Page last updated: 2024-08-17

ethinyl estradiol and Carcinoma, Hepatocellular

ethinyl estradiol has been researched along with Carcinoma, Hepatocellular in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	26 (61.90)	18.7374
1990's	9 (21.43)	18.2507
2000's	5 (11.90)	29.6817
2010's	1 (2.38)	24.3611
2020's	1 (2.38)	2.80

Authors

Authors	Studies
Kauffmann, HM; Schrenk, D	1
Heo, JH; Hong, EJ; Jeong, SH; Jo, SL; Ko, JW; Kwun, HJ; Lee, SR	1
Chen, H; Han, SJ; Jia, WD; Liu, WB; Ren, WH; Wang, W; Wang, YC; Xu, GL; Zhang, CH	1
Ankley, GT; Hornung, MW; Schmieder, PK	1
Bertrand, C; Etienne, PY; Gerard, R; Henrion, J; Mansvelt, B	1
Bianchi, L; Reichlin, B; Rüedi, T; Stalder, GA	1
Huang, SN; Lisbona, R; Mishkin, S; Steinbrecher, UP	1
Akobiantz, A; Altorfer, J; Bühler, H; Maranta, E; Pirovino, M; Schmid, M; Weitzel, M	1
Medline, A; Wanless, IR	1
Pees, HW; Uhl, UJ	1
Fritzemeier, KH; Hilgenfeldt, U; Knauthe, R; Krattenmacher, R; Parczyk, K; Walker, A	1
Ab, G; Calkhoven, CF; Snippe, L	1
Andersson-Ross, C; Barkhem, T; Höglund, M; Nilsson, S	1
Chen, J; Lavigne, JA; Li, Y; Trush, MA; Yager, JD	1
Di Pippo, VA; Kanamori, H; Krieg, S; Mao, C; Shapiro, DJ; Wang, S; Zajchowski, DA	1
Regidor, M; Regidor, PA; Schindler, EM; Speer, K	1
Browne-Martin, K; Longcope, C	1
Chan, CK; Detmer, DE	1
Barrows, G; Christopherson, WM; Mays, ET	1
Algaba, F; Autonell, J; Rius, X; Trias, R	1
Chan, SH; Oon, CJ; Yo, SL	1
Sternberg, SS; Sussman, EB	1
Bergqvist, A; Grabowski, M; Stenram, U	1
Davis, M; Portmann, B; Searle, M; Williams, R; Wright, R	1
Benton, B; Edmondson, HA; Henderson, B	1
Balázs, M; Gergely, R; Winkler, G	1
Balázs, M	1
Menzies-Gow, N	1
Kinch, R; Lough, J	1
Higashi, S; Mizumoto, R; Shimomura, M	1
Altmann, C; Wedig, MP	1
Higashi, S; Mizumoto, R; Yamagiwa, K	1
Breckwoldt, M; Quaas, L; Wilhelm, C; Zahradnik, HP	1
DeSchryver-Kecskemeti, K; Grigsby, P; Huggins, MB; Lamar, DJ; Meyer, JS; Sicard, GA	1
Black, WC; Bredfeldt, JE; Gyorffy, EJ	1
Azuma, T; Mizumoto, R	1
Hartmann, H; Siegel, EG	1
Ferrara, BE; Rutland, ED	1
Balslev, I; Christensen, M; Støckel, M	1
Baum, JK; Bookstein, JJ; Holtz, F; Klein, EW	1
Poel, WE	1
Baker, WH; McArthur, JW; Quinby, WC; Reiss, AM; Russfield, AB; Toll, GD	1

Trials

1 trial(s) available for ethinyl estradiol and Carcinoma, Hepatocellular

Article	Year
[Long-term side-effects following cyproterone acetate containing therapy in gynecology]. Zentralblatt fur Gynakologie, 2000, Volume: 122, Issue:5 Topics: Adult; Androgen Antagonists; Carcinoma, Hepatocellular; Cyproterone Acetate; Dose-Response Relationship, Drug; Drug Combinations; Ethinyl Estradiol; Female; Follow-Up Studies; Hirsutism; Humans; Liver Neoplasms; Risk Factors	2000

Other Studies

41 other study(ies) available for ethinyl estradiol and Carcinoma, Hepatocellular

