ethosuximide has been researched along with Depressive Disorder in 2 studies
Ethosuximide: An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
ethosuximide : A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results suggest that seizure activity is necessary for the expression of depression-like behavioral symptoms and confirm that epileptogenesis can be prevented by early and chronic treatment." | 1.36 | Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms. ( Kulikov, MA; Kuznetsova, GD; Sarkisova, KY; van Luijtelaar, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tian, Z | 1 |
| Dong, C | 1 |
| Zhang, K | 1 |
| Chang, L | 1 |
| Hashimoto, K | 1 |
| Sarkisova, KY | 1 |
| Kuznetsova, GD | 1 |
| Kulikov, MA | 1 |
| van Luijtelaar, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Parallel-group，Placebo-controlled, Double-blind Clinical Trial to Evaluate the Efficacy and Safety of Ethosuximide in Chinese Patients With Treatment-Resistant Depression.[NCT03887624] | Early Phase 1 | 16 participants (Actual) | Interventional | 2019-05-21 | Terminated (stopped due to Participates could not stand the side effects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for ethosuximide and Depressive Disorder
| Article | Year |
|---|---|
Lack of Antidepressant Effects of Low-Voltage-Sensitive T-Type Calcium Channel Blocker Ethosuximide in a Chronic Social Defeat Stress Model: Comparison with (R)-Ketamine.
Topics: Animals; Antidepressive Agents; Calcium Channel Blockers; Calcium Channels, T-Type; Depressive Disor | 2018 |
Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder; | 2010 |