Page last updated: 2024-10-28

ethidium and Melanoma

ethidium has been researched along with Melanoma in 14 studies

Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"The relationship between DNA crosslinks and cell death as a result of exposure to melphalan (MLN) was studied in the F1 variant of B16 melanoma cells."7.67Correlation between the cytotoxicity of melphalan and DNA crosslinks as detected by the ethidium bromide fluorescence assay in the F1 variant of B16 melanoma cells. ( Garcia, ST; McQuillan, A; Panasci, L, 1988)
" Fluorescence microscopy using AO/EB (acridine orange/ethidium bromide) staining indicated that KA can induce both apoptosis and necrosis in HL-60 cell cultures, which corroborate the findings with MTT."3.75Kauren-19-oic acid induces DNA damage followed by apoptosis in human leukemia cells. ( Bezerra, DP; Câmara, CA; Cavalcanti, BC; Costa-Lotufo, LV; Lima, MA; Magalhães, HI; Moraes, MO; Pessoa, C; Rao, VS; Silveira, ER, 2009)
"The relationship between DNA crosslinks and cell death as a result of exposure to melphalan (MLN) was studied in the F1 variant of B16 melanoma cells."3.67Correlation between the cytotoxicity of melphalan and DNA crosslinks as detected by the ethidium bromide fluorescence assay in the F1 variant of B16 melanoma cells. ( Garcia, ST; McQuillan, A; Panasci, L, 1988)
" In contrast, sequential tumor biopsies from a melanoma patient on methotrexate-citrovorum factor rescue therapy showed no changes."3.65Flow microfluorometric patterns of human bone marrow and tumor cells in response to cancer chemotherapy. ( Frei, E; Krishan, A; Paika, KD; Pitman, SW; Smith, DC; Tattersall, HN, 1976)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-199010 (71.43)18.7374
1990's2 (14.29)18.2507
2000's2 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cavalcanti, BC1
Bezerra, DP1
Magalhães, HI1
Moraes, MO1
Lima, MA1
Silveira, ER1
Câmara, CA1
Rao, VS1
Pessoa, C1
Costa-Lotufo, LV1
Eskandarpour, M1
Kiaii, S1
Zhu, C1
Castro, J1
Sakko, AJ1
Hansson, J1
Ghelelovitch, S1
Lessin, SR1
Abraham, SR1
Nicolini, C1
Kuhlmann, KF1
Mosher, CW1
Poot, M1
Hiller, KH1
Heimpel, S1
Schuster, A1
Köhler, J1
Hoehn, H1
Lucas, P1
Milroy, DA1
Thomas, BJ1
Moss, SH1
Pouton, CW1
Krishan, A1
Pitman, SW1
Tattersall, HN1
Paika, KD1
Smith, DC1
Frei, E1
Pavelic, K1
Beerman, TA1
Bernacki, RJ1
Bucana, C1
Saiki, I1
Nayar, R1
Garcia, ST1
McQuillan, A1
Panasci, L1
Birkmayer, GD3
Miller, F2
Balda, BR3

Other Studies

14 other studies available for ethidium and Melanoma

ArticleYear
Kauren-19-oic acid induces DNA damage followed by apoptosis in human leukemia cells.
    Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:7

    Topics: Acridine Orange; Apoptosis; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Comet Assay; Di

2009
Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells.
    International journal of cancer, 2005, May-20, Volume: 115, Issue:1

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Codon; Coloring Agents; Cyclin D1; Down-Regulation;

2005
Effect of the inhibition of nucleic acids and protein synthesis upon the development of melanotic tumors in Drosophila.
    Experimental cell biology, 1983, Volume: 51, Issue:4

    Topics: Animals; Cell Division; Chloramphenicol; Cycloheximide; Dactinomycin; Drosophila melanogaster; Ethid

1983
Biophysical identification and sorting of high metastatic variants from B16 melanoma tumor.
    Cytometry, 1982, Volume: 2, Issue:6

    Topics: Animals; Cell Line; Cell Membrane; Cell Separation; DNA, Neoplasm; Ethidium; Flow Cytometry; Fluores

1982
New dimeric analogues of ethidium; synthesis, interaction with DNA, and antitumor activity.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:11

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; DNA; DNA, Neoplasm; Ethidium; Leukemi

1981
Heterogeneity of bromodeoxyuridine sensitivity of cultured cells from melanoma metastases.
    Cytometry, 1995, Sep-01, Volume: 21, Issue:1

    Topics: Bisbenzimidazole; Bromodeoxyuridine; Cell Division; Ethidium; Flow Cytometry; G2 Phase; Genetic Hete

1995
Pharmaceutical and biological properties of poly(amino acid)/DNA polyplexes.
    Journal of drug targeting, 1999, Volume: 7, Issue:2

    Topics: Amino Acids; Animals; Cations; DNA; Ethidium; Gene Transfer Techniques; Melanoma; Mice; Polymers; Tr

1999
Flow microfluorometric patterns of human bone marrow and tumor cells in response to cancer chemotherapy.
    Cancer research, 1976, Volume: 36, Issue:10

    Topics: Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cytarabine; Ethidium; Fluorometry; Humans;

1976
An evaluation of the effects of combination chemotherapy in vitro using DNA-reactive agents.
    Cancer drug delivery, 1985,Fall, Volume: 2, Issue:4

    Topics: Animals; Antineoplastic Agents; Bleomycin; Cell Line; Cisplatin; Colonic Neoplasms; DNA; Doxorubicin

1985
Uptake and accumulation of the vital dye hydroethidine in neoplastic cells.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1986, Volume: 34, Issue:9

    Topics: Animals; Cell Line; Cytophotometry; Ethidium; Fibrosarcoma; Flow Cytometry; Fluorescent Dyes; Humans

1986
Correlation between the cytotoxicity of melphalan and DNA crosslinks as detected by the ethidium bromide fluorescence assay in the F1 variant of B16 melanoma cells.
    Biochemical pharmacology, 1988, Aug-15, Volume: 37, Issue:16

    Topics: Cell Line; Cell Survival; DNA Damage; DNA, Neoplasm; Ethidium; Fluorescence; Humans; Melanoma; Melph

1988
Inhibition of high molecular weight RNA synthesis in a hamster melanoma by ethidium bromide in vivo.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1972, Volume: 353, Issue:11

    Topics: Animals; Antiviral Agents; Cell Fractionation; Centrifugation, Density Gradient; Cricetinae; DNA Nuc

1972
Drug effects in melanoma: tumor-specific interactions of proflavine and ethidiumbromide.
    The Yale journal of biology and medicine, 1973, Volume: 46, Issue:5

    Topics: Acridines; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Centrifugation, Density

1973
Oncorna-viral information in human melanoma.
    European journal of cancer, 1974, Volume: 10, Issue:7

    Topics: Brain Neoplasms; Dactinomycin; DNA Nucleotidyltransferases; Ethidium; Humans; Lymphatic Metastasis;

1974