Compounds > ethinyl estradiol
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ethinyl estradiol and Bile Duct Obstruction

ethinyl estradiol has been researched along with Bile Duct Obstruction in 118 studies

Research

Studies (118)

TimeframeStudies, this research(%)All Research%
pre-199052 (44.07)18.7374
1990's19 (16.10)18.2507
2000's20 (16.95)29.6817
2010's22 (18.64)24.3611
2020's5 (4.24)2.80

Authors

AuthorsStudies
Ananthanarayanan, M; Arrese, M; Boyer, JL; Keppler, D; Koeppel, TA; Schlosser, SF; Soroka, CJ; Suchy, FJ; Trauner, M1
Boyer, JL; Lee, JM; Meier, PJ; Soroka, CJ; Stieger, B; Trauner, M1
Huang, L; Meijer, DK; Smit, JW; Vore, M1
Arias, A; Banchio, C; Catania, VA; Mottino, AD; Rigalli, JP; Ruiz, ML; Villanueva, S; Vore, M1
Cai, H; Chen, X; Kong, WC; Wang, XZ; Xing, MT; Yu, ZX; Zhang, LY; Zou, MZ1
Lei, L; Li, Z; Ling, L; Liu, Y; Shao, Y; Xiong, Z1
Cai, H; Kong, W; Li, X; Wang, X; Zhang, L; Zhang, Y; Zou, M1
Liu, D; Song, H; Wu, T1
Masoud, MA; Mohamed, AH; Rizk, HA; Sayed, HM; Wadie, W1
Cermanova, J; Faistova, H; Faradonbeh, FA; Hroch, M; Lastuvkova, H; Micuda, S; Mokry, J; Nachtigal, P; Nova, Z; Pavek, P; Sa, II; Uher, M1
Brauers, K; Coonen, MLJ; Jennen, D; Kleinjans, JCS; Olde Damink, SWM; Schaap, FG; Van den Hof, WFPM; van Herwijnen, M1
Boatto, G; Burrai, L; Chegaev, K; Di Guida, F; Lama, A; Lazzarato, L; Magliocca, S; Meli, R; Mollica, MP; Nieddu, M; Pirozzi, C; Raso, GM; Rimoli, MG; Russo, R; Santoro, A; Sodano, F1
Chi, HY; Choi, MK; Choi, YA; Kang, YJ; Kim, MJ; Kwon, M; Shim, CK; Song, IS; Yoo, HH1
Choi, YH; Lee, MG; Lee, YK1
Kučerová, V; Leníček, M; Muchová, L; Petr, T; Smíd, F; Smíd, V; Váňová, K; Vítek, L1
Cai, HJ; Chang, MJ; Li, XP; Liu, D; Wu, T; Xu, YJ; Zhang, CL1
Lehmann, GL; Marinelli, RA; Marrone, J; Molinas, S; Pellegrino, JM; Soria, LR1
Cerny, D; Dolezelova, E; Farghali, H; Fuksa, L; Lenicek, M; Micuda, S; Muchova, L; Suk, J; Vanova, K; Vitek, L; Vreman, HJ; Wong, RJ; Zelenkova, M1
Chen, X; Huo, X; Liu, K; Liu, Q; Liu, Z; Meng, Q; Sun, H; Sun, P; Wang, C; Yao, J1
Gore, E; Groothuis, GM; Olinga, P; Pennings, JL; Vatakuti, S1
Danielli, M; Larocca, MC; Lehmann, GL; Marinelli, RA; Marrone, J; Soria, LR1
Chen, X; Hylemon, PB; Jiang, Z; Li, X; Liu, R; Luo, L; Sun, L; Wang, T; Yu, L; Zhang, L; Zhou, H1
Groothuis, GMM; Olinga, P; Pennings, JLA; Vatakuti, S1
Chen, H; Hu, Y; Wang, X; Yu, P; Zhou, F1
Hassan, HM; Jiang, Z; Li, X; Liu, R; Sun, R; Yang, H; Yuan, Z; Zhang, L1
Jiang, Z; Li, X; Liu, X; Yang, H; Yu, L; Yuan, Z; Zhang, L1
Banárová, A; Koller, T; Kollerová, J; Ondrias, F; Payer, J1
Choi, MK; Chung, SJ; Hong, SS; Jin, HE; Kim, DD; Maeng, HJ; Shim, CK1
Hu, Y; Huang, X; Jiang, ZZ; Liu, L; Shang, J; Wang, JY; Wang, T; Zhang, LY; Zhang, S; Zhang, Y; Zhou, ZX; Zhu, D1
Cermanova, J; Cervinkova, Z; Dolezelova, E; Hirsova, P; Hroch, M; Kadova, Z; Karlasova, G; Kucera, O; Lenicek, M; Micuda, S; Pavek, P; Sispera, L; Tomsik, P; Vitek, L; Zagorova, M1
Hussein, MA1
Isoherranen, N; Thummel, KE1
Emmanuel, J; Micheline, D; Serge, E1
Dietrich, CG; Gartung, C; Geier, A; Gerloff, T; Haendly, J; Kullak-Ublick, GA; Matern, S; Meier, PJ; Stieger, B1
Catania, VA; Crocenzi, FA; Luquita, MG; Mottino, AD; Pellegrino, JM; Rodríguez Garay, EA; Roma, MG; Sánchez Pozzi, EJ1
Chang, P; Hung, DY; Roberts, MS; Siebert, GA1
Catania, VA; Crocenzi, FA; D'Andrea, V; Luquita, MG; Mottino, AD; Ochoa, JE; Pellegrino, JM; Sánchez Pozzi, EJ1
Asciutti, S; Baldoni, M; Camaioni, E; Castellani, D; Clementi, M; Clerici, C; Fiorucci, S; Giuliano, V; Mazzocchi, A; Morelli, A; Morelli, O; Nardi, E; O'Connell, NC; Orlandi, S; Pellicciari, R; Renga, B; Sabatino, G; Sadeghpour, B; Setchell, KD1
Catania, VA; Crocenzi, FA; Luquita, MG; Mottino, AD; Pellegrino, JM; Pozzi, EJ; Roma, MG1
Cowan, A; Inan, S1
Axelson, M; Fernández-Pérez, L; Flores-Morales, A; Henríquez-Hernández, LA; Nilsson, P; Norstedt, G; Santana-Farré, R1
Calamita, G; Carreras, FI; Ferri, D; Lehmann, GL; Marinelli, RA; Tioni, MF1
Chamorro, G; Garduño-Siciliano, L; Labarrios, F; Moreno, MG; Muriel, P; Tamariz, J1
Dráber, P; Jirkovská, M; Majer, F; Marecek, Z; Shaik, GM; Smíd, F; Smídová, J; Stríteský, J; Vítek, L1
Jirkovská, M; Majer, F; Marecek, Z; Smíd, F; Trnka, L; Vítek, L1
Jeffries, GH; Kreek, MJ; Sleisenger, MH1
Coleman, R; Elias, E; Hickey, A; Iqbal, S; Knutton, S1
Elson, MK; Goodman, M; Knodell, RG; Shafer, RB; Stanley, LN1
Schachter, D; Storch, J1
Chiarantini, E1
Brock, WJ; Durham, S; Vore, M1
Hart, FE; Hew, JT; Willson, RA1
LaRusso, NF; Lopez del Pino, VH1
Hadd, H; Slikker, W; Vore, M1
Jaeschke, H; Krell, H; Pfaff, E1
Barsacchi, P; Sardelli, G; Subissi, A1
Killenberg, PG; Kirkpatrick, RB1
Arena, U; Chiarantini, E; Chieca, R; Coletta, D; Gentilini, P; Mazzanti, R; Orlandini, F1
Balazs, T; Boelsterli, UA; Idris, A; Kotik, H1
Balistreri, WF; Olinger, EJ; Ostrow, JD; Tarao, K1
Holtermann, M; Reimold, WV1
Di Padova, C; Dioguardi, ML; Festorazzi, S; Podda, M; Zuin, M1
Dioguardi, ML; Festorazzi, S; Podda, M; Zuin, M1
De Vos, R; Desmet, V1
Hellman, L; Rosenfeld, RS; Zumoff, B1
Di Padova, C; Rovagnati, P; Tritapepe, R1
Di Padova, C; Galli-Kienle, M; Gualano, M; Rovagnati, P; Stramentinoli, G1
Accatino, L; Arrese, M; Koenig, C; Pizarro, M; Solís, N1
Accatino, L; Figueroa, C; Pizarro, M; Solís, N1
Thibault, N1
Bygrave, FL; Hamada, Y; Karjalainen, A2
Eckfeldt, J; Levitt, MD; Pieper-Bigelow, C1
Bouchard, G; Tuchweber, B; Yousef, IM1
Dumont, M; Erlinger, S; Jacquemin, E; Mallet, A1
Bossard, R; Fricker, G; Meier, PJ; O'Neill, B; Stieger, B1
Anderson, JM1
Accatino, L; Chianale, J; Koenig, CS; Pizarro, M; Solís, N; Vollrath, V1
Fortune, J; Gartung, C; Iwahashi, M; Simon, FR; Sutherland, E; Wolkoff, A1
Alvaro, D; Attili, AF; Capocaccia, L; Carli, L; Fraioli, F; Francia, C; Gigliozzi, A; Piat, C; Romeo, R1
Moseley, RH1
Havinga, R; Jansen, PL; Koopen, NR; Kuipers, F; Müller, M; Vonk, RJ; Wolters, H1
Kuyama, Y; Sano, N; Takamori, Y; Takikawa, H; Yamanaka, M1
Almar, M; Collado, PS; Cuevas, MJ; González-Gallego, J; Mauriz, JL1
Coleman, R; Crocenzi, FA; Favre, CO; Mottino, AD; Pellegrino, JM; Rodríguez Garay, EA; Roma, MG; Sánchez Pozzi, EJ1
Almar, M; Cuevas, MJ; González-Gallego, J1
Frezza, M; Parco, S; Piccinini, C; Tiribelli, C1
Boyer, JL; Elias, E1
Mackinnon, M; Simon, F1
Berk, PD; Javitt, NB1
Hirano, Y; Naito, K; Ohashi, K; Yamamoto, S; Yamashita, S1
Holzbach, RT1
Davis, RA; Jensen, RT; Kern, F1
Curstedt, T; Eriksson, H; Kern, F; Sjövall, J1
Boyer, JL; Layden, TJ1
Bradley, SE; Herz, R1
Grabner, G; Horak, W1
Lunazzi, G; Rodriguez, JV; Tiribelli, C; Torres, AM1
Duane, WC; Eckfeldt, JH; Furne, J; Hillstrom, J; Levitt, MD1
Corsi, R; Gazzin, B; Lunazzi, GC; Miccio, M; Orzes, N; Tiribelli, C1
Baker, PR; Siow, YF; Vitale, GC1
Gordon, ER; Smith, DJ1
Goldsmith, MA; Jones, AL; Schiff, JM; Underdown, BJ1
Cantoni, L; Dal Fiume, D; Di Padova, C; Graziani, A; Rizzardini, M; Rovagnati, P; Tritapepe, R1
Elias, E; Iqbal, S; Mills, CO2
Ekelund, P1
Arias, IM; Simon, FR1
Berthelot, P; Dhumeaux, D; Metreau, JM1
Accatino, L; Contreras, A; Gumucio, JJ; Macho, AM1
Elgee, NJ1
Arias, IM; Gatmaitan, Z; Levi, AJ; Reyes, H1
Beermann, B; Ericsson, JL; Hellström, K; Wengle, B; Werner, B1
Watanabe, H1
Baskir, S; Erek, E; Gürakar, M; Ucak, A1
Pihl, E; Rais, O; Zeuchner, E1
Fritsch, H; Kaess, H2

