ethionamide and Liver-Diseases

The possible development of hepatotoxic effects as a result of high dosages of isoniazid, rifampin, pyrazinamide, and ethionamide was assessed in 56 young children (median age, 22 months) treated for severe tuberculous meningitis (TBM). Only one of the 56 children became jaundiced, probably as result of hepatitis A infection. Of 33 children observed for at least eight weeks, only five (15%) had normal serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase levels throughout, but in only three patients were AST or ALT values greater than 200 U/L, and enzyme levels tended to normalize toward the end of the period. In this group of 33 children, those at stage III TBM had higher enzyme levels than did those at stage II. The remaining 23 children were observed for a mean period of only four weeks, and 18 (75%) had at least one abnormal liver function test result.

Topics: Alanine Transaminase; Antitubercular Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Combinations; Ethionamide; gamma-Glutamyltransferase; Humans; Infant; Isoniazid; Liver Diseases; Pyrazinamide; Rifampin; Tuberculosis, Meningeal

Topics: Aminoglycosides; Anti-Bacterial Agents; Arsphenamine; Cephalosporins; Chemical and Drug Induced Liver Injury; Ethionamide; Humans; Japan; Liver Diseases; Penicillins; Thorium Dioxide

Topics: Alanine Transaminase; Amides; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Ethionamide; Humans; Isonicotinic Acids; Liver Diseases; Sulfides; Tablets, Enteric-Coated

Topics: Antitubercular Agents; Biopsy; Chemical and Drug Induced Liver Injury; Ethionamide; Humans; Liver Diseases; Necrosis; Pyrazinamide; Tuberculosis, Pulmonary

Topics: Adolescent; Adult; Age Factors; Alcoholism; Ethionamide; Female; Finland; Humans; Injections, Intravenous; Isoniazid; Liver Diseases; Male; Methods; Middle Aged; Phenotype; Phenylthiourea; Sex Factors; Spectrophotometry; Time Factors; Tuberculosis, Pulmonary

Topics: Bile Acids and Salts; Bilirubin; Biopsy; Chemical and Drug Induced Liver Injury; Ethionamide; Fatty Liver; Humans; Liver Diseases; Pyrazinamide; Transaminases; Tuberculosis, Miliary; Tuberculosis, Pulmonary

Topics: Animals; Carbon Tetrachloride; Cholinesterases; Clinical Enzyme Tests; Electrophoresis; Esterases; Ethionamide; Formates; Humans; Liver; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Male; Mice; Starch

Topics: Amyloidosis; Antitubercular Agents; Cycloserine; Deafness; Drug Hypersensitivity; Duodenal Ulcer; Ethionamide; Isoniazid; Kidney Diseases; Liver Diseases; Neuritis; Psychotic Disorders; Pyrazinamide; Toxicology; Tuberculosis; Tuberculosis, Pulmonary; Vertigo; Viomycin