ethyl-cellulose and Urinary-Tract-Infections

Thiazolidinedione-8 (TZD-8) is an anti-quorum-sensing molecule that has the potential to effectively prevent catheter-associated urinary tract infections, a major healthcare challenge. Sustained-release drug-delivery systems can enhance drugs' therapeutic potential, by maintaining their therapeutic level and reducing their side effects. Varnishes for sustained release of TZD-8 based on ethylcellulose or ammonio methacrylate copolymer type A (Eudragit(®) RL) were developed. The main factors affecting release rate were found to be film thickness and presence of a hydrophilic or swellable polymer in the matrix. The release mechanism of ethylcellulose-based systems matched the Higuchi model. Selected varnishes were retained on catheters for at least 8 days. Sustained-release delivery systems of TZD-8 were active against Candida albicans biofilms. The present study demonstrates promising results en route to developing applications for the prevention of catheter-associated infections.

Topics: Anti-Bacterial Agents; Biofilms; Candida albicans; Catheter-Related Infections; Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Kinetics; Models, Chemical; Polymers; Solubility; Technology, Pharmaceutical; Thiazolidinediones; Urinary Catheterization; Urinary Catheters; Urinary Tract Infections