ethidium has been researched along with Demyelinating Diseases in 94 studies
Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.
Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental models of demyelination based on the use of toxins, while not attempting to accurately mimic a disease with complex etiology and pathogenesis such as MS, have nevertheless proven extremely useful for studying the biology of remyelination." | 2.44 | Remyelination in experimental models of toxin-induced demyelination. ( Blakemore, WF; Franklin, RJ, 2008) |
| "Multifocal demyelination was induced by injection of ethidium bromide (EB), either at the time of transection or twice during transection and at 5 days post-injury." | 1.72 | Forced Remyelination Promotes Axon Regeneration in a Rat Model of Spinal Cord Injury. ( Bekisz, M; Kwaśniewska, A; Miazga, K; Niedziółka, S; Sławińska, U; Yeghiazaryan, M; Zawadzka, M, 2022) |
| "Pathological evidence of demyelination was observed in pontine tissue and higher levels of caspase-3 activity were detected compared to control rats." | 1.51 | LINGO-1 siRNA nanoparticles promote central remyelination in ethidium bromide-induced demyelination in rats. ( Abdelmonsif, DA; Dief, AE; El Azhary, NM; El-Fetiany, OS; Youssef, AEH, 2019) |
| "Following ethidium bromide induced demyelination, levels of neurofilament medium (NF-M) and heavy (NF-H) phosphorylation were unaffected." | 1.48 | Internode length is reduced during myelination and remyelination by neurofilament medium phosphorylation in motor axons. ( Barry, DM; Byers, N; Calcutt, NA; Dale, JM; Downer, NL; Frizzi, K; Garcia, ML; Jones, MR; Landayan, DS; Villalón, E, 2018) |
| "Propentofylline (PPF) is a xanthine derivative with pharmacological effects that are distinct from those of classic methylxanthines." | 1.43 | Propentofylline treatment on open field behavior in rats with focal ethidium bromide-induced demyelination in the ventral surface of the brainstem. ( Bernardi, MM; Bondan, EF; Martins-Júnior, JL, 2016) |
| " The dose of 100 mg/kg showed a better dose-response to the protective effects." | 1.42 | Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination. ( Abdalla, FH; Aiello, G; Amaral, MG; Andrade, CM; Bohnert, C; Carvalho, FB; Duarte, MM; Gutierres, JM; Lopes, ST; Oliveira, SM; Palma, HE; Pippi, NL; Spanevello, RM; Vieira, JM; Zago, AM, 2015) |
| "Two stages were observed: phase of demyelination (peak on day 7) and phase of remyelination (peak on day 21 post-injection)." | 1.40 | Neuroprotective role of quercetin in locomotor activities and cholinergic neurotransmission in rats experimentally demyelinated with ethidium bromide. ( Abdalla, FH; Aiello, G; Andrades, AO; Beckmann, DV; Carvalho, FB; Dos Santos, RP; Graça, DL; Gutierres, JM; Mazzanti, A; Mazzanti, CM; Oliveira, LS; Rippilinger, A; Schetinger, MR, 2014) |
| "EB-induced VWM demyelination significantly reduced spared VWM and Basso Mouse Scale (BMS) scores persisting out to 2 months." | 1.39 | Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord. ( Enzmann, GU; James, KT; Kuypers, NJ; Magnuson, DS; Whittemore, SR, 2013) |
| "EB caused dorsolateral demyelination at C2-C3 followed by significant spontaneous remyelination at 14 days post-EB." | 1.39 | Cervical spinal demyelination with ethidium bromide impairs respiratory (phrenic) activity and forelimb motor behavior in rats. ( Duncan, ID; Johnson, RA; Mitchell, GS; Nichols, NL; Punzo, AM, 2013) |
| "In the demyelination phase, there was a significant decrease (p < 0." | 1.38 | Complete blood count and acetylcholinesterase activity of lymphocytes of demyelinated and ovariectomized rats treated with resveratrol. ( Costa, MM; Facco, G; França, R; Lopes, ST; Maciel, RM; Mann, T; Martins, DB; Mazzanti, A; Mazzanti, CM; Morsch, V; Oliveira, L; Pagnoncelli, M; Schmatz, R; Visentini, D, 2012) |
| "In ethidium bromide treated rats, gabapentin administered at 300 mg/kg increased cortical MDA by 66%." | 1.38 | The effect of gabapentin on oxidative stress in a model of toxic demyelination in rat brain. ( Abdel-Salam, OM; Khadrawy, YA; Mohammed, NA; Youness, ER, 2012) |
