ethionamide has been researched along with Mycobacterium-Infections* in 36 studies
1 review(s) available for ethionamide and Mycobacterium-Infections
Article | Year |
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The treatment of infection due to "atypical" mycobacteria.
Topics: Aminosalicylic Acids; Collapse Therapy; Cycloserine; Ethambutol; Ethionamide; Humans; Isoniazid; Microbial Sensitivity Tests; Mycobacterium Infections; Pneumonectomy; Preoperative Care; Streptomycin; Viomycin | 1969 |
35 other study(ies) available for ethionamide and Mycobacterium-Infections
Article | Year |
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Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.
Spontaneous mutants of Mycobacterium tuberculosis that were resistant to the anti-tuberculosis drugs ethionamide and isoniazid were isolated and found to map to mshA, a gene encoding the first enzyme involved in the biosynthesis of mycothiol, a major low-molecular-weight thiol in M. tuberculosis. Seven independent missense or frameshift mutations within mshA were identified and characterized. Precise null deletion mutations of the mshA gene were generated by specialized transduction in three different strains of M. tuberculosis. The mshA deletion mutants were defective in mycothiol biosynthesis, were only ethionamide-resistant and required catalase to grow. Biochemical studies suggested that the mechanism of ethionamide resistance in mshA mutants was likely due to a defect in ethionamide activation. In vivo, a mycothiol-deficient strain grew normally in immunodeficient mice, but was slightly defective for growth in immunocompetent mice. Mutations in mshA demonstrate the non-essentiality of mycothiol for growth in vitro and in vivo, and provide a novel mechanism of ethionamide resistance in M. tuberculosis. Topics: Amino Acid Sequence; Animals; Antitubercular Agents; Bacterial Proteins; Catalase; Corynebacterium glutamicum; Cysteine; Drug Resistance, Bacterial; Ethionamide; Glycopeptides; Glycosyltransferases; Humans; Inositol; Isoniazid; Mice; Mice, Inbred C57BL; Mice, SCID; Microbial Sensitivity Tests; Mixed Function Oxygenases; Molecular Sequence Data; Mycobacterium Infections; Mycobacterium tuberculosis; Sequence Alignment; Sequence Deletion; Tuberculosis, Multidrug-Resistant | 2008 |
[Extrathoracic tuberculosis in Siberia and the Far East].
The incidence and pattern of extrathoracic tuberculosis in the Siberian and Far Eastern areas are analyzed. The statements are illustrated by two clinical cases. Topics: Adult; Antitubercular Agents; Catchment Area, Health; Ethionamide; Female; Humans; Male; Middle Aged; Mycobacterium Infections; Russia; Skin Diseases; Tuberculosis | 2005 |
Mycobacterium malmoense in the north-east of England.
We report a 6 year experience (1979-1984) of isolating Mycobacterium malmoense in the north-east of England. Eleven subjects were involved of whom 10 had active infection--9 pulmonary, one cervical adenitis. The 11 new isolates represent 0.7% of all new mycobacterial isolates during this period and 10% of new non-tuberculous isolates. In all but 2 cases there was pre-existing pulmonary disease and/or a recognised predisposing factor to mycobacterial infection. The organisms were generally insensitive to isoniazid but sensitive to both rifampicin and ethionamide. The results of chemotherapy are described. Topics: Adult; Drug Therapy, Combination; England; Ethionamide; Female; Humans; Infant; Lung Diseases; Lymphadenitis; Male; Middle Aged; Mycobacterium; Mycobacterium Infections; Rifampin; Tuberculosis, Pulmonary | 1985 |
[Experimental infections caused by atypical mycobacteria. 6. Experimental Mycobacterium fortuitum infection and trial chemotherapy].
Topics: Animals; Drug Evaluation, Preclinical; Ethionamide; Kanamycin; Male; Mice; Mycobacterium Infections; Mycobacterium Infections, Nontuberculous; Sulfisoxazole | 1983 |
[Atypical mycobacterial infection due to Mycobacterium fortuitum].
The case is presented of a 48-year-old woman who, in association with repeated septic temperatures, developed abscesses in the region of the right shoulder and in the right ankly. Histological examination from excisates revealed caseous tuberculoid granulomas. Mycobacterium fortuitum was isolated from the pus of both abscesses. Although the Mycobacterium fortuitum was resistant to nine commonly used tuberculostatics, it was found to be sensitive to ethionamide and capreomycine. The use of these two drugs in combination with local measures proved successful. Topics: Ankle; Capreomycin; Ethionamide; Female; Humans; Immobilization; Middle Aged; Mycobacterium; Mycobacterium Infections; Shoulder | 1978 |
Mycobacterium fortuitum infections: a review with two illustrative cases.
