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ethoxzolamide and Glaucoma

ethoxzolamide has been researched along with Glaucoma in 23 studies

Ethoxzolamide: A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.
ethoxzolamide : A sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic.

Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Research Excerpts

ExcerptRelevanceReference
"Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application."7.78Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy. ( Alvarez-Lorenzo, C; Chiappetta, DA; Concheiro, A; Ribeiro, A; Sosnik, A; Veiga, F, 2012)
" These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration."7.72Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004)
") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions."7.70Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000)
"Ethoxzolamide is a potent carboxyanhydrase inhibitor, and its use in chronic glaucoma and in the acute glaucoma attack is described in the present investigation."7.66[Clinical tests on the use of ethoxzolamide in glaucoma therapy (author's transl)]. ( Mewe, L, 1978)
" These derivatives also showed a potent reduction of the intraocular pressure (IOP) in hypertensive rabbits, amounting to 13-21 mmHg at 1 h postadministration (compared to 5 mmHg obtained with dorzolamide, a clinically used drug), and the decreased IOP was maintained for 4-5 h after the administration."3.72Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. ( Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT, 2004)
") strongly lowered intraocular pressure (IOP) when applied topically, directly into the normotensive/glaucomatous rabbit eye, as 2% water solutions."3.70Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. ( Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT, 2000)
"A newly synthesized topical carbonic anhydrase inhibitor, 6-hydroxyethoxy-2-benzothiazole sulfonamide (6-HS), was administered systemically and topically to alpha-chymotrypsin-induced glaucoma rabbits to evaluate its ocular hypotensive effect."3.68The study of ocular hypotensive effect of 6-hydroxyethoxy-2-benzothiazole sulfonamide: a topical carbonic anhydrase inhibitor. ( Chiang, CH; Kao, KD; Lu, DW; Wen, LY, 1990)
"An analogue of ethoxzolamide, 6-hydroxyethoxzolamide, was synthesized to enhance corneal permeability yet retain carbonic anhydrase inhibitory activity for use in lowering intraocular pressure."3.67Ethoxzolamide analogue gel. A topical carbonic anhydrase inhibitor. ( Barfknecht, CF; Eller, MG; Lewis, RA; Phelps, CD; Schoenwald, RD, 1984)
"Four carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, ethoxzolamide, and methazolamide) cause ocular hypotony in normotensive and glaucomatous Beagles."3.66Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles. ( Gelatt, KN; Gum, G; Gwin, RM; Williams, LW, 1979)
"Ethoxzolamide is a potent carboxyanhydrase inhibitor, and its use in chronic glaucoma and in the acute glaucoma attack is described in the present investigation."3.66[Clinical tests on the use of ethoxzolamide in glaucoma therapy (author's transl)]. ( Mewe, L, 1978)
"Methazolamide was next."2.64Patient tolerance to carbonic anhydrase inhibitors. ( Beall, OV; Lichter, PR; Newman, LP; Wheeler, NC, 1978)
"Such an agent would be useful in the treatment of glaucoma."1.28Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity. ( Anderson, PS; Baldwin, JJ; Best, DB; Christy, ME; Freedman, MB; Gautheron, P; Graham, SL; Habecker, CN; Hoffman, JM; Shepard, KL, 1989)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199013 (56.52)18.7374
1990's2 (8.70)18.2507
2000's7 (30.43)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Graham, SL1
Shepard, KL1
Anderson, PS1
Baldwin, JJ2
Best, DB1
Christy, ME2
Freedman, MB2
Gautheron, P1
Habecker, CN2
Hoffman, JM1
Ponticello, GS1
Lyle, PA1
Schwam, H1
Varga, SL1
Randall, WC1
Schoenwald, RD2
Eller, MG2
Dixson, JA1
Barfknecht, CF2
Scozzafava, A7
Menabuoni, L4
Mincione, F6
Briganti, F1
Mincione, G1
Supuran, CT7
Casini, A4
Ilies, MA1
Starnotti, M3
de Leval, X1
Ilies, M1
Dogné, JM1
Masini, E2
Vullo, D2
Innocenti, A1
Nishimori, I1
Pastorek, J1
Pastoreková, S1
Bacciottini, L1
Scrivanti, C1
Ribeiro, A1
Sosnik, A1
Chiappetta, DA1
Veiga, F1
Concheiro, A1
Alvarez-Lorenzo, C1
POSNER, A1
DRANCE, SM2
ELIEZER, CP1
de CARVALHO, C1
PARDUCCI, F1
NUCCI, E1
Lewis, RA1
Phelps, CD1
Gelatt, KN1
Gum, G1
Williams, LW1
Gwin, RM1
Lichter, PR1
Newman, LP1
Wheeler, NC1
Beall, OV1
Mewe, L1
Lu, DW2
Chiang, CH2
Kao, KD2
Wen, LY1
Huang, HS1
Kass, MA1

Trials

1 trial available for ethoxzolamide and Glaucoma

ArticleYear
Patient tolerance to carbonic anhydrase inhibitors.
    American journal of ophthalmology, 1978, Volume: 85, Issue:4