Article	Year
Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochemical and biophysical research communications, 1998, Apr-17, Volume: 245, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Binding Sites; Carcinoma, Hepatocellular; Cisplatin; Clofibrate; Cloning, Molecular; Ethinyl Estradiol; Gene Expression Regulation, Neoplastic; Genes, MDR; Genes, Reporter; Phenobarbital; Rats; RNA, Messenger; Sequence Analysis, DNA; Transfection; Tumor Cells, Cultured	1998
Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin. International journal of molecular sciences, 2021, Nov-22, Volume: 22, Issue:22 Topics: Androgens; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Disease Progression; Ethinyl Estradiol; Humans; Liver Neoplasms; Male; Mice; Sex Characteristics; Sex Hormone-Binding Globulin	2021
Estrogen suppresses metastasis in rat hepatocellular carcinoma through decreasing interleukin-6 and hepatocyte growth factor expression. Inflammation, 2012, Volume: 35, Issue:1 Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Estrogens; Ethinyl Estradiol; Female; Hepatocyte Growth Factor; Interleukin-6; Liver Neoplasms, Experimental; Lung Neoplasms; Nitrosamines; Ovariectomy; Rats; Rats, Sprague-Dawley; Tumor Microenvironment	2012
Induction of an estrogen-responsive reporter gene in rainbow trout hepatoma cells (RTH 149) at 11 or 18 degrees C. Environmental toxicology and chemistry, 2003, Volume: 22, Issue:4 Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogens; Ethinyl Estradiol; Fulvestrant; Gene Expression Regulation; Genes, Reporter; Oncorhynchus mykiss; Receptors, Estrogen; Temperature; Tetrahydronaphthalenes	2003
Hepatocellular carcinoma associated with precocious puberty and oral contraceptives. A case report. Acta chirurgica Belgica, 2003, Volume: 103, Issue:4 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral, Hormonal; Estrogens; Ethinyl Estradiol; Female; Hepatectomy; Humans; Liver Neoplasms; Puberty, Precocious; Tomography, X-Ray Computed; Treatment Outcome	2003
[Co-occurring liver cell adenoma and focal nodular hyperplasia due to contraceptives. Case report]. Schweizerische medizinische Wochenschrift, 1980, May-31, Volume: 110, Issue:22 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral; Contraceptives, Oral, Combined; Contraceptives, Oral, Sequential; Ethinyl Estradiol; Female; Humans; Liver; Liver Neoplasms; Lynestrenol; Megestrol	1980
Complete regression of hepatocellular adenoma after withdrawal of oral contraceptives. Digestive diseases and sciences, 1981, Volume: 26, Issue:11 Topics: Adult; Carcinoma, Hepatocellular; Drug Combinations; Ethinyl Estradiol; Female; Humans; Liver Neoplasms; Neoplasm Regression, Spontaneous; Norgestrel; Time Factors	1981
Regression of liver cell adenoma. A follow-up study of three consecutive patients after discontinuation of oral contraceptive use. Gastroenterology, 1982, Volume: 82, Issue:4 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Ethinyl Estradiol; Female; Follow-Up Studies; Humans; Liver Neoplasms; Lynestrenol; Mestranol; Neoplasm Regression, Spontaneous; Norgestrel; Radionuclide Imaging; Time Factors	1982
Role of estrogens as promoters of hepatic neoplasia. Laboratory investigation; a journal of technical methods and pathology, 1982, Volume: 46, Issue:3 Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Diethylstilbestrol; Dose-Response Relationship, Drug; Drug Synergism; Ethinyl Estradiol; Female; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Models, Biological; Rats; Rats, Inbred F344; Sex Factors	1982
[Budd-Chiari syndrome, liver cell adenoma and polycythemia following contraceptives]. Die Medizinische Welt, 1983, Jun-24, Volume: 34, Issue:25-26 Topics: Adult; Budd-Chiari Syndrome; Carcinoma, Hepatocellular; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Ethinyl Estradiol; Female; Humans; Liver Neoplasms; Polycythemia	1983