Two outbreaks of postoperative wound infections by organisms of the Mycobacterium fortuitum complex have focused attention on this notoriously drug resistant organism. In this report 2 cases are presented which developed infections with this organism, one of which responded to systemic antimicrobials despite discouraging in vitro sensitivities. Surgical debridement must remain the choice of treatment; however, systemic antibiotics may prove effective in some cases. Topics: Adult; Antitubercular Agents; Drug Resistance, Microbial; Ethambutol; Ethionamide; Humans; Isoniazid; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium; Mycobacterium Infections; Rifampin; Surgical Wound Infection | 1978 |
The pathogenicity of Mycobacterium fortuitum and Mycobacterium chelonei in man: a report of seven cases.
The clinical records of 7 patients referred to the National Jewish Hospital and Research Center over a 6-year period for evaluation of an abnormal chest x-ray and repeated sputum isolates of rapidly growing mycobacteria (Runyon's Group IV) were reviewed to determine the potential pathogenicity of these organisms. Mycobacterium fortuitum was isolated from 5 patients and Mycobacterium chelonei from 2. Haemoptysis, cough and weight loss were prominent in 6. Three had rheumatoid arthritis. Although two demonstrated cutaneous anergy, lymphocyte responsiveness to PHA was normal. PPD-F was not useful in skin testing or in the in vitro evaluation of lymphocyte function. Histologic examination of the lungs of 2 patients demonstrated caseating granulomata. One patient died of massive pulmonary haemorrhage soon after intiation of therapy. Multi-drug treatment regimens generally resulted in progressive sterilization of the sutum and improvement in the appearance of the chest x-ray. We conclude that some rapidly growing mycobacteria can cause potentially fatal cavitary lung disease and that intensive anti-tuberculosis therapy may successfully alter its course. Topics: Adult; Aged; Antitubercular Agents; Ethionamide; Female; Humans; Lung Diseases; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium; Mycobacterium Infections; Tetracycline | 1976 |
Clinical aspects of atypical mycobacterial infection.
Atypical mycobacterial infections may give rise to various clinical difficulties. Case reports of six patients--three adult patients with pulmonary lesions, two children with cervical lymphadentis and one patient in whom the atypical mycobacterium appeared to be present as a commensal--illustrate these difficulties. Determination of the significance of the organism and differentiation of condition from tuberculosis and others requires consideration of the clinical picture, the results of skin testing, histologic features and cultural characteristics. Three patients, including the two children, were treated with a combination of surgery and chemotherapy, with satisfactory results. An elderly patient with chronic bronchitis and a pulmonary infection due to M. kansasii was treated successfully with antiuberculosis agents alone. Chemotherapy is being tried on a fifth patient with cavitary disease due to M. intracellulare, but is seems likely that an operation will also be required. Topics: Adult; Aged; Child, Preschool; Cycloserine; Diagnosis, Differential; Ethambutol; Ethionamide; Female; Humans; Isoniazid; Lung; Lung Diseases; Lymph Nodes; Lymphadenitis; Male; Mycobacterium Infections; Skin Tests; Sputum; Tuberculosis, Pulmonary | 1975 |
Nontuberculous mycobacterial infections of man.
Topics: Capreomycin; Child; Drug Resistance, Microbial; Ethambutol; Ethionamide; Humans; Isoniazid; Kanamycin; Lung Diseases; Lymphadenitis; Mycobacterium; Mycobacterium Infections; Rifampin; Skin Diseases, Infectious; Sputum; Streptomycin | 1974 |
[Atypical mycobacterial infections with disseminated localisations].
Topics: Adolescent; Adult; Aged; Anemia; Biopsy; Blood Cell Count; Child; Child, Preschool; Cycloserine; Diagnosis, Differential; Ethionamide; Fever; Hepatomegaly; Humans; Infant; Leukocytosis; Middle Aged; Mycobacterium; Mycobacterium Infections; Skin Tests; Thrombocytopenia; Thrombocytosis | 1974 |
Thyroiditis due to Mycobacterium chelonei.
Topics: Abscess; Biopsy, Needle; Child, Preschool; Ethionamide; Female; Humans; Microbial Sensitivity Tests; Mycobacterium Infections; Thyroidectomy; Thyroiditis | 1974 |
A ten-year clinical experience with Mycobacterium kansasii.
Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Antitubercular Agents; Child; Cycloserine; Ethambutol; Ethionamide; Female; Follow-Up Studies; Humans; Isoniazid; Lung Diseases; Male; Middle Aged; Mycobacterium; Mycobacterium Infections; Pneumonectomy; Pyrazinamide; Rifampin; Sputum; Streptomycin | 1974 |
Permanently successful chemotherapy in two cases with severe pulmonary mycobacterial disease due to Mycobacterium kansasii and fortuitum, respectively.
