublecortin Protein; Drug Therapy, Combination; Glucose; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Insulin-Like Growth Factor I; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Pyruvates; Rats; Rats, Sprague-Dawley	2015
Effects of ethyl pyruvate on leukocyte-endothelial interactions in the mesenteric microcirculation during early sepsis treatment. Clinics (Sao Paulo, Brazil), 2015, Volume: 70, Issue:7 Topics: Animals; Cell Communication; Disease Models, Animal; Endothelial Cells; Escherichia coli Infections; Leukocytes; Male; Mesenteric Veins; Microcirculation; Pyruvates; Rats; Rats, Wistar; Sepsis	2015
Ethyl pyruvate reduces hepatic mitochondrial swelling and dysfunction in a rat model of sepsis. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:7 Topics: Animals; Aquaporins; Benzimidazoles; Carbocyanines; Disease Models, Animal; Humans; Liver; Liver Diseases; Male; Mitochondria, Liver; Mitochondrial Swelling; Pyruvates; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis	2015
Preventive Effect of Ethyl Pyruvate on Postoperative Adhesion Formation Following Abdominal Surgery. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2016, Volume: 29, Issue:5 Topics: Animals; Antioxidants; Biocompatible Materials; Cecum; Digestive System Surgical Procedures; Disease Models, Animal; Hyaluronic Acid; Injections, Intraperitoneal; Male; Malondialdehyde; Membranes, Artificial; Nitric Oxide; Pyruvates; Rats; Rats, Wistar; Tissue Adhesions	2016
Effects of N-acetylcysteine and ethyl pyruvate on ischemia-reperfusion injury in experimental electrical burn model. The American journal of emergency medicine, 2016, Volume: 34, Issue:7 Topics: Acetylcysteine; Animals; Burns, Electric; Disease Models, Animal; Female; Free Radical Scavengers; Male; Pyruvates; Rats; Rats, Wistar; Reperfusion Injury	2016
Intratracheal instillation of ethyl pyruvate nanoparticles prevents the development of shunt-flow-induced pulmonary arterial hypertension in a rat model. International journal of nanomedicine, 2016, Volume: 11 Topics: Animals; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Interleukin-6; Lung; Male; Nanoparticles; Polyesters; Polyethylene Glycols; Protective Agents; Pulmonary Artery; Pyruvates; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vascular Remodeling	2016
Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice. Journal of vascular surgery, 2016, Volume: 64, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Aorta, Thoracic; Apoptosis; Apoptosis Regulatory Proteins; Constriction; Disease Models, Animal; Inflammation; Inflammation Mediators; Male; Mice, Inbred C57BL; Neuroprotective Agents; Paralysis; Pyruvates; Regional Blood Flow; Reperfusion Injury; Signal Transduction; Spinal Cord; Spinal Cord Ischemia; Time Factors	2016
Anti-apoptotic and myocardial protective effects of ethyl pyruvate after regional ischaemia/reperfusion myocardial damage in an in vivo rat model. Singapore medical journal, 2017, Volume: 58, Issue:9 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Disease Models, Animal; DNA Fragmentation; Male; Myocardial Reperfusion Injury; Myocardium; Proto-Oncogene Proteins c-bcl-2; Pyruvates; Rats; Rats, Sprague-Dawley	2017
Protective effects of ethyl pyruvate on lipopolysaccharide‑induced acute lung injury through inhibition of autophagy in neutrophils. Molecular medicine reports, 2017, Volume: 15, Issue:3 Topics: Acute Lung Injury; Animals; Autophagy; Biomarkers; Cell Line; Cytokines; Disease Models, Animal; Inflammation Mediators; Lipopolysaccharides; Male; Mice; Neutrophil Infiltration; Neutrophils; Protective Agents; Pyruvates	2017