Estrogen action on hepatic synthesis of angiotensinogen and IGF-I: direct and indirect estrogen effects. The Journal of steroid biochemistry and molecular biology, 1994, Volume: 48, Issue:2-3 Topics: Angiotensinogen; Animals; Base Sequence; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Estradiol; Ethinyl Estradiol; Female; Hypophysectomy; Insulin-Like Growth Factor I; Kinetics; Liver; Liver Neoplasms; Molecular Sequence Data; Organ Size; Ovariectomy; Rats; Rats, Wistar; RNA, Messenger; Tumor Cells, Cultured; Uterus	1994
Differential stimulation by CCAAT/enhancer-binding protein alpha isoforms of the estrogen-activated promoter of the very-low-density apolipoprotein II gene. European journal of biochemistry, 1997, Oct-01, Volume: 249, Issue:1 Topics: Animals; Apolipoproteins; Base Sequence; Binding Sites; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Chickens; DNA Probes; DNA-Binding Proteins; Estradiol Congeners; Estrogens; Ethinyl Estradiol; Female; Humans; In Vitro Techniques; Lipoproteins, VLDL; Nuclear Proteins; Promoter Regions, Genetic; Protein Binding; Receptors, Estrogen; Transcription Factors; Transfection; Tumor Cells, Cultured	1997
Characterization of the "estrogenicity" of tamoxifen and raloxifene in HepG2 cells: regulation of gene expression from an ERE controlled reporter vector versus regulation of the endogenous SHBG and PS2 genes. The Journal of steroid biochemistry and molecular biology, 1997, Volume: 62, Issue:1 Topics: Alkaline Phosphatase; Carcinoma, Hepatocellular; Clone Cells; Estradiol; Estradiol Congeners; Estrogen Antagonists; Ethinyl Estradiol; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Kinetics; Liver Neoplasms; Piperidines; Placenta; Pregnancy; Protein Biosynthesis; Proteins; Raloxifene Hydrochloride; Receptors, Estrogen; Recombinant Fusion Proteins; Sex Hormone-Binding Globulin; Tamoxifen; Tetradecanoylphorbol Acetate; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins	1997
Increased mitochondrial superoxide production in rat liver mitochondria, rat hepatocytes, and HepG2 cells following ethinyl estradiol treatment. Toxicological sciences : an official journal of the Society of Toxicology, 1999, Volume: 51, Issue:2 Topics: Animals; Carcinoma, Hepatocellular; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Cells, Cultured; Estradiol; Estradiol Congeners; Estrogen Receptor Modulators; Ethinyl Estradiol; Fulvestrant; Glutathione; Liver; Liver Neoplasms; Male; Mitochondria, Liver; Rats; Rats, Inbred F344; Superoxides; Tumor Cells, Cultured	1999
Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells. The Journal of biological chemistry, 2000, Feb-25, Volume: 275, Issue:8 Topics: Apoptosis; Base Sequence; Blotting, Northern; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Estrogen Antagonists; Estrogens; Ethinyl Estradiol; Gene Expression Regulation; Granzymes; Humans; Liver; Molecular Sequence Data; Promoter Regions, Genetic; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Serine Proteinase Inhibitors; Serpins; Time Factors; Transcription, Genetic; Tumor Cells, Cultured	2000
Regulation of sex hormone-binding globulin secretion in human hepatoma G2 cells. Steroids, 2001, Volume: 66, Issue:8 Topics: Antineoplastic Agents, Hormonal; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Estradiol; Estradiol Congeners; Estrone; Ethinyl Estradiol; Humans; Liver Neoplasms; Sex Hormone-Binding Globulin; Tamoxifen; Time Factors; Tumor Cells, Cultured	2001
Proper management of hepatic adenoma associated with oral contraceptives. Surgery, gynecology & obstetrics, 1977, Volume: 144, Issue:5 Topics: Adenoma; Adult; Carcinoma, Hepatocellular; Chlormadinone Acetate; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Dimethisterone; Ethinyl Estradiol; Ethynodiol Diacetate; Female; Humans; Liver Neoplasms; Mestranol; Norgestrel; Pregnancy	1977
Hepatocellular carcinoma in young women on oral contraceptives. Lancet (London, England), 1978, Jul-01, Volume: 2, Issue:8079 Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Estradiol Congeners; Ethinyl Estradiol; Female; Humans; Liver Neoplasms; Mestranol; Middle Aged	1978
Hepatocarcinoma and oral contraceptives. Lancet (London, England), 1978, Apr-15, Volume: 1, Issue:8068 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral; Ethinyl Estradiol; Female; Humans; Liver Neoplasms; Norgestrel	1978