Topics: Adult; Antitubercular Agents; Cycloserine; Drug Combinations; Drug Resistance, Microbial; Ethionamide; Female; Humans; Lung Diseases; Male; Mycobacterium; Mycobacterium Infections; Oxytetracycline; Tetracycline | 1972 |
Mycobacterium fortuitum infections involving the extremities. Report of three cases.
Topics: Adult; Amputation, Surgical; Amputation, Traumatic; Arm Injuries; Drainage; Drug Resistance, Microbial; Ethionamide; Humans; Isoniazid; Kanamycin; Leg Injuries; Male; Military Medicine; Mycobacterium Infections; Surgical Wound Infection; Tetracycline; Tuberculin Test; United States; Vietnam; Wound Infection | 1972 |
A new analogous model for the detection and evaluation of chemotherapeutic products effective in leprosy.
Topics: Aniline Compounds; Animals; Dapsone; Disease Models, Animal; Drug Combinations; Ethionamide; Humans; Isoniazid; Leprosy; Mice; Models, Biological; Mycobacterium Infections; Phenazines; Pyrazines; Rabbits; Rifampin; Sulfonamides; Trimethoprim | 1972 |
Pulmonary Mycobacterium scrofulaceum infection in a child.
Topics: Biopsy; Bronchoscopy; Child, Preschool; Diagnosis, Differential; Ethionamide; Female; Humans; Lung Diseases; Mycobacterium; Mycobacterium Infections; Rifampin; Tuberculosis, Pulmonary | 1972 |
Systemic chemotherapy in mice experimentally infected with Mycobacterium marinum.
Topics: Administration, Oral; Animals; Dapsone; Demeclocycline; Ethionamide; Female; Isoniazid; Mice; Mice, Inbred Strains; Mycobacterium Infections; Phenylthiourea; Pyrazines; Rifampin; Sulfonamides | 1971 |
Rifampin alone and combined with other drugs in Mycobacterium kansasii and Mycobacterium intracellulare infections of mice.
Topics: Animals; Drug Resistance, Microbial; Drug Synergism; Ethionamide; Female; Heart; Isoniazid; Kidney; Mice; Mice, Inbred Strains; Mycobacterium Infections; Rifampin; Streptomycin | 1971 |
Tropical fish aquariums. A source of Mycobacterium marinum infections resembling sporotrichosis.
Topics: Adult; Amphotericin B; Animals; Cycloserine; Diagnosis, Differential; Ethambutol; Ethionamide; Female; Fishes; Hobbies; Humans; Male; Middle Aged; Mycobacterium; Mycobacterium Infections; Skin; Skin Diseases, Infectious; Sporotrichosis; Vancomycin | 1970 |
[Effect of pyruvic acid on mycobacterial growth and antibiograms].
Topics: Acids; Anti-Bacterial Agents; Antitubercular Agents; Depression, Chemical; Ethionamide; Hydrogen-Ion Concentration; Mycobacterium; Mycobacterium Infections; Pyruvates; Stimulation, Chemical | 1970 |
[A case of left sub-maxillary and preauricular adenitis due to Battey's mycobacterium (M. intracellulare)].
Topics: Aminosalicylic Acids; Child; Drug Resistance, Microbial; Erythromycin; Ethionamide; Humans; Isoniazid; Lymphadenitis; Male; Mycobacterium; Mycobacterium Infections; Neck; Streptomycin | 1970 |
[Activity of Isoxyl on Mycobacterium kansasii; studies in vitro and in the pneumoconiotic guinea pig].
Topics: Administration, Oral; Animals; Body Weight; Drug Combinations; Ethambutol; Ethionamide; Guinea Pigs; Isoniazid; Lung; Mycobacterium; Mycobacterium Infections; Phenylthiourea; Pneumoconiosis; Radiography; Time Factors; Tuberculosis, Pulmonary | 1970 |
Experimental therapy with rifampicin.
Topics: Animals; Drug Combinations; Drug Resistance, Microbial; Ethambutol; Ethionamide; Isoniazid; Mice; Mycobacterium Infections; Phenylthiourea; Rifampin; Streptomycin; Time Factors; Tuberculosis | 1970 |
Studies on atypical mycobacteria. IX. Chemotherapy gainst exprimentally atypical mycobacteriosis of mice--experiments on Morita strain infection in mice.
Topics: Aminosalicylic Acids; Animals; Anti-Bacterial Agents; Cycloserine; Ethambutol; Ethionamide; Injections, Subcutaneous; Isoniazid; Kanamycin; Lung; Male; Mice; Mycobacterium Infections; Spleen; Streptomycin; Sulfonamides | 1969 |
Pulmonary disease due to Mycobacterium Kansasii. An analysis of some factors affecting prognosis.
