ethoxzolamide has been researched along with Intraocular Pressure in 23 studies
Ethoxzolamide: A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.
ethoxzolamide : A sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A topical carbonic anhydrase inhibitor, 6-amino-2-benzothiazolesulfonamide (aminozolamide), which is an analogue of ethoxzolamide, was studied in 18 patients with ocular hypertension." | 9.06 | Aminozolamide gel. A trial of a topical carbonic anhydrase inhibitor in ocular hypertension. ( Barfknecht, CF; Lewis, RA; Phelps, CD; Schoenwald, RD, 1986) |
| " These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration." | 7.72 | Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004) |
| ") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions." | 7.70 | Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000) |
| "A topical carbonic anhydrase inhibitor, 6-amino-2-benzothiazolesulfonamide (aminozolamide), which is an analogue of ethoxzolamide, was studied in 18 patients with ocular hypertension." | 5.06 | Aminozolamide gel. A trial of a topical carbonic anhydrase inhibitor in ocular hypertension. ( Barfknecht, CF; Lewis, RA; Phelps, CD; Schoenwald, RD, 1986) |
| " These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration." | 3.72 | Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004) |
| ") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions." | 3.70 | Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000) |
| "A newly synthesized topical carbonic anhydrase inhibitor, 6-hydroxyethoxy-2-benzothiazole sulfonamide (6-HS), was administered systemically and topically to alpha-chymotrypsin-induced glaucoma rabbits to evaluate its ocular hypotensive effect." | 3.68 | The study of ocular hypotensive effect of 6-hydroxyethoxy-2-benzothiazole sulfonamide: a topical carbonic anhydrase inhibitor. ( Chiang, CH; Kao, KD; Lu, DW; Wen, LY, 1990) |
| "An analogue of ethoxzolamide, 6-hydroxyethoxzolamide, was synthesized to enhance corneal permeability yet retain carbonic anhydrase inhibitory activity for use in lowering intraocular pressure." | 3.67 | Ethoxzolamide analogue gel. A topical carbonic anhydrase inhibitor. ( Barfknecht, CF; Eller, MG; Lewis, RA; Phelps, CD; Schoenwald, RD, 1984) |
| "Four carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, ethoxzolamide, and methazolamide) cause ocular hypotony in normotensive and glaucomatous Beagles." | 3.66 | Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles. ( Gelatt, KN; Gum, G; Gwin, RM; Williams, LW, 1979) |
| "Methazolamide was next." | 2.64 | Patient tolerance to carbonic anhydrase inhibitors. ( Beall, OV; Lichter, PR; Newman, LP; Wheeler, NC, 1978) |
| "8 mmHg by 2 min) and aqueous flow (33% and 40% by 5 min) following intravenous dosing with either methazolamide or ethoxzolamide." | 1.29 | A comparison between the effect of topical and systemic carbonic anhydrase inhibitors on aqueous humor secretion. ( Brechue, WF; Maren, TH, 1993) |
| "Such an agent would be useful in the treatment of glaucoma." | 1.28 | Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity. ( Anderson, PS; Baldwin, JJ; Best, DB; Christy, ME; Freedman, MB; Gautheron, P; Graham, SL; Habecker, CN; Hoffman, JM; Shepard, KL, 1989) |
| "Ethoxzolamide was used because of its very high activity against carbonic anhydrase and experience showing that there is little or no other receptor in tissues." | 1.28 | Relations among IOP reduction, ocular disposition and pharmacology of the carbonic anhydrase inhibitor ethoxzolamide. ( Bar-Ilan, A; Brechue, WF; Maren, TH, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (52.17) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Graham, SL | 2 |
| Shepard, KL | 1 |
| Anderson, PS | 1 |
| Baldwin, JJ | 1 |
| Best, DB | 1 |
| Christy, ME | 1 |
| Freedman, MB | 1 |
| Gautheron, P | 1 |
| Habecker, CN | 1 |
| Hoffman, JM | 2 |
| Woltersdorf, OW | 1 |
| Schwam, H | 1 |
| Bicking, JB | 1 |
| Brown, SL | 1 |
| deSolms, SJ | 1 |
| Fishman, DR | 1 |
| Gautheron, PD | 1 |
| Larson, RD | 1 |
| Scozzafava, A | 6 |
| Menabuoni, L | 4 |
| Mincione, F | 6 |
| Briganti, F | 2 |
| Mincione, G | 2 |
| Supuran, CT | 6 |
| Casini, A | 4 |
| Ilies, MA | 1 |
| Starnotti, M | 3 |
| de Leval, X | 1 |
| Ilies, M | 1 |
| Dogné, JM | 1 |
| Masini, E | 2 |
| Bacciottini, L | 1 |
| Scrivanti, C | 1 |
| Vullo, D | 1 |
| DRANCE, SM | 1 |
| ELIEZER, CP | 1 |
| de CARVALHO, C | 1 |
| Eller, MG | 2 |
| Schoenwald, RD | 5 |
| Lewis, RA | 2 |
| Barfknecht, CF | 4 |
| Phelps, CD | 2 |
| Loftsson, T | 1 |
| Frithriksdóttir, H | 1 |
| Stefánsson, E | 1 |
| Thórisdóttir, S | 1 |
| Guthmundsson, O | 1 |
| Sigthórsson, T | 1 |
| Brechue, WF | 2 |
| Maren, TH | 2 |
| Gelatt, KN | 1 |
| Gum, G | 1 |
| Williams, LW | 1 |
| Gwin, RM | 1 |
| Lichter, PR | 1 |
| Newman, LP | 1 |
| Wheeler, NC | 1 |
| Beall, OV | 1 |
| Bar-Ilan, A | 2 |
| Campbell, DA | 2 |
| Duffel, MW | 2 |
| Lu, DW | 1 |
| Chiang, CH | 1 |
| Kao, KD | 1 |
| Wen, LY | 1 |
| Kass, MA | 1 |
| Pessah, NI | 1 |
| Putnam, ML | 1 |
| Segarra, TM | 1 |
2 trials available for ethoxzolamide and Intraocular Pressure
| Article | Year |
|---|---|
Patient tolerance to carbonic anhydrase inhibitors.
