ethoxzolamide has been researched along with Glaucoma in 23 studies
Ethoxzolamide: A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.
ethoxzolamide : A sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application." | 7.78 | Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy. ( Alvarez-Lorenzo, C; Chiappetta, DA; Concheiro, A; Ribeiro, A; Sosnik, A; Veiga, F, 2012) |
| " These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration." | 7.72 | Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004) |
| ") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions." | 7.70 | Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000) |
| "Ethoxzolamide is a potent carboxyanhydrase inhibitor, and its use in chronic glaucoma and in the acute glaucoma attack is described in the present investigation." | 7.66 | [Clinical tests on the use of ethoxzolamide in glaucoma therapy (author's transl)]. ( Mewe, L, 1978) |
| " These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration." | 3.72 | Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004) |
| ") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions." | 3.70 | Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000) |
| "A newly synthesized topical carbonic anhydrase inhibitor, 6-hydroxyethoxy-2-benzothiazole sulfonamide (6-HS), was administered systemically and topically to alpha-chymotrypsin-induced glaucoma rabbits to evaluate its ocular hypotensive effect." | 3.68 | The study of ocular hypotensive effect of 6-hydroxyethoxy-2-benzothiazole sulfonamide: a topical carbonic anhydrase inhibitor. ( Chiang, CH; Kao, KD; Lu, DW; Wen, LY, 1990) |
| "An analogue of ethoxzolamide, 6-hydroxyethoxzolamide, was synthesized to enhance corneal permeability yet retain carbonic anhydrase inhibitory activity for use in lowering intraocular pressure." | 3.67 | Ethoxzolamide analogue gel. A topical carbonic anhydrase inhibitor. ( Barfknecht, CF; Eller, MG; Lewis, RA; Phelps, CD; Schoenwald, RD, 1984) |
| "Four carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, ethoxzolamide, and methazolamide) cause ocular hypotony in normotensive and glaucomatous Beagles." | 3.66 | Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles. ( Gelatt, KN; Gum, G; Gwin, RM; Williams, LW, 1979) |
| "Ethoxzolamide is a potent carboxyanhydrase inhibitor, and its use in chronic glaucoma and in the acute glaucoma attack is described in the present investigation." | 3.66 | [Clinical tests on the use of ethoxzolamide in glaucoma therapy (author's transl)]. ( Mewe, L, 1978) |
| "Methazolamide was next." | 2.64 | Patient tolerance to carbonic anhydrase inhibitors. ( Beall, OV; Lichter, PR; Newman, LP; Wheeler, NC, 1978) |
| "Such an agent would be useful in the treatment of glaucoma." | 1.28 | Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity. ( Anderson, PS; Baldwin, JJ; Best, DB; Christy, ME; Freedman, MB; Gautheron, P; Graham, SL; Habecker, CN; Hoffman, JM; Shepard, KL, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (56.52) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Graham, SL | 1 |
| Shepard, KL | 1 |
| Anderson, PS | 1 |
| Baldwin, JJ | 2 |
| Best, DB | 1 |
| Christy, ME | 2 |
| Freedman, MB | 2 |
| Gautheron, P | 1 |
| Habecker, CN | 2 |
| Hoffman, JM | 1 |
| Ponticello, GS | 1 |
| Lyle, PA | 1 |
| Schwam, H | 1 |
| Varga, SL | 1 |
| Randall, WC | 1 |
| Schoenwald, RD | 2 |
| Eller, MG | 2 |
| Dixson, JA | 1 |
| Barfknecht, CF | 2 |
| Scozzafava, A | 7 |
| Menabuoni, L | 4 |
| Mincione, F | 6 |
| Briganti, F | 1 |
| Mincione, G | 1 |
| Supuran, CT | 7 |
| Casini, A | 4 |
| Ilies, MA | 1 |
| Starnotti, M | 3 |
| de Leval, X | 1 |
| Ilies, M | 1 |
| Dogné, JM | 1 |
| Masini, E | 2 |
| Vullo, D | 2 |
| Innocenti, A | 1 |
| Nishimori, I | 1 |
| Pastorek, J | 1 |
| Pastoreková, S | 1 |
| Bacciottini, L | 1 |
| Scrivanti, C | 1 |
| Ribeiro, A | 1 |
| Sosnik, A | 1 |
| Chiappetta, DA | 1 |
| Veiga, F | 1 |
| Concheiro, A | 1 |
| Alvarez-Lorenzo, C | 1 |
| POSNER, A | 1 |
| DRANCE, SM | 2 |
| ELIEZER, CP | 1 |
| de CARVALHO, C | 1 |
| PARDUCCI, F | 1 |
| NUCCI, E | 1 |
| Lewis, RA | 1 |
| Phelps, CD | 1 |
| Gelatt, KN | 1 |
| Gum, G | 1 |
| Williams, LW | 1 |
| Gwin, RM | 1 |
| Lichter, PR | 1 |
| Newman, LP | 1 |
| Wheeler, NC | 1 |
| Beall, OV | 1 |
| Mewe, L | 1 |
| Lu, DW | 2 |
| Chiang, CH | 2 |
| Kao, KD | 2 |
| Wen, LY | 1 |
| Huang, HS | 1 |
| Kass, MA | 1 |
1 trial available for ethoxzolamide and Glaucoma
| Article | Year |
|---|---|
Patient tolerance to carbonic anhydrase inhibitors.