Topics: Adult; Aged; Drug Resistance, Microbial; Ethionamide; Female; Hospitalization; Humans; Isoniazid; Lung Diseases; Male; Middle Aged; Mycobacterium; Mycobacterium Infections; Prognosis; Radiography; Sputum; Streptomycin | 1969 |
Mycobacterium kansasii in East Kent. A report of seven pulmonary infections with an environmental study.
Topics: Cycloserine; England; Environment; Ethionamide; Humans; Lung Diseases; Male; Middle Aged; Mycobacterium; Mycobacterium Infections; Pneumoconiosis; Pulmonary Emphysema; Radiography; Respiratory Tract Infections; Sputum; Tuberculin Test | 1969 |
Sporotrichoid cutaneous infection with Mycobacterium kansasii.
Topics: Adolescent; Aminosalicylic Acids; Diagnosis, Differential; Drug Resistance, Microbial; Ethambutol; Ethionamide; Female; Humans; Isoniazid; Male; Middle Aged; Mycobacterium; Mycobacterium Infections; Pyridoxine; Skin Diseases, Infectious; Sporotrichosis; Streptomycin | 1969 |
[Chemotherapy of so-called atypical mycobacterioses].
Topics: Animals; Antitubercular Agents; Cycloserine; Dapsone; Disease Models, Animal; Drug Synergism; Ethambutol; Ethionamide; Mice; Mycobacterium Infections; Phenylthiourea; Rabbits; Streptomycin; Thioacetazone | 1968 |
Fatal disseminated scotochromogenic mycobacteriosis in a child.
Topics: Bone Marrow; Candidiasis; Child, Preschool; Eczema; Ethionamide; Female; Humans; Kanamycin; Macrophages; Mononuclear Phagocyte System; Mycobacterium Infections; Prednisone; Thrombocytopenia; Tuberculin Test | 1967 |
Infection of synovial tissues by mycobacteria other than Mycobacterium tuberculosis.
Topics: Adult; Aged; Bursitis; Ethionamide; Female; Finger Joint; Humans; Joint Diseases; Male; Middle Aged; Mycobacterium Infections; Streptomycin; Synovitis; Tendinopathy; Tendons; Tuberculin Test; Wrist Joint | 1967 |
Activity of certain antibacillary substances in the experimental infection of guinea-pigs exposed to dust by Mycobacterium kansasii.
Topics: Animals; Coal; Dust; Ethambutol; Ethionamide; Guinea Pigs; Isoniazid; Lung Diseases; Mycobacterium; Mycobacterium Infections; Pneumoconiosis; Radiography | 1967 |
RECENT ADVANCES IN TREATMENT OF ORGAN TUBERCULOSIS.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Child; Cycloserine; Ethionamide; Isoniazid; Kanamycin; Mycobacterium Infections; Prednisone; Pyrazinamide; Streptomycin; Tuberculosis; Tuberculosis, Cardiovascular; Tuberculosis, Meningeal; Tuberculosis, Miliary; Tuberculosis, Osteoarticular; Tuberculosis, Pleural; Tuberculosis, Pulmonary; Tuberculosis, Urogenital; Viomycin | 1964 |
[THE CLINICAL ASPECTS OF ATYPICAL PULMONARY MYCOBACTERIOSIS].
Topics: Classification; Cycloserine; Drug Resistance; Drug Resistance, Microbial; Epidemiology; Ethionamide; Humans; Kanamycin; Lung Diseases; Microbiology; Mycobacterium; Mycobacterium Infections; Tuberculosis; Tuberculosis, Pulmonary | 1964 |
PULMONARY TUBERCULOSIS.
Topics: Adrenal Cortex Hormones; Aminosalicylic Acid; Aminosalicylic Acids; Child; Cycloserine; Drug Resistance; Drug Resistance, Microbial; Ethambutol; Ethionamide; Isoniazid; Kanamycin; Mycobacterium Infections; Pharmacology; Prognosis; Pyrazinamide; Streptomycin; Surgical Procedures, Operative; Thiosemicarbazones; Toxicology; Tuberculosis; Tuberculosis, Miliary; Tuberculosis, Pulmonary; Viomycin | 1964 |
MYCOBACTERIAL SKIN ULCERS IN UGANDA: DESCRIPTION OF A NEW MYCOBACTERIUM (MYCOBACTERIUM BURULI).
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Bacteriological Techniques; Biomedical Research; Diagnosis; Ethionamide; Isoniazid; Mice; Mycobacterium; Mycobacterium Infections; Mycobacterium ulcerans; Pharmacology; Phenazines; Skin Ulcer; Streptomycin; Thiosemicarbazones; Uganda; Viomycin | 1964 |