| "The extent of demyelination, myelin staining intensity, and expression of myelin basic protein and caspase-3 were investigated using histological and immunoblotting verification." | 1.36 | Vitamins E and D3 attenuate demyelination and potentiate remyelination processes of hippocampal formation of rats following local injection of ethidium bromide. ( Goudarzvand, M; Javan, M; Mirnajafi-Zadeh, J; Mozafari, S; Tiraihi, T, 2010) |
| "Conduction was delayed during demyelination, but the mexiletine-injected group demonstrated shortened latencies and reductions in the demyelination area when compared to the control." | 1.36 | Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords. ( Chung, MA; Lee, BH; Lee, HJ; Lee, KH; Sohn, JH; Yoon, DH, 2010) |
| "Transient demyelination does not cause lasting functional deficits." | 1.36 | Transient demyelination increases the efficiency of retrograde AAV transduction. ( Gray, SJ; Hollis, ER; Jamshidi, P; Lee, JK; Lorenzana, AO; Samulski, RJ; Tuszynski, MH; Zheng, B, 2010) |
| "Demyelination is a major cause of neurological disability within the human population, and the end product of a number of pathological processes, though the most common is the disease multiple sclerosis." | 1.33 | A technique for producing demyelination of the rat optic nerves. ( Guazzo, EP, 2005) |
| "We conclude that stathmin expression in demyelinating disorders could have a dual role." | 1.33 | Expression of stathmin, a developmentally controlled cytoskeleton-regulating molecule, in demyelinating disorders. ( Bruck, W; Casaccia-Bonnefil, P; Liu, A; Mastronardi, FG; Moscarello, M; Sobel, A; Stadelmann, C, 2005) |
| "Chronic demyelination is a pathophysiologic component of compressive spinal cord injury (SCI) and a characteristic finding in demyelinating diseases including multiple sclerosis (MS)." | 1.33 | Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes. ( Bunge, MB; Liu, Y; Loy, DN; Qiu, MS; Rao, MS; Talbott, JF; Whittemore, SR, 2005) |
| "Using a gliotoxin model of demyelination we were therefore able to ascertain the in vivo effect of rhGGF-2 following local CNS delivery in a model that is not confounded by the concurrent presence of an immune-mediated process." | 1.32 | Increasing local levels of neuregulin (glial growth factor-2) by direct infusion into areas of demyelination does not alter remyelination in the rat CNS. ( Dunning, MD; Franklin, RJ; Lakatos, A; Li, WW; Marchionni, M; Penderis, J; Woodruff, RH; Zhao, C, 2003) |
| "Using a toxin model of demyelination, in which the demyelinated axons are remyelinated in an age-dependent manner by both oligodendrocytes and Schwann cells, we have compared the expression of SCIP/Oct-6 mRNA with that of an OP marker (PDGF-alphaR), a marker of myelinating oligodendrocytes (PLP), and markers of myelinating Schwann cells (P(0) and Krox-20) by in situ hybridization." | 1.31 | Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS. ( Franklin, RJ; Lakatos, A; Li, WW; Sim, FJ; Zhao, C, 2002) |
| "During the demyelination stage and early stage of remyelination, large cells strongly expressing PDGFalphaR mRNA were observed in the border of the demyelinating lesion, and with immunohistochemistry they exhibited positive labeling of the astrocytic marker glial fibrillary acidic protein (GFAP)." | 1.31 | The reaction of glial progenitor cells in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord. ( Fushimi, S; Shirabe, T, 2002) |
| "Demyelination was induced by a single 10 microl intracisternal injection of 0." | 1.31 | The effect of cyclophosphamide on brainstem remyelination following local ethidium bromide injection in Wistar rats. ( Bondan, EF; Graça, DL; Lallo, MA; Pereira, LA; Sinhorini, IL, 2000) |
