ethosuximide has been researched along with Disease Models, Animal in 108 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (13.89) | 18.7374 |
| 1990's | 7 (6.48) | 18.2507 |
| 2000's | 36 (33.33) | 29.6817 |
| 2010's | 43 (39.81) | 24.3611 |
| 2020's | 7 (6.48) | 2.80 |
| Authors | Studies |
|---|---|
| Bharathwajan, N; Patel, SK; Ragavendran, JV; Reddy, IV; Sriram, D; Stables, J; Yogeeswari, P | 1 |
| Kavya, R; Nageswari, Y; Ragavendran, JV; Sreevatsan, N; Sriram, D; Stables, J; Vanitha, K; Yogeeswari, P | 1 |
| Kotapati, S; Ragavendran, JV; Sriram, D; Stables, J; Yogeeswari, P | 1 |
| Kharya, MD; Raghuvanshi, K; Rajak, H; Sah, AK; Sharma, PC; Singh Pawar, R; Singh Thakur, B; Singh, A; Veerasamy, R | 1 |
| Bahare, RS; Khan, SA; Malik, S | 1 |
| Chlebek, I; Kamiński, K; Obniska, J; Rzepka, S; Wiklik, B | 1 |
| Chońska, J; Dawidowski, M; Mika, W; Turło, J | 1 |
| Baker, MT; Mishra, RK | 1 |
| Filipek, B; Kamiński, K; Kieć-Kononowicz, K; Latacz, G; Obniska, J; Rapacz, A; Łuszczki, JJ | 1 |
| Andres-Mach, M; Kamiński, K; Kieć-Kononowicz, K; Latacz, G; Rapacz, A; Zagaja, M; Łuszczki, JJ | 1 |
| Filipek, B; Kamiński, K; Obniska, J; Pękala, E; Powroźnik, B; Rapacz, A; Rybka, S; Żmudzki, P | 1 |
| Edayadulla, N; Ramesh, P | 1 |
| Abram, M; Andres-Mach, M; Kamiński, K; Obniska, J; Rapacz, A; Zagaja, M; Łuszczki, JJ | 1 |
| Góra, M; Kamiński, K; Obniska, J; Rapacz, A; Rybka, S; Sałat, K; Żmudzki, P | 1 |
| Du Nguyen, H; Horaguchi, Y; Kasanami, Y; Kawabata, A; Kitamura, S; Nishikawa, H; Okada, T; Sekiguchi, F; Toyooka, N; Tsubota, M; Yamaoka, S; Yoshida, S | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Buschhoff, AS; de Mooij-van Malsen, JG; Scherließ, R; Schiffelholz, T; Stephani, U; Wulff, P | 1 |
| Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ | 1 |
| Gureviciene, I; Jin, N; Tanila, H; Ziyatdinova, S | 1 |
| Contreras-Murillo, G; González-Trujano, ME; Hidalgo-Flores, FJ; López-Najera, CA; Magdaleno-Madrigal, VM; Navarrete-Castro, A; Sánchez, CG | 1 |
| Buommino, E; Calignano, A; Citraro, R; Constanti, A; Coretti, L; Cuomo, M; De Caro, C; De Sarro, G; Iannone, LF; Iannone, M; Lembo, F; Leo, A; Marascio, N; Nesci, V; Palumbo, D; Quirino, A; Russo, E; Russo, R; Tallarico, M | 1 |
| Barth, DS; Dudek, FE; Poulsen, DJ; Smith, ZZ; Tatum, S; Taylor, JA | 1 |
| Miyaoka, H; Saito, M; Soma, M; Takahashi, M; Watanabe, S | 1 |
| Biraben, A; Costet, N; Dieuset, G; Hadjadj, S; Kuchenbuch, M; Martin, B; Pawluski, JL; Vercueil, L | 1 |
| Abe, K; Hashimura, M; Iha, HA; Iwai, C; Kato, M; Kawaji, S; Kawakita, K; Kunisawa, N; Ogawa, M; Ohno, Y; Shimizu, S | 1 |
| Chang, L; Dong, C; Hashimoto, K; Tian, Z; Zhang, K | 1 |
| Barclay, JW; Burgoyne, RD; Cunliffe, VT; Dodd, S; Grimes, D; Jones, A; Marson, AG; Morgan, A; Sills, GJ; Wong, SQ | 1 |
| Chen, Y; Sun, M; van Luijtelaar, G; Wang, J; Wang, Q | 1 |
| Agosti, F; Ardid, D; Bourinet, E; Carvalho, FA; Daulhac, L; Eschalier, A; Mallet, C; Picard, E | 1 |
| Citraro, R; De Sarro, G; Fedosova, E; Iannone, M; Leo, A; Nesci, V; Russo, E; Sarkisova, K; Tallarico, M | 1 |
| Caro, C; Citraro, R; Constanti, A; Iannone, M; Leo, A; Nesci, V; Palma, E; Russo, E; Sarro, G; Tallarico, M | 1 |
| Bashyal, C; Blumenfeld, H; Burinov, J; Coman, D; Coquillette, M; Covolato, G; Danielson, N; Edelbroek, P; Frankenmolen, N; Hyder, F; Janeczko, K; Kiemeneij, A; Lüttjohann, A; Mishra, AM; Niermann, H; Schaapsmeerders, P; van Luijtelaar, G; van Rijn, CM | 1 |
| Jin, DI; Kang, JW; Lee, JE; Lee, SH; Lin, T | 1 |
| Filipek, B; Kamiński, K; Obniska, J; Rapacz, A; Rybka, S | 1 |
| Asadi-Shekaari, M; Eslami, A; Joukar, S; Kalantaripour, T | 1 |