Blockade of HMGB1 preserves vascular homeostasis and improves blood perfusion in rats of acute limb ischemia/reperfusion. Microvascular research, 2017, Volume: 112 Topics: Actins; Animals; Anti-Inflammatory Agents; Blood Flow Velocity; Disease Models, Animal; Hemorheology; Heparin; Hindlimb; HMGB1 Protein; Inflammation Mediators; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Muscle, Skeletal; Pyruvates; Rats, Wistar; Recovery of Function; Regional Blood Flow; Reperfusion Injury; Signal Transduction; Vascular Remodeling	2017
Systemic release of high mobility group box 1 protein during severe murine influenza. Journal of immunology (Baltimore, Md. : 1950), 2008, Jul-15, Volume: 181, Issue:2 Topics: Animals; Autoantibodies; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Humans; Influenza A Virus, H2N2 Subtype; Influenza, Human; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Pyruvates	2008
Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats. World journal of gastroenterology, 2008, Jul-28, Volume: 14, Issue:28 Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Creatinine; Disease Models, Animal; HMGB1 Protein; Kaplan-Meier Estimate; Kidney; Liver; Lung; Male; Pancreatitis; Pyruvates; Rats; Rats, Wistar; Reperfusion Injury; Severity of Illness Index; Tumor Necrosis Factor-alpha	2008
Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury. Shock (Augusta, Ga.), 2009, Volume: 32, Issue:2 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Fas Ligand Protein; Gene Expression Regulation; Humans; Inflammation; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Peroxidase; Phosphorylation; Pyruvates; Spinal Cord Injuries; Time Factors; Tyrosine	2009
Effect of ethyl pyruvate on physical and immunological barriers of the small intestine in a rat model of sepsis. The Journal of trauma, 2009, Volume: 66, Issue:5 Topics: Analysis of Variance; Animals; Bacterial Translocation; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunohistochemistry; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Kaplan-Meier Estimate; Male; Probability; Pyruvates; Random Allocation; Rats; Rats, Wistar; Sepsis; Survival Analysis	2009
Anti-inflammatory resuscitation improves survival in hemorrhage with trauma. The Journal of trauma, 2009, Volume: 66, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Fluid Therapy; Hemorrhage; Male; Pyruvates; Rats; Rats, Sprague-Dawley; Resuscitation; Systemic Inflammatory Response Syndrome; Tumor Necrosis Factor-alpha; Wounds and Injuries	2009
Ethyl pyruvate prevents intestinal inflammatory response and oxidative stress in a rat model of extrahepatic cholestasis. The Journal of surgical research, 2010, May-15, Volume: 160, Issue:2 Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Apoptosis; Aspartate Aminotransferases; Bilirubin; Cholestasis, Extrahepatic; Disease Models, Animal; Enteritis; gamma-Glutamyltransferase; Glutathione; Ileum; Interleukin-6; Intestinal Absorption; Jaundice, Obstructive; Liver; Male; Malondialdehyde; NF-kappa B; Oxidative Stress; Peroxidase; Pyruvates; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha	2010
Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain. Neurotoxicity research, 2010, Volume: 17, Issue:1 Topics: Animals; Aspirin; Astringents; Astrocytes; Brain Infarction; Cells, Cultured; Cerebral Cortex; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glucose; Hypoxia; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; NF-kappa B; Polysaccharides; Pyruvates; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Severity of Illness Index; Time Factors; Zinc Sulfate	2010
[Effects of ethyl pyruvate on injuries of sepsis in mice]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2009, Volume: 21, Issue:8 Topics: Alkaline Phosphatase; Animals; Disease Models, Animal; Intestines; Lactic Acid; Lung; Male; Mice; Pyruvates; Pyruvic Acid; Sepsis; Uric Acid	2009