Reviews

6 review(s) available for ethinyl estradiol and Bile Duct Obstruction

ArticleYear
Crosstalk between calcium- and cyclic AMP-mediated signalling systems and the short-term modulation of bile flow in normal and cholestatic rat liver.
    Cellular signalling, 1994, Volume: 6, Issue:1

    Topics: Animals; Bile; Calcium; Cholestasis; Cyclic AMP; Ethinyl Estradiol; Glucagon; Liver; Rats; Signal Transduction; Vasopressins

1994
Mechanisms of intrahepatic cholestasis.
    Progress in liver diseases, 1979, Volume: 6

    Topics: Animals; Bile; Bile Acids and Salts; Cell Membrane Permeability; Chlorpromazine; Cholestasis; Cytoskeleton; Disease Models, Animal; Ethinyl Estradiol; Haplorhini; Humans; Infant; Infant, Newborn; Macaca mulatta; Rats

1979
Hyperbilirubinemia and cholestasis.
    The American journal of medicine, 1978, Volume: 64, Issue:2

    Topics: Animals; Bile Acids and Salts; Bilirubin; Binding Sites; Cholestasis; Ethinyl Estradiol; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Liver; Protein Binding; Proteins; Syndrome

1978
Jaundice in pregnancy--1976.
    The American journal of medicine, 1976, Volume: 61, Issue:3

    Topics: Anabolic Agents; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptives, Oral, Synthetic; Estradiol Congeners; Ethinyl Estradiol; Fatty Liver; Female; Hepatitis A; Hepatitis B; Humans; Jaundice; Liver; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Progesterone Congeners; Recurrence; Reye Syndrome

1976
Oral contraceptives and the liver.
    Digestion, 1972, Volume: 7, Issue:5

    Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Cholestasis; Contraceptives, Oral; Enzyme Induction; Ethinyl Estradiol; Female; Humans; Jaundice; Liver; Liver Function Tests; Menopause; Mestranol; Pregnancy; Pregnancy Complications; Progestins; Pruritus; Recurrence; Structure-Activity Relationship; Sulfobromophthalein; Thymol

1972
Medical aspects of oral contraceptives.
    Annals of internal medicine, 1970, Volume: 72, Issue:3

    Topics: Adrenal Glands; Amenorrhea; Blood Glucose; Blood Pressure; Candidiasis, Vulvovaginal; Carbohydrate Metabolism; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptives, Oral; Diabetes Complications; Ethinyl Estradiol; Eye Diseases; Female; Humans; Hypertension; Hypothyroidism; Lipids; Liver Function Tests; Lupus Erythematosus, Systemic; Mestranol; Pituitary-Adrenal Function Tests; Pregnancy; Pregnancy Complications; Pregnancy in Diabetics; Retinal Vessels; Skin Diseases; Thromboembolism; Thrombosis; Thyroid Function Tests; Thyroid Gland; Uterine Cervical Diseases

1970

Other Studies

112 other study(ies) available for ethinyl estradiol and Bile Duct Obstruction

ArticleYear
The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis.
    Gastroenterology, 1997, Volume: 113, Issue:1

    Topics: Animals; ATP-Binding Cassette Transporters; Bile Canaliculi; Blotting, Northern; Blotting, Western; Cholestasis; Cholestasis, Intrahepatic; Common Bile Duct; Down-Regulation; Drug Resistance, Multiple; Ethinyl Estradiol; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Lipopolysaccharides; Male; Multidrug Resistance-Associated Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger

1997
Expression of the bile salt export pump is maintained after chronic cholestasis in the rat.
    Gastroenterology, 2000, Volume: 118, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Bile Ducts; Carrier Proteins; Cholestasis; Chronic Disease; Drug Resistance, Multiple; Ethinyl Estradiol; Ligation; Lipopolysaccharides; Membrane Proteins; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Dependent; Rats; Rats, Sprague-Dawley; RNA, Messenger; Symporters

