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ethoxzolamide and Intraocular Pressure

ethoxzolamide has been researched along with Intraocular Pressure in 23 studies

Ethoxzolamide: A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.
ethoxzolamide : A sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic.

Intraocular Pressure: The pressure of the fluids in the eye.

Research Excerpts

ExcerptRelevanceReference
"A topical carbonic anhydrase inhibitor, 6-amino-2-benzothiazolesulfonamide (aminozolamide), which is an analogue of ethoxzolamide, was studied in 18 patients with ocular hypertension."9.06Aminozolamide gel. A trial of a topical carbonic anhydrase inhibitor in ocular hypertension. ( Barfknecht, CF; Lewis, RA; Phelps, CD; Schoenwald, RD, 1986)
" These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration."7.72Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004)
") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions."7.70Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000)
"A topical carbonic anhydrase inhibitor, 6-amino-2-benzothiazolesulfonamide (aminozolamide), which is an analogue of ethoxzolamide, was studied in 18 patients with ocular hypertension."5.06Aminozolamide gel. A trial of a topical carbonic anhydrase inhibitor in ocular hypertension. ( Barfknecht, CF; Lewis, RA; Phelps, CD; Schoenwald, RD, 1986)
" These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration."3.72Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004)
") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions."3.70Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000)
"A newly synthesized topical carbonic anhydrase inhibitor, 6-hydroxyethoxy-2-benzothiazole sulfonamide (6-HS), was administered systemically and topically to alpha-chymotrypsin-induced glaucoma rabbits to evaluate its ocular hypotensive effect."3.68The study of ocular hypotensive effect of 6-hydroxyethoxy-2-benzothiazole sulfonamide: a topical carbonic anhydrase inhibitor. ( Chiang, CH; Kao, KD; Lu, DW; Wen, LY, 1990)
"An analogue of ethoxzolamide, 6-hydroxyethoxzolamide, was synthesized to enhance corneal permeability yet retain carbonic anhydrase inhibitory activity for use in lowering intraocular pressure."3.67Ethoxzolamide analogue gel. A topical carbonic anhydrase inhibitor. ( Barfknecht, CF; Eller, MG; Lewis, RA; Phelps, CD; Schoenwald, RD, 1984)
"Four carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, ethoxzolamide, and methazolamide) cause ocular hypotony in normotensive and glaucomatous Beagles."3.66Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles. ( Gelatt, KN; Gum, G; Gwin, RM; Williams, LW, 1979)
"Methazolamide was next."2.64Patient tolerance to carbonic anhydrase inhibitors. ( Beall, OV; Lichter, PR; Newman, LP; Wheeler, NC, 1978)
"8 mmHg by 2 min) and aqueous flow (33% and 40% by 5 min) following intravenous dosing with either methazolamide or ethoxzolamide."1.29A comparison between the effect of topical and systemic carbonic anhydrase inhibitors on aqueous humor secretion. ( Brechue, WF; Maren, TH, 1993)
"Such an agent would be useful in the treatment of glaucoma."1.28Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity. ( Anderson, PS; Baldwin, JJ; Best, DB; Christy, ME; Freedman, MB; Gautheron, P; Graham, SL; Habecker, CN; Hoffman, JM; Shepard, KL, 1989)
"Ethoxzolamide was used because of its very high activity against carbonic anhydrase and experience showing that there is little or no other receptor in tissues."1.28Relations among IOP reduction, ocular disposition and pharmacology of the carbonic anhydrase inhibitor ethoxzolamide. ( Bar-Ilan, A; Brechue, WF; Maren, TH, 1992)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199012 (52.17)18.7374
1990's6 (26.09)18.2507
2000's5 (21.74)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Graham, SL2
Shepard, KL1
Anderson, PS1
Baldwin, JJ1
Best, DB1
Christy, ME1
Freedman, MB1
Gautheron, P1
Habecker, CN1
Hoffman, JM2
Woltersdorf, OW1
Schwam, H1
Bicking, JB1
Brown, SL1
deSolms, SJ1
Fishman, DR1
Gautheron, PD1
Larson, RD1
Scozzafava, A6
Menabuoni, L4
Mincione, F6
Briganti, F2
Mincione, G2
Supuran, CT6
Casini, A4
Ilies, MA1
Starnotti, M3
de Leval, X1
Ilies, M1
Dogné, JM1
Masini, E2
Bacciottini, L1
Scrivanti, C1
Vullo, D1
DRANCE, SM1
ELIEZER, CP1
de CARVALHO, C1
Eller, MG2
Schoenwald, RD5
Lewis, RA2
Barfknecht, CF4
Phelps, CD2
Loftsson, T1
Frithriksdóttir, H1
Stefánsson, E1
Thórisdóttir, S1
Guthmundsson, O1
Sigthórsson, T1
Brechue, WF2
Maren, TH2
Gelatt, KN1
Gum, G1
Williams, LW1
Gwin, RM1
Lichter, PR1
Newman, LP1
Wheeler, NC1
Beall, OV1
Bar-Ilan, A2
Campbell, DA2
Duffel, MW2
Lu, DW1
Chiang, CH1
Kao, KD1
Wen, LY1
Kass, MA1
Pessah, NI1
Putnam, ML1
Segarra, TM1

Trials

2 trials available for ethoxzolamide and Intraocular Pressure

ArticleYear
Patient tolerance to carbonic anhydrase inhibitors.
    American journal of ophthalmology, 1978, Volume: 85, Issue:4