Topics: Acetazolamide; Anorexia; Carbonic Anhydrase Inhibitors; Confusion; Dichlorphenamide; Drug Evaluation | 1978 |
22 other studies available for ethoxzolamide and Glaucoma
| Article | Year |
|---|---|
Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.
Topics: Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Glaucoma; Guinea Pigs; Intrao | 1989 |
Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors.
Topics: Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Erythrocytes; Glaucoma; Heterocyclic C | 1987 |
Topical carbonic anhydrase inhibitors.
Topics: Animals; Carbonic Anhydrase Inhibitors; Ethoxzolamide; Glaucoma; Rabbits; Thiazoles | 1984 |
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; | 2000 |
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.
Topics: Animals; Carbonic Anhydrase Inhibitors; Cornea; Eye; Glaucoma; Hydrogen-Ion Concentration; Intraocul | 2000 |
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chelating Agents; Chloroform; Chromatog | 2002 |
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.
Topics: Administration, Topical; Animals; Benzolamide; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic | 2003 |
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Topics: Administration, Topical; Animals; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase In | 2004 |
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Topics: Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Drug Design; Glaucoma; Hu | 2005 |
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
Topics: Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, | 2005 |
Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy.
Topics: Administration, Topical; Animals; Carbonic Anhydrase Inhibitors; Chick Embryo; Chickens; Chorioallan | 2012 |
Use of a new carbonic anhydrase inhibitor (cardrase) in glaucoma.
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Ethoxzolamide; Glaucoma; Humans | 1958 |
Ethoxzolamide (cardrase) in the management of chronic simple glaucoma.
Topics: Carbonic Anhydrase Inhibitors; Ethoxzolamide; Glaucoma; Glaucoma, Open-Angle; Humans | 1960 |
The effects of ethoxzolamide (cardrase) on intraocular pressure.
Topics: Acetazolamide; Ethoxzolamide; Eye Diseases; Glaucoma; Intraocular Pressure; Tonometry, Ocular | 1959 |
[Reduction of intraocular pressure induced by ethoxzolamide].
Topics: Acetazolamide; Ethoxzolamide; Eye Diseases; Glaucoma; Humans; Intraocular Pressure; Tonometry, Ocula | 1959 |
[On a new preparation with antiglaucomatous action: cardrase (6-ethoxy-2-benzothiazolosulfonamide)].
Topics: Carbonic Anhydrase Inhibitors; Ethoxzolamide; Glaucoma; Humans; Sulfanilamide; Sulfanilamides; Sulfo | 1961 |
Ethoxzolamide analogue gel. A topical carbonic anhydrase inhibitor.
Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chymotrypsin; Ethoxzolamide; Gels; Glaucoma; | 1984 |
Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles.
Topics: Acetazolamide; Administration, Oral; Animals; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Dog D | 1979 |
[Clinical tests on the use of ethoxzolamide in glaucoma therapy (author's transl)].
Topics: Drug Evaluation; Ethoxzolamide; Glaucoma; Humans; Thiazoles | 1978 |
The study of ocular hypotensive effect of 6-hydroxyethoxy-2-benzothiazole sulfonamide: a topical carbonic anhydrase inhibitor.
Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chymotrypsin; Disease Models, Animal; Ethoxz | 1990 |
Corneal and scleral penetration studies of 6-hydroxyethoxy-2-benzothiazole sulfonamide: a topical carbonic anhydrase inhibitor.
Topics: Administration, Topical; Animals; Aqueous Humor; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chym | 1990 |
Topical carbonic anhydrase inhibitors.
Topics: Administration, Topical; Benzothiazoles; Carbonic Anhydrase Inhibitors; Ethoxzolamide; Gels; Glaucom | 1989 |