| Burghardt, NS; Denny, CA; Drew, LJ; Friedman, D; Hen, R; Hsieh, J; Iyengar, SS; LaFrancois, JJ; Scharfman, HE; Wu, MV | 1 |
| Chang, YF; Chen, YL; Cheng, JK; Hung, YC; Lin, CS; Shiue, SJ; Tsaur, ML; Wang, SW; Wang, TY; Wang, YC | 1 |
| Barclay, JW; Burgoyne, RD; Chen, X; Kashyap, SS; Kraemer, BC; McCue, HV; Morgan, A; Wong, SQ | 1 |
| Agarwal, S; Chaturvedi, RK; Choubey, V; Gupta, SK; Karmakar, M; Seth, B; Sharma, A; Tiwari, SK; Yadav, A | 1 |
| Borowicz, KK; Popławska, M; Wróblewska, D | 1 |
| Aiba, I; Bomben, VC; Herlitze, S; Mark, MD; Noebels, JL; Qian, J | 1 |
| Chimirri, A; Citraro, R; De Fazio, S; De Sarro, G; Di Paola, ED; Gitto, R; Marra, R; Russo, E | 1 |
| Thompson, SM; Wang, G | 1 |
| Campbell, KP; Chang, D; Chang, YT; Chen, CC; Chen, JJ; Chen, YC; Chen, YH; Chiang, CS; Chieng, H; Huang, CH; Shin, HS | 1 |
| Aleem, IS; Ashraf, A; Cortez, MA; Kanawaty, A; Liu, CC; Sadeghnia, HR; Shen, L; Snead, OC; Stewart, L; Trepanier, CH; Wu, Y | 1 |
| Chuang, SH; Shaw, FZ; Shieh, KR; Wang, YJ | 1 |
| Chen, SY; Hu, SH; Huang, WC; Liu, DM; Liu, KH | 1 |
| Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 1 |
| Kulikov, MA; Kuznetsova, GD; Sarkisova, KY; van Luijtelaar, G | 1 |
| Citraro, R; Constanti, A; De Fazio, S; De Sarro, G; Di Paola, ED; Russo, E; Scicchitano, F | 1 |
| Akin, D; Carçak, N; Gülhan Aker, R; Onat, FY; Sakalli, E; Tezcan, K | 1 |
| Covey, DF; Handforth, A; Homanics, GE; Krishnan, K; Lee, JY; Martin, FC; Quesada, A; Sakimura, K | 1 |
| Chen, SD; Huang, YH; Shaw, FZ; Yeh, KH | 1 |
| Andres-Mach, M; Barcicka-Klosowska, B; Czuczwar, SJ; Florek-Luszczki, M; Haratym-Maj, A; Luszczki, JJ | 1 |
| Citraro, R; Scicchitano, F; van Luijtelaar, G; van Rijn, C; Wilde, M | 1 |
| Arani, MN; Banafshe, HR; Hamidi, GA; Mesdaghinia, A; Ramezani, MH; Talaei, SA | 1 |
| Aoto, T; Baulac, S; Boillot, M; Fumoto, N; Ikeda, A; Ishida, S; Kuwamura, M; LeGuern, E; Mashimo, T; Ohno, Y; Serikawa, T; Takahashi, R; Takizawa, A; Ueda, M | 1 |
| Corrales, A; Flórez, J; García, S; Martínez, P; Martínez-Cué, C; Rueda, N; Sharma, A; Vidal, V | 1 |
| Borowicz, KK; Czuczwar, SJ; Piskorska, B; Stępniak, B | 1 |
| Bílková, E; Haugvicová, R; Kubová, H; Mares, P | 1 |
| Baraban, SC; Barbaro, NM; Smyth, MD | 1 |
| Corley, SM; Gilbert, TH; Teskey, GC | 1 |
| Shaw, FZ | 1 |
| Barnes, D; Bowery, NG; Caccia, S; Crunelli, V; Leresche, N; Manning, JP; Richards, DA; Rombola, L | 1 |
| Hartings, JA; Lu, XM; Moreton, JE; Tortella, FC; Williams, AJ | 1 |
| Borowicz, KK; Czuczwar, SJ; Luszczki, JJ | 1 |
| Czuczwar, SJ; Dekundy, A; Kaminski, RM; Tochman, AM; Turski, WA | 1 |
| Beyer, B; Frankel, WN; Letts, VA; Maxwell, CR; Pretel, S; Siegel, SJ | 1 |
| Delorey, TM; Handforth, A; Homanics, GE; Olsen, RW | 1 |
| Aypak, C; Gören, MZ; Küçükibrahimoğlu, E; Onat, FY; Ozkaynakçi, AE; Terzioğlu, B | 1 |
| Brevard, ME; Ferris, CF; King, JA; Kulkarni, P | 1 |
| Burnham, WM; Chan, KF; Cortez, MA; Jia, Z; Snead, OC | 1 |
| Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 1 |
| Chen, CC; Cheng, JK; Chiou, LC; Lin, CS; Yang, JR | 1 |
| Gilbert, TH; Teskey, GC | 1 |
| Friedman, L; Gallaugher, L; Hill, A; Lander, ES; Lynn, A; Nadeau, J; Singer, JB; Strohl, KP | 1 |
| Calderon, A; Palencia, G; Sotelo, J | 1 |
| Broicher, T; Budde, T; Kanyshkova, T; Meuth, P; Meuth, SG; Munsch, T; Pape, HC; Seidenbecher, T | 1 |
| Berkovic, SF; Chiu, C; Clarke, AL; Davies, PJ; Dibbens, L; Jones, MV; Krestel, H; Mulley, JC; Murphy, S; Petrou, S; Reid, CA; Sakmann, B; Seeburg, PH; Single, FN; Sprengel, R; Tan, HO | 1 |
| Agarwal, RK; Bashyal, C; Blumenfeld, H; Englot, DJ; Giblin, K; Khera, DS; Klein, JP; Levin, AR; Mission, J; Motelow, J; Nersesyan, H; Paul-Laughinghouse, C; Phadke, A; Rice, T; Schridde, U; Vestal, M; Wang, F; Waxman, SG | 1 |
