Page last updated: 2024-10-26

ethosuximide and Child Behavior Disorders

ethosuximide has been researched along with Child Behavior Disorders in 6 studies

Ethosuximide: An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
ethosuximide : A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.

Child Behavior Disorders: Disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depression. This concept does not include psychoneuroses, psychoses, or personality disorders with fixed patterns.

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shinnar, RC1
Shinnar, S1
Cnaan, A1
Clark, P1
Dlugos, D1
Hirtz, DG1
Hu, F1
Liu, C1
Masur, D1
Weiss, EF1
Glauser, TA1
Roulet Perez, E1
Davidoff, V1
Despland, PA1
Deonna, T1
Groh, C1
Rosenmayr, FW2
Groh, CH1
Gregoriades, AD1
Smith, WL1
Philippus, MJ1
Guard, HL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study[NCT00088452]Phase 3453 participants (Actual)Interventional2004-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Attention Deficit as Measured by the Confidence Index of the CPT-II and the K-CPT

A Confidence Index of 0.60 or higher on the Conners' Continuous Performance Test at the visit at 16 or 20 weeks or at an earlier visit when treatment was discontinued (as long as the discontinuation occurred 1 month or more after the baseline visit and was not due to intolerable adverse events). A Confidence Index of 0.60 corresponds to a 60% probability that the child has clinical attention deficit disorder. (NCT00088452)
Timeframe: First 16-20 weeks of double blind therapy

InterventionParticipants (Count of Participants)
Ethosuximide35
Lamotrigine25
Valproic Acid52

Number of Participants With Freedom From Treatment Failure at 12 Months of Double Blind Therapy

Treatment failure was defined as persistence of absence seizures at 12 months of double blind therapy, a generalized tonic-clonic seizure at any time, excessive drug-related systemic toxicity, a moderately severe rash (possibly drug-related), pancreatitis, or increase in the body-mass index of at least 3.0 from baseline, dose-limiting toxicity after a single downward dose modification, or withdrawal initiated by the parent or physician. (NCT00088452)
Timeframe: First 12 months of double blind therapy

InterventionParticipants (Count of Participants)
Ethosuximide70
Lamotrigine31
Valproic Acid64

Number of Participants With Freedom From Treatment Failure at 16-20 Weeks of Double Blind Therapy

Treatment failure was defined as persistence of absence seizures at week 16 or week 20, a generalized tonic-clonic seizure at any time, excessive drug-related systemic toxicity, a moderately severe rash (possibly drug-related), pancreatitis, or increase in the body-mass index of at least 3.0 from baseline, dose-limiting toxicity after a single downward dose modification, or withdrawal initiated by the parent or physician. (NCT00088452)
Timeframe: First 16-20 weeks of double blind therapy

InterventionParticipants (Count of Participants)
Ethosuximide81
Lamotrigine43
Valproic Acid85

Trials

2 trials available for ethosuximide and Child Behavior Disorders

ArticleYear
Pretreatment behavior and subsequent medication effects in childhood absence epilepsy.
    Neurology, 2017, Oct-17, Volume: 89, Issue:16

    Topics: Adolescent; Anticonvulsants; Checklist; Child; Child Behavior Disorders; Child, Preschool; Cross-Ove

2017
Psychometric study of children with learning problems and 14-6 positive spike EEG patterns, treated with ethosuximide (Zarontin) and placebo.
    Archives of disease in childhood, 1968, Volume: 43, Issue:231

    Topics: Adolescent; Child; Child Behavior Disorders; Clinical Trials as Topic; Electroencephalography; Ethos

1968

Other Studies

4 other studies available for ethosuximide and Child Behavior Disorders

ArticleYear
Mental and behavioural deterioration of children with epilepsy and CSWS: acquired epileptic frontal syndrome.
    Developmental medicine and child neurology, 1993, Volume: 35, Issue:8

    Topics: Brain; Brain Diseases; Child; Child Behavior Disorders; Cognition Disorders; Electroencephalography;

1993
[Borderline between antiepileptic and psychopharmacological drugs (author's transl)].
    Padiatrie und Padologie, 1975, Volume: 10, Issue:2

    Topics: Amitriptyline; Anticonvulsants; Antipsychotic Agents; Barbiturates; Carbamazepine; Child; Child Beha

1975
[Isolated petit mal status epilepticus. A new epilepsy syndrome characterised by paroxysmal behavioural disturbances (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Mar-01, Volume: 99, Issue:9

    Topics: Benzodiazepinones; Child; Child Behavior Disorders; Cognition Disorders; Diagnosis, Differential; Di

1974
A medical and social survey of 231 children with seizures.
    Epilepsia, 1972, Volume: 13, Issue:1

    Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog

1972