ethyl-cellulose and Dental-Plaque

Ethylcellulose inserts of niridazole fabricated by casting were studied for in vitro release and in vivo clinical effectiveness. The in vitro drug release was steady and sustained for over 7 days and followed diffusion kinetics. Selected batch, EN3, was evaluated clinically in patients with periodontitis for 6 months. A significant improvement (alpha < or = 0.05) in clinical indices from baseline was observed. Intergroup study revealed a significant (alpha < or = 0.01) change in the bleeding index, gingival index, plaque index, calculus criteria, and pocket depth. Significant reduction in total bacterial count in gingival crevicular fluid was observed before and postdevice insertion, as well as between control and treatment groups.

Topics: Adolescent; Adult; Biological Availability; Cellulose; Delayed-Action Preparations; Dental Calculus; Dental Plaque; Drug Delivery Systems; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Niridazole; Orphan Drug Production; Periodontal Diseases; Periodontal Index; Periodontal Pocket; Periodontitis; Pilot Projects; Single-Blind Method; Time Factors; Treatment Outcome

Topics: Administration, Topical; Cellulose; Chronic Disease; Dental Plaque; Dibutyl Phthalate; Humans; Methylmethacrylates; Metronidazole; Periodontal Diseases

The release of chlorhexidine from an ethyl cellulose-based dosage form (SRD) has been shown to be effective in the reduction of the flora associated with periodontal pockets as well as in reducing probing depths. In this study, treatment with this dosage form was compared to routine maintenance therapy (RMT) in a 2-year, split mouth clinical trial. Ten patients with 84 pockets greater than or equal to 5 mm who had not received any periodontal therapy or systemic antibiotics over the last 6 months were included. The patients all received a full mouth scaling and root planing together with through oral hygiene instruction. Two months later (baseline) plaque index (P1I), bleeding on probing (BOP), pocket probing depth (PD), and attachment levels (AL) were assessed at all selected sites. Pockets on the control side then received RMT while the experimental pockets were treated with the SRD only. Treatment was repeated every 3 months for 2 years. The SRD treatment resulted in an improvement of greater than or equal to 3 mm in PD of at least 1 pocket in 8 of 10 patients, while RMT resulted in a similar improvement in only 1 of 10 patients (P = 0.012). Similarly a gain of attachment of greater than or equal to 3 mm was found in at least 1 SRD pocket in 8 of 10 patients. The RMT resulted in a similar improvement in only 2 patients (P = 0.012).(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Adult; Cellulose; Chlorhexidine; Delayed-Action Preparations; Dental Plaque; Dental Plaque Index; Dental Prophylaxis; Dental Scaling; Epithelial Attachment; Female; Gingival Hemorrhage; Humans; Male; Oral Hygiene; Periodontal Index; Periodontal Pocket; Root Planing

We studied the effectiveness of a sustained-release delivery system for chlorhexidine in plaque prevention. A clinical trial in a group of eight students wearing orthodontic appliances coated by ethyl cellulose polymer containing the drug demonstrated that plaque accumulation was decreased for a period of four days. All oral procedures had been withdrawn during the clinical study. No side-effects of chlorhexidine, such as tooth staining and unpleasant taste, were observed.

Topics: Adult; Cellulose; Chlorhexidine; Delayed-Action Preparations; Dental Plaque; Diffusion; Humans; Orthodontic Appliances, Removable; Polymers

The aim of this work was to test the effectiveness of a local sustained release application of chlorhexidine in prevention of plaque formation in a group of five partial denture wearers when oral hygiene procedures were withdrawn. The clinical study demonstrates that coating of the partial dentures with ethyl cellulose polymer containing the drug, prevents accumulation of plaque during a period of 12 days. No typical side effects of chlorhexidine such as tooth staining and unpleasant taste were observed during the study.

Topics: Aged; Cellulose; Chlorhexidine; Delayed-Action Preparations; Dental Plaque; Denture, Partial, Removable; Diffusion; Female; Humans; Male; Middle Aged; Oral Hygiene; Streptococcus mutans