ethosuximide has been researched along with Child Behavior Disorders in 6 studies
Ethosuximide: An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
ethosuximide : A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Child Behavior Disorders: Disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depression. This concept does not include psychoneuroses, psychoses, or personality disorders with fixed patterns.
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (66.67) | 18.7374 |
1990's | 1 (16.67) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Shinnar, RC | 1 |
Shinnar, S | 1 |
Cnaan, A | 1 |
Clark, P | 1 |
Dlugos, D | 1 |
Hirtz, DG | 1 |
Hu, F | 1 |
Liu, C | 1 |
Masur, D | 1 |
Weiss, EF | 1 |
Glauser, TA | 1 |
Roulet Perez, E | 1 |
Davidoff, V | 1 |
Despland, PA | 1 |
Deonna, T | 1 |
Groh, C | 1 |
Rosenmayr, FW | 2 |
Groh, CH | 1 |
Gregoriades, AD | 1 |
Smith, WL | 1 |
Philippus, MJ | 1 |
Guard, HL | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study[NCT00088452] | Phase 3 | 453 participants (Actual) | Interventional | 2004-07-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
A Confidence Index of 0.60 or higher on the Conners' Continuous Performance Test at the visit at 16 or 20 weeks or at an earlier visit when treatment was discontinued (as long as the discontinuation occurred 1 month or more after the baseline visit and was not due to intolerable adverse events). A Confidence Index of 0.60 corresponds to a 60% probability that the child has clinical attention deficit disorder. (NCT00088452)
Timeframe: First 16-20 weeks of double blind therapy
Intervention | Participants (Count of Participants) |
---|---|
Ethosuximide | 35 |
Lamotrigine | 25 |
Valproic Acid | 52 |
Treatment failure was defined as persistence of absence seizures at 12 months of double blind therapy, a generalized tonic-clonic seizure at any time, excessive drug-related systemic toxicity, a moderately severe rash (possibly drug-related), pancreatitis, or increase in the body-mass index of at least 3.0 from baseline, dose-limiting toxicity after a single downward dose modification, or withdrawal initiated by the parent or physician. (NCT00088452)
Timeframe: First 12 months of double blind therapy
Intervention | Participants (Count of Participants) |
---|---|
Ethosuximide | 70 |
Lamotrigine | 31 |
Valproic Acid | 64 |
Treatment failure was defined as persistence of absence seizures at week 16 or week 20, a generalized tonic-clonic seizure at any time, excessive drug-related systemic toxicity, a moderately severe rash (possibly drug-related), pancreatitis, or increase in the body-mass index of at least 3.0 from baseline, dose-limiting toxicity after a single downward dose modification, or withdrawal initiated by the parent or physician. (NCT00088452)
Timeframe: First 16-20 weeks of double blind therapy
Intervention | Participants (Count of Participants) |
---|---|
Ethosuximide | 81 |
Lamotrigine | 43 |
Valproic Acid | 85 |
2 trials available for ethosuximide and Child Behavior Disorders
Article | Year |
---|---|
Pretreatment behavior and subsequent medication effects in childhood absence epilepsy.
Topics: Adolescent; Anticonvulsants; Checklist; Child; Child Behavior Disorders; Child, Preschool; Cross-Ove | 2017 |
Psychometric study of children with learning problems and 14-6 positive spike EEG patterns, treated with ethosuximide (Zarontin) and placebo.
Topics: Adolescent; Child; Child Behavior Disorders; Clinical Trials as Topic; Electroencephalography; Ethos | 1968 |
4 other studies available for ethosuximide and Child Behavior Disorders
Article | Year |
---|---|
Mental and behavioural deterioration of children with epilepsy and CSWS: acquired epileptic frontal syndrome.
Topics: Brain; Brain Diseases; Child; Child Behavior Disorders; Cognition Disorders; Electroencephalography; | 1993 |
[Borderline between antiepileptic and psychopharmacological drugs (author's transl)].
Topics: Amitriptyline; Anticonvulsants; Antipsychotic Agents; Barbiturates; Carbamazepine; Child; Child Beha | 1975 |
[Isolated petit mal status epilepticus. A new epilepsy syndrome characterised by paroxysmal behavioural disturbances (author's transl)].
Topics: Benzodiazepinones; Child; Child Behavior Disorders; Cognition Disorders; Diagnosis, Differential; Di | 1974 |
A medical and social survey of 231 children with seizures.
Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog | 1972 |