| "Ethidium bromide (EB) is a gliotoxic chemical that when injected locally within the CNS, induce demyelination." | 1.31 | Behaviour of oligodendrocytes and Schwann cells in an experimental model of toxic demyelination of the central nervous system. ( Bondan, EF; Fernandes, CG; Graça, DL; Maiorka, PC; Pereira, LA, 2001) |
| "We conclude that demyelination produces detectable behavioural deficits which disappear following spontaneous remyelination." | 1.30 | Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination. ( Blakemore, WF; Jeffery, ND, 1997) |
| "While the demyelination alone is sufficient to block conduction and thereby cause symptoms, there is increasing evidence that the inflammation may also contribute significantly to the conduction block, although the mechanisms are not understood." | 1.30 | Nitric oxide donors reversibly block axonal conduction: demyelinated axons are especially susceptible. ( Kapoor, R; Redford, EJ; Smith, KJ, 1997) |
| "The ethidium bromide model of demyelination has been employed to study the central nervous system response to several episodes of demyelination." | 1.30 | [Demyelination and remyelination after multiple intramedullary injections of ethidium bromide in Wistar rats]. ( Fernandes, CG; Graça, DL; Pereira, LA, 1997) |
| "Experimentally induced demyelination due to the direct injection of gliotoxic agents has provided powerful models for studying the biology of remyelination." | 1.30 | Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/anti-galactocerebroside: a comparative study. ( Franklin, RJ; Woodruff, RH, 1999) |
| "However, following demyelination the Ca(2+)-ATPase activity was expressed continuously along both the exposed, previously internodal axolemma of entirely naked axons, and it was particularly prominent at sites of contact between axons and glial-cell processes." | 1.29 | Changes in the distribution of a calcium-dependent ATPase during demyelination and remyelination in the central nervous system. ( Felts, PA; Smith, KJ, 1996) |
| "The process of demyelination consisting of the withdrawal of myelin sheaths from their axons is a characteristic feature of multiple sclerosis, the most common human demyelinating disease." | 1.29 | Biology of the repair of central nervous system demyelinated lesions: an appraisal. ( Cruz-Höfling, MA; Dertkigil, MS; Graça, DL; Peireira, LA, 1996) |
| "Areas of persistent demyelination were created in the dorsal columns of the cat spinal cord by injecting ethidium bromide into white matter which had previously been exposed to 40 Grays of X-irradiation." | 1.27 | The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system. ( Blakemore, WF; Crang, AJ, 1985) |
| "These patterns of demyelination and remyelination observed in ethidium bromide-treated rats were compared with those observed in other demyelinating conditions of varied etiology such as experimental allergic encephalomyelitis, diphtheria toxin, or lysolecithin injection and cuprizone intoxication." | 1.26 | Demyelination and remyelination in the rat central nervous system following ethidium bromide injection. ( Suzuki, K; Yajima, K, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (10.64) | 18.7374 |
| 1990's | 17 (18.09) | 18.2507 |
| 2000's | 39 (41.49) | 29.6817 |
| 2010's | 25 (26.60) | 24.3611 |
| 2020's | 3 (3.19) | 2.80 |
| Authors | Studies |
|---|---|
| Kapoor, T | 1 |
| Mehan, S | 1 |
| Suri, M | 1 |
| Sharma, N | 1 |
| Kumar, N | 1 |
| Narula, AS | 1 |
| Alshammari, A | 1 |
| Alasmari, AF | 1 |
| Alharbi, M | 1 |
| Assiri, MA | 1 |
| Kalfin, R | 1 |
| Zawadzka, M | 1 |
| Yeghiazaryan, M | 1 |
| Niedziółka, S | 1 |
| Miazga, K | 1 |
| Kwaśniewska, A | 1 |
| Bekisz, M | 1 |
| Sławińska, U | 1 |
| Barzegarzadeh, B | 1 |
| Hatami, H | 1 |
| Dehghan, G | 1 |
| Khajehnasiri, N | 1 |
| Khoobi, M | 1 |
| Sadeghian, R | 1 |
| Bondan, E | 1 |
| Cardoso, C | 1 |
| Martins, MF | 2 |
| Villalón, E | 1 |
| Barry, DM | 1 |
| Byers, N | 1 |
| Frizzi, K | 1 |
| Jones, MR | 1 |
| Landayan, DS | 1 |
| Dale, JM | 1 |
| Downer, NL | 1 |
| Calcutt, NA | 1 |
| Garcia, ML | 1 |
| Hooijmans, CR | 1 |
| Hlavica, M | 1 |
| Schuler, FAF | 1 |
| Good, N | 1 |