2000
Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats.
    Hepatology (Baltimore, Md.), 2000, Volume: 32, Issue:1

    Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cholestasis; Estradiol; Male; Multidrug Resistance-Associated Proteins; Rats; Rats, Sprague-Dawley; Rats, Wistar; Taurocholic Acid

2000
Induction of hepatic multidrug resistance-associated protein 3 by ethynylestradiol is independent of cholestasis and mediated by estrogen receptor.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:2

    Topics: Animals; Bile; Bile Acids and Salts; Cells, Cultured; Cholestasis; Dactinomycin; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Ethinyl Estradiol; Fulvestrant; Glutathione; Liver; Male; Multidrug Resistance-Associated Proteins; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Primary Cell Culture; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA, Messenger; Time Factors; Up-Regulation

2013
Activation of natural killer T cells contributes to Th1 bias in the murine liver after 14 d of ethinylestradiol exposure.
    World journal of gastroenterology, 2022, Jul-14, Volume: 28, Issue:26

    Topics: Animals; Cholestasis; Cholestasis, Intrahepatic; Ethinyl Estradiol; Female; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Pregnancy

2022
Resveratrol modulates the gut microbiota of cholestasis in pregnant rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2022, Volume: 73, Issue:2

    Topics: Alanine; Alanine Transaminase; Animals; Aspartic Acid; Bile Acids and Salts; Cholestasis; Cholestasis, Intrahepatic; Dysbiosis; Ethinyl Estradiol; Female; Gastrointestinal Microbiome; Glutamates; Pregnancy; Pregnancy Complications; Rats; Resveratrol; RNA, Ribosomal, 16S; Ursodeoxycholic Acid

2022
iNKT17 cells play a pathogenic role in ethinylestradiol-induced cholestatic hepatotoxicity.
    Archives of toxicology, 2023, Volume: 97, Issue:2

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Ethinyl Estradiol; Interleukin-17; Mice; Mice, Inbred C57BL; Mice, Knockout; Natural Killer T-Cells; Nuclear Receptor Subfamily 1, Group F, Member 3

2023
Calculus Bovis Sativus up-regulates hepatic protein 2 (Mrp2) and Mrp4 in 17α-ethynylestradiol-induced cholestasis via a regulatory effect on ER signaling.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2019, Volume: 39, Issue:3

    Topics: Animals; ATP-Binding Cassette Transporters; Cholestasis; Drugs, Chinese Herbal; Endoplasmic Reticulum; Ethinyl Estradiol; Liver; Male; Multidrug Resistance-Associated Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Up-Regulation

2019
Protective impact of lycopene on ethinylestradiol-induced cholestasis in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:3

    Topics: Albumins; Animals; Cholestasis; Ethinyl Estradiol; Glutathione; Liver; Lycopene; Male; Peroxidase; Protective Agents; Rats, Wistar; Silymarin; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha

2021
Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice.
    Chemico-biological interactions, 2021, Aug-25, Volume: 345

    Topics: Animals; Bile Acids and Salts; Cholestasis; Ethinyl Estradiol; Female; Hepatocytes; Homeostasis; Intestinal Absorption; Metformin; Mice; Mice, Inbred C57BL

2021
Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.
    Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 44

    Topics: Animals; Bile Acids and Salts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Cyclosporine; Ethinyl Estradiol; Hep G2 Cells; Hepatocytes; Humans; Liver; Mice; Transcriptome

2017
Galactosylated Pro-Drug of Ursodeoxycholic Acid: Design, Synthesis, Characterization, and Pharmacological Effects in a Rat Model of Estrogen-Induced Cholestasis.
    Molecular pharmaceutics, 2018, 01-02, Volume: 15, Issue:1

    Topics: Animals; Cholestasis; Cyclooxygenase 2; Estrogens; Ethinyl Estradiol; Hep G2 Cells; Humans; Interleukin-1beta; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Prodrugs; Rats; Rats, Wistar; Solubility; Tumor Necrosis Factor-alpha; Ursodeoxycholic Acid

2018
Ursodeoxycholate Restores Biliary Excretion of Methotrexate in Rats with Ethinyl Estradiol Induced-Cholestasis by Restoring Canalicular Mrp2 Expression.
    International journal of molecular sciences, 2018, Apr-09, Volume: 19, Issue:4

    Topics: Administration, Oral; Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis; Down-Regulation; Drug Administration Schedule; Ethinyl Estradiol; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Rats; Treatment Outcome; Ursodeoxycholic Acid

2018
Effects of 17α-ethynylestradiol-induced cholestasis on the pharmacokinetics of doxorubicin in rats: reduced biliary excretion and hepatic metabolism of doxorubicin.
    Xenobiotica; the fate of foreign compounds in biological systems, 2013, Volume: 43, Issue:10

    Topics: Administration, Intravenous; Animals; Antibiotics, Antineoplastic; Area Under Curve; Bile; Cholestasis; Cytochrome P-450 CYP3A; Doxorubicin; Drug Interactions; Ethinyl Estradiol; Female; Liver; Microsomes, Liver; Rats; Rats, Sprague-Dawley

2013
The effect of heme oxygenase on ganglioside redistribution within hepatocytes in experimental estrogen-induced cholestasis.
    Physiological research, 2014, Volume: 63, Issue:3

    Topics: Animals; Antioxidants; Cholestasis; Disease Models, Animal; Enzyme Activation; Ethinyl Estradiol; Female; G(M1) Ganglioside; Heme Oxygenase (Decyclizing); Hepatocytes; Rats, Wistar

2014
Beneficial effect of Calculus Bovis Sativus on 17α-ethynylestradiol-induced cholestasis in the rat.
    Life sciences, 2014, Sep-15, Volume: 113, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Cholestasis; Cholic Acid; Ethinyl Estradiol; Gallstones; Male; Malondialdehyde; Medicine, Chinese Traditional; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase; Time Factors

2014
Adenoviral transfer of human aquaporin-1 gene to rat liver improves bile flow in estrogen-induced cholestasis.
    Gene therapy, 2014, Volume: 21, Issue:12

    Topics: Adenoviridae; Alanine Transaminase; Alkaline Phosphatase; Animals; Aquaporin 1; Aquaporins; Aspartate Aminotransferases; Bile; Cholestasis; Disease Models, Animal; Down-Regulation; Estrogens; Ethinyl Estradiol; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Hepatocytes; Humans; Hydro-Lyases; Liver; Male; Rats; Rats, Wistar

2014
Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis.
    Journal of cellular and molecular medicine, 2015, Volume: 19, Issue:5

    Topics: Alkaline Phosphatase; Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Bilirubin; Cells, Cultured; Cholestasis; Enzyme Induction; Ethinyl Estradiol; Female; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Hepatocytes; Multidrug Resistance-Associated Proteins; Primary Cell Culture; Protective Agents; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Taurocholic Acid

2015
Protective Effects of Alisol B 23-Acetate Via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Estrogen-Induced Cholestatic Liver Injury in Mice.
    Pharmaceutical research, 2015, Volume: 32, Issue:11

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Cholestasis; Cholestenones; Cholesterol 7-alpha-Hydroxylase; Disease Models, Animal; Ethinyl Estradiol; Hepatocytes; Liver Function Tests; Male; Membrane Transport Proteins; Mice, Inbred C57BL; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Dependent; Primary Cell Culture; Receptors, Cytoplasmic and Nuclear; Steroid 12-alpha-Hydroxylase; Symporters

2015
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
    Chemical research in toxicology, 2016, Mar-21, Volume: 29, Issue:3

    Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis; Colchicine; Cyclosporine; Diethylnitrosamine; Drug-Related Side Effects and Adverse Reactions; Ethinyl Estradiol; Female; Gene Expression Profiling; Hepatocytes; Humans; Liver; Male; Methyltestosterone; Middle Aged; Necrosis; Phenotype; Toxicogenetics; Young Adult

