ethidium has been researched along with Trypanosomiasis, African in 35 studies
Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Non-compartmental pharmacokinetic analysis showed that the values for t(12)beta of 75." | 1.31 | The effects of drug-sensitive and drug-resistant Trypanosoma congolense infections on the pharmacokinetics of homidium in Boran cattle. ( Eisler, MC; Holmes, PH; Murilla, GA; Ndung'u, JM; Peregrine, AS, 2002) |
| " Absorption was rapid, with a tmax of 15 min and a mean Cmax (+/-SD) of 268." | 1.29 | Bioavailability, pharmacokinetics, and tissue distribution of 14C homidium after parenteral administration to Boran cattle. ( Ismail, AA; Karanja, WM; Mdachi, RE; Murilla, GA, 1996) |
| " The combination was also more toxic to the mice but the inclusion of nitrobenzylthioinosinate in the therapy significantly alleviated the toxicity of the drug combination." | 1.26 | Effect of nitrobenzylthioinosinate on the toxicity of tubercidin and ethidium against Trypanosoma gambiense. ( Ikediobi, CO; Ogbunude, PO, 1982) |
| "[14C]ethidium bromide has been used to determine drug levels in tissues and body fluids of rabbits and calves following intramuscular injection." | 1.26 | Ethidium bromide: pharmacokinetics and efficacy against trypanosme infections in rabbits and calves. ( Gilbert, RJ; Newton, BA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (42.86) | 18.7374 |
| 1990's | 12 (34.29) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 3 (8.57) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Okello, I | 3 |
| Mafie, E | 3 |
| Nzalawahe, J | 3 |
| Eastwood, G | 3 |
| Mboera, LEG | 3 |
| Hakizimana, JN | 3 |
| Ogola, K | 3 |
| Ward, CP | 1 |
| Burgess, KE | 1 |
| Burchmore, RJ | 1 |
| Barrett, MP | 1 |
| de Koning, HP | 1 |
| Roy Chowdhury, A | 1 |
| Bakshi, R | 1 |
| Wang, J | 1 |
| Yildirir, G | 1 |
| Liu, B | 1 |
| Pappas-Brown, V | 1 |
| Tolun, G | 1 |
| Griffith, JD | 1 |
| Shapiro, TA | 1 |
| Jensen, RE | 1 |
| Englund, PT | 1 |
| Adeyemi, OS | 1 |
| Sulaiman, FA | 1 |
| Olila, D | 1 |
| McDermott, JJ | 1 |
| Eisler, MC | 3 |
| Mitema, ES | 1 |
| Patzelt, RJ | 1 |
| Clausen, PH | 1 |
| Poetzsch, CJ | 1 |
| Zessin, KH | 1 |
| Mehlitz, D | 1 |
| Peregrine, AS | 5 |
| KARIB, AA | 1 |
| FORD, EJ | 1 |
| WILMSHURST, EC | 1 |
| THIENPONT, D | 1 |
| HERIN, V | 1 |
| STEPHEN, LE | 2 |
| WILLIAMSON, J | 3 |
| Jamal, S | 1 |
| Sigauque, I | 1 |
| Macuamule, C | 1 |
| Neves, L | 1 |
| Penzhorn, BL | 1 |
| Marcotty, T | 2 |
| Van Den Bossche, P | 1 |
| Ogbunude, PO | 1 |
| Ikediobi, CO | 1 |
| Ono, T | 1 |
| Nakabayashi, T | 1 |
| Poltera, AA | 2 |
| Hochmann, A | 1 |
| Rudin, W | 1 |
| Lambert, PH | 1 |
| Gilbert, RJ | 1 |
| Newton, BA | 1 |
| Jennings, FW | 2 |
| Urquhart, GM | 2 |
| Murray, PK | 1 |
| Miller, BM | 1 |