| Bearden, LJ; Snead, OC | 1 |
| Frieder, B; Karpiak, SE; Rapport, MM | 1 |
| Hirohashi, M; Kitano, Y; Nomura, M; Takasuna, K; Usui, C | 1 |
| Mares, P | 1 |
| David, J; Joseph, S; Joseph, T | 1 |
| Fukuda, H; Ishige, K; Ito, Y | 1 |
| D'Mello, SR; LoTurco, JJ; Rattan, S; Sarkisian, MR | 1 |
| Cespuglio, R; Debilly, G; Faradji, H; Rousset, C; Vergnes, M | 1 |
| Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J | 1 |
| Endo, H; Ishige, K; Ito, Y; Saito, H | 1 |
| David, J; Joseph, T; Kumaresan, S | 1 |
| David, J; Joseph, T; Subramanyam, K | 1 |
| Snead, OC | 1 |
| Horton, RW; Meldrum, BS; Toseland, PA | 1 |
| Crawford, RD; Davis, HL; Johnson, DD | 2 |
| Lai, AA; Levy, RH; Lockard, JS; Patel, IH | 1 |
| Congdon, WC; DuCharme, LL; Levy, RH; Lockard, JS; Patel, IH | 1 |
| Gloor, P; Guberman, A; Sherwin, AL | 1 |
| Mares, P; Stanková, L | 1 |
| Boyet, S; Marescaux, C; Nehlig, A; Vergnes, M | 1 |
| Shouse, MN; Stroh, PJ; Vreeken, T | 1 |
| Fromm, GH | 1 |
| Depaulis, A; Marescaux, C; Micheletti, G; Reis, J; Rumbach, L; Vergnes, M; Warter, JM | 1 |
| Dailey, JW; Jobe, PC | 1 |
| Löscher, W; Nau, H | 1 |
| Krip, G; Vazquez, AJ | 1 |
2 review(s) available for ethosuximide and Disease Models, Animal
| Article | Year |
|---|---|
Pharmacological and biochemical studies in epileptic fowl.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Chickens; Disease Models, Animal; Ethosuximide; Female; Humans; Male; Mutation; Phenobarbital; Phenytoin; Photic Stimulation; Primidone; Seizures; Valproic Acid | 1979 |
Effects of different classes of antiepileptic drugs on brain-stem pathways.
Topics: Animals; Anticonvulsants; Baclofen; Brain Stem; Carbamazepine; Disease Models, Animal; Electroshock; Ethosuximide; Phenytoin; Reticular Formation; Valproic Acid | 1985 |
1 trial(s) available for ethosuximide and Disease Models, Animal
| Article | Year |
|---|---|
Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Avoidance Learning; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Fluorescent Antibody Technique; Fluoxetine; Male; Memory, Long-Term; Mice; Motor Activity; Pentylenetetrazole; Seizures; Selective Serotonin Reuptake Inhibitors; Valproic Acid | 2012 |
105 other study(ies) available for ethosuximide and Disease Models, Animal
| Article | Year |
|---|---|
Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.
Topics: Anilides; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hydrazones; Male; Mice; Phthalimides; Rotarod Performance Test; Seizures; Structure-Activity Relationship | 2007 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; Mice; Pain; Pain Measurement; Peripheral Nerve Injuries; Peripheral Nervous System Diseases; Rats; Semicarbazones; Structure-Activity Relationship; Touch | 2007 |
Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Epilepsy; Fever; gamma-Aminobutyric Acid; Mice; Molecular Structure; Rats; Rats, Wistar; Seizures, Febrile | 2008 |
Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: a natural product coupled approach to semicarbazones for antiepileptic activity.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Binding Sites; Cyclohexenes; Disease Models, Animal; gamma-Aminobutyric Acid; Limonene; Monoterpenes; Oxadiazoles; Protein Binding; Rats; Seizures; Semicarbazones; Structure-Activity Relationship; Terpenes | 2013 |
Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: a hybrid pharmacophore approach.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Electroshock; Injections, Intraperitoneal; Mice; Molecular Structure; Quinazolines; Rats; Rats, Wistar; Seizures; Thiazoles; Thioamides | 2013 |
Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones.