2016
Hepatic gene transfer of human aquaporin-1 improves bile salt secretory failure in rats with estrogen-induced cholestasis.
    Hepatology (Baltimore, Md.), 2016, Volume: 64, Issue:2

    Topics: Animals; Aquaporin 1; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Bile Canaliculi; Cholestasis; Ethinyl Estradiol; Genetic Therapy; Hepatocytes; Humans; Male; Rats, Wistar

2016
Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats.
    Archives of toxicology, 2017, Volume: 91, Issue:1

    Topics: Active Transport, Cell Nucleus; AMP-Activated Protein Kinases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cells, Cultured; Cholestasis; Cyclic AMP; Disease Models, Animal; Enzyme Activation; Estrogens; Ethinyl Estradiol; Hepatocytes; Male; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Random Allocation; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA Interference; Second Messenger Systems

2017
Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.
    Archives of toxicology, 2017, Volume: 91, Issue:3

    Topics: 1-Naphthylisothiocyanate; Aged; Chlorpromazine; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Gene Expression Profiling; Humans; Liver; Male; Methyltestosterone; Middle Aged; Signal Transduction; Transcriptome; Young Adult

2017
Hypoxia-induced regulation of placental REDD1 and mTOR was impaired in a rat model of estrogen-induced cholestasis.
    Archives of gynecology and obstetrics, 2016, Volume: 294, Issue:6

    Topics: Animals; Cholestasis; Disease Models, Animal; Ethinyl Estradiol; Female; Glucose; Hypoxia-Inducible Factor 1, alpha Subunit; Placenta; Pregnancy; Rats; Rats, Sprague-Dawley; Reperfusion; TOR Serine-Threonine Kinases; Transcription Factors

2016
UDCA and CDCA alleviate 17α-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats.
    Toxicology and applied pharmacology, 2016, Nov-15, Volume: 311

    Topics: Adenylate Kinase; Animals; Carrier Proteins; Cells, Cultured; Chenodeoxycholic Acid; Cholestasis; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Ethinyl Estradiol; Female; Male; Membrane Glycoproteins; Phosphorylation; Pregnancy; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Ursodeoxycholic Acid

2016
Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury.
    Toxicology letters, 2016, Dec-15, Volume: 264

    Topics: Animals; Anti-Inflammatory Agents; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Ethinyl Estradiol; Gene Expression; Hepatocyte Nuclear Factor 1-alpha; Heterocyclic Compounds, 4 or More Rings; Liver; Male; Mice; Mice, Inbred C57BL; Primary Cell Culture; Protective Agents; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering; Signal Transduction

2016
[Acute cholestasis following treatment with nimesulide and oral contraception: case report and review].
    Vnitrni lekarstvi, 2008, Volume: 54, Issue:6

    Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cholestasis; Contraceptives, Oral, Synthetic; Cyclooxygenase Inhibitors; Drug Interactions; Ethinyl Estradiol; Female; Humans; Liver; Norgestrel; Sulfonamides

2008
Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis.
    Pharmaceutical research, 2009, Volume: 26, Issue:3

    Topics: Animals; Blood Proteins; Blotting, Western; Catecholamine Plasma Membrane Transport Proteins; Cholestasis; Chromatography, High Pressure Liquid; Down-Regulation; Ethinyl Estradiol; Glucose; Glucose Tolerance Test; Hepatocytes; Hypoglycemic Agents; Injections, Intravenous; Liver; Male; Metabolic Clearance Rate; Metformin; Protein Binding; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substrate Specificity; Tissue Distribution

2009
Beneficial effects of colchicine on 17alpha-ethynylestradiol-induced cholestasis in rats.
    Arzneimittel-Forschung, 2011, Volume: 61, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biological Transport, Active; Blotting, Western; Body Weight; Cholestasis; Cholesterol 7-alpha-Hydroxylase; Colchicine; Enzymes; Estradiol Congeners; Ethinyl Estradiol; Gout Suppressants; Liver; Male; Organ Size; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear

2011
Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2.
    Toxicology, 2013, Jan-07, Volume: 303

    Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Catechin; Cholestasis; Cholestenones; Cholesterol 7-alpha-Hydroxylase; Down-Regulation; Ethinyl Estradiol; Female; Glutathione; Hepatocytes; Homeostasis; Ileum; Permeability; Rats; Rats, Wistar; Up-Regulation

2013
Prophylactic effect of resveratrol against ethinylestradiol-induced liver cholestasis.
    Journal of medicinal food, 2013, Volume: 16, Issue:3

    Topics: Animals; Antioxidants; Bile Acids and Salts; Bilirubin; Cholestasis; Cholesterol; Ethinyl Estradiol; Female; Hepatocytes; Liver; Liver Diseases; Malondialdehyde; Nitric Oxide; Phytotherapy; Plant Extracts; Rats; Rats, Inbred Strains; Resveratrol; Stilbenes; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha

2013
Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:2

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adrenal Glands; Animals; Aryldialkylphosphatase; ATP-Binding Cassette Transporters; Carboxylesterase; Cholestasis; Cotinine; Cytochrome P-450 Enzyme System; Estradiol; Estrogen Receptor alpha; Estrogens; Ethinyl Estradiol; Female; Fetus; Gene Expression Regulation, Developmental; Glucuronosyltransferase; Hepatocytes; Humans; Hydroxyprogesterones; Intestine, Small; Kidney; Liver; Lung; Male; Maternal Behavior; Membrane Transport Proteins; Minor Histocompatibility Antigens; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Pesticides; Placenta; Pregnancy; Progesterone; Retinoic Acid 4-Hydroxylase; RNA, Messenger; Smoking; Taurocholic Acid

2013
Effect of Ursodeoxycholic Acid on the Expression of the Hepatocellular Bile Acid Transporters (Ntcp and bsep) in Rats With Estrogen-Induced Cholestasis.
    Journal of pediatric gastroenterology and nutrition, 2002, Volume: 35, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biological Transport, Active; Carrier Proteins; Cholestasis; Estradiol Congeners; Ethinyl Estradiol; Glutathione; Hydroxysteroid Dehydrogenases; Immunoblotting; Male; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters, Sodium-Dependent; Rats; Rats, Sprague-Dawley; RNA, Messenger; Symporters; Ursodeoxycholic Acid

2002
Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat.
    Biochimica et biophysica acta, 2003, Jan-10, Volume: 1609, Issue:1

    Topics: Animals; Base Sequence; Basement Membrane; Blotting, Northern; Blotting, Western; Cholestasis; DNA Primers; Ethinyl Estradiol; Male; Organic Anion Transporters; Protein Binding; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factors

2003
Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:1

    Topics: Animals; Bile; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis; Estrogens; Ethinyl Estradiol; Hepatocytes; Kinetics; Lipids; Liver; Male; Microsomes, Liver; Rats; Rats, Wistar; Taurochenodeoxycholic Acid; Ursodeoxycholic Acid

2003
Hepatic pharmacokinetics of taurocholate in the normal and cholestatic rat liver.
    British journal of pharmacology, 2005, Volume: 145, Issue:1

    Topics: Animals; Biological Transport; Cholestasis; Dose-Response Relationship, Drug; Ethinyl Estradiol; Liver; Male; Models, Biological; Rats; Rats, Wistar; Taurocholic Acid

2005
Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:7

    Topics: Animals; Bile; Cholestasis; Ethinyl Estradiol; Hepatocytes; Male; Mitochondrial Proteins; Protein Transport; Rats; Rats, Wistar; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Ursodeoxycholic Acid

2005
3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats.
    Toxicology and applied pharmacology, 2006, Jul-15, Volume: 214, Issue:2

    Topics: Animals; Bile; Bile Ducts; Cholanes; Cholestasis; Cholesterol 7-alpha-Hydroxylase; Chromatography, High Pressure Liquid; Deoxycholic Acid; Dose-Response Relationship, Drug; Ethinyl Estradiol; Gas Chromatography-Mass Spectrometry; Male; Micelles; Molecular Structure; Phospholipids; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid 12-alpha-Hydroxylase; Steroids, Fluorinated; Ursodeoxycholic Acid

