ethisterone and Disorders-of-Sex-Development

Various changes that have been observed after intrauterine exposure to exogenous hormones are presented. Often, alterations observed after exogenous maternal hormone therapy consist of varying degrees of masculinization of the female genitalia. The following specific drug interactions are described in some detail: 1) effects of progestational agents and androgens on female genitalia; 2) relationship of corticosteroids to the development of cleft palate; and 3) effects of synthetic estrogens (e.g., diethylstilbestrol) on the female reproductive tract. The discussion closes with a review of the association of therapy with such drugs to the delayed appearance of clear-cell adenocarcinoma of the genital tract in young women.

Topics: Abnormalities, Drug-Induced; Adenocarcinoma; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Bone and Bones; Cleft Palate; Diethylstilbestrol; Disorders of Sex Development; Estrogens, Conjugated (USP); Ethinyl Estradiol; Ethisterone; Female; Fetus; Genital Neoplasms, Female; Gestational Age; Hormones; Humans; Infant, Newborn; Medroxyprogesterone; Mestranol; Methandrostenolone; Methyltestosterone; Norethindrone; Pregnancy; Pregnancy Complications; Progesterone; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adsorption; Adult; Chemistry, Clinical; Child; Child, Preschool; Cushing Syndrome; Disorders of Sex Development; Ethisterone; Female; Glucuronidase; Hirsutism; Humans; Infant; Magnesium; Methods; Pituitary-Adrenal Function Tests; Polycystic Ovary Syndrome; Pregnanetriol; Puberty, Precocious; Silicon Dioxide; Tetrazolium Salts