Topics: Administration, Oral; Animals; Anticonvulsants; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Disease Models, Animal; Drug Design; Electroshock; Humans; Male; Mannich Bases; Mice; Microsomes, Liver; Motor Activity; Pentylenetetrazole; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 2013 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Halogenation; Hydrocarbons, Fluorinated; Male; Mice; Molecular Structure; Pentylenetetrazole; Pilocarpine; Pyrazines; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 2014 |
Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model.
Topics: Animals; Anticonvulsants; Cymenes; Disease Models, Animal; Monoterpenes; Phenols; Psychomotor Performance; Seizures; Thymol | 2014 |
Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.
Topics: Amides; Animals; Anticonvulsants; Benzylamines; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; Humans; Imidazoles; Male; Mice; Microsomes, Liver; Molecular Structure; Motor Activity; Pentylenetetrazole; Propionates; Pyrrolidines; Rotarod Performance Test; Seizures; Small Molecule Libraries; Structure-Activity Relationship | 2015 |
Design, synthesis, and anticonvulsant activity of new hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)propanamides and 2-(2,5-dioxopyrrolidin-1-yl)butanamides.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; HEK293 Cells; Humans; Mice; Models, Molecular; Molecular Structure; Motor Activity; Piperazines; Seizures; Structure-Activity Relationship; Succinimides | 2015 |
Design, synthesis and biological activity of new amides derived from 3-methyl-3-phenyl-2,5-dioxo-pyrrolidin-1-yl-acetic acid.
Topics: Acetates; Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; Injections, Intraperitoneal; Mice; Molecular Structure; Pyrrolidines; Seizures | 2015 |
Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Cyclic S-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Thiazines | 2015 |
New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Mice; Molecular Structure; Pain; Pain Measurement; Pentylenetetrazole; Piperazines; Pyrrolidinones; Seizures | 2016 |
Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids.
Topics: Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Molecular Structure; Pentylenetetrazole; Pyrrolidines; Seizures | 2016 |
Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.
Topics: Action Potentials; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Drug Design; Flavonoids; HEK293 Cells; Humans; Inhibitory Concentration 50; Male; Mice; Neuralgia; Patch-Clamp Techniques; Structure-Activity Relationship | 2018 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Intrathecal application of ethosuximide is highly efficient in suppressing seizures in a genetic model of absence epilepsy.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Ethosuximide; Models, Genetic; Rats; Rats, Wistar; Seizures | 2022 |
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethosuximide; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Seizures; Time Factors; Valproic Acid; Vigabatrin | 2020 |
Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs.
Topics: 3-Hydroxybutyric Acid; Action Potentials; Alzheimer Disease; Animals; Anticonvulsants; Atropine; Disease Models, Animal; Donepezil; Drug Administration Schedule; Electroencephalography; Epilepsy; Ethosuximide; GABA Antagonists; Humans; Injections, Intraperitoneal; Lactic Acid; Levetiracetam; Male; Mice; Mice, Transgenic; Nootropic Agents; Organophosphorus Compounds; Parasympatholytics; Plaque, Amyloid; Pyruvic Acid; Video Recording | 2020 |
Anticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Computer Simulation; Disease Models, Animal; Electroencephalography; Ethosuximide; Iridoids; Male; Pentylenetetrazole; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Seizures; Time Factors; Valerian | 2021 |
First evidence of altered microbiota and intestinal damage and their link to absence epilepsy in a genetic animal model, the WAG/Rij rat.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Bacteroidetes; Butyrates; Colon; Disease Models, Animal; DNA, Bacterial; DNA, Ribosomal; Electroencephalography; Epilepsy, Absence; Ethosuximide; Fatty Acids, Volatile; Fecal Microbiota Transplantation; Firmicutes; Gastrointestinal Microbiome; Gastrointestinal Motility; Haptoglobins; Ileum; Propionates; Protein Precursors; Proteobacteria; Rats; Rats, Wistar; Seizures | 2021 |
Sensitivity of unilateral- versus bilateral-onset spike-wave discharges to ethosuximide and carbamazepine in the fluid percussion injury rat model of traumatic brain injury.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Carbamazepine; Disease Models, Animal; Electrocorticography; Epilepsy; Ethosuximide; Male; Percussion; Rats; Rats, Wistar; Seizures | 2021 |
A novel device for continuous long-term electroencephalogram recording and drug administration in mice with a nice, powerful and sophisticated wired system.
Topics: Animals; Anticonvulsants; Brain; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Wiring; Electroencephalography; Epilepsy; Ethosuximide; Longitudinal Studies; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Pilocarpine; Synaptosomal-Associated Protein 25; Wakefulness | 2017 |
Long-term negative impact of an inappropriate first antiepileptic medication on the efficacy of a second antiepileptic medication in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Epilepsy, Absence; Ethosuximide; Inappropriate Prescribing; Male; Mice; Mice, Inbred Strains; Saline Solution; Treatment Outcome; Valproic Acid; Vigabatrin | 2018 |
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbamazepine; Diazepam; Disease Models, Animal; Essential Tremor; Ethosuximide; Male; Mice, Inbred Strains; Nicotine; Phenobarbital; Propranolol; Pyridines; Valproic Acid | 2018 |
Lack of Antidepressant Effects of Low-Voltage-Sensitive T-Type Calcium Channel Blocker Ethosuximide in a Chronic Social Defeat Stress Model: Comparison with (R)-Ketamine.