2006
Galactosamine prevents ethinylestradiol-induced cholestasis.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:6

    Topics: Animals; Bile; Cholestasis; Ethinyl Estradiol; Galactosamine; Liver; Male; Rats; Rats, Wistar; Taurochenodeoxycholic Acid; Uridine; Uridine Diphosphate Glucuronic Acid

2006
Nalfurafine, a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 85, Issue:1

    Topics: Animals; Behavior, Animal; Cholestasis; Ethinyl Estradiol; Injections, Subcutaneous; Male; Morphinans; Pruritus; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spiro Compounds

2006
Role of pituitary hormones on 17alpha-ethinylestradiol-induced cholestasis in rat.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:2

    Topics: Animals; Bile Acids and Salts; Cholestanetriol 26-Monooxygenase; Cholestasis; Ethinyl Estradiol; Fatty Acids; Gene Expression Profiling; Growth Hormone; Hypophysectomy; Liver; Male; Pituitary Hormones; Rats; Rats, Sprague-Dawley; RNA, Messenger

2007
Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogen-induced cholestasis.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:3

    Topics: Animals; Aquaporins; Cell Membrane; Cell Membrane Permeability; Cholestasis; Cysteine Proteinase Inhibitors; Down-Regulation; Estradiol; Estrogens; Ethinyl Estradiol; Gene Expression; Hepatocytes; Leupeptins; Liver; Lysosomes; Male; Rats; Rats, Wistar; Water

2007
Effect of alpha-asarone and a derivative on lipids, bile flow and Na+/K+-ATPase in ethinyl estradiol-induced cholestasis in the rat.
    Fundamental & clinical pharmacology, 2007, Volume: 21, Issue:1

    Topics: Alkaline Phosphatase; Allylbenzene Derivatives; Animals; Anisoles; Bile; Cell Membrane; Cholestasis; Cholesterol; Estrogens; Ethinyl Estradiol; Hepatocytes; Hypolipidemic Agents; Male; Phenoxyacetates; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Triglycerides

2007
Changes in GM1 ganglioside content and localization in cholestatic rat liver.
    Glycoconjugate journal, 2007, Volume: 24, Issue:4-5

    Topics: Animals; Biomarkers; Cholestasis; Cholesterol; Ethinyl Estradiol; Female; G(M1) Ganglioside; Hepatocytes; Liver; Propylene Glycols; Rats; Rats, Wistar; Reference Values

2007
Estrogen-induced cholestasis results in a dramatic increase of b-series gangliosides in the rat liver.
    Biomedical chromatography : BMC, 2007, Volume: 21, Issue:5

    Topics: Animals; Cholestasis; Chromatography, Thin Layer; Ethinyl Estradiol; Female; Gangliosides; Liver; Rats; Rats, Wistar

2007
Recurrent cholestatic jaundice of pregnancy with demonstrated estrogen sensitivity.
    The American journal of medicine, 1967, Volume: 43, Issue:5

    Topics: Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Cholestasis; Cholesterol; Ethinyl Estradiol; Female; Humans; Liver; Liver Function Tests; Menorrhagia; Pregnancy; Pregnancy Complications; Prothrombin Time; Serum Globulins; Sulfobromophthalein

1967
Increased tight junction permeability: a possible mechanism of oestrogen cholestasis.
    European journal of clinical investigation, 1983, Volume: 13, Issue:5

    Topics: Animals; Bile; Bile Acids and Salts; Bile Canaliculi; Bile Ducts, Intrahepatic; Bilirubin; Cell Membrane Permeability; Cholestasis; Ethinyl Estradiol; Intercellular Junctions; Inulin; Male; Phenolphthalein; Phenolphthaleins; Rats; Rats, Inbred Strains; Sucrose; Sulfobromophthalein

1983
Effect of cholestasis on hepatic transport of 99mtechnetium p-isopropyl-iminodiacetic acid.
    The Journal of laboratory and clinical medicine, 1984, Volume: 104, Issue:4

    Topics: Alkaline Phosphatase; Animals; Bilirubin; Biological Transport; Cholestasis; Cholestasis, Intrahepatic; Ethinyl Estradiol; Imino Acids; Liver; Male; Organotechnetium Compounds; Rats; Technetium

1984
A dietary regimen alters hepatocyte plasma membrane lipid fluidity and ameliorates ethinyl estradiol cholestasis in the rat.
    Biochimica et biophysica acta, 1984, Mar-22, Volume: 798, Issue:1

    Topics: Animals; Bile; Cell Membrane; Cholestasis; Diet; Ethinyl Estradiol; In Vitro Techniques; Liver; Male; Membrane Fluidity; Rats

1984
Hepatocyte taurocholic acid uptake in the regression of ethinyl estradiol cholestasis. Preliminary results.
    Bollettino della Societa italiana di biologia sperimentale, 1984, Mar-30, Volume: 60, Issue:3

    Topics: Animals; Cholestasis; Ethinyl Estradiol; Female; Liver; Perfusion; Rats; Rats, Inbred Strains; Taurocholic Acid

1984
Characterization of the interaction between estrogen metabolites and taurocholate for uptake into isolated hepatocytes. Lack of correlation between cholestasis and inhibition of taurocholate uptake.
    Journal of steroid biochemistry, 1984, Volume: 20, Issue:5

    Topics: Animals; Cholestasis; Dihydrotestosterone; Estradiol; Estriol; Estrogens; Ethinyl Estradiol; Female; In Vitro Techniques; Liver; Rats; Rats, Inbred Strains; Taurocholic Acid

1984
Experimental hepatobiliary injury. Comparison of in vivo drug elimination with in vitro drug-metabolizing enzyme capacity in the rat.
    Digestive diseases and sciences, 1981, Volume: 26, Issue:1

    Topics: 1-Naphthylisothiocyanate; Aminopyrine; Aminopyrine N-Demethylase; Animals; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Cholestasis; Cytochrome P-450 Enzyme System; Ethinyl Estradiol; Hepatic Duct, Common; In Vitro Techniques; Liver; Metabolic Clearance Rate; Rats

1981
Dissociation of bile flow and biliary lipid secretion from biliary lysosomal enzyme output in experimental cholestasis.
    Journal of lipid research, 1981, Volume: 22, Issue:2

    Topics: Acetylglucosaminidase; Animals; beta-Galactosidase; Bile; Cholestasis; Ethinyl Estradiol; Glucuronidase; Lipid Metabolism; Liver; Lysosomes; Male; Proteins; Rats

1981
Ethynylestradiol-17 beta D-ring glucuronide conjugates are potent cholestatic agents in the rat.
    Life sciences, 1983, Jun-27, Volume: 32, Issue:26

    Topics: Animals; Bile; Cholestasis; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Isomerism; Rats; Rats, Inbred Strains

1983
No increase of biliary permeability in ethinylestradiol-treated rats.
    Gastroenterology, 1983, Volume: 85, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Bile Acids and Salts; Biliary Tract; Cholestasis; Ethinyl Estradiol; Inulin; Male; Permeability; Rats; Rats, Inbred Strains; Sucrose

1983
Effects of cicloxilic acid on bile flow and lipid composition in rats with ethinylestradiol-induced cholestasis.
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:10

    Topics: Animals; Bile; Cholagogues and Choleretics; Cholestasis; Cholesterol; Cyclohexanecarboxylic Acids; Ethinyl Estradiol; Lipid Metabolism; Male; Phosphatidylcholines; Rats; Rats, Inbred Strains

1982
Effects of ethinylestradiol on enzymes catalyzing bile acid conjugation and sulfation.
    Journal of lipid research, 1980, Volume: 21, Issue:7

