ethyl-cellulose and Asthma

ethyl-cellulose has been researched along with Asthma* in 1 studies

Other Studies

1 other study(ies) available for ethyl-cellulose and Asthma

ArticleYear
Design and optimization of colon-targeted system of theophylline for chronotherapy of nocturnal asthma.
    Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:5

    The objective of the present work was to develop a delayed-onset controlled-release colon-targeted system of theophylline, and to achieve the chronotherapy of nocturnal asthma. The formulation consisted of a core tablet containing hydroxypropyl methylcellulose used for achieving controlled release of drug, and a Eudragit S100:ethyl cellulose (EC) coating capable of delaying the drug release. The system was optimized using a 3(2) full factorial design, wherein two factors [ratio of Eudragit S100:EC and the coating level (% w/w)] were evaluated for lag time, t(50) and t(80) . The optimum formulation consisted of Eudragit S100:EC in a 60:40 ratio and a coating level of 7.5% (w/w). Results showed that the tablets prepared according to the optimized values released no drug in the upper part of gastrointestinal tract; drug release was initiated at pH 6.4 (colon) after a lag time of 5 h. In vivo evaluation (pharmacokinetic studies and roentgenography) in rabbits revealed that the tablet remained intact until it reaches the colon and the drug release was initiated after a lag time of 5 h. Thus, it can be concluded that the developed system exhibited a promising colonic targeting and hence may be used for chronotherapy of nocturnal asthma.

    Topics: Animals; Asthma; Bronchodilator Agents; Cellulose; Chronotherapy; Colon; Delayed-Action Preparations; Drug Stability; Polymethacrylic Acids; Rabbits; Theophylline

2011