| Good, A | 1 |
| Baumgartner, L | 1 |
| Galeno, G | 1 |
| Schneider, MP | 1 |
| Jung, T | 1 |
| de Vries, R | 1 |
| Ineichen, BV | 1 |
| Youssef, AEH | 1 |
| Dief, AE | 1 |
| El Azhary, NM | 1 |
| Abdelmonsif, DA | 1 |
| El-Fetiany, OS | 1 |
| McMurran, CE | 1 |
| Zhao, C | 9 |
| Franklin, RJM | 1 |
| Kuypers, NJ | 1 |
| James, KT | 1 |
| Enzmann, GU | 2 |
| Magnuson, DS | 2 |
| Whittemore, SR | 4 |
| Bondan, EF | 12 |
| Monteiro Martins, Mde F | 1 |
| Beckmann, DV | 2 |
| Carvalho, FB | 2 |
| Mazzanti, CM | 9 |
| Dos Santos, RP | 1 |
| Andrades, AO | 1 |
| Aiello, G | 2 |
| Rippilinger, A | 1 |
| Graça, DL | 21 |
| Abdalla, FH | 2 |
| Oliveira, LS | 1 |
| Gutierres, JM | 2 |
| Schetinger, MR | 7 |
| Mazzanti, A | 9 |
| Bohnert, C | 1 |
| Zago, AM | 1 |
| Vieira, JM | 1 |
| Palma, HE | 1 |
| Oliveira, SM | 1 |
| Spanevello, RM | 5 |
| Duarte, MM | 1 |
| Lopes, ST | 2 |
| Amaral, MG | 1 |
| Pippi, NL | 1 |
| Andrade, CM | 1 |
| Martins, Mde F | 2 |
| Bernardi, MM | 4 |
| Salem, NA | 1 |
| Assaf, N | 1 |
| Ismail, MF | 1 |
| Khadrawy, YA | 2 |
| Samy, M | 1 |
| Martins-Júnior, JL | 1 |
| Leal, CAM | 1 |
| Leal, DBR | 1 |
| Adefegha, SA | 1 |
| Morsch, VM | 7 |
| Castilhos, LG | 1 |
| Thorstenberg, MLP | 1 |
| Jaques, JADS | 1 |
| Souza, VDCG | 1 |
| Farias, JG | 1 |
| Martins, CC | 1 |
| Schetinger, MRC | 1 |
| Dossa, PD | 1 |
| Viebig, LB | 1 |
| Cardoso, CV | 1 |
| Martins, JL | 1 |
| Lallo, MA | 7 |
| Spanevello, R | 2 |
| Ahmed, M | 4 |
| Pereira, LB | 2 |
| Gonçalves, JF | 3 |
| Corrêa, M | 3 |
| Schmatz, R | 4 |
| Stefanello, N | 1 |
| Leal, DB | 1 |
| Ramos, AT | 1 |
| Martins, TB | 1 |
| Danesi, CC | 1 |
| Goudarzvand, M | 1 |
| Javan, M | 1 |
| Mirnajafi-Zadeh, J | 1 |
| Mozafari, S | 1 |
| Tiraihi, T | 1 |
| Kirschner, DA | 1 |
| Avila, RL | 1 |
| Gamez Sazo, RE | 1 |
| Luoma, A | 1 |
| Agrawal, D | 1 |
| Inouye, H | 1 |
| Bunge, MB | 2 |
| Kocsis, J | 1 |
| Peters, A | 1 |
| Custódio, PR | 1 |
| Bentubo, HD | 1 |
| Lee, KH | 1 |
| Yoon, DH | 1 |
| Chung, MA | 1 |
| Sohn, JH | 1 |
| Lee, HJ | 1 |
| Lee, BH | 1 |
| Hollis, ER | 1 |
| Jamshidi, P | 1 |
| Lorenzana, AO | 1 |
| Lee, JK | 1 |
| Gray, SJ | 1 |
| Samulski, RJ | 1 |
| Zheng, B | 1 |
| Tuszynski, MH | 1 |
| Huang, SF | 1 |
| Ding, Y | 1 |
| Ruan, JW | 1 |
| Zhang, W | 1 |
| Wu, JL | 1 |
| He, B | 1 |
| Zhang, YJ | 1 |
| Li, Y | 1 |
| Zeng, YS | 1 |
| Branco, AM | 1 |
| Zambonin, JL | 1 |
| Ohno, N | 1 |
| Campbell, GR | 1 |
| Engeham, S | 1 |
| Ziabreva, I | 1 |
| Schwarz, N | 1 |
| Lee, SE | 1 |
| Frischer, JM | 1 |
| Turnbull, DM | 1 |
| Trapp, BD | 1 |
| Lassmann, H | 1 |
| Franklin, RJ | 18 |
| Mahad, DJ | 1 |
| Hansmann, F | 1 |
| Pringproa, K | 1 |
| Ulrich, R | 1 |
| Sun, Y | 1 |
| Herder, V | 1 |
| Kreutzer, M | 1 |
| Baumgärtner, W | 1 |
| Wewetzer, K | 1 |
| Martins, DB | 1 |
| Costa, MM | 1 |
| França, R | 1 |
| Pagnoncelli, M | 1 |
| Maciel, RM | 1 |
| Oliveira, L | 1 |
| Morsch, V | 1 |
| Facco, G | 1 |
| Visentini, D | 1 |
| Mann, T | 1 |
| Abdel-Salam, OM | 1 |
| Mohammed, NA | 1 |
| Youness, ER | 1 |
| Nichols, NL | 1 |
| Punzo, AM | 1 |
| Duncan, ID | 1 |
| Mitchell, GS | 1 |
| Johnson, RA | 1 |
| Sim, FJ | 2 |
| Li, WW | 5 |
| Lakatos, A | 2 |
| Fushimi, S | 2 |
| Shirabe, T | 2 |
| Penderis, J | 4 |
| Shields, SA | 3 |
| Chari, DM | 3 |
| Huang, WL | 1 |
| Blakemore, WF | 22 |
| Woodruff, RH | 2 |
| Dunning, MD | 1 |
| Marchionni, M | 1 |
| Ibanez, C | 1 |
| El-Etr, M | 1 |
| Baulieu, EE | 1 |
| Schumacher, M | 2 |
| Gilson, JM | 4 |
| Crang, AJ | 13 |
| Baz, EI | 1 |
| Sinhorini, IL | 3 |
| Setzu, A | 1 |
| Arnett, HA | 1 |
| Fancy, SP | 1 |
| Alberta, JA | 1 |
| Plant, SR | 1 |
| Kaing, S | 1 |
| Raine, CS | 1 |
| Rowitch, DH | 1 |
| Stiles, CD | 1 |
| Guazzo, EP | 1 |
| Liu, A | 1 |
| Stadelmann, C | 1 |
| Moscarello, M | 1 |
| Bruck, W | 1 |
| Sobel, A | 1 |
| Mastronardi, FG | 1 |
| Casaccia-Bonnefil, P | 1 |
| Talbott, JF | 1 |
| Loy, DN | 2 |
| Liu, Y | 1 |
| Qiu, MS | 1 |
| Rao, MS | 1 |
| Kotter, MR | 1 |
| Fang, Z | 1 |
| Duthoit, N | 1 |