    Topics: Acyltransferases; Animals; Bile Acids and Salts; Cholestasis; Cholic Acids; Coenzyme A Ligases; Dose-Response Relationship, Drug; Ethinyl Estradiol; Glycocholic Acid; Lithocholic Acid; Liver; Male; Organ Size; Propylene Glycols; Rats; Sulfotransferases; Sulfurtransferases; Time Factors

1980
Pathogenesis and rebound phenomenon in ethinyl estradiol cholestasis in rats.
    Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1982, Volume: 23, Issue:A

    Topics: Animals; Cholestasis; Ethinyl Estradiol; Female; Rats; Rats, Inbred Strains

1982
Effect of a low-protein diet on contraceptive steroid-induced cholestasis in rats.
    Research communications in chemical pathology and pharmacology, 1982, Volume: 36, Issue:2

    Topics: Animals; Bile; Body Weight; Cholestasis; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Diet; Ethinyl Estradiol; Female; Norethindrone; Organ Size; Protein Deficiency; Rats; Rats, Inbred Strains

1982
Impaired bile acid efflux from hepatocytes isolated from the liver of rats with cholestasis.
    The American journal of physiology, 1982, Volume: 243, Issue:4

    Topics: Animals; Cholestasis; Cholic Acids; Ethinyl Estradiol; Glycocholic Acid; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains; Taurocholic Acid

1982
[Effect of estradiol and ethinyl estradiol on biliary bile acid excretion and bile flow].
    Die Medizinische Welt, 1982, Dec-03, Volume: 33, Issue:48

    Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Estradiol; Ethinyl Estradiol; Male; Rats; Rats, Inbred Strains; Secretory Rate

1982
Effect of dihydroxydibutylether (DHBE) on bile flow and composition in rats with ethynylestradiol-induced cholestasis.
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:12

    Topics: Animals; Bile; Butanols; Cholestasis; Ethers; Ethinyl Estradiol; Female; Rats

1980
Effect of epomediol on bile flow and composition in normal rats and in rats with ethynylestradiol-induced cholestasis.
    Il Farmaco; edizione pratica, 1981, Volume: 36, Issue:8

    Topics: Animals; Bile; Bile Acids and Salts; Bridged Bicyclo Compounds, Heterocyclic; Cholagogues and Choleretics; Cholestasis; Ethinyl Estradiol; Rats; Terpenes

1981
Morphology of liver cell tight junctions in ethinyl estradiol induced cholestasis.
    Pathology, research and practice, 1981, Volume: 171, Issue:3-4

    Topics: Animals; Cholestasis; Ethinyl Estradiol; Female; Freeze Fracturing; Intercellular Junctions; Liver; Microscopy, Electron, Scanning; Rats

1981
Selective elevation of plasma free cholesterol concentration by administration of estrogen in the presence of total biliary obstruction.
    Atherosclerosis, 1981, Volume: 40, Issue:2

    Topics: Aged; Cholestasis; Cholesterol; Cholesterol Esters; Ethinyl Estradiol; Female; Humans; Phospholipids; Prospective Studies; Triglycerides

1981
Spontaneous reversal of ethinyl estradiol-induced cholestasis in the rat.
    Experientia, 1980, May-15, Volume: 36, Issue:5

    Topics: Animals; Bile; Cholestasis; Ethinyl Estradiol; Female; Rats

1980
Ethynylestradiol-induced impairment of bile secretion in the rat: protective effects of S-adenosyl-L-methionine and its implication in estrogen metabolism.
    Gastroenterology, 1981, Volume: 80, Issue:1

    Topics: Animals; Bile; Cholestasis; Chromatography, Gas; Estrogens; Ethinyl Estradiol; Female; Lipids; Methylation; Rats; S-Adenosylmethionine

1981
Enhanced biliary excretion of canalicular membrane enzymes in ethynylestradiol-induced cholestasis. Effects of ursodeoxycholic acid administration.
    Biochemical pharmacology, 1995, Oct-12, Volume: 50, Issue:8

    Topics: Alkaline Phosphatase; Animals; Bile; Bile Acids and Salts; Bile Canaliculi; Cell Fractionation; Cell Membrane; Cholestasis; Ethinyl Estradiol; gamma-Glutamyltransferase; Liver; Male; Rats; Rats, Wistar; Secretory Rate; Ursodeoxycholic Acid

1995
Enhanced biliary excretion of canalicular membrane enzymes in estrogen-induced and obstructive cholestasis, and effects of different bile acids in the isolated perfused rat liver.
    Journal of hepatology, 1995, Volume: 22, Issue:6

    Topics: Alkaline Phosphatase; Animals; Bile Acids and Salts; Cell Membrane; Cholestasis; Ethinyl Estradiol; gamma-Glutamyltransferase; Male; Perfusion; Rats; Rats, Wistar

1995
Scanning laser cytometry: alterations induced by cholestatic agents in isolated rat hepatocyte couplets.
    Cell biology and toxicology, 1994, Volume: 10, Issue:5-6

    Topics: Actins; Animals; Bile Canaliculi; Calcium; Cell Aggregation; Cell Separation; Cells, Cultured; Cholestasis; Cytoplasm; Ethinyl Estradiol; Homeostasis; Liver; Male; Methyltestosterone; Microscopy, Confocal; Rats

1994
Hormone-induced bile flow and hepatobiliary calcium fluxes are attenuated in the perfused liver of rats made cholestatic with ethynylestradiol in vivo and with phalloidin in vitro.
    Hepatology (Baltimore, Md.), 1995, Volume: 21, Issue:5

    Topics: Animals; Bile; Calcium; Cholestasis; Ethinyl Estradiol; Glucagon; Glucose; Liver; Male; Oxygen Consumption; Perfusion; Phalloidine; Rats; Rats, Wistar; Vasopressins

1995
Sensitivity of HPLC and conventional bilirubin measurements in the detection of early cholestasis.
    The Journal of laboratory and clinical medicine, 1995, Volume: 125, Issue:5

    Topics: Animals; Bile Ducts; Bilirubin; Cholestasis; Chromatography, High Pressure Liquid; Cyclosporine; Ethinyl Estradiol; Guinea Pigs; Ligation; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity

1995
Decreased biliary glutathione content is responsible for the decline in bile salt-independent flow induced by ethinyl estradiol in rats.
    Toxicology letters, 1994, Volume: 74, Issue:3

    Topics: Analysis of Variance; Animals; Bile; Bile Acids and Salts; Body Weight; Cholestasis; Disease Models, Animal; Ethinyl Estradiol; Glutathione; Glutathione Disulfide; Liver; Male; Organ Size; Osmosis; Oxidation-Reduction; Rats; Rats, Sprague-Dawley

1994
Ursodeoxycholic acid improves ethinyl estradiol-induced cholestasis in the rat.
    European journal of clinical investigation, 1993, Volume: 23, Issue:12

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bile; Bile Acids and Salts; Cholestasis; Ethinyl Estradiol; Female; Rats; Rats, Sprague-Dawley; Sucrose; Ursodeoxycholic Acid

1993
Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:6

    Topics: Adenosine; Animals; Bile; Bile Canaliculi; Biological Transport; Blood Chemical Analysis; Body Weight; Cell Membrane; Cell Polarity; Cholestasis; Ethinyl Estradiol; Glutathione; Glycine; Liver; Male; Organ Size; Rats; Rats, Sprague-Dawley; Sulfates; Taurocholic Acid

1993
Leaky junctions and cholestasis: a tight correlation.
    Gastroenterology, 1996, Volume: 110, Issue:5

    Topics: Animals; Bile Ducts; Cholestasis; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Ethinyl Estradiol; Ligation; Liver; Permeability; Rats; Tight Junctions

1996
Modulation of hepatic content and biliary excretion of P-glycoproteins in hepatocellular and obstructive cholestasis in the rat.
    Journal of hepatology, 1996, Volume: 25, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Cell Membrane; Cholestasis; Cholestasis, Intrahepatic; Ethinyl Estradiol; Gene Expression; Genes, MDR; Immunohistochemistry; Liver; Male; Rats; Rats, Wistar

