Page last updated: 2024-10-28

ethidium and Huntington Disease

ethidium has been researched along with Huntington Disease in 2 studies

Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research Excerpts

ExcerptRelevanceReference
"The expanded CAG repeat in the Huntington's disease (HD) gene may display tissue-specific variability (e."1.35DNA instability in replicating Huntington's disease lymphoblasts. ( Cannella, M; Frati, L; Li, GM; Maglione, V; Martino, T; Ragona, G; Squitieri, F, 2009)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cannella, M1
Maglione, V1
Martino, T1
Ragona, G1
Frati, L1
Li, GM1
Squitieri, F1
Valdes, JM1
Tagle, DA1
Elmer, LW1
Collins, FS1

Other Studies

2 other studies available for ethidium and Huntington Disease

ArticleYear
DNA instability in replicating Huntington's disease lymphoblasts.
    BMC medical genetics, 2009, Feb-11, Volume: 10

    Topics: Cell Division; Cell Line; Cross-Linking Reagents; Ethidium; Ethyl Methanesulfonate; Female; Humans;

2009
A simple non-radioactive method for diagnosis of Huntington's disease.
    Human molecular genetics, 1993, Volume: 2, Issue:6

    Topics: DNA; Electrophoresis, Polyacrylamide Gel; Ethidium; Humans; Huntington Disease; Polymerase Chain Rea

1993