Topics: Acetazolamide; Anorexia; Carbonic Anhydrase Inhibitors; Confusion; Dichlorphenamide; Drug Evaluation | 1978 |
Aminozolamide gel. A trial of a topical carbonic anhydrase inhibitor in ocular hypertension.
Topics: Administration, Topical; Adult; Benzothiazoles; Carbonic Anhydrase Inhibitors; Clinical Trials as To | 1986 |
21 other studies available for ethoxzolamide and Intraocular Pressure
| Article | Year |
|---|---|
Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.
Topics: Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Glaucoma; Guinea Pigs; Intrao | 1989 |
Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide.
Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Cornea; Ethox | 1989 |
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
Topics: Administration, Topical; Animals; Aqueous Humor; Benzene Derivatives; Carbonic Anhydrase Inhibitors; | 1999 |
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; | 2000 |
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.
Topics: Animals; Carbonic Anhydrase Inhibitors; Cornea; Eye; Glaucoma; Hydrogen-Ion Concentration; Intraocul | 2000 |
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.
Topics: Administration, Topical; Animals; Benzolamide; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic | 2003 |
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Topics: Administration, Topical; Animals; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase In | 2004 |
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
Topics: Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, | 2005 |
The effects of ethoxzolamide (cardrase) on intraocular pressure.
Topics: Acetazolamide; Ethoxzolamide; Eye Diseases; Glaucoma; Intraocular Pressure; Tonometry, Ocular | 1959 |
[Reduction of intraocular pressure induced by ethoxzolamide].
Topics: Acetazolamide; Ethoxzolamide; Eye Diseases; Glaucoma; Humans; Intraocular Pressure; Tonometry, Ocula | 1959 |
Determination of ethoxzolamide in the iris/ciliary body of the rabbit eye by high-performance liquid chromatography: comparison of tissue levels following intravenous and topical administrations.
Topics: Administration, Topical; Animals; Chromatography, High Pressure Liquid; Ciliary Body; Ethoxzolamide; | 1984 |
Ethoxzolamide analogue gel. A topical carbonic anhydrase inhibitor.
Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chymotrypsin; Ethoxzolamide; Gels; Glaucoma; | 1984 |
Topically effective ocular hypotensive acetazolamide and ethoxyzolamide formulations in rabbits.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetazolamide; Administration, Topical; Animals; beta-Cyclodextri | 1994 |
A comparison between the effect of topical and systemic carbonic anhydrase inhibitors on aqueous humor secretion.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; | 1993 |
Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles.
Topics: Acetazolamide; Administration, Oral; Animals; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Dog D | 1979 |
Relations among IOP reduction, ocular disposition and pharmacology of the carbonic anhydrase inhibitor ethoxzolamide.
Topics: Animals; Carbonic Anhydrases; Ciliary Body; Dose-Response Relationship, Drug; Ethoxzolamide; Intraoc | 1992 |
Characterization of arylamine acetyltransferase in the rabbit eye.
Topics: 4-Aminobenzoic Acid; Acetylation; Administration, Topical; Animals; Arylamine N-Acetyltransferase; B | 1991 |
The study of ocular hypotensive effect of 6-hydroxyethoxy-2-benzothiazole sulfonamide: a topical carbonic anhydrase inhibitor.
Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chymotrypsin; Disease Models, Animal; Ethoxz | 1990 |
Topical carbonic anhydrase inhibitors.
Topics: Administration, Topical; Benzothiazoles; Carbonic Anhydrase Inhibitors; Ethoxzolamide; Gels; Glaucom | 1989 |
On the use of ketamine in ocular pharmacological studies.
Topics: Animals; Aqueous Humor; Ascorbic Acid; Body Temperature; Ethoxzolamide; Eye; Intraocular Pressure; K | 1986 |
Ocular disposition of aminozolamide in the rabbit eye.
Topics: Animals; Aqueous Humor; Benzothiazoles; Carbonic Anhydrase Inhibitors; Ciliary Body; Cornea; Ethoxzo | 1987 |