1996
Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters.
    The American journal of physiology, 1996, Volume: 271, Issue:6 Pt 1

    Topics: Animals; Carrier Proteins; Cell Membrane; Cholestasis; Ethinyl Estradiol; Liver; Male; Membrane Fluidity; Organic Anion Transporters, Sodium-Dependent; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Symporters

1996
Inhibition of biliary bicarbonate secretion in ethinyl estradiol-induced cholestasis is not associated with impaired activity of the Cl-/HCO-3 exchanger in the rat.
    Journal of hepatology, 1997, Volume: 26, Issue:1

    Topics: Animals; Antiporters; Bicarbonates; Bile; Body Weight; Chloride-Bicarbonate Antiporters; Chlorides; Cholestasis; Estradiol Congeners; Ethinyl Estradiol; Glucagon; In Vitro Techniques; Male; Organ Size; Perfusion; Rats; Rats, Wistar; Secretory Rate

1997
A molecular basis for jaundice in intrahepatic and extrahepatic cholestasis.
    Hepatology (Baltimore, Md.), 1997, Volume: 26, Issue:6

    Topics: Adenosine Triphosphatases; Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Ducts; Blotting, Northern; Blotting, Western; Carrier Proteins; Cholestasis; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Down-Regulation; Estradiol Congeners; Ethinyl Estradiol; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Jaundice; Rats; RNA, Messenger

1997
Impaired activity of the bile canalicular organic anion transporter (Mrp2/cmoat) is not the main cause of ethinylestradiol-induced cholestasis in the rat.
    Hepatology (Baltimore, Md.), 1998, Volume: 27, Issue:2

    Topics: Animals; Anion Transport Proteins; Bile; Bile Acids and Salts; Bilirubin; Blotting, Western; Body Weight; Carrier Proteins; Cell Membrane; Cholestasis; Estradiol Congeners; Ethinyl Estradiol; Lipids; Liver; Male; Membrane Transport Proteins; Organ Size; Organic Anion Transporters, Sodium-Dependent; Rats; Rats, Mutant Strains; Rats, Wistar; Symporters; Time Factors

1998
Changes in biliary excretory mechanisms in rats with ethinyloestradiol-induced cholestasis.
    Journal of gastroenterology and hepatology, 1998, Volume: 13, Issue:2

    Topics: Animals; Bile; Bile Acids and Salts; Biological Transport; Cholestasis; Estradiol Congeners; Ethinyl Estradiol; Male; Rats; Rats, Sprague-Dawley

1998
Effect of epomediol on ethinyloestradiol-induced changes in bile acid and cholesterol metabolism in rats.
    Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:8

    Topics: Animals; Bile Acids and Salts; Bridged Bicyclo Compounds, Heterocyclic; Cholagogues and Choleretics; Cholestasis; Cholesterol; Drug Interactions; Estradiol Congeners; Ethinyl Estradiol; Male; Protective Agents; Rats; Rats, Wistar; RNA, Messenger; Terpenes

2001
Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets.
    Hepatology (Baltimore, Md.), 2001, Volume: 34, Issue:2

    Topics: Alkaline Phosphatase; Animals; ATP Binding Cassette Transporter, Subfamily B; Bile; Bile Acids and Salts; Cell Membrane; Cholestasis; Elasticity; Estradiol Congeners; Ethinyl Estradiol; Hepatocytes; Liver; Male; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Rats; Rats, Wistar; Silymarin

2001
Effects of epomediol on ethinyloestradiol-induced changes in glutathione homeostasis in the rat.
    Pharmacology & toxicology, 2002, Volume: 90, Issue:3

    Topics: Animals; Bile; Bridged Bicyclo Compounds, Heterocyclic; Cholagogues and Choleretics; Cholestasis; Cysteine; Drug Interactions; Ethinyl Estradiol; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Homeostasis; Kidney; Liver; Male; Rats; Rats, Wistar; Terpenes

2002
[Gamma-glutamyltranspeptidase activity in steroid-induced cholestasis in the rat].
    Bollettino della Societa italiana di biologia sperimentale, 1977, Oct-30, Volume: 53, Issue:20

    Topics: Animals; Bilirubin; Cholestasis; Ethinyl Estradiol; Female; gamma-Glutamyltransferase; Liver; Methyltestosterone; Rats

1977
Pharmacological reversal of cholestasis-associated decrease in hepatic cytochrome P-450.
    Biochemical pharmacology, 1975, Mar-15, Volume: 24, Issue:6

    Topics: Animals; Bile Ducts; Cholestasis; Cytochrome P-450 Enzyme System; Depression, Chemical; Ethinyl Estradiol; Glucose-6-Phosphatase; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats

1975
[A case of anovlar-induced intrahepatic cholestasis with positive antimitochondrial antibody (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1977, Volume: 74, Issue:11

    Topics: Adult; Antibodies; Cholestasis; Drug Combinations; Ethinyl Estradiol; Female; Humans; Liver; Mitochondria; Norethindrone

1977
Increased sulfation and decreased 7alpha-hydroxylation of deoxycholic acid in ethinyl estradiol-induced cholestasis in rats.
    Gastroenterology, 1977, Volume: 73, Issue:2

    Topics: Animals; Carbon Radioisotopes; Cholestasis; Deoxycholic Acid; Ethinyl Estradiol; Hydroxylation; Liver; Male; Rats

1977
Effect of ethynylestradiol on biliary excretion of bile acids, phosphatidylcolines, and cholesterol in the bile fistula rat.
    Journal of lipid research, 1977, Volume: 18, Issue:5

    Topics: Animals; Bile; Bile Acids and Salts; Biliary Fistula; Cholestasis; Cholesterol; Cholic Acids; Chromatography, Gas; Ethinyl Estradiol; Female; Gallbladder; Male; Mass Spectrometry; Phosphatidylcholines; Phospholipids; Rats; Sex Factors

1977
Scanning electron microscopy of the rat liver. Studies of the effect of taurolithocholate and other models of cholestasis.
    Gastroenterology, 1975, Volume: 69, Issue:3

    Topics: Animals; Bile; Bile Ducts, Intrahepatic; Cholestasis; Dilatation, Pathologic; Disease Models, Animal; Ethinyl Estradiol; Female; Ligation; Lithocholic Acid; Liver; Male; Microscopy, Electron, Scanning; Rats; Secretory Rate; Taurocholic Acid

1975
[Biliary clearance and intrahepatic distribution of sucrose and sodium ferrocyanide in cholestasis due to ethinyl estradiol].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1975, Volume: 81

    Topics: Animals; Cholestasis; Ethinyl Estradiol; Ferrocyanides; Gallbladder; Liver; Male; Rats; Sucrose

1975
[Physiology of bile secretion].
    Acta medica Austriaca, 1975, Volume: 2, Issue:3

    Topics: Amiloride; Animals; Bile; Bile Acids and Salts; Biological Transport, Active; Chenodeoxycholic Acid; Cholelithiasis; Cholestasis; Cholesterol; Ethinyl Estradiol; Humans; Liver; Liver Circulation; Phospholipids; Rabbits; Rats; Sodium; Solubility

1975
Effect of ethinylestradiol and epomediol on bile flow and biliary lipid composition in rat.
    Biochemical pharmacology, 1992, Mar-17, Volume: 43, Issue:6

    Topics: Animals; Bile; Bile Acids and Salts; Bridged Bicyclo Compounds, Heterocyclic; Cholagogues and Choleretics; Cholestasis; Cholesterol; Ethinyl Estradiol; Liver; Male; Phospholipids; Rats; Rats, Inbred Strains; Terpenes

