ethyl-cellulose and Arthritis

ethyl-cellulose has been researched along with Arthritis* in 1 studies

Other Studies

1 other study(ies) available for ethyl-cellulose and Arthritis

ArticleYear
Development of iron/ethylcellulose (core/shell) nanoparticles loaded with diclofenac sodium for arthritis treatment.
    International journal of pharmaceutics, 2009, Dec-01, Volume: 382, Issue:1-2

    Diclofenac sodium is a non-steroidal anti-inflammatory drug of choice to treat arthritis because of its potential anti-inflammatory and analgesic activity. Because of its shorter biological half-life, it is needed to be given frequently and at high doses to elicit the required therapeutic activity, simultaneously leading to severe side effects. We hypothesized that the efficient delivery of diclofenac sodium to inflammation using a magnetic colloid could reduce the dose required to bring out sufficient therapeutic response. Hence, we have developed a diclofenac sodium-loaded magnetic nanomedicine, consisting of a magnetic core (iron) and a biocompatible polymeric shell (ethylcellulose) for parenteral administration. These core/shell nanoparticles were synthesized by an emulsion solvent evaporation process. Two drug loading methods were analyzed: the first one being drug addition prior to the emulsion solvent evaporation process (leading to drug entrapment into the polymeric network), and the second method based on diclofenac sodium surface adsorption onto the preformed nanoparticles. Compared to drug adsorption, the entrapment of this active agent into the polymeric matrix yielded a higher drug loading and a slower drug release profile. Such nanocomposites possessed very important characteristics such as unusually high drug loading, enhanced magnetic susceptibility and prolonged drug release, indicating their potential use as nanocarriers for efficient delivery of diclofenac sodium to inflammation sites.

    Topics: Absorption; Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diclofenac; Drug Carriers; Drug Compounding; Emulsions; Iron; Kinetics; Magnetics; Metal Nanoparticles; Particle Size; Solubility; Solvents; Surface Properties; Surface-Active Agents; Technology, Pharmaceutical

2009