Compounds > ethosuximide
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ethosuximide and Epilepsy, Tonic-Clonic

ethosuximide has been researched along with Epilepsy, Tonic-Clonic in 46 studies

Ethosuximide: An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
ethosuximide : A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.

Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)

Research Excerpts

ExcerptRelevanceReference
"The action of ethosuximide (125 or 250 mg/kg, IP) against picrotoxin-induced seizures (3-6 mg/kg, IP) was assessed in rats 12, 18, 25, and 90 days old."7.68Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats. ( Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J, 1993)
"The action of ethosuximide (125 or 250 mg/kg, IP) against picrotoxin-induced seizures (3-6 mg/kg, IP) was assessed in rats 12, 18, 25, and 90 days old."3.68Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats. ( Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J, 1993)
"Ethosuximide concentration in serum was monitored during the last trimester of pregnancy in a patient."3.66Ethosuximide pharmacokinetics in a pregnant patient and her newborn. ( Cohen, ME; Koup, JR; Rose, JQ, 1978)
"Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given."1.27[Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983)
"Features of both systemic lupus erythematosus and scleroderma developed in a young Chinese girl while on multiple anticonvulsant therapy."1.25Lupus-scleroderma syndrome induced by ethosuximide. ( Chan, HL; Teoh, PC, 1975)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199040 (86.96)18.7374
1990's3 (6.52)18.2507
2000's1 (2.17)29.6817
2010's2 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yau, M1
Rao, N1
Nimkarn, S1
Vogiatzi, M1
Vining, EP1
BAIRD, HW1
KIORBOE, E1
PALUDAN, J1
TROLLE, E1
OVERVAD, E1
LORENTZDEHAAS, AM1
KUILMAN, M1
CURRIER, RD1
GASTAUT, H1
FREY, HH1
Schmitt, B1
Kovacevic-Preradovic, T1
Critelli, H1
Molinari, L1
Schmidt, D1
Reynolds, EH1
Shorvon, SD1
Velísková, J1
Velísek, L1
Mares, P2
Rokyta, R1
Micianiková, D1
Kubová, H1
Mocková, M1
Deisenhammer, E1
Sommer, R1
Koup, JR1
Rose, JQ1
Cohen, ME1
Borgheresi, S1
Luti, E1
Mecherini, L1
Buti Cossi, D1
Bardini, MR1
Karbowski, K1
Robert, F1
Fierz, L1
Englander, RN1
Johnson, RN1
Brickley, JJ1
Hanna, GR1
Gibberd, FB3
Richens, A1
Teoh, PC1
Chan, HL1
Doose, H2
Schwartz, I1
Findeis, B1
Dieterich, E1
Baier, WK1
Fichsel, H1
Krip, G1
Vazquez, AJ1
Falconer, MA1
Davidson, S1
Parsonage, M1
Meyer, JG1
Favel, P1
Cartier, J1
Gratadou, JP1
Gratadou, G1
Peterson, DI1
Zweig, RW1
Engel, E1
Böhl, I1
Schulz, H1
Millichap, JG1
Hagberg, B1
Hansson, O1
Hooshmand, H1
Suter, CG1
Wilson, J1
Proto, A1
Gentilucci, C1
Hohenauer, I1
Schmoigl, S1
Livingston, S1
Torres, I1
Pauli, LL1
Rider, RV1
Green, JB1
Charlton, MH1
Yahr, MD1
Dreyer, R1
Beaumanoir, A1
Martin, F1
Bergamini, L1
Inghirami, L1
Riccio, A1
Degen, R1

Trials

1 trial available for ethosuximide and Epilepsy, Tonic-Clonic

ArticleYear
[Therapy of generalized epilepsies using Acrisuxine].
    Revue neurologique, 1969, Volume: 120, Issue:6

    Topics: Behavior; Child; Clinical Trials as Topic; Electroencephalography; Epilepsy, Absence; Epilepsy, Toni

1969

Other Studies

45 other studies available for ethosuximide and Epilepsy, Tonic-Clonic

ArticleYear
Effect of ethosuximide on cortisol metabolism in the treatment of congenital adrenal hyperplasia.
    Journal of pediatric endocrinology & metabolism : JPEM, 2014, Volume: 27, Issue:5-6

    Topics: Adrenal Hyperplasia, Congenital; Anti-Inflammatory Agents; Anticonvulsants; Child; Drug Interactions

2014
Ethosuximide in childhood absence epilepsy--older and better.
    The New England journal of medicine, 2010, Mar-04, Volume: 362, Issue:9

    Topics: Anticonvulsants; Child; Diagnosis, Differential; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuxi

2010
CONVULSIONS IN INFANCY AND CHILDHOOD.
    Pediatric clinics of North America, 1963, Volume: 10

    Topics: Anticonvulsants; Child; Electroencephalography; Encephalitis; Epilepsy; Epilepsy, Absence; Epilepsy,