Hepatocellular carcinoma in a patient on oral contraception who had been exposed to hepatitis B virus. Lancet (London, England), 1979, Jul-28, Volume: 2, Issue:8135 Topics: Adult; Antibodies, Viral; Carcinoma, Hepatocellular; Carrier State; Drug Combinations; Estradiol Congeners; Ethinyl Estradiol; Female; Hepatitis B; Hepatitis B Antibodies; Humans; Liver Neoplasms; Norethindrone	1979
Hereditary hemorrhagic telangiectasia. A case with hepatocellular carcinoma and acquired hepatocerebral degeneration. Archives of pathology, 1975, Volume: 99, Issue:2 Topics: Aged; Arteriovenous Malformations; Aspartate Aminotransferases; Autopsy; Blood Transfusion; Blood Urea Nitrogen; Brain; Carcinoma, Hepatocellular; Ethinyl Estradiol; Female; Hepatolenticular Degeneration; Humans; Iron-Dextran Complex; Liver; Liver Cirrhosis; Liver Neoplasms; Telangiectasia, Hereditary Hemorrhagic	1975
Focal nodular hyperplasia of the liver, benign hepatomas, oral contraceptives and other drugs affecting the liver. Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1975, Volume: 83, Issue:6 Topics: Adolescent; Adult; Aged; Barbiturates; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Child; Contraceptives, Oral; Ethinyl Estradiol; Female; Humans; Hydantoins; Hyperplasia; Liver; Liver Neoplasms; Lynestrenol; Male; Mestranol; Middle Aged	1975
Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives. British medical journal, 1975, Nov-29, Volume: 4, Issue:5995 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral; Ethinyl Estradiol; Female; Hepatectomy; Humans; Liver Neoplasms; Megestrol; Neoplasms, Multiple Primary	1975
Liver-cell adenomas associated with use of oral contraceptives. The New England journal of medicine, 1976, Feb-26, Volume: 294, Issue:9 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral; Ethinyl Estradiol; Female; Humans; Liver; Liver Neoplasms; Mestranol; Middle Aged; Risk; Time Factors	1976
[Primary liver cancer following prolonged use of contraceptive drugs]. Orvosi hetilap, 1977, Feb-06, Volume: 118, Issue:6 Topics: Adult; Carcinoma, Hepatocellular; Drug Combinations; Ethinyl Estradiol; Female; Humans; Liver; Liver Neoplasms; Mestranol; Norethynodrel	1977
Electron microscopic study of benign hepatoma in a patient on oral contraceptives. Beitrage zur Pathologie, 1976, Volume: 159, Issue:3 Topics: Adult; Capillaries; Carcinoma, Hepatocellular; Contraceptives, Oral; Ethinyl Estradiol; Female; Humans; Liver Neoplasms; Microscopy, Electron; Mitochondria; Norethynodrel	1976
Hepatocellular carcinoma associated with oral contraceptives. The British journal of surgery, 1978, Volume: 65, Issue:5 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral; Contraceptives, Oral, Combined; Ethinyl Estradiol; Female; Humans; Liver Neoplasms; Norethindrone	1978
Focal nodular hyperplasia of the liver and oral contraceptives. American journal of obstetrics and gynecology, 1978, Dec-01, Volume: 132, Issue:7 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Contraceptives, Oral, Synthetic; Ethinyl Estradiol; Female; Humans; Hyperplasia; Liver; Liver Neoplasms; Mestranol; Middle Aged; Norethindrone; Norgestrel	1978
32P-postlabeling analysis of DNA adducts in rats during estrogen-induced hepatocarcinogenesis and effect of tamoxifen on DNA adduct level. Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:5 Topics: Animals; Autoradiography; Carcinoma, Hepatocellular; DNA, Neoplasm; Estrogens; Ethinyl Estradiol; Female; Liver; Liver Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen	1992
[Hormonal contraception and focal nodular hyperplasia]. Zentralblatt fur Gynakologie, 1991, Volume: 113, Issue:24 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral, Hormonal; Ethinyl Estradiol; Ethinyl Estradiol-Norgestrel Combination; Female; Humans; Hyperplasia; Liver; Liver Neoplasms; Norgestrel; Precancerous Conditions; Risk Factors	1991