1992
Lack of benefit of ursodeoxycholic acid in drug-induced cholestasis in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 200, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cyclosporine; Ethinyl Estradiol; Male; Rats; Rats, Inbred Strains; Ursodeoxycholic Acid

1992
Reversal of ethinylestradiol-induced cholestasis by epomediol in rat. The role of liver plasma-membrane fluidity.
    Biochemical pharmacology, 1989, Oct-15, Volume: 38, Issue:20

    Topics: Animals; Bile; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cholagogues and Choleretics; Cholestasis; Ethinyl Estradiol; Liver; Male; Membrane Fluidity; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Terpenes

1989
Medroxyprogesterone acetate- and ethinylestradiol-induced changes in biliary bile acids of the rat studied by high-performance liquid chromatography.
    Journal of chromatography, 1987, Dec-25, Volume: 423

    Topics: Animals; Bile Acids and Salts; Cholestasis; Chromatography, High Pressure Liquid; Ethinyl Estradiol; Indicators and Reagents; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; Rats; Rats, Inbred Strains

1987
Role of liver plasma membrane fluidity in the pathogenesis of estrogen-induced cholestasis.
    The Journal of laboratory and clinical medicine, 1988, Volume: 112, Issue:6

    Topics: Animals; Bile; Cholestasis; Ethinyl Estradiol; Fluorescence Polarization; Liver; Male; Membrane Fluidity; Membrane Lipids; Phospholipids; Rats; Rats, Inbred Strains; Sphingomyelins; Spironolactone; Structure-Activity Relationship

1988
Alterations in protein transport events in rat liver after estrogen treatment.
    The American journal of physiology, 1987, Volume: 253, Issue:2 Pt 1

    Topics: Animals; Asialoglycoproteins; Biological Transport; Cholestasis; Ethinyl Estradiol; Immunoglobulin A; Kinetics; Liver; Male; Orosomucoid; Proteins; Rats; Rats, Inbred Strains

1987
Effects of iron overload on bile secretion and hepatic porphyrin metabolism in ethinyl estradiol-treated rats.
    Toxicology, 1986, Volume: 38, Issue:2

    Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Drug Synergism; Ethinyl Estradiol; Female; Iron; Liver; Porphyrins; Rats; Rats, Inbred Strains; Uroporphyrinogen Decarboxylase

1986
Selectively reduced biliary excretion of cholyldiglycylhistamine but not of cholyltetraglycylhistamine in ethinyl estradiol-treated rats. A possible indicator of increased bile canalicular permeability.
    Journal of hepatology, 1985, Volume: 1, Issue:3

    Topics: Animals; Bile; Bile Canaliculi; Bile Ducts, Intrahepatic; Cholestasis; Cholic Acids; Ethinyl Estradiol; Histamine; Iodine Radioisotopes; Male; Permeability; Rats; Rats, Inbred Strains

1985
Biliary permeability during ethinyl estradiol-induced cholestasis studied by segmented retrograde intrabiliary injections in rats.
    Journal of hepatology, 1985, Volume: 1, Issue:3

    Topics: Animals; Bile; Bile Acids and Salts; Bile Ducts; Carbon Radioisotopes; Cholestasis; Ethinyl Estradiol; Glycocholic Acid; Histamine; Injections; Inulin; Iodine Radioisotopes; Male; Permeability; Rats; Rats, Inbred Strains; Sucrose; Taurocholic Acid

1985
A cytological study of extra- and intrahepatic cholestasis in the rat.
    Annales medicinae experimentalis et biologiae Fenniae, 1971, Volume: 49, Issue:1

    Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Bile Ducts, Intrahepatic; Cholestasis; Ethinyl Estradiol; Female; Liver; Rats; Staining and Labeling; Time Factors

1971
Alteration of bile canalicular enzymes in cholestasis. A possible cause of bile secretory failure.
    The Journal of clinical investigation, 1973, Volume: 52, Issue:4

    Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Bile; Bilirubin; Biological Transport; Carbohydrate Metabolism; Cell Membrane; Cholestasis; Cholesterol; Electrophoresis, Polyacrylamide Gel; Ethinyl Estradiol; Kinetics; Ligation; Liver; Magnesium; Male; Microscopy, Electron; Neuraminic Acids; Nucleotidases; Phospholipids; Rats

1973
Effect of phenobarbital on the ethynyl estradiol-induced cholestasis in the rat.
    Gastroenterology, 1973, Volume: 65, Issue:4

    Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cycloheximide; Dactinomycin; Ethinyl Estradiol; Female; Injections, Intraperitoneal; Injections, Intravenous; Liver; Phenobarbital; Rats; Stimulation, Chemical; Time Factors

1973
Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and cholestasis.
    The Journal of clinical investigation, 1971, Volume: 50, Issue:11

    Topics: Allyl Compounds; Animals; Benzopyrenes; Cholestasis; DDT; Densitometry; Dieldrin; Dwarfism, Pituitary; Electrophoresis, Disc; Ethinyl Estradiol; Hypophysectomy; Indocyanine Green; Liver; Male; Methylcholanthrene; Phenobarbital; Protein Binding; Proteins; Rats; Sulfobromophthalein; Thyroid Hormones; Thyroidectomy

1971
Transient cholestasis during treatment with ajmaline, and chronic xanthomatous cholestasis after administration of ajmaline, methyltestosterone and ethinylestradiol. Two case reports.
    Acta medica Scandinavica, 1971, Volume: 190, Issue:4

    Topics: Acute Disease; Ajmaline; Bile Ducts, Intrahepatic; Bilirubin; Cholestasis; Chronic Disease; Drug Synergism; Ethinyl Estradiol; Female; Humans; Liver; Liver Function Tests; Male; Methyltestosterone; Microscopy, Electron; Middle Aged; Mononuclear Phagocyte System; Plants, Medicinal; Rauwolfia

1971
Effect of 17 alpha-ethinylestradiol on the biliary metabolites of 17 beta-[6,7-3H2]estradiol in the rat.
    Biochimica et biophysica acta, 1971, Mar-16, Volume: 231, Issue:2

    Topics: 17-Ketosteroids; Animals; Bile; Biliary Tract; Body Temperature; Catheterization; Cholestasis; Chromatography, Gas; Chromatography, Thin Layer; Common Bile Duct; Crystallization; Depression, Chemical; Estradiol; Estranes; Estrone; Ethinyl Estradiol; Female; Glucuronates; Liver; Metabolism; Microsomes; Oxidation-Reduction; Rats; Sterols; Time Factors; Tritium

1971
[Medicamentous jaundice with intrahepatic cholestasis following administration of ovulation inhibitors].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1967, Volume: 27, Issue:5

    Topics: Adult; Cholestasis; Contraceptives, Oral; Ethinyl Estradiol; Female; Humans; Pregnancy; Testosterone

1967
Functional and morphological liver changes in women taking oral contraceptives. A clinical and ultrastructural study with special reference to the occurrence of cholestasis.
    Acta chirurgica Scandinavica, 1968, Volume: 134, Issue:8

    Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Biopsy; Chemical and Drug Induced Liver Injury; Cholangiography; Cholelithiasis; Cholestasis; Contraceptives, Oral; Ethinyl Estradiol; Female; Gallstones; Humans; Male; Mestranol; Microscopy, Electron; Middle Aged; Mitochondria, Liver; Norethindrone; Pregnancy

1968
[Jaundice after ovulation inhibiting steroids].
    Medizinische Klinik, 1969, May-09, Volume: 64, Issue:19

    Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptives, Oral; Ethinyl Estradiol; Ethisterone; Female; Hepatitis; Humans; Liver; Norethindrone; Prednisolone; Prednisone

1969
[Cholestatic jaundice following ovulation inhibitors].
    Geburtshilfe und Frauenheilkunde, 1969, Volume: 29, Issue:3

    Topics: Adult; Alkaline Phosphatase; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptives, Oral; Ethinyl Estradiol; Female; Humans; Pregnancy; Transaminases

1969