Topics: Animals; Antidepressive Agents; Calcium Channel Blockers; Calcium Channels, T-Type; Depressive Disorder; Disease Models, Animal; Dominance-Subordination; Dose-Response Relationship, Drug; Ethosuximide; Ketamine; Male; Mice, Inbred C57BL; Random Allocation; Stress, Psychological; Treatment Failure | 2018 |
A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action.
Topics: Animals; Anticonvulsants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Convulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Ethosuximide; Pentylenetetrazole; Receptors, GABA-A; Seizures | 2018 |
The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Ethosuximide; Female; Gliosis; Hippocampus; Lamotrigine; Lithium; Neurons; Neuroprotective Agents; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2019 |
Inhibition of Ca
Topics: Animals; Benzeneacetamides; Calcium Channel Blockers; Calcium Channels, T-Type; Colon; Dextran Sulfate; Disease Models, Animal; Ethosuximide; Ganglia, Spinal; Heterocyclic Compounds, 2-Ring; Inflammation; Inflammatory Bowel Diseases; Interleukin-6; Irritable Bowel Syndrome; Male; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Pyridines; Sulfonamides | 2019 |
Cognitive impairment in the WAG/Rij rat absence model is secondary to absence seizures and depressive-like behavior.
Topics: Age Factors; Animals; Behavior, Animal; Cognitive Dysfunction; Comorbidity; Depression; Disease Models, Animal; Ethosuximide; Male; Rats; Rats, Inbred Strains; Seizures | 2019 |
Antiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary.
Topics: Animals; Anticonvulsants; Behavior, Animal; Depression; Disease Models, Animal; Duration of Therapy; Epilepsy, Absence; Ethosuximide; Levetiracetam; Male; Motor Activity; Rats; Rats, Inbred Strains; Seizures; Time Factors | 2019 |
Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Depression; Diffusion Tensor Imaging; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy, Absence; Ethosuximide; Evoked Potentials; Male; Rats; Rats, Inbred Strains; Stress, Psychological; Swimming | 2013 |
Teratogenic potential of antiepileptic drugs in the zebrafish model.
Topics: Acetamides; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Ethosuximide; Female; Fructose; Humans; Lacosamide; Lamotrigine; Levetiracetam; Piracetam; Pregnancy; Teratogenesis; Topiramate; Triazines; United States; Valproic Acid; Zebrafish | 2013 |
Synthesis, physicochemical, and anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; Ethosuximide; Male; Mannich Bases; Mice; Molecular Structure; Motor Activity; Neurotoxicity Syndromes; Pentylenetetrazole; Pyrrolidines; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Valproic Acid | 2014 |
Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethosuximide; Flumazenil; Juglans; Male; Pentylenetetrazole; Plant Extracts; Rats; Rats, Wistar; Seizures | 2014 |
Suppression of adult neurogenesis increases the acute effects of kainic acid.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Electroencephalography; Ethosuximide; Excitatory Amino Acid Agonists; Ganciclovir; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neural Stem Cells; Neurogenesis; Neuropeptides; Seizures; Thymidine Kinase; Valganciclovir; X-Rays | 2015 |
Chronic intrathecal infusion of mibefradil, ethosuximide and nickel attenuates nerve ligation-induced pain in rats.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Ethosuximide; Ligation; Male; Mibefradil; Neuralgia; Nickel; Rats; Rats, Sprague-Dawley | 2015 |
Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Ethosuximide; Forkhead Transcription Factors; Gene Expression; Mutation; Phenotype; Signal Transduction; Transcription Factors | 2015 |
Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; beta Catenin; Cell Differentiation; Cell Proliferation; Cognition Disorders; Disease Models, Animal; Ethosuximide; Hippocampus; Neurogenesis; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Wnt Proteins | 2015 |
Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Male; Mice; Morpholines; Motor Skills; Pentylenetetrazole; Phenobarbital; Reboxetine; Valproic Acid | 2015 |
Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.
Topics: Animals; Anticonvulsants; Calcium Channels, N-Type; Disease Models, Animal; Epilepsy, Absence; Ethosuximide; Excitatory Postsynaptic Potentials; Female; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Disorders; Mutation; Neurons; Reaction Time; Receptors, Neurotensin; Thalamus; Visual Cortex | 2016 |
Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Epilepsy, Absence; Ethosuximide; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Receptors, AMPA; Tetrahydroisoquinolines | 2008 |
Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions.
Topics: Action Potentials; Adaptation, Physiological; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Causalgia; Denervation; Disease Models, Animal; Ethosuximide; Hyperalgesia; Male; Neuronal Plasticity; Organ Culture Techniques; Pain, Intractable; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Spinothalamic Tracts; Syndrome; Thalamus; Ventral Thalamic Nuclei | 2008 |
The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice.
