ethyl-cellulose and Alzheimer-Disease

The current study focuses on development of nasal mucoadhesive microspheres for nose-to-brain delivery of rivastigmine for Alzheimer treatment. A systematic development was employed for optimization of the formulation and process parameters influential on the quality attributes of the microspheres. The risk assessment study revealed major influence of the polymer concentration (ethylcellulose: chitosan), the concentration of surfactant solution (polyvinyl alcohol), and stirring speed as the critical factors for optimization of the microspheres. These factors were systematically optimized using Box-Behnken design and microspheres were evaluated for the particle size, entrapment efficiency, and in vitro drug release as the response variables. The optimized microspheres containing 4.4% wt/vol polymers, 1% wt/vol surfactant, and stirring speed at 1500 rpm showed particle size of 19.9 µm, entrapment efficiency of 77.8%, and drug release parameters as T

Topics: Adhesiveness; Administration, Intranasal; Alzheimer Disease; Animals; Brain; Cellulose; Chitosan; Cholinesterase Inhibitors; Drug Compounding; Drug Delivery Systems; Drug Liberation; Goats; In Vitro Techniques; Lectins; Microspheres; Nasal Mucosa; Particle Size; Rivastigmine