| Stevenson, P | 3 |
| Sones, KR | 1 |
| Gicheru, MM | 1 |
| Mwangi, EK | 1 |
| Kinabo, LD | 1 |
| Gray, MA | 1 |
| Kimarua, RW | 1 |
| Codjia, V | 1 |
| Mulatu, W | 2 |
| Majiwa, PA | 2 |
| Leak, SG | 1 |
| Rowlands, GJ | 1 |
| Authié, E | 1 |
| d'Ieteren, GD | 1 |
| Agbe, A | 1 |
| Yielding, KL | 1 |
| Murilla, GA | 2 |
| Mdachi, RE | 1 |
| Ismail, AA | 1 |
| Karanja, WM | 1 |
| Kageruka, P | 2 |
| Kabore, H | 1 |
| Ibouesse, JF | 1 |
| De Deken, R | 2 |
| Geerts, S | 2 |
| Lemmouchi, Y | 2 |
| Schacht, E | 2 |
| Mulugeta, W | 1 |
| Wilkes, J | 1 |
| Masake, R | 1 |
| Brandt, JR | 1 |
| Kazadi, JM | 1 |
| Diarra, B | 1 |
| Holmes, PH | 2 |
| Bawa, EK | 1 |
| Ogwu, D | 1 |
| Sekoni, VO | 1 |
| Oyedipe, EO | 1 |
| Esievo, KA | 1 |
| Kambai, JE | 1 |
| Ndung'u, JM | 1 |
| Jadin, JM | 1 |
| Trouet, A | 1 |
| Van Hoof, F | 1 |
| Bioul-Marchand, M | 1 |
| Maldague, P | 1 |
| Jadin-Nyssens, M | 1 |
| Whitelaw, DD | 1 |
| Mohamed-Ahmed, MM | 1 |
| Rahman, AH | 1 |
| Abdel Karim, EI | 1 |
| Dolan, RB | 2 |
| Stevenson, PG | 1 |
| Alushula, H | 2 |
| Okech, G | 2 |
| Mutugi, M | 1 |
| Sayer, PD | 1 |
| Njogu, AR | 1 |
| Schönefeld, A | 1 |
| Röttcher, D | 2 |
| Moloo, SK | 1 |
| Schillinger, D | 1 |
1 review available for ethidium and Trypanosomiasis, African
| Article | Year |
|---|---|
Pharmacology of existing drugs for animal trypanosomiasis.
Topics: Animals; Arsenicals; Diminazene; Ethidium; Phenanthridines; Quinolinium Compounds; Suramin; Trypanoc | 1993 |
2 trials available for ethidium and Trypanosomiasis, African
| Article | Year |
|---|---|
Comparison of isometamidium chloride and homidium bromide as prophylactic drugs for trypanosomiasis in cattle at Nguruman, Kenya.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethidium; Kenya; Male; Phenanthridines; Seasons; Trypa | 1995 |
Prophylactic effects of isometamidium- and ethidium-sustained release devices against Trypanosoma congolense in cattle.
Topics: Animals; Cattle; Ethidium; Female; Infusion Pumps, Implantable; Microbial Sensitivity Tests; Phenant | 1997 |
32 other studies available for ethidium and Trypanosomiasis, African
| Article | Year |
|---|---|
Trypanosoma Congolense Resistant to Trypanocidal Drugs Homidium and Diminazene and their Molecular Characterization in Lambwe, Kenya.
Topics: Animals; Cattle; Diminazene; Ethidium; Kenya; Mice; Phylogeny; Trypanocidal Agents; Trypanosoma cong | 2023 |
Trypanosoma Congolense Resistant to Trypanocidal Drugs Homidium and Diminazene and their Molecular Characterization in Lambwe, Kenya.
Topics: Animals; Cattle; Diminazene; Ethidium; Kenya; Mice; Phylogeny; Trypanocidal Agents; Trypanosoma cong | 2023 |
Trypanosoma Congolense Resistant to Trypanocidal Drugs Homidium and Diminazene and their Molecular Characterization in Lambwe, Kenya.