| Wicher, G | 1 |
| Källskog, O | 1 |
| Ambartsumian, N | 1 |
| Lukanidin, E | 1 |
| Takenaga, K | 1 |
| Kozlova, EN | 1 |
| Black, JA | 1 |
| Waxman, SG | 1 |
| Smith, KJ | 3 |
| Trigueiro, AH | 1 |
| Ribeiro, CP | 1 |
| Kaizer, R | 2 |
| Zanin, R | 3 |
| Cargnelutti, D | 1 |
| Hannel, L | 2 |
| Festugatto, R | 3 |
| Graça, D | 2 |
| Sallis, ES | 2 |
| Pereira, LA | 7 |
| Arroteia, KF | 1 |
| Fustigatto, R | 1 |
| Pelizzari, C | 1 |
| Rodrigues, A | 1 |
| Orsini, H | 1 |
| Bentubo, HL | 1 |
| Yazbek, A | 1 |
| Macrini, DJ | 1 |
| Maldonado, PA | 1 |
| Morsch, A | 2 |
| Loro, VL | 1 |
| Salbego, FZ | 1 |
| Battisti, V | 1 |
| Rosenbluth, J | 1 |
| Reynolds, R | 1 |
| Wilkin, GP | 1 |
| Groves, AK | 1 |
| Barnett, SC | 1 |
| Mayer, M | 1 |
| Noble, M | 1 |
| Felts, PA | 1 |
| Peireira, LA | 1 |
| Cruz-Höfling, MA | 2 |
| Dertkigil, MS | 2 |
| Jeffery, ND | 2 |
| O'Leary, MT | 2 |
| Redford, EJ | 1 |
| Kapoor, R | 1 |
| Fernandes, CG | 4 |
| Hodge, SJ | 1 |
| Iwashita, Y | 1 |
| Fawcett, JW | 1 |
| Maiorka, PC | 1 |
| Smith, PM | 1 |
| Riet-Correa, G | 1 |
| Zhang, YP | 1 |
| Onifer, SM | 1 |
| Mills, MD | 1 |
| Cao, QL | 1 |
| Darnall, JB | 1 |
| Fajardo, LC | 1 |
| Burke, DA | 1 |
| Yajima, K | 1 |
| Suzuki, K | 1 |
| Curtis, R | 1 |
5 reviews available for ethidium and Demyelinating Diseases
| Article | Year |
|---|---|
Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, E | 2019 |
Remyelination in experimental models of toxin-induced demyelination.
Topics: Animals; Antibodies; Cats; Demyelinating Diseases; Disease Models, Animal; Ethidium; Galactosylceram | 2008 |
The response of oligodendrocytes to chemical injury.
Topics: 6-Aminonicotinamide; Animals; Axons; Cuprizone; Demyelinating Diseases; Ethidium; Isoniazid; Mice; M | 1984 |
Transplanted cultured type-1 astrocytes can be used to reconstitute the glia limitans of the CNS: the structure which prevents Schwann cells from myelinating CNS axons.
Topics: Animals; Astrocytes; Axons; Cell Division; Cells, Cultured; Central Nervous System; Demyelinating Di | 1992 |
Transplantation of glial cell cultures into areas of demyelination in the adult CNS.
Topics: Animals; Brain Tissue Transplantation; Cells, Cultured; Demyelinating Diseases; Ethidium; Mice; Mice | 1990 |
89 other studies available for ethidium and Demyelinating Diseases
| Article | Year |
|---|---|
Forskolin, an Adenylcyclase/cAMP/CREB Signaling Activator Restoring Myelin-Associated Oligodendrocyte Destruction in Experimental Ethidium Bromide Model of Multiple Sclerosis.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cytokines; Demyelinating Diseases; Donepezil; Ethidium; Fingo | 2022 |
Forced Remyelination Promotes Axon Regeneration in a Rat Model of Spinal Cord Injury.
Topics: Animals; Axons; Demyelinating Diseases; Ethidium; Nerve Regeneration; Rats; Remyelination; Spinal Co | 2022 |
Conjugated Linoleic Acid-Curcumin Attenuates Cognitive Deficits and Oxidative Stress Parameters in the Ethidium Bromide-Induced Model of Demyelination.
Topics: Animals; Cognitive Dysfunction; Curcumin; Demyelinating Diseases; Enzyme Inhibitors; Ethidium; Linol | 2021 |
Curcumin decreases astrocytic reaction after gliotoxic injury in the rat brainstem.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Brain Stem; Curcumin; Demyelinating Di | 2017 |
Internode length is reduced during myelination and remyelination by neurofilament medium phosphorylation in motor axons.
Topics: Animals; Axons; Demyelinating Diseases; Ethidium; Male; Mice; Motor Neurons; Mutagenesis, Site-Direc | 2018 |
LINGO-1 siRNA nanoparticles promote central remyelination in ethidium bromide-induced demyelination in rats.
Topics: Administration, Intranasal; Animals; Ataxia; Caspase 3; Chitosan; Demyelinating Diseases; Disease Mo | 2019 |
Toxin-Based Models to Investigate Demyelination and Remyelination.
Topics: Animals; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Ethidium; Lysophosphatidylcholin | 2019 |
Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord.