    Topics: Acetazolamide; Anorexia; Carbonic Anhydrase Inhibitors; Confusion; Dichlorphenamide; Drug Evaluation

1978
Aminozolamide gel. A trial of a topical carbonic anhydrase inhibitor in ocular hypertension.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1986, Volume: 104, Issue:6

    Topics: Administration, Topical; Adult; Benzothiazoles; Carbonic Anhydrase Inhibitors; Clinical Trials as To

1986

Other Studies

21 other studies available for ethoxzolamide and Intraocular Pressure

ArticleYear
Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:12

    Topics: Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Glaucoma; Guinea Pigs; Intrao

1989
Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:11

    Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Cornea; Ethox

1989
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
    Journal of medicinal chemistry, 1999, Jul-15, Volume: 42, Issue:14

    Topics: Administration, Topical; Animals; Aqueous Humor; Benzene Derivatives; Carbonic Anhydrase Inhibitors;

1999
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
    Journal of medicinal chemistry, 2000, Nov-16, Volume: 43, Issue:23

    Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases;

2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.
    Journal of medicinal chemistry, 2000, Dec-14, Volume: 43, Issue:25

    Topics: Animals; Carbonic Anhydrase Inhibitors; Cornea; Eye; Glaucoma; Hydrogen-Ion Concentration; Intraocul

2000
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.
    Bioorganic & medicinal chemistry letters, 2003, Sep-01, Volume: 13, Issue:17

    Topics: Administration, Topical; Animals; Benzolamide; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic

2003
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
    Journal of medicinal chemistry, 2004, May-20, Volume: 47, Issue:11

    Topics: Administration, Topical; Animals; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase In

2004
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
    Bioorganic & medicinal chemistry letters, 2005, Sep-01, Volume: 15, Issue:17

    Topics: Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models,

2005
The effects of ethoxzolamide (cardrase) on intraocular pressure.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1959, Volume: 62

    Topics: Acetazolamide; Ethoxzolamide; Eye Diseases; Glaucoma; Intraocular Pressure; Tonometry, Ocular

1959
[Reduction of intraocular pressure induced by ethoxzolamide].
    Revista brasileira de oftalmologia, 1959, Volume: 18

    Topics: Acetazolamide; Ethoxzolamide; Eye Diseases; Glaucoma; Humans; Intraocular Pressure; Tonometry, Ocula

1959
Determination of ethoxzolamide in the iris/ciliary body of the rabbit eye by high-performance liquid chromatography: comparison of tissue levels following intravenous and topical administrations.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:9

    Topics: Administration, Topical; Animals; Chromatography, High Pressure Liquid; Ciliary Body; Ethoxzolamide;

1984
Ethoxzolamide analogue gel. A topical carbonic anhydrase inhibitor.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1984, Volume: 102, Issue:12

    Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chymotrypsin; Ethoxzolamide; Gels; Glaucoma;

1984
Topically effective ocular hypotensive acetazolamide and ethoxyzolamide formulations in rabbits.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:6

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetazolamide; Administration, Topical; Animals; beta-Cyclodextri

1994
A comparison between the effect of topical and systemic carbonic anhydrase inhibitors on aqueous humor secretion.
    Experimental eye research, 1993, Volume: 57, Issue:1

    Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases;

1993
Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles.
    American journal of veterinary research, 1979, Volume: 40, Issue:3

    Topics: Acetazolamide; Administration, Oral; Animals; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Dog D

1979
Relations among IOP reduction, ocular disposition and pharmacology of the carbonic anhydrase inhibitor ethoxzolamide.
    Experimental eye research, 1992, Volume: 55, Issue:1

    Topics: Animals; Carbonic Anhydrases; Ciliary Body; Dose-Response Relationship, Drug; Ethoxzolamide; Intraoc

1992
Characterization of arylamine acetyltransferase in the rabbit eye.
    Investigative ophthalmology & visual science, 1991, Volume: 32, Issue:8

    Topics: 4-Aminobenzoic Acid; Acetylation; Administration, Topical; Animals; Arylamine N-Acetyltransferase; B

1991
The study of ocular hypotensive effect of 6-hydroxyethoxy-2-benzothiazole sulfonamide: a topical carbonic anhydrase inhibitor.
    Journal of ocular pharmacology, 1990,Winter, Volume: 6, Issue:4

    Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chymotrypsin; Disease Models, Animal; Ethoxz

1990
Topical carbonic anhydrase inhibitors.
    American journal of ophthalmology, 1989, Mar-15, Volume: 107, Issue:3

    Topics: Administration, Topical; Benzothiazoles; Carbonic Anhydrase Inhibitors; Ethoxzolamide; Gels; Glaucom

1989
On the use of ketamine in ocular pharmacological studies.
    Journal of ocular pharmacology, 1986,Fall, Volume: 2, Issue:4

    Topics: Animals; Aqueous Humor; Ascorbic Acid; Body Temperature; Ethoxzolamide; Eye; Intraocular Pressure; K

1986
Ocular disposition of aminozolamide in the rabbit eye.
    Investigative ophthalmology & visual science, 1987, Volume: 28, Issue:8

    Topics: Animals; Aqueous Humor; Benzothiazoles; Carbonic Anhydrase Inhibitors; Ciliary Body; Cornea; Ethoxzo

1987