Topics: Animals; Cattle; Diminazene; Ethidium; Kenya; Mice; Phylogeny; Trypanocidal Agents; Trypanosoma cong | 2023 |
Trypanosoma Congolense Resistant to Trypanocidal Drugs Homidium and Diminazene and their Molecular Characterization in Lambwe, Kenya.
Topics: Animals; Cattle; Diminazene; Ethidium; Kenya; Mice; Phylogeny; Trypanocidal Agents; Trypanosoma cong | 2023 |
A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes.
Topics: Amidines; Animals; Chromatography, High Pressure Liquid; Ethidium; Female; Fluorescence; Fluorescent | 2010 |
The killing of African trypanosomes by ethidium bromide.
Topics: Antiprotozoal Agents; DNA Replication; DNA, Kinetoplast; DNA, Z-Form; Ethidium; Genome, Mitochondria | 2010 |
Biochemical and morphological changes in Trypanosoma brucei brucei-infected rats treated with homidium chloride and diminazene aceturate.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Diminazene; Ethidi | 2012 |
Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda.
Topics: Animals; Cattle; Diminazene; Disease Models, Animal; Drug Resistance; Ethidium; Female; Goat Disease | 2002 |
Studies on ethidium bromide. V. The treatment of cattle infected with resistant strains of Trypanosoma congolense.
Topics: Animals; Cattle; Cattle Diseases; Ethidium; Quinolines; Trypanosoma congolense; Trypanosomiasis; Try | 1954 |
[Ethidium bromide in therapy of bovine trypanosomiasis caused by Trypanosoma vivax; control in the bush in Astrida (Ruanda-Urundi)].
Topics: Animals; Black People; Burundi; Cattle; Cattle Diseases; Ethidium; Humans; Quinolines; Rwanda; Trypa | 1955 |
Suramin complexes. V. Ethidium complex: attempts to overcome the injection-site reaction in cattle.
Topics: Animals; Black People; Cattle; Cattle Diseases; Ethidium; Humans; Quinolines; Suramin; Trypanosomias | 1958 |
Suramin complexes. VII. Further attempts to overcome the ethidium complex injection-site reaction.
Topics: Animals; Cattle; Cattle Diseases; Ethidium; Quinolines; Sheep; Sheep Diseases; Suramin; Trypanosomia | 1961 |
The susceptibility of Trypanosoma congolense isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride.
Topics: Animals; Diminazene; Drug Resistance; Ethidium; Mice; Mozambique; Parasitic Sensitivity Tests; Phena | 2005 |
Effect of nitrobenzylthioinosinate on the toxicity of tubercidin and ethidium against Trypanosoma gambiense.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Ethidium; Inosine; Male; Mice; Ribonucleosides; | 1982 |
Therapeutic effect of bleomycin on experimental infection of mice with Trypanosoma gambiense and Trypanosoma evansi.
Topics: Animals; Bleomycin; Drug Resistance; Ethidium; Mice; Rosaniline Dyes; Trypanosoma; Trypanosoma bruce | 1980 |
Drug sensitivity of pleomorphic Trypanosoma rhodesiense.
Topics: Animals; Arsenicals; Drug Resistance, Microbial; Ethidium; Mice; Pentamidine; Quinolinium Compounds; | 1983 |
Trypanosoma brucei brucei: a model for cerebral trypanosomiasis in mice--an immunological, histological and electronmicroscopic study.
Topics: Animals; Brain; Brain Diseases; Disease Models, Animal; Ethidium; Female; Fluorescent Antibody Techn | 1980 |
Ethidium bromide: pharmacokinetics and efficacy against trypanosme infections in rabbits and calves.
Topics: Animals; Body Fluids; Cattle; Ethidium; Feces; Rabbits; Tissue Distribution; Trypanosoma; Trypanosom | 1982 |
Immunopathological and chemotherapeutic studies in experimental trypanosomiasis with special reference to the heart and brain.