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme In | 2013 |
Cyclosporine improves remyelination in diabetic rats submitted to a gliotoxic demyelinating model in the brainstem.
Topics: Animals; Brain Stem; Cyclosporine; Demyelinating Diseases; Diabetes Mellitus, Experimental; Disease | 2013 |
Neuroprotective role of quercetin in locomotor activities and cholinergic neurotransmission in rats experimentally demyelinated with ethidium bromide.
Topics: Animals; Antioxidants; Cholinergic Neurons; Demyelinating Diseases; Ethidium; Male; Motor Activity; | 2014 |
Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination.
Topics: Aldehydes; Animals; Anthocyanins; Antioxidants; Calcium-Transporting ATPases; Demyelinating Diseases | 2015 |
Propentofylline reverses delayed remyelination in streptozotocin-induced diabetic rats.
Topics: Animals; Astrocytes; Demyelinating Diseases; Diabetes Mellitus, Experimental; Disease Models, Animal | 2015 |
Ozone Therapy in Ethidium Bromide-Induced Demyelination in Rats: Possible Protective Effect.
Topics: Animals; Antioxidants; Demyelinating Diseases; Ethidium; Interleukin-1beta; Male; Motor Activity; Ox | 2016 |
Propentofylline treatment on open field behavior in rats with focal ethidium bromide-induced demyelination in the ventral surface of the brainstem.
Topics: Animals; Brain Stem; Demyelinating Diseases; Ethidium; Exploratory Behavior; Male; Motor Activity; N | 2016 |
Effects of chlorogenic acid on adenine nucleotides hydrolyzing enzyme activities and expression in platelets of rats experimentally demyelinated with ethidium bromide.
Topics: Adenine Nucleotides; Adenosine Deaminase; Animals; Blood Platelets; Chlorogenic Acid; Demyelinating | 2016 |
Propentofylline reduces glial scar development following gliotoxic damage in the rat brainstem.
Topics: Animals; Astrocytes; Brain Stem; Demyelinating Diseases; Disease Models, Animal; Ethidium; Glial Fib | 2016 |
Ultrastructural study of the effects of cyclosporine in the brainstem of Wistar rats submitted to the ethidium bromide demyelinating model.
Topics: Animals; Brain Stem; Cyclosporine; Demyelinating Diseases; Disease Models, Animal; Drug Evaluation, | 2008 |
Pre-treatment with ebselen and vitamin E modulate acetylcholinesterase activity: interaction with demyelinating agents.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Antioxidants; Azoles; Brain; Cholinergic Fibers; Demye | 2009 |
Vitamins E and D3 attenuate demyelination and potentiate remyelination processes of hippocampal formation of rats following local injection of ethidium bromide.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Cholecalciferol; Demyelinating Diseases; Enzyme Inhibit | 2010 |
Rapid assessment of internodal myelin integrity in central nervous system tissue.
Topics: Aging; Animals; Central Nervous System; Demyelinating Diseases; Disease Models, Animal; Ethidium; Ma | 2010 |
Ethidium bromide-induced demyelination in the sciatic nerve of diabetic rats.
Topics: Animals; Demyelinating Diseases; Diabetes Mellitus, Experimental; Ethidium; Microscopy, Electron, Tr | 2009 |
Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords.
Topics: Animals; Anti-Arrhythmia Agents; Demyelinating Diseases; Ethidium; Evoked Potentials, Motor; Male; M | 2010 |
Transient demyelination increases the efficiency of retrograde AAV transduction.
Topics: Animals; Demyelinating Diseases; Dependovirus; Ethidium; Female; Genetic Vectors; Immunohistochemist | 2010 |
An experimental electro-acupuncture study in treatment of the rat demyelinated spinal cord injury induced by ethidium bromide.
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Electroacupuncture; Ethidium; Male; Nerve R | 2011 |
Semi-quantitative analysis of the effects of cyclosporine on remyelination following gliotoxic injection in the brainstem.
Topics: Animals; Brain Stem; Cyclosporine; Demyelinating Diseases; Disease Models, Animal; Ethidium; Immunos | 2011 |
Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Ax | 2011 |
Highly malignant behavior of a murine oligodendrocyte precursor cell line following transplantation into the demyelinated and nondemyelinated central nervous system.
Topics: Animals; Antigens; Cell Differentiation; Cell Line; Demyelinating Diseases; Ethidium; Glial Fibrilla | 2012 |
Complete blood count and acetylcholinesterase activity of lymphocytes of demyelinated and ovariectomized rats treated with resveratrol.
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Cell Count; Demyelinat | 2012 |
The effect of gabapentin on oxidative stress in a model of toxic demyelination in rat brain.
Topics: Amines; Animals; Antioxidants; Cerebral Cortex; Cyclohexanecarboxylic Acids; Demyelinating Diseases; | 2012 |
Cervical spinal demyelination with ethidium bromide impairs respiratory (phrenic) activity and forelimb motor behavior in rats.
Topics: Animals; Cervical Vertebrae; Demyelinating Diseases; Diaphragm; Ethidium; Forelimb; Motor Activity; | 2013 |
Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS.