    Topics: Acetazolamide; Anorexia; Carbonic Anhydrase Inhibitors; Confusion; Dichlorphenamide; Drug Evaluation

1978

Other Studies

22 other studies available for ethoxzolamide and Glaucoma

ArticleYear
Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:12

    Topics: Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Glaucoma; Guinea Pigs; Intrao

1989
Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:4

    Topics: Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Erythrocytes; Glaucoma; Heterocyclic C

1987
Topical carbonic anhydrase inhibitors.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:6

    Topics: Animals; Carbonic Anhydrase Inhibitors; Ethoxzolamide; Glaucoma; Rabbits; Thiazoles

1984
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
    Journal of medicinal chemistry, 2000, Nov-16, Volume: 43, Issue:23

    Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases;

2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.
    Journal of medicinal chemistry, 2000, Dec-14, Volume: 43, Issue:25

    Topics: Animals; Carbonic Anhydrase Inhibitors; Cornea; Eye; Glaucoma; Hydrogen-Ion Concentration; Intraocul

2000
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
    Journal of medicinal chemistry, 2002, Mar-28, Volume: 45, Issue:7

    Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chelating Agents; Chloroform; Chromatog

2002
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.
    Bioorganic & medicinal chemistry letters, 2003, Sep-01, Volume: 13, Issue:17

    Topics: Administration, Topical; Animals; Benzolamide; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic

2003
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
    Journal of medicinal chemistry, 2004, May-20, Volume: 47, Issue:11

    Topics: Administration, Topical; Animals; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase In

2004
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
    Bioorganic & medicinal chemistry letters, 2005, Feb-15, Volume: 15, Issue:4

    Topics: Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Drug Design; Glaucoma; Hu

2005
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
    Bioorganic & medicinal chemistry letters, 2005, Sep-01, Volume: 15, Issue:17

    Topics: Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models,

2005
Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy.
    Journal of the Royal Society, Interface, 2012, Sep-07, Volume: 9, Issue:74

    Topics: Administration, Topical; Animals; Carbonic Anhydrase Inhibitors; Chick Embryo; Chickens; Chorioallan

2012
Use of a new carbonic anhydrase inhibitor (cardrase) in glaucoma.
    American journal of ophthalmology, 1958, Volume: 45, Issue:2

    Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Ethoxzolamide; Glaucoma; Humans

1958
Ethoxzolamide (cardrase) in the management of chronic simple glaucoma.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1960, Volume: 64

    Topics: Carbonic Anhydrase Inhibitors; Ethoxzolamide; Glaucoma; Glaucoma, Open-Angle; Humans

1960
The effects of ethoxzolamide (cardrase) on intraocular pressure.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1959, Volume: 62

    Topics: Acetazolamide; Ethoxzolamide; Eye Diseases; Glaucoma; Intraocular Pressure; Tonometry, Ocular

1959
[Reduction of intraocular pressure induced by ethoxzolamide].
    Revista brasileira de oftalmologia, 1959, Volume: 18

    Topics: Acetazolamide; Ethoxzolamide; Eye Diseases; Glaucoma; Humans; Intraocular Pressure; Tonometry, Ocula

1959
[On a new preparation with antiglaucomatous action: cardrase (6-ethoxy-2-benzothiazolosulfonamide)].
    Annali di ottalmologia e clinica oculistica, 1961, Volume: 87

    Topics: Carbonic Anhydrase Inhibitors; Ethoxzolamide; Glaucoma; Humans; Sulfanilamide; Sulfanilamides; Sulfo

1961
Ethoxzolamide analogue gel. A topical carbonic anhydrase inhibitor.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1984, Volume: 102, Issue:12

    Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chymotrypsin; Ethoxzolamide; Gels; Glaucoma;

1984
Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles.
    American journal of veterinary research, 1979, Volume: 40, Issue:3

    Topics: Acetazolamide; Administration, Oral; Animals; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Dog D

1979
[Clinical tests on the use of ethoxzolamide in glaucoma therapy (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1978, Volume: 173, Issue:3

    Topics: Drug Evaluation; Ethoxzolamide; Glaucoma; Humans; Thiazoles

1978
The study of ocular hypotensive effect of 6-hydroxyethoxy-2-benzothiazole sulfonamide: a topical carbonic anhydrase inhibitor.
    Journal of ocular pharmacology, 1990,Winter, Volume: 6, Issue:4

    Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chymotrypsin; Disease Models, Animal; Ethoxz

1990
Corneal and scleral penetration studies of 6-hydroxyethoxy-2-benzothiazole sulfonamide: a topical carbonic anhydrase inhibitor.
    Journal of ocular pharmacology, 1990,Winter, Volume: 6, Issue:4

    Topics: Administration, Topical; Animals; Aqueous Humor; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chym

1990
Topical carbonic anhydrase inhibitors.
    American journal of ophthalmology, 1989, Mar-15, Volume: 107, Issue:3

    Topics: Administration, Topical; Benzothiazoles; Carbonic Anhydrase Inhibitors; Ethoxzolamide; Gels; Glaucom

1989