Topics: Angiotensin II; Animals; Animals, Newborn; Aorta; Blood Pressure; Calcineurin; Calcium Channel Blockers; Calcium Channels, T-Type; Calcium Signaling; Cardiomegaly; Cells, Cultured; Constriction; Disease Models, Animal; Ethosuximide; Genes, Reporter; Hypertension; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; NFATC Transcription Factors; Time Factors | 2009 |
Infantile spasms and Down syndrome: a new animal model.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Baclofen; Brain; Disease Models, Animal; Down Syndrome; Electroencephalography; Ethosuximide; GABA Agonists; Genotype; Humans; Infant; Mice; Mice, Mutant Strains; Organophosphorus Compounds; Phenotype; Receptors, GABA-A; Receptors, GABA-B; Spasms, Infantile; Time Factors; Valproic Acid; Vigabatrin | 2009 |
Depression- and anxiety-like behaviors of a rat model with absence epileptic discharges.
Topics: Action Potentials; Animals; Anticonvulsants; Anxiety; Depression; Disease Models, Animal; Epilepsy, Absence; Escape Reaction; Ethosuximide; Exploratory Behavior; Immobility Response, Tonic; Male; Rats; Rats, Long-Evans; Rats, Wistar | 2009 |
A flexible drug delivery chip for the magnetically-controlled release of anti-epileptic drugs.
Topics: Animals; Anticonvulsants; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Compounding; Epilepsy; Ethosuximide; Feasibility Studies; Ferric Compounds; Injections, Intraperitoneal; Kinetics; Magnetics; Male; Models, Chemical; Nanoparticles; Pilot Projects; Rats; Rats, Long-Evans; Rats, Wistar; Silicon Dioxide; Solubility; Technology, Pharmaceutical | 2009 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Levetiracetam; Male; Mice; Pentylenetetrazole; Phenobarbital; Piracetam; Seizures; Valproic Acid | 2009 |
Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Ethosuximide; Exploratory Behavior; Immobility Response, Tonic; Male; Models, Genetic; Motor Activity; Rats; Rats, Inbred Strains; Rats, Wistar; Seizures; Swimming | 2010 |
Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy.
Topics: Age Factors; Analysis of Variance; Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Disease Models, Animal; Epilepsy, Absence; Ethosuximide; Levetiracetam; Male; Piracetam; Rats; Rats, Mutant Strains; Time Factors | 2010 |
Localized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS).
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Absence; Ethosuximide; Kindling, Neurologic; Male; Rats; Rats, Wistar | 2010 |
T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.
Topics: Analysis of Variance; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cyclopropanes; Disease Models, Animal; Essential Tremor; Estranes; Ethosuximide; Harmaline; Isoxazoles; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Naphthalenes; Nitriles; Receptors, GABA-A; Zonisamide | 2010 |
Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy, Absence; Ethosuximide; Infusions, Intraventricular; Male; Pentylenetetrazole; Rats; Rats, Long-Evans; Rats, Wistar | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Clonazepam; Disease Models, Animal; Drug Synergism; Ethosuximide; Hand Strength; Male; Mice; Morpholines; Naphthalenes; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 2011 |
Does antiepileptogenesis affect sleep in genetic epileptic rats?
Topics: Animals; Anticonvulsants; Brain; Depression; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Absence; Ethosuximide; Male; Random Allocation; Rats; Sleep; Sleep, REM; Time Factors | 2012 |
Ethosuximide reduces allodynia and hyperalgesia and potentiates morphine effects in the chronic constriction injury model of neuropathic pain.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Cold Temperature; Constriction; Disease Models, Animal; Drug Synergism; Ethosuximide; Hot Temperature; Hyperalgesia; Male; Morphine; Neuralgia; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Time Factors | 2012 |
A rat model for LGI1-related epilepsies.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Reflex; Ethosuximide; Heterozygote; Homozygote; Humans; Intercellular Signaling Peptides and Proteins; Levetiracetam; Molecular Sequence Data; Mutation, Missense; Neurons; Phenytoin; Piracetam; Proteins; Rats, Mutant Strains | 2012 |
Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cognition; Cyclohexanecarboxylic Acids; Disease Models, Animal; Down Syndrome; Ethosuximide; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Gabapentin; gamma-Aminobutyric Acid; Male; Mice | 2012 |
Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Electroencephalography; Electrophysiology; Epilepsies, Myoclonic; Ethosuximide; Humans; Male; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Seizures | 2002 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electroencephalography; Epilepsy; Ethosuximide; Female; Hippocampus; In Vitro Techniques; Lamotrigine; Methylazoxymethanol Acetate; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Triazines; Valproic Acid | 2002 |
Conventional anticonvulsant drugs in the guinea pig kindling model of partial seizures: effects of acute phenobarbital, valproate, and ethosuximide.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Partial; Ethosuximide; Female; Forecasting; Guinea Pigs; Kindling, Neurologic; Male; Phenobarbital; Valproic Acid | 2002 |
Is spontaneous high-voltage rhythmic spike discharge in Long Evans rats an absence-like seizure activity?
Topics: Animals; Anticonvulsants; Arousal; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Electromyography; Epilepsy, Absence; Ethosuximide; Female; Immobilization; Penicillins; Pentylenetetrazole; Rats; Rats, Inbred Strains; Rats, Long-Evans; Sleep; Time Factors; Wakefulness | 2004 |
Targeting thalamic nuclei is not sufficient for the full anti-absence action of ethosuximide in a rat model of absence epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Delivery Systems; Epilepsy, Absence; Ethosuximide; Rats; Rats, Wistar; Thalamic Nuclei | 2003 |
Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.