Topics: Animals; Biomarkers; Brain; Cell Line; Cells, Cultured; Cyclic AMP; Demyelinating Diseases; Ethidium | 2002 |
The reaction of glial progenitor cells in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord.
Topics: Animals; Astrocytes; Cell Differentiation; Demyelinating Diseases; Enzyme Inhibitors; Ethidium; Glia | 2002 |
Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system.
Topics: Animals; Demyelinating Diseases; Ethidium; Female; In Situ Hybridization; Myelin Sheath; Nerve Regen | 2003 |
Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue.
Topics: Animals; Antigens; Cell Count; Cell Survival; Cells, Cultured; Demyelinating Diseases; Enzyme Inhibi | 2003 |
Increasing local levels of neuregulin (glial growth factor-2) by direct infusion into areas of demyelination does not alter remyelination in the rat CNS.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Division; Cells, Cultured; Central Nervous System; Demy | 2003 |
Systemic progesterone administration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demyelination in male rats.
Topics: Aging; Animals; Brain; Delayed-Action Preparations; Demyelinating Diseases; Ethidium; Male; Neurotox | 2004 |
The presence of astrocytes in areas of demyelination influences remyelination following transplantation of oligodendrocyte progenitors.
Topics: Animals; Astrocytes; Brain Tissue Transplantation; Cell Differentiation; Demyelinating Diseases; Enz | 2003 |
[Ultrastructural study of the remyelinating process following local ethidium bromide injection in the brainstem of dexamethasone-immunosuppressed rats].
Topics: Animals; Anti-Inflammatory Agents; Brain Stem; Demyelinating Diseases; Dexamethasone; Disease Models | 2004 |
The remyelinating potential and in vitro differentiation of MOG-expressing oligodendrocyte precursors isolated from the adult rat CNS.
Topics: Animals; Axons; Benzimidazoles; Blotting, Western; Bone Morphogenetic Proteins; Bromodeoxyuridine; C | 2004 |
Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord.
Topics: Animals; Demyelinating Diseases; Ethidium; Injections, Spinal; Male; Mice; Mice, Inbred BALB C; Myel | 2004 |
Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Bromodeoxyuridine; CD11b Antigen; Cell Count; Cell | 2005 |
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
Topics: Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Brain; Cell Nucleus; Cupriz | 2004 |
A technique for producing demyelination of the rat optic nerves.
Topics: Animals; Coloring Agents; Demyelinating Diseases; Ethidium; Female; Fluorescent Dyes; Male; Myelin S | 2005 |
Expression of stathmin, a developmentally controlled cytoskeleton-regulating molecule, in demyelinating disorders.
Topics: Animals; Apoptosis; Brain; Cell Differentiation; Cells, Cultured; Demyelinating Diseases; Epilepsy, | 2005 |
Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes.
Topics: Animals; Antigens, Differentiation; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Cell C | 2005 |
Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system.
Topics: Adrenal Cortex Hormones; Animals; Central Nervous System; Demyelinating Diseases; Ethidium; Female; | 2006 |
Intracellular calcium-binding protein S100A4 influences injury-induced migration of white matter astrocytes.
Topics: Animals; Astrocytes; Cell Movement; Cells, Cultured; Central Nervous System; Demyelinating Diseases; | 2006 |
Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier.
Topics: Animals; Axons; Demyelinating Diseases; Ethidium; Kv1.2 Potassium Channel; Myelin Sheath; NAV1.6 Vol | 2006 |
Delayed Schwann cell and oligodendrocyte remyelination after ethidium bromide injection in the brainstem of Wistar rats submitted to streptozotocin diabetogenic treatment.
Topics: Animals; Brain Stem; Demyelinating Diseases; Diabetes Mellitus, Experimental; Ethidium; Male; Micros | 2006 |
Apyrase and 5'-nucleotidase activities in synaptosomes from the cerebral cortex of rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Animals; Apyrase; Cerebral Cortex; Demyelinating Diseases; Enz | 2006 |
OSP-Immunofluorescent remyelinating oligodendrocytes in the brainstem of toxically-demyelinated Wistar rats.
Topics: Animals; Brain Stem; Claudins; Cyclosporine; Demyelinating Diseases; Disease Models, Animal; Ethidiu | 2006 |
Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS.
Topics: Aging; Animals; Animals, Newborn; Castration; Demyelinating Diseases; Ethidium; Female; Male; Micros | 2006 |
Acetylcholinesterase activity in rats experimentally demyelinated with ethidium bromide and treated with interferon beta.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Demyelinating Diseases; Ethidium; I | 2006 |
[Evaluation of locomotor activity after a local induction of toxic demyelination in the brainstem of Wistar rats].
