ethyl-cellulose has been researched along with Crohn-Disease* in 2 studies
2 other study(ies) available for ethyl-cellulose and Crohn-Disease
| Article | Year |
|---|---|
Colon targeting with bacteria-sensitive films adapted to the disease state.
The aim of this study was to identify novel polymeric films allowing for the site-specific delivery of drugs to the colon of patients suffering from inflammatory bowel diseases. Ethylcellulose was blended with different types of bacteria-sensitive starch derivatives. The water uptake and dry mass loss kinetics of the systems were monitored upon exposure to media simulating the contents of the stomach, small intestine and colon (including fresh fecal samples from Crohn's Disease and Ulcerative Colitis patients). Importantly, ethylcellulose:Nutriose FB 06 and ethylcellulose:Peas starch N-735 films showed highly promising water uptake and dry mass loss kinetics in all the investigated media, indicating their potential to minimize premature drug release in the upper gastro-intestinal tract, and allowing for controlled release once the colon is reached. This can be attributed to the fact that the starch derivatives serve as substrates for the enzymes, which are secreted by the bacteria present in the colon of inflammatory bowel disease patients. Thus, the identified new polymeric films are adapted to the pathophysiological conditions in the gastro-intestinal tract in the disease state. Furthermore, Nutriose is known to provide pre-biotic effects, which can be of great benefit for these patients. Topics: Adult; Animals; Bacteria; Cattle; Cellulose; Colitis, Ulcerative; Colon; Crohn Disease; Drug Delivery Systems; Humans; Middle Aged; Rats; Young Adult | 2009 |
[Comparative roentgen study of the small intestine with single and double contrast].
The experiences from a total of 303 small intestine examinations of different techniques show that especially the double-contrast representation using barium sulfate and air achieves the best diagnostical findings. The double-contrast representation can be achieved by an antegrade small intestine enema (enteroclysis) or within the conventional small intestine passage by retrograde air insufflation. These examination techniques make optimal fine diagnostics especially of the lower ileum possible. The indications for the different methods are explained. Topics: Air; Barium Sulfate; Cellulose; Contrast Media; Crohn Disease; Diverticulum; Enema; Humans; Intestinal Diseases; Intestine, Small; Methylcellulose; Radiography; Tissue Adhesions; Water | 1983 |