1963
ZARONTIN (ETHOSUXIMIDE) IN THE TREATMENT OF PETIT MAL AND RELATED DISORDERS.
    Epilepsia, 1964, Volume: 5

    Topics: Adolescent; Anticonvulsants; Biomedical Research; Child; Denmark; Drug Therapy; Epilepsy; Epilepsy,

1964
ETHOSUXIMIDE (ALPHA-ETHYL-ALPHA-METHYLSUCCINIMIDE) AND GRAND MAL.
    Epilepsia, 1964, Volume: 5

    Topics: Anticonvulsants; Biomedical Research; Drug Therapy; Electroencephalography; Epilepsy; Epilepsy, Abse

1964
HINTS ON SEIZURE MANAGEMENT.
    GP, 1964, Volume: 30

    Topics: Anticonvulsants; Drug Therapy; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Hu

1964
CERTAIN BASIC CONCEPTS CONCERNING THE TREATMENT OF THE EPILEPSIES.
    The British journal of clinical practice, 1964, Volume: 18

    Topics: Amphetamine; Anticonvulsants; Barbiturates; Child; Drug Therapy; Electroencephalography; Epilepsy; E

1964
NOTE ON THE INTERACTIONS OF AMPHETAMINE WITH ANTICONVULSANT DRUGS.
    Acta pharmacologica et toxicologica, 1964, Volume: 21

    Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Electricity; Electroshock; Epilepsy; Epilepsy,

1964
Is ethosuximide a risk factor for generalised tonic-clonic seizures in absence epilepsy?
    Neuropediatrics, 2007, Volume: 38, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy, Absence; Epi

2007
[Pharmacotherapy of epilepsy--current problems and controversies].
    Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:11

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy,

1983
Monotherapy or polytherapy for epilepsy?
    Epilepsia, 1981, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Carbamazepine; Clonazepam; Drug Combinations; Drug Interactions; Drug Therapy, Co

1981
Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:4

    Topics: Animals; Anticonvulsants; Behavior, Animal; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Ethosuxim

1993
Two models of epileptic spike-and-wave rhythm in rats are differently influenced by ethosuximide.
    Physiological research, 1997, Volume: 46, Issue:5

    Topics: Animals; Anticonvulsants; Electroencephalography; Epilepsy, Tonic-Clonic; Ethosuximide; Models, Neur

1997
[Blood level of antiepileptic drugs and therapeutic effect in mono- and polytherapy (author's transl)].
    Der Nervenarzt, 1978, Volume: 49, Issue:11

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Comb

1978
Ethosuximide pharmacokinetics in a pregnant patient and her newborn.
    Epilepsia, 1978, Volume: 19, Issue:6

    Topics: Adult; Dose-Response Relationship, Drug; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Fe

1978
[Primary generalized epilepsy in childhood. Clinico-statistical study].
    Minerva pediatrica, 1979, Nov-30, Volume: 31, Issue:22

    Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Clonazepam; Electroencephalography; Epilepsy,

1979
[Atypical petit mal status. Case contribution on diagnostic difficulties].
    Der Nervenarzt, 1977, Volume: 48, Issue:2

    Topics: Adult; Cerebral Ventricle Neoplasms; Diagnostic Errors; Electroencephalography; Epilepsy, Absence; E

1977
Effects of antiepileptic drugs on thalamocortical excitability.
    Neurology, 1977, Volume: 27, Issue:12

    Topics: Animals; Bicuculline; Cats; Computers; Diazepam; Electric Stimulation; Electroencephalography; Epile

1977
Diseases of the central nervous system: Epilepsy.
    British medical journal, 1975, Nov-01, Volume: 4, Issue:5991

    Topics: Age Factors; Diazepam; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Eth

1975
Sensible prescribing. XI.--Juvenile and adult epilepsy.
    The Practitioner, 1975, Volume: 215, Issue:1289

    Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Clonazepam; Epilepsy; Epilepsy, Absence; Epile

1975
Lupus-scleroderma syndrome induced by ethosuximide.
    Archives of disease in childhood, 1975, Volume: 50, Issue:8

    Topics: Adolescent; Anemia; Epilepsy, Tonic-Clonic; Ethosuximide; Female; Humans; Lupus Erythematosus, Syste

1975
[Pyknoleptic petit mal and secondary grand mal].
    Der Nervenarzt, 1976, Volume: 47, Issue:5

    Topics: Adolescent; Adult; Age Factors; Barbiturates; Drug Therapy, Combination; Educational Status; Epileps

1976
[Possibility for provoking grand mal series in ethosuximide therapy--2 case reports].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1990, Volume: 42, Issue:9