Topics: Animals; Brain; Disease Models, Animal; Ethidium; Female; Humans; Melarsoprol; Mice; Myocardium; Tim | 1980 |
'Berenil' and nitroimidazole combinations in the treatment of Trypanosoma brucei infection with central nervous system involvement.
Topics: Amidines; Animals; Benzamidines; Central Nervous System Diseases; Diminazene; Ethidium; Female; Isox | 1980 |
Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethidium; Kenya; Phenanthridines; Trypanocidal Agents; | 1993 |
Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of populations of Trypanosoma congolense resistant to diminazene, isometamidium and homidium.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethidium; Ethiopia; Phenanthridines; Species Specifici | 1993 |
Kinetoplasts play an important role in the drug responses of Trypanosoma brucei.
Topics: Acriflavine; Animals; Azides; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Ethidiu | 1995 |
Bioavailability, pharmacokinetics, and tissue distribution of 14C homidium after parenteral administration to Boran cattle.
Topics: Absorption; Animals; Biological Availability; Carbon Radioisotopes; Cattle; Ethidium; Half-Life; Inj | 1996 |
Comparative evaluation of the prophylactic effect of slow release devices containing homidium bromide and isometamidium on Trypanosoma congolense in rabbits.
Topics: Animals; Drug Evaluation, Preclinical; Drug Implants; Drug Resistance; Ethidium; Female; Injections, | 1996 |
Long-term occurrence of Trypanosoma congolense resistant to diminazene, isometamidium and homidium in cattle at Ghibe, Ethiopia.
Topics: Animals; Biological Assay; Cattle; Chromosomes; Diminazene; Drug Resistance, Microbial; Drug Resista | 1997 |
Effects of Trypanosoma vivax on pregnancy of Yankasa sheep and the results of homidum chloride chemotherapy.
Topics: Animals; Ethidium; Female; Fetal Resorption; Fetal Weight; Gestational Age; Pregnancy; Pregnancy Com | 2000 |
The effects of drug-sensitive and drug-resistant Trypanosoma congolense infections on the pharmacokinetics of homidium in Boran cattle.
Topics: Animals; Cattle; Cattle Diseases; Disease Models, Animal; Drug Resistance, Microbial; Enzyme-Linked | 2002 |
[Comparative study of lysosomotropic chemotherapy of Chagas' disease and nagana].
Topics: Animals; Chagas Disease; Ethidium; Lysosomes; Mice; Mice, Inbred C57BL; Trypanocidal Agents; Trypano | 1977 |
The relationship between duration of infection with Trypanosoma brucei in mice and the efficacy of chemotherapy.
Topics: Amidines; Animals; Diminazene; Drug Resistance, Microbial; Ethidium; Female; Mice; Recurrence; Time | 1977 |
Multiple drug-resistant bovine trypanosomes in South Darfur Province, Sudan.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethidium; Phenanthridines; Sudan; Time Factors; Trypan | 1992 |
Failure of chemoprophylaxis against bovine trypanosomiasis on Galana Ranch in Kenya.
Topics: Animals; Cattle; Ethidium; Kenya; Male; Phenanthridines; Trypanocidal Agents; Trypanosomiasis, Afric | 1992 |
Homidium bromide as a chemoprophylactic for cattle trypanosomiasis in Kenya.
Topics: Animals; Cattle; Diminazene; Ethidium; Hematocrit; Kenya; Male; Trypanocidal Agents; Trypanosoma con | 1990 |
The sensitivity to trypanocidal drugs of Trypanosoma vivax isolated in Kenya and Somalia.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethidium; Kenya; Male; Phenanthridines; Quinolinium Co | 1987 |
Multiple drug resistance in Trypanosoma vivax in the Tana River District of Kenya.
Topics: Animals; Cattle; Diminazene; Drug Resistance, Microbial; Ethidium; Kenya; Phenanthridines; Quinolini | 1985 |