Effect of alcohol ingestion on carcinogenesis by synthetic estrogen and progestin in the rat liver. Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:7 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cell Nucleus; Cytosol; DNA; Estradiol Congeners; Ethanol; Ethinyl Estradiol; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Norethindrone; Norethindrone Acetate; Phosphorus Radioisotopes; Progestins; Rats; Rats, Inbred Strains; Receptors, Estrogen	1991
[Oral contraceptive-induced liver tumors and pregnancy]. Geburtshilfe und Frauenheilkunde, 1990, Volume: 50, Issue:10 Topics: Adenoma; Carcinoma, Hepatocellular; Contraceptives, Oral; Ethinyl Estradiol; Female; Humans; Liver; Liver Neoplasms; Mestranol; Pregnancy; Pregnancy Complications, Neoplastic; Prenatal Diagnosis	1990
Hepatic adenoma within a spindle cell carcinoma in a woman with a long history of oral contraceptives. Journal of surgical oncology, 1987, Volume: 35, Issue:3 Topics: Adult; alpha 1-Antitrypsin; Biopsy, Needle; Carcinoma; Carcinoma, Hepatocellular; Contraceptives, Oral, Combined; Ethinyl Estradiol; Female; Histocytochemistry; Humans; Keratins; Liver; Liver Neoplasms; Microscopy, Electron; Norethindrone; Time Factors	1987
Transformation of hepatic cell adenoma to hepatocellular carcinoma due to oral contraceptive use. Annals of internal medicine, 1989, Mar-15, Volume: 110, Issue:6 Topics: Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Contraceptives, Oral, Hormonal; Ethinyl Estradiol; Ethinyl Estradiol-Norgestrel Combination; Female; Humans; Liver Neoplasms; Middle Aged; Norgestrel; Precancerous Conditions	1989
[Synthetic female hormones-induced liver cancer]. Gan no rinsho. Japan journal of cancer clinics, 1989, Volume: Spec No Topics: Animals; Carcinoma, Hepatocellular; Contraceptives, Oral, Synthetic; Estradiol Congeners; Ethinyl Estradiol; Female; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Norethindrone; Norethindrone Acetate; Progesterone Congeners; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen	1989
[Spontaneous regression of a large liver tumor with markedly elevated serum enzyme levels]. Zeitschrift fur Gastroenterologie, 1987, Volume: 25, Issue:12 Topics: Adult; Carcinoma, Hepatocellular; Diagnosis, Differential; Enzymes; Ethinyl Estradiol; Ethinyl Estradiol-Norgestrel Combination; Female; Humans; Hyperplasia; Liver; Liver Function Tests; Liver Neoplasms; Neoplasm Regression, Spontaneous; Norgestrel; Tomography, X-Ray Computed; Ultrasonography	1987
Liver tumor in long-term user of oral contraceptives. Postgraduate medicine, 1988, Nov-01, Volume: 84, Issue:6 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral, Combined; Estrogens; Ethinyl Estradiol; Female; Hemorrhage; Humans; Liver Neoplasms; Norgestrel; Rupture, Spontaneous	1988
Liver-cell adenoma. Case report. Acta chirurgica Scandinavica, 1986, Volume: 152 Topics: Adult; Carcinoma, Hepatocellular; Contraceptives, Oral, Combined; Ethinyl Estradiol; Female; Humans; Levonorgestrel; Liver; Liver Neoplasms; Norgestrel; Radionuclide Imaging	1986
Possible association between benign hepatomas and oral contraceptives. Lancet (London, England), 1973, Oct-27, Volume: 2, Issue:7835 Topics: Adult; Angiography; Carcinoma, Hepatocellular; Contraceptives, Oral; Dimethisterone; Ethinyl Estradiol; Female; Follow-Up Studies; Hepatic Artery; Humans; Liver Neoplasms; Mestranol; Norethynodrel; Norgestrel	1973
Pituitary tumors in mice after prolonged feeding of synthetic progestins. Science (New York, N.Y.), 1966, Oct-21, Volume: 154, Issue:3747 Topics: Animals; Biological Assay; Carcinoma, Hepatocellular; Ethinyl Estradiol; Female; Liver Neoplasms; Mice; Norethindrone; Norethynodrel; Pituitary Neoplasms	1966
Sexual precocity attributable to ectopic gonadotropin secretion by hepatoblastoma. The American journal of medicine, 1973, Volume: 54, Issue:3 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Carcinoma, Hepatocellular; Child, Preschool; Dactinomycin; Estrogens; Ethinyl Estradiol; Gonadotropins; Hormones, Ectopic; Humans; Liver; Liver Neoplasms; Luteinizing Hormone; Male; Neutralization Tests; Puberty, Precocious; Testosterone	1973