ethosuximide has been researched along with Aging in 15 studies
Ethosuximide: An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
ethosuximide : A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ethosuximide was administered by intraperitoneal injection every other day from post-natal day seven (P7) until the mice were 8 weeks of age." | 5.46 | Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss. ( Entenman, S; Ma, X; Min, L; Sang, L; Su, Y; Zhang, X; Zheng, Q; Zheng, T, 2017) |
| "Ethosuximide was reliably effective against metrazol only in adult rats; in young animals it did not significantly change CD50s." | 5.27 | Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats. ( Mares, P; Velísek, L, 1983) |
| "Ethosuximide (ESX) is a drug of choice for the symptomatic treatment of absence seizures." | 3.79 | Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy. ( Blumenfeld, H; Dezsi, G; Jones, NC; O'Brien, TJ; Ozturk, E; Powell, KL; Stanic, D, 2013) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| "Ethosuximide was administered by intraperitoneal injection every other day from post-natal day seven (P7) until the mice were 8 weeks of age." | 1.46 | Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss. ( Entenman, S; Ma, X; Min, L; Sang, L; Su, Y; Zhang, X; Zheng, Q; Zheng, T, 2017) |
| "Ethosuximide is a medication used to treat seizure disorders in humans, and we previously demonstrated that ethosuximide can delay age-related changes and extend the lifespan of the nematode Caenorhabditis elegans." | 1.35 | The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan. ( Collins, JJ; Evason, K; Kornfeld, K; Pickett, CL; Schneider, DL, 2008) |
| "Ethosuximide was reliably effective against metrazol only in adult rats; in young animals it did not significantly change CD50s." | 1.27 | Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats. ( Mares, P; Velísek, L, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sang, L | 1 |
| Zheng, T | 1 |
| Min, L | 1 |
| Zhang, X | 1 |
| Ma, X | 1 |
| Entenman, S | 1 |
| Su, Y | 1 |
| Zheng, Q | 1 |
| Dezsi, G | 1 |
| Ozturk, E | 1 |
| Stanic, D | 1 |
| Powell, KL | 1 |
| Blumenfeld, H | 1 |
| O'Brien, TJ | 1 |
| Jones, NC | 1 |
| Tauffenberger, A | 1 |
| Julien, C | 1 |
| Parker, JA | 1 |
| Collins, JJ | 2 |
| Evason, K | 5 |
| Pickett, CL | 1 |
| Schneider, DL | 1 |
| Kornfeld, K | 5 |
| Huang, C | 1 |
| Yamben, I | 1 |
| Covey, DF | 1 |
| Hughes, SE | 1 |
| Xiong, C | 1 |
| Mares, P | 3 |
| Velísek, L | 1 |
| Morselli, PL | 1 |
| Franco-Morselli, R | 1 |
| Hvidberg, EF | 1 |
| Dam, M | 1 |
| Rane, A | 1 |
| Wilson, JT | 1 |
| Stanková, L | 1 |
| Maresová, D | 1 |
| Langmeier, M | 1 |
| Trojan, S | 1 |
| Charlton, MH | 1 |
| Yahr, MD | 1 |
3 reviews available for ethosuximide and Aging
| Article | Year |
|---|---|
Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans.
Topics: Aging; Animals; Anticonvulsants; Antioxidants; Blueberry Plants; Caenorhabditis elegans; Ethosuximid | 2006 |
Clinical pharmacokinetics of antiepileptic drugs in adults.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H | 1980 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
12 other studies available for ethosuximide and Aging
| Article | Year |
|---|---|
Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss.
Topics: Aging; Animals; Apoptosis; Calcium Channels, T-Type; Calcium Signaling; Cochlea; Ethosuximide; Heari | 2017 |
Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy.
Topics: Aging; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Body Weight; Brain; DNA (Cytosine-5-)-Me | 2013 |
Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.
Topics: Aging; Animals; Caenorhabditis elegans; Chromans; DNA-Binding Proteins; Ethosuximide; Longevity; Mot | 2013 |
The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan.
Topics: Aging; Amino Acid Sequence; Animals; Anticonvulsants; Caenorhabditis elegans; Caenorhabditis elegans | 2008 |
Anticonvulsant medications extend worm life-span.
Topics: Aging; Aldicarb; Animals; Anticonvulsants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; | 2005 |
Effects of anticonvulsant drugs on life span.
Topics: Aging; Animals; Anticonvulsants; Caenorhabditis elegans; Cell Survival; Cellular Senescence; Drug Ev | 2006 |
Genetic and pharmacological factors that influence reproductive aging in nematodes.
Topics: Aging; Animals; Caenorhabditis elegans; Disorders of Sex Development; Environment; Ethosuximide; Fem | 2007 |
Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Ethosuximide; Male; Pentylenetetrazole; Rats; Rats | 1983 |
Clinical pharmacokinetics in infants and children.
Topics: Aging; Body Water; Carbamazepine; Child; Child, Preschool; Clindamycin; Dextropropoxyphene; Diazoxid | 1976 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru | 1992 |
[The effect of ethosuximide on epileptic after-discharges induced by thalamic stimulation in young laboratory rats].
Topics: Aging; Animals; Electroencephalography; Epilepsy; Ethosuximide; Rats; Rats, Inbred Strains; Thalamus | 1990 |
Long-term follow-up of patients with petit mal.
Topics: Adolescent; Adult; Aging; Child; Electroencephalography; Epilepsy, Absence; Epilepsy, Tonic-Clonic; | 1967 |