Role of high-mobility group box 1 protein in the pathogenesis of intestinal barrier injury in rats with severe acute pancreatitis. Pancreas, 2010, Volume: 39, Issue:2 Topics: Acute Disease; Amine Oxidase (Copper-Containing); Amylases; Animals; Anti-Inflammatory Agents; Bacterial Translocation; Biomarkers; Blotting, Western; Disease Models, Animal; Endotoxins; HMGB1 Protein; Ileum; Immunohistochemistry; Intestinal Mucosa; Male; Neutrophil Infiltration; Pancreas; Pancreatitis; Permeability; Peroxidase; Pyruvates; Rats; Rats, Wistar; Severity of Illness Index; Taurocholic Acid; Time Factors; Up-Regulation	2010
Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model. Respiratory research, 2009, Oct-02, Volume: 10 Topics: Acute Lung Injury; Animals; Blotting, Western; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Inflammation Mediators; Injections, Intraperitoneal; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred BALB C; Permeability; Pyruvates; Respiratory System Agents; Severity of Illness Index; Time Factors; Tumor Necrosis Factor-alpha	2009
Effects of ethyl pyruvate and other α-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion. The Journal of surgical research, 2011, Volume: 165, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Cytoprotection; Disease Models, Animal; Fluid Therapy; Glyoxylates; Intestinal Mucosa; Ischemia; Lipid Peroxidation; Liver; Male; Mandelic Acids; Permeability; Phenylpyruvic Acids; Pyruvates; Rats; Reperfusion Injury; Structure-Activity Relationship; Tumor Necrosis Factor-alpha	2011
Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms. Neurobiology of disease, 2010, Volume: 37, Issue:3 Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Calcium Signaling; Calpain; Cell Death; Cytoprotection; Disease Models, Animal; Encephalitis; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Inflammation Mediators; Microglia; Nerve Degeneration; Neurons; Neuroprotective Agents; NF-kappa B; Pyruvates; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome	2010
Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model. Biochemical and biophysical research communications, 2010, Apr-09, Volume: 394, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line; Disease Models, Animal; Dopamine; Dopamine Agents; Extracellular Signal-Regulated MAP Kinases; Humans; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Parkinson Disease; Pyruvates; Substantia Nigra	2010
Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion. The Journal of trauma, 2011, Volume: 70, Issue:1 Topics: Adenosine Triphosphate; Animals; Antithrombin III; Disease Models, Animal; Inflammation; Interleukin-1; Lactates; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Peptide Hydrolases; Peroxidase; Pyruvates; Reperfusion Injury; Thrombosis	2011
Ethyl pyruvate reduces acute lung injury via regulation of iNOS and HO-1 expression in endotoxemic rats. The Journal of surgical research, 2011, May-15, Volume: 167, Issue:2 Topics: Acute Lung Injury; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Endotoxemia; Enzyme Inhibitors; Heme Oxygenase-1; Interleukin-6; Lipopolysaccharides; Male; Metalloporphyrins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitric Oxide Synthase Type II; Protoporphyrins; Pyruvates; Rats; Rats, Wistar; Signal Transduction; Tumor Necrosis Factor-alpha	2011
Preventive effects of ethyl pyruvate on endotoxin-induced uveitis in rats. Investigative ophthalmology & visual science, 2011, Jul-11, Volume: 52, Issue:8 Topics: Animals; Aqueous Humor; Blotting, Western; Cell Survival; Cells, Cultured; Ciliary Body; Cyclooxygenase 2; Disease Models, Animal; Endotoxins; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Humans; Lipopolysaccharides; Male; Microscopy, Fluorescence; NF-kappa B; Pyruvates; Rats; Rats, Inbred Lew; Reactive Oxygen Species; Treatment Outcome; Tumor Necrosis Factor-alpha; Uveitis	2011
Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's disease. Journal of immunology (Baltimore, Md. : 1950), 2011, Jul-15, Volume: 187, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cells, Cultured; Coculture Techniques; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Antagonists; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Neuroglia; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Pyruvates; Rats; Rats, Sprague-Dawley; Substantia Nigra	2011
Inhaled nitric oxide aggravates phosgene model of acute lung injury. Inhalation toxicology, 2011, Volume: 23, Issue:13 Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Synergism; Enzyme Inhibitors; Irritants; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosgene; Plethysmography, Whole Body; Proteins; Pyruvates; Rats; Rats, Wistar	2011
Ethyl pyruvate improves healing of colonic anastomosis in a rat model of peritonitis. Surgical innovation, 2012, Volume: 19, Issue:4 Topics: Analysis of Variance; Anastomosis, Surgical; Animals; Colon; Disease Models, Animal; Hydroxyproline; Male; Peritonitis; Pressure; Pyruvates; Rats; Rats, Wistar; Sepsis; Wound Healing	2012
Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation. Investigative ophthalmology & visual science, 2012, Sep-25, Volume: 53, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Cell Migration Assays, Leukocyte; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Keratitis; Leukocytes; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Ophthalmic Solutions; Pyruvates; Receptors, Chemokine; Transcription Factor RelA; Tumor Necrosis Factor-alpha	2012
Ethyl pyruvate protects against experimental acute-on-chronic liver failure in rats. World journal of gastroenterology, 2012, Oct-28, Volume: 18, Issue:40 Topics: Animals; Biomarkers; Cytokines; Cytoprotection; Disease Models, Animal; End Stage Liver Disease; Endotoxins; Female; HMGB1 Protein; Inflammation Mediators; Liver; Liver Failure, Acute; Protective Agents; Pyruvates; Rats; Rats, Wistar; Severity of Illness Index; Time Factors	2012
Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion. Intensive care medicine, 2003, Volume: 29, Issue:11 Topics: Analysis of Variance; Animals; Blood Pressure; Capillary Permeability; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Free Radical Scavengers; Ileum; Intestinal Mucosa; Ischemia; Laser-Doppler Flowmetry; Liver; Male; Mesenteric Vascular Occlusion; Mesentery; Mice; Mice, Inbred C57BL; NF-kappa B; Pyruvates; Reperfusion Injury; Time Factors; Tumor Necrosis Factor-alpha	2003
Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney international, 2003, Volume: 64, Issue:5 Topics: Acute Kidney Injury; Aging; Animals; Anti-Bacterial Agents; Blood Coagulation; Cecum; Cysteine-Rich Protein 61; Disease Models, Animal; Fibrinolysis; Fluid Therapy; Gene Expression; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney Tubules; Ligation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Multiple Organ Failure; Pyruvates; RNA, Messenger; Sepsis; Tumor Necrosis Factor-alpha; Wounds, Stab	2003
[Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2005, Volume: 17, Issue:1 Topics: Animals; Burns; Cell Proliferation; Disease Models, Animal; Interleukin-2; Lymphocyte Activation; Male; Pyruvates; Random Allocation; Rats; Rats, Wistar; Receptors, Interleukin-2; Spleen; T-Lymphocytes	2005
[Effects of ethyl pyruvate on splenocyte proliferation and apoptosis in burn rats with delayed resuscitation]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2005, Volume: 17, Issue:7 Topics: Animals; Apoptosis; Burns; Cell Proliferation; Disease Models, Animal; Male; Pyruvates; Random Allocation; Rats; Rats, Wistar; Spleen; T-Lymphocytes	2005
Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia. Critical care medicine, 2005, Volume: 33, Issue:9 Topics: Acidosis; Animals; Blood Pressure; Disease Models, Animal; Diuresis; Endotoxemia; Hemodynamics; Lipid Peroxidation; Lipopolysaccharides; Liver Circulation; Nitrates; Nitrites; Oxygen; Oxygen Consumption; Prospective Studies; Pulmonary Circulation; Pyruvates; Random Allocation; Respiration, Artificial; Resuscitation; Splanchnic Circulation; Swine	2005
Ethyl pyruvate ameliorates ileus induced by bowel manipulation in mice. Surgery, 2005, Volume: 138, Issue:3 Topics: Animals; Disease Models, Animal; Gastrointestinal Transit; Ileus; Intestine, Small; Mice; Mice, Inbred C57BL; Postoperative Complications; Pyruvates; Reference Values	2005
Ethyl pyruvate enhances ATP levels, reduces oxidative stress and preserves cardiac function in a rat model of off-pump coronary bypass. Heart, lung & circulation, 2005, Volume: 14, Issue:1 Topics: Adenosine Triphosphate; Animals; Cardiac Output; Coronary Artery Bypass, Off-Pump; Disease Models, Animal; Lipid Peroxidation; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Pyruvates; Rats; Rats, Wistar; Ventricular Pressure	2005
Oxidative damage to lens in culture: reversibility by pyruvate and ethyl pyruvate. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2006, Volume: 220, Issue:1 Topics: Animals; Cataract; Culture Media; Disease Models, Animal; Lens, Crystalline; Mice; Oxidative Stress; Pyruvates; Pyruvic Acid; Reactive Oxygen Species; Tissue Culture Techniques	2006
[Effect of treatment with ethyl pyruvate on multiple organ dysfunction and mortality following delayed resuscitation after burn injury in rat]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2006, Volume: 18, Issue:3 Topics: Animals; Burns; Disease Models, Animal; Male; Multiple Organ Failure; Pyruvates; Random Allocation; Rats; Rats, Wistar; Resuscitation	2006
[Effect of ethyl pyruvate on peroxidation injury of intestinal mucosa in rats with severe abdominal infection]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2006, Volume: 18, Issue:3 Topics: Abdominal Cavity; Animals; Disease Models, Animal; Female; Infections; Intestinal Mucosa; Lipid Peroxidation; Male; Malondialdehyde; Peroxidase; Pyruvates; Random Allocation; Rats; Rats, Sprague-Dawley	2006
Beneficial effects of ethyl pyruvate in septic shock from peritonitis. Archives of surgery (Chicago, Ill. : 1960), 2007, Volume: 142, Issue:2 Topics: Animals; Disease Models, Animal; Female; Flavoring Agents; Follow-Up Studies; Infusions, Intravenous; Interleukin-6; Peritonitis; Prospective Studies; Pyruvates; Sheep; Shock, Septic; Treatment Outcome	2007
Ethyl pyruvate inhibits hypoxic pulmonary vasoconstriction and attenuates pulmonary artery cytokine expression. The Journal of surgical research, 2008, Volume: 145, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Down-Regulation; Hypoxia; Interleukin-1; Lung; Male; Pulmonary Artery; Pyruvates; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Vasoconstriction	2008
[Effect of ethyl pyruvate on renal high mobility group box-1 protein expression and acute kidney injury in rats with delayed resuscitation after thermal injury]. Zhonghua wai ke za zhi [Chinese journal of surgery], 2007, Sep-01, Volume: 45, Issue:17 Topics: Acute Disease; Animals; Blood Urea Nitrogen; Blotting, Western; Burns; Disease Models, Animal; HMGB1 Protein; Immunohistochemistry; Kidney; Kidney Diseases; Male; Pyruvates; Random Allocation; Rats; Rats, Wistar; Resuscitation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors	2007
[Effect of ethyl pyruvate on indices of tissue oxygenation and perfusion in dogs with septic shock]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2008, Volume: 20, Issue:1 Topics: Animals; Disease Models, Animal; Dogs; Male; Oxygen Consumption; Pyruvates; Shock, Septic	2008
Bull's eye missed by the magic bullet: preclinical investigations, publication bias, and promising new interventions. Critical care medicine, 2008, Volume: 36, Issue:4 Topics: Animals; Cytokines; Disease Models, Animal; Lipopolysaccharides; Mice; NF-kappa B; Publication Bias; Pyruvates; Sepsis	2008