Topics: Amines; Animals; Anticonvulsants; Brain Infarction; Brain Injuries; Brain Ischemia; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electroencephalography; Ethosuximide; Gabapentin; gamma-Aminobutyric Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Felbamate; Female; Humans; Lethal Dose 50; Mice; Motor Activity; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Phenylcarbamates; Propylene Glycols; Seizures; Valproic Acid | 2004 |
Ethosuximide and valproate display high efficacy against lindane-induced seizures in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethosuximide; GABA Agents; Hexachlorocyclohexane; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Pentylenetetrazole; Seizures; Valproic Acid | 2004 |
Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain Mapping; Chromosome Mapping; Disease Models, Animal; Epilepsy, Absence; Ethosuximide; Inbreeding; Mice; Mice, Inbred C3H; Models, Genetic; Theta Rhythm | 2005 |
Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome.
Topics: Angelman Syndrome; Animals; Anticonvulsants; Baclofen; Cerebral Cortex; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Ethosuximide; Female; GABA Agonists; GABA Antagonists; Humans; Male; Mice; Mice, Mutant Strains; Neural Pathways; Organophosphorus Compounds; Parietal Lobe; Receptors, GABA-A; Thalamus | 2005 |
The effects of ethosuximide on amino acids in genetic absence epilepsy rat model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Ethosuximide; gamma-Aminobutyric Acid; Glutamic Acid; Microdialysis; Motor Cortex; Rats; Rats, Wistar; Time Factors; Ventral Thalamic Nuclei | 2006 |
Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures.
Topics: Animals; Brain Mapping; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Ethosuximide; Hippocampus; Magnetic Resonance Imaging; Male; Neural Pathways; Oxygen; Pentylenetetrazole; Pilot Projects; Prosencephalon; Rats; Rats, Sprague-Dawley; Seizures; Thalamic Nuclei; Thalamus | 2006 |
GABAB receptor antagonism abolishes the learning impairments in rats with chronic atypical absence seizures.
Topics: Animals; Anticholesteremic Agents; Anticonvulsants; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Absence; Ethosuximide; Female; GABA Antagonists; GABA-B Receptor Antagonists; Hippocampus; Learning Disabilities; Maze Learning; Memory Disorders; Organophosphorus Compounds; Rats; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2006 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Male; Mice; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 2006 |
Effects of intrathecal injection of T-type calcium channel blockers in the rat formalin test.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Ethosuximide; Formaldehyde; Hindlimb; Injections, Spinal; Long-Term Potentiation; Male; Mibefradil; Neural Inhibition; Neuronal Plasticity; Nickel; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Cord | 2007 |
Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Electric Stimulation; Epilepsies, Partial; Ethosuximide; Female; Guinea Pigs; Kindling, Neurologic; Male; Phenobarbital; Phenytoin; Predictive Value of Tests; Reproducibility of Results; Species Specificity; Treatment Outcome; Valproic Acid | 2007 |
Sleep-related epilepsy in the A/J mouse.
Topics: Alleles; Animals; Anticonvulsants; Chromosomes, Mammalian; Diazepam; Disease Models, Animal; Electroencephalography; Electromyography; Epilepsy; Ethosuximide; Female; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenotype; Sleep | 2007 |
Thalidomide inhibits pentylenetetrazole-induced seizures.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Ethosuximide; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Severity of Illness Index; Valproic Acid | 2007 |
T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Electroencephalography; Epilepsy, Absence; Ethosuximide; Interneurons; Membrane Potentials; Mibefradil; Patch-Clamp Techniques; Rats; Rats, Inbred ACI; Thalamus | 2007 |
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Ethosuximide; Genetic Predisposition to Disease; Mice; Phenotype; Protein Subunits; Receptors, GABA-A | 2007 |
Early treatment suppresses the development of spike-wave epilepsy in a rat model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cerebral Cortex; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Ethosuximide; Female; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; NAV1.1 Voltage-Gated Sodium Channel; NAV1.6 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Phenotype; Potassium Channels; Rats; Rats, Wistar; Severity of Illness Index; Sodium Channels | 2008 |
Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Endorphins; Enkephalins; Epilepsy, Absence; Ethosuximide; Male; Rats; Receptors, Opioid; Seizures; Trimethadione; Valproic Acid | 1980 |
Effect of antiepileptic drugs and an anticonvulsant on epileptiform activity induced by antibodies to ganglioside.
Topics: Action Potentials; Aminooxyacetic Acid; Animals; Anticonvulsants; Cobalt; Diazepam; Disease Models, Animal; Electroencephalography; Ethosuximide; Gangliosides; Immune Sera; Male; Phenytoin; Rabbits; Rats; Rats, Inbred Strains; Seizures | 1982 |
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; Ear; Electrodes; Electroshock; Ethosuximide; Injections, Intravenous; Male; Mice; Morphine; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1996 |
Ontogeny of ethosuximide action against two seizure models in rats is different.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Ethosuximide; Pentylenetetrazole; Rats; Seizures | 1998 |
Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Electroshock; Ethosuximide; Flunarizine; Male; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Seizures; Valproic Acid | 1998 |
Pharmacological profiles of absence seizure-induced increases in CRE- and AP-1 DNA-binding activities in gamma-butyrolactone-treated mice.
Topics: 4-Butyrolactone; Activating Transcription Factor 2; Animals; Anticonvulsants; Brain; Brain Chemistry; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; DNA-Binding Proteins; Epilepsy, Absence; Ethosuximide; GABA Antagonists; Mice; Organophosphorus Compounds; Phosphinic Acids; Thalamus; Transcription Factor AP-1; Transcription Factors | 1998 |
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Ethosuximide; Female; Male; Models, Genetic; Mutation; Phenobarbital; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Valproic Acid | 1999 |
Sleep and epilepsy: A key role for nitric oxide?
Topics: Animals; Anticonvulsants; Brain; Cerebral Cortex; Circadian Rhythm; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Rats; Rats, Wistar; Sleep; Valproic Acid; Wakefulness | 2000 |
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions.
Topics: Animals; Anticonvulsants; Avoidance Learning; Clonazepam; Disease Models, Animal; Drug Interactions; Epilepsies, Myoclonic; Ethosuximide; Indazoles; Male; Mice; Motor Skills; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Seizures | 2000 |
Repeated administration of CGP 46381, a gamma-aminobutyric acidB antagonist, and ethosuximide suppresses seizure-associated cyclic adenosine 3'5' monophosphate response element- and activator protein-1 DNA-binding activities in lethargic (lh/lh) mice.
Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy, Absence; Ethosuximide; GABA Antagonists; GABA-B Receptor Antagonists; Hippocampus; Mice; Phosphinic Acids; Sleep Stages; Thalamus; Transcription Factor AP-1; Treatment Outcome | 2001 |
Comparative profiles of sodium valproate and ethosuximide on electro-behavioural correlates in gamma-hydroxybutyrate and pentylenetetrazol induced absence seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Ethosuximide; Male; Pentylenetetrazole; Rats; Rats, Wistar; Sodium Oxybate; Species Specificity; Valproic Acid | 2000 |
Interaction of flunarizine with sodium valproate or ethosuximide in gamahydroxybutyrate induced absence seizures in rats.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Drug Interactions; Drug Synergism; Electroencephalography; Epilepsy, Absence; Ethosuximide; Flunarizine; Male; Rats; Rats, Wistar; Sodium Oxybate; Valproic Acid | 2001 |
Gamma hydroxybutyrate in the monkey. II. Effect of chronic oral anticonvulsant drugs.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Ethosuximide; Haplorhini; Hydroxybutyrates; Levodopa; Macaca mulatta; Phenobarbital; Phenytoin | 1978 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Drug Evaluation, Preclinical; Electroencephalography; Ethosuximide; Female; Glycine; Male; Myoclonus; Papio; Phenobarbital; Phenytoin; Photic Stimulation; Primidone; Seizures; Thiazines | 1975 |
Efficacy testing of valproic acid compared to ethosuximide in monkey model: I. Dosage regimen design in the presence of diurnal oscillations.
Topics: Animals; Biopharmaceutics; Circadian Rhythm; Disease Models, Animal; Ethosuximide; Haplorhini; Macaca mulatta; Male; Seizures; Valerates; Valproic Acid | 1977 |
Efficacy testing of valproic acid compared to ethosuximide in monkey model: II. Seizure, EEG, and diurnal variations.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Electroencephalography; Ethosuximide; Haplorhini; Macaca mulatta; Male; Seizures; Valerates; Valproic Acid | 1977 |
Epileptiform seizures in domestic fowl. IX. Implications of the absence of anticonvulsant activity of ethosuximide in a pharmacological model of epilepsy.
Topics: Animals; Anticonvulsants; Chickens; Disease Models, Animal; Epilepsy; Ethosuximide; Light; Poultry Diseases | 1978 |
Response of generalized penicillin epilepsy in the cat to ethosuximide and diphenylhydantoin.
Topics: Animals; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroencephalography; Ethosuximide; Penicillins; Phenytoin; Seizures | 1975 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes; Electroencephalography; Epilepsy; Ethosuximide; Injections, Intraperitoneal; Male; Pentylenetetrazole; Phenobarbital; Prohibitins; Rats; Rats, Wistar; Valproic Acid | 1992 |
Mapping of cerebral energy metabolism in rats with genetic generalized nonconvulsive epilepsy.
Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Electroencephalography; Energy Metabolism; Epilepsy, Absence; Ethosuximide; Glucose; Haloperidol; Male; Rats; Rats, Inbred Strains; Reference Values | 1992 |
Temporal lobe and petit mal antiepileptics differentially affect ventral lateral thalamic and motor cortex excitability patterns.
Topics: Animals; Carbamazepine; Cats; Disease Models, Animal; Epilepsy, Absence; Ethosuximide; Evoked Potentials; Motor Cortex; Reference Values; Sleep; Temporal Lobe; Thalamus | 1988 |
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Absence; Ethosuximide; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Trimethadione; Valproic Acid | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease Models, Animal; Epilepsy; Ethosuximide; Imipramine; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1985 |
Pharmacological evaluation of various metabolites and analogues of valproic acid. Anticonvulsant and toxic potencies in mice.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Disease Models, Animal; Epilepsy; Ethosuximide; Male; Mice; Structure-Activity Relationship; Valproic Acid | 1985 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Parasympathomimetics; Phenytoin; Physostigmine; Pilocarpine; Scopolamine; Seizures; Synaptic Transmission; Trimethadione | 1971 |