Topics: Animals; Brain Stem; Demyelinating Diseases; Disease Models, Animal; Ethidium; Male; Motor Activity; | 2006 |
Activities of enzymes that hydrolyze adenine nucleotides in platelets from rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Animals; Antigens, CD; Apyrase; Blood Platelets; Demyelinating | 2007 |
Cyclosporine A inhibits acetylcholinesterase activity in rats experimentally demyelinated with ethidium bromide.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Antirheumatic Agents; Brain; Cyclosporine; Demy | 2007 |
Previous treatment with ebselen and vitamin E alters adenine nucleotide hydrolysis in platelets from adult rats experimentally demyelinated with ethidium bromide.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Trip | 2007 |
Structural specializations in cat of chronically demyelinated spinal cord axons as seen in freeze-fracture replicas.
Topics: Animals; Astrocytes; Axons; Cats; Chronic Disease; Demyelinating Diseases; Ethidium; Freeze Fracturi | 1984 |
Cellular reaction to an acute demyelinating/remyelinating lesion of the rat brain stem: localisation of GD3 ganglioside immunoreactivity.
Topics: Animals; Astrocytes; Axons; Brain Stem; Cisterna Magna; Demyelinating Diseases; Ethidium; Fluorescen | 1993 |
Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells.
Topics: Animals; Astrocytes; beta-Galactosidase; Cells, Cultured; Demyelinating Diseases; DNA; Drug Carriers | 1993 |
Changes in the distribution of a calcium-dependent ATPase during demyelination and remyelination in the central nervous system.
Topics: Animals; Axons; Calcium-Transporting ATPases; Central Nervous System; Demyelinating Diseases; Ethidi | 1996 |
Biology of the repair of central nervous system demyelinated lesions: an appraisal.
Topics: Animals; Demyelinating Diseases; Dogs; Ethidium; Humans; Myelin Sheath; Oligodendroglia; Rats; Schwa | 1996 |
Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination.
Topics: Animals; Demyelinating Diseases; Ethidium; Female; Locomotion; Rats; Rats, Sprague-Dawley; Regenerat | 1997 |
Use of a rat Y chromosome probe to determine the long-term survival of glial cells transplanted into areas of CNS demyelination.
Topics: Animals; Axons; Carbonic Anhydrases; Cell Survival; Demyelinating Diseases; Ethidium; Female; Graft | 1997 |
Nitric oxide donors reversibly block axonal conduction: demyelinated axons are especially susceptible.
Topics: Animals; Axons; Cattle; Demyelinating Diseases; Ethidium; Lysophosphatidylcholines; Microinjections; | 1997 |
[Demyelination and remyelination after multiple intramedullary injections of ethidium bromide in Wistar rats].
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Ethidium; Female; Male; Myelin Sheath; Rats | 1997 |
Inflammatory response of the spinal cord to multiple episodes of blood-brain barrier disruption and toxic demyelination in Wistar rats.
Topics: Animals; Blood-Brain Barrier; Central Nervous System; Demyelinating Diseases; Ethidium; Female; Inje | 1998 |
Dynamics of remyelination in the brain of adult rats after exposure to ethidium bromide.
Topics: Animals; Brain Stem; Demyelinating Diseases; Disease Models, Animal; Ethidium; Female; Male; Myelin | 1998 |
Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/anti-galactocerebroside: a comparative study.
Topics: Animals; Cerebellum; Complement System Proteins; Demyelinating Diseases; Ethidium; Female; Galactosy | 1999 |
Behavioural consequences of oligodendrocyte progenitor cell transplantation into experimental demyelinating lesions in the rat spinal cord.
Topics: Animals; Axons; Behavior, Animal; Brain Tissue Transplantation; Cerebral Cortex; Demyelinating Disea | 1999 |
Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination.
Topics: Aging; Animals; Cerebellar Nuclei; Demyelinating Diseases; Ethidium; Female; Fluorescent Dyes; Gliot | 1999 |
Schwann cells transplanted into normal and X-irradiated adult white matter do not migrate extensively and show poor long-term survival.
Topics: Animals; beta-Galactosidase; Cell Count; Cell Movement; Cell Survival; Cells, Cultured; Demyelinatin | 2000 |
The effect of cyclophosphamide on brainstem remyelination following local ethidium bromide injection in Wistar rats.
Topics: Animals; Brain Stem; Cyclophosphamide; Demyelinating Diseases; Ethidium; Immunosuppressive Agents; M | 2000 |
Behaviour of oligodendrocytes and Schwann cells in an experimental model of toxic demyelination of the central nervous system.
Topics: Animals; Axons; Brain Stem; Central Nervous System Diseases; Cyclophosphamide; Cyclosporine; Demyeli | 2001 |
The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin-induced demyelination.
Topics: Animals; Cyclophosphamide; Cyclosporine; Demyelinating Diseases; Drug Therapy, Combination; Enzyme I | 2001 |
Ethidium bromide-induced demyelination of the sciatic nerve of adult Wistar rats.
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Ethidium; Female; Fluorescent Dyes; Male; M | 2002 |
Functional redundancy of ventral spinal locomotor pathways.
Topics: Animals; Anterior Horn Cells; Blood-Brain Barrier; Cell Count; Demyelinating Diseases; Ethidium; Evo | 2002 |
The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation.
Topics: Age Factors; Aging; Animals; Cell Differentiation; Cell Division; Cerebellum; Demyelinating Diseases | