Page last updated: 2024-10-28

ethidium and Lupus Erythematosus, Systemic

ethidium has been researched along with Lupus Erythematosus, Systemic in 8 studies

Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.

Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Research Excerpts

ExcerptRelevanceReference
"Purified IgG from patients with Systemic Lupus Erythematosus (SLE) containing anti-dsDNA antibodies competes with EB for binding to DNA resulting in a decrease in fluorescence."1.26The binding of anti-DNA antibodies as measured fluorometrically by ethidium bromide. ( Fritzler, MJ; Shepherd, JD; van de Sande, JH; Watson, JI, 1978)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19907 (87.50)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Miyashita, H1
Chikazawa, M1
Otaki, N1
Hioki, Y1
Shimozu, Y1
Nakashima, F1
Shibata, T1
Hagihara, Y1
Maruyama, S1
Matsumi, N1
Uchida, K1
Gilliam, AC1
Lang, D1
LoSpalluto, JJ1
Shepherd, JD1
Fritzler, MJ1
Watson, JI1
van de Sande, JH1
Okudaira, K1
Nakai, H1
Hayakawa, T1
Kashiwado, T1
Tanimoto, K1
Horiuchi, Y1
Juji, T1
Steinman, CR1
Davis, P1
Burrington, M1
Russell, AS1
Morgan, AR1
Tsay, GJ1
Chan, EK1
Peebles, CL1
Pollard, KM1
Tan, EM1
Riboldi, P1
Asero, R1

Other Studies

8 other studies available for ethidium and Lupus Erythematosus, Systemic

ArticleYear
Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins.
    Scientific reports, 2014, Jun-18, Volume: 4

    Topics: Amino Acid Sequence; Animals; Benzothiazoles; Diamines; DNA; Ethidium; Female; Fluorescent Dyes; Hum

2014
Antibodies to double-stranded DNA: purification and characterization of binding specificities.
    Journal of immunology (Baltimore, Md. : 1950), 1980, Volume: 125, Issue:2

    Topics: Animals; Antibodies; Binding Sites, Antibody; Binding, Competitive; Buffers; Cattle; Chromatography,

1980
The binding of anti-DNA antibodies as measured fluorometrically by ethidium bromide.
    The Journal of rheumatology, 1978,Winter, Volume: 5, Issue:4

    Topics: Antibodies, Antinuclear; Binding Sites, Antibody; Binding, Competitive; DNA; Epitopes; Ethidium; Hum

1978
Detection of antilymphocyte antibody with two-color method in systemic lupus erythematosus and its heterogeneous specificities against human T-cell subsets.
    The Journal of clinical investigation, 1979, Volume: 64, Issue:5

    Topics: Antibody Specificity; Autoantibodies; Cytotoxicity Tests, Immunologic; Ethidium; Fluoresceins; Human

1979
Quantitation of submicrogram concentrations of DNA by a modified Laurell electrophoresis method.
    Journal of immunological methods, 1979, Volume: 31, Issue:3-4

    Topics: Animals; Cattle; Deoxyribonucleases; DNA; Ethidium; Fluorescent Antibody Technique; Guanidines; Huma

1979
Analysis of DNA structure by hydroxyapatite columns and ethidium bromide fluorescence techniques. A comparative study and effect on DNA binding.
    Arthritis and rheumatism, 1978, Volume: 21, Issue:4

    Topics: Antibodies; Antibody Specificity; Chromatography; DNA; DNA Helicases; DNA Replication; DNA, Single-S

1978
An immunoassay differentiating sera with antibodies to Sm alone, antibodies to Sm/RNP complex, and antibodies to RNP alone.
    Arthritis and rheumatism, 1987, Volume: 30, Issue:4

    Topics: Autoantibodies; Autoantigens; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Enzyme

1987
Ethidium bromide in the detection of antibodies to DNA and of circulating DNA by two-stage counterimmunoelectrophoresis.
    Journal of immunological methods, 1985, Dec-17, Volume: 85, Issue:1

    Topics: Autoantibodies; Counterimmunoelectrophoresis; DNA; Ethidium; Humans; Lupus Erythematosus, Systemic

1985