ethosuximide has been researched along with Depression in 10 studies
Ethosuximide: An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
ethosuximide : A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic pain is a heavy burden disease." | 5.51 | Ethosuximide improves chronic pain-induced anxiety- and depression-like behaviors. ( Boudieu, L; Bourdier, J; Daulhac, L; Eschalier, A; Kerckhove, N; Mallet, C; Ourties, G, 2019) |
| " ethosuximide), using specific protocols, prevent the development of spontaneous absence seizures." | 3.91 | Antiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary. ( Caro, C; Citraro, R; Constanti, A; Iannone, M; Leo, A; Nesci, V; Palma, E; Russo, E; Sarro, G; Tallarico, M, 2019) |
| "The beneficial effects of chronic and early pharmacological treatment with ethosuximide on epileptogenesis were studied in a genetic absence epilepsy model comorbid for depression." | 3.79 | Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model. ( Bashyal, C; Blumenfeld, H; Burinov, J; Coman, D; Coquillette, M; Covolato, G; Danielson, N; Edelbroek, P; Frankenmolen, N; Hyder, F; Janeczko, K; Kiemeneij, A; Lüttjohann, A; Mishra, AM; Niermann, H; Schaapsmeerders, P; van Luijtelaar, G; van Rijn, CM, 2013) |
| " However, zonisamide- and carbamazepine-treated animals had IT values similar to those of controls, but only zonisamide significantly decreased absence seizure development." | 3.77 | Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model. ( Citraro, R; Constanti, A; De Fazio, S; De Sarro, G; Di Paola, ED; Perrota, I; Perrotta, I; Russo, E; Scicchitano, F, 2011) |
| "Chronic pain is a heavy burden disease." | 1.51 | Ethosuximide improves chronic pain-induced anxiety- and depression-like behaviors. ( Boudieu, L; Bourdier, J; Daulhac, L; Eschalier, A; Kerckhove, N; Mallet, C; Ourties, G, 2019) |
| "Consistently, it is possible that absence seizures, depressive-like behavior and cognitive deficit may arise independently and separately in lifetime from the same underlying network disease, as previously suggested for the behavioral features associated with other epileptic syndromes." | 1.51 | Cognitive impairment in the WAG/Rij rat absence model is secondary to absence seizures and depressive-like behavior. ( Citraro, R; De Sarro, G; Fedosova, E; Iannone, M; Leo, A; Nesci, V; Russo, E; Sarkisova, K; Tallarico, M, 2019) |
| "The results suggest that seizure activity is necessary for the expression of depression-like behavioral symptoms and confirm that epileptogenesis can be prevented by early and chronic treatment." | 1.36 | Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms. ( Kulikov, MA; Kuznetsova, GD; Sarkisova, KY; van Luijtelaar, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kerckhove, N | 1 |
| Boudieu, L | 1 |
| Ourties, G | 1 |
| Bourdier, J | 1 |
| Daulhac, L | 1 |
| Eschalier, A | 1 |
| Mallet, C | 1 |
| Leo, A | 2 |
| Citraro, R | 4 |
| Tallarico, M | 2 |
| Iannone, M | 2 |
| Fedosova, E | 1 |
| Nesci, V | 2 |
| De Sarro, G | 2 |
| Sarkisova, K | 1 |
| Russo, E | 3 |
| Caro, C | 1 |
| Palma, E | 1 |
| Constanti, A | 2 |
| Sarro, G | 1 |
| van Luijtelaar, G | 3 |
| Mishra, AM | 1 |
| Edelbroek, P | 1 |
| Coman, D | 1 |
| Frankenmolen, N | 1 |
| Schaapsmeerders, P | 1 |
| Covolato, G | 1 |
| Danielson, N | 1 |
| Niermann, H | 1 |
| Janeczko, K | 1 |
| Kiemeneij, A | 1 |
| Burinov, J | 1 |
| Bashyal, C | 1 |
| Coquillette, M | 1 |
| Lüttjohann, A | 1 |
| Hyder, F | 1 |
| Blumenfeld, H | 1 |
| van Rijn, CM | 1 |
| Shaw, FZ | 1 |
| Chuang, SH | 1 |
| Shieh, KR | 1 |
| Wang, YJ | 1 |
| Sarkisova, KY | 1 |
| Kuznetsova, GD | 1 |
| Kulikov, MA | 1 |
| Scicchitano, F | 2 |
| De Fazio, S | 1 |
| Perrotta, I | 1 |
| Perrota, I | 1 |
| Di Paola, ED | 1 |
| Wilde, M | 1 |
| van Rijn, C | 1 |
| Wolf, P | 1 |
| Inoue, Y | 1 |
| Röder-Wanner, UU | 1 |
| Tsai, JJ | 1 |
| Wells, CE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Parallel-group，Placebo-controlled, Double-blind Clinical Trial to Evaluate the Efficacy and Safety of Ethosuximide in Chinese Patients With Treatment-Resistant Depression.[NCT03887624] | Early Phase 1 | 16 participants (Actual) | Interventional | 2019-05-21 | Terminated (stopped due to Participates could not stand the side effects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 other studies available for ethosuximide and Depression
| Article | Year |
|---|---|
Ethosuximide improves chronic pain-induced anxiety- and depression-like behaviors.
Topics: Animals; Anticonvulsants; Anxiety; Calcium Channel Blockers; Calcium Channels, T-Type; Chronic Pain; | 2019 |
Cognitive impairment in the WAG/Rij rat absence model is secondary to absence seizures and depressive-like behavior.
Topics: Age Factors; Animals; Behavior, Animal; Cognitive Dysfunction; Comorbidity; Depression; Disease Mode | 2019 |
Antiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary.
Topics: Animals; Anticonvulsants; Behavior, Animal; Depression; Disease Models, Animal; Duration of Therapy; | 2019 |
Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Depression; Diffusion Tensor Imaging; Disease Mod | 2013 |
Depression- and anxiety-like behaviors of a rat model with absence epileptic discharges.
Topics: Action Potentials; Animals; Anticonvulsants; Anxiety; Depression; Disease Models, Animal; Epilepsy, | 2009 |
Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder; | 2010 |
Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Depression; Dose-Response Relationship, Drug; Electr | 2011 |
Does antiepileptogenesis affect sleep in genetic epileptic rats?
Topics: Animals; Anticonvulsants; Brain; Depression; Disease Models, Animal; Electrodes, Implanted; Electroe | 2012 |
Psychiatric complications of absence therapy and their relation to alteration of sleep.
Topics: Delusions; Depression; Epilepsy, Absence; Ethosuximide; Female; Humans; Hypochondriasis; Hysteria; M | 1984 |
Petit mal status presenting as psychasis.
Topics: Anticonvulsants; Depression; Electroencephalography; Epilepsy, Absence; Ethosuximide; Female; Humans | 1973 |