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Epilepsy, Absence; Epilep

1990
Longterm follow-up of childhood epilepsy with absences. II. Absence-epilepsy with initial grand mal.
    Neuropediatrics, 1985, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Female; Follow-Up Studie

1985
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
    Electroencephalography and clinical neurophysiology, 1971, Volume: 30, Issue:5

    Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy;

1971
Coarse features in epilepsy as a consequence of anticonvulsant therapy. Report of cases in two pairs of identical twins.
    Lancet (London, England), 1973, Nov-17, Volume: 2, Issue:7838

    Topics: Acromegaly; Adult; Anticonvulsants; Carbamazepine; Child; Diazepam; Diseases in Twins; Epilepsy; Epi

1973
Epilepsy.
    The Practitioner, 1974, Volume: 213, Issue:1276 SPEC

    Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec

1974
[Inheritance of spike-wave complexes and febrile seizures in three generations].
    Deutsche medizinische Wochenschrift (1946), 1973, Sep-14, Volume: 98, Issue:37

    Topics: Adult; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Ethosuximi

1973
Depamide in the treatment of epilepsy. A clinical trial.
    Epilepsia, 1973, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Amides; Anticonvulsants; Barbiturates; Child; Child, Preschool; Electroencephalog

1973
Absorption of anticonvulsants after jejunoileal bypass.
    Bulletin of the Los Angeles neurological societies, 1974, Volume: 39, Issue:2

    Topics: Adult; Anticonvulsants; Diazepam; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Female; H

1974
[Outpatient therapy of epilepsy].
    Zeitschrift fur arztliche Fortbildung, 1970, Jul-15, Volume: 64, Issue:14

    Topics: Anticonvulsants; Barbiturates; Depression, Chemical; Drug Eruptions; Drug Hypersensitivity; Epilepsi

1970
Drug treatment of convulsive disorders.
    The New England journal of medicine, 1972, Mar-02, Volume: 286, Issue:9

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E

1972
[Anticonvulsants. 7. Treatment of myclonic-astatic epilepsy in small children].
    Lakartidningen, 1971, Oct-18, Volume: 68

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Child, Preschool; Diazepam; Epilepsy, Absence; Epilepsy,

1971
Classification and treatment of seizure disorders in children.
    Virginia medical monthly, 1970, Volume: 97, Issue:2

    Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child,

1970
Epilepsy.
    British medical journal, 1969, Nov-01, Volume: 4, Issue:5678

    Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T

1969
Drug treatment of epilepsy in childhood.
    British medical journal, 1969, Nov-22, Volume: 4, Issue:5681

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Absence; Epil

1969
[Clinical experience with propericiazine or an adjuvant in the therapy of epileptic syndromes].
    Giornale di psichiatria e di neuropatologia, 1968, Volume: 96, Issue:4

    Topics: Adolescent; Adult; Drug Synergism; Electroencephalography; Epilepsy, Temporal Lobe; Epilepsy, Tonic-

1968
The prognosis of petit mal in adults.
    Epilepsia, 1972, Volume: 13, Issue:1

    Topics: Adult; Age Factors; Aged; Electroencephalography; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosux

1972
[Experience with a combination of ethosuximide and mepacrine (Acrisuxin) in the treatment of chronic epileptic seizures in children].
    Padiatrie und Padologie, 1972, Volume: 7, Issue:4

    Topics: Child; Child, Preschool; Chronic Disease; Drug Combinations; Epilepsy; Epilepsy, Absence; Epilepsy,

1972
Petit mal epilepsy. Results of a prolonged follow-up study of 117 patients.
    JAMA, 1965, Oct-18, Volume: 194, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy, Absence; Epilepsy, Tonic-Clon

1965
Self-induced seizures.
    Archives of neurology, 1966, Volume: 15, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsy, Absence; Epilepsy, Tonic-Clon

1966
Long-term follow-up of patients with petit mal.
    Archives of neurology, 1967, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Aging; Child; Electroencephalography; Epilepsy, Absence; Epilepsy, Tonic-Clonic;

1967
[Extrapyramidal symptoms during the use of anticonvulsants].
    Der Nervenarzt, 1969, Volume: 40, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Consciousness; Epilepsy, Tonic-Clonic; Ethosux

1969
[Importance of adequate and early therapy of simple petit mal].
    Minerva pediatrica, 1968, Jan-28, Volume: 20, Issue:4

    Topics: Anticonvulsants; Barbiturates; Child; Child, Preschool; Epilepsy, Absence; Epilepsy, Tonic-Clonic; E

1968
[Experiences with suxilep in childhood epilepsy].
    Das Deutsche Gesundheitswesen, 1969, Jan-16, Volume: 24, Issue:3

    Topics: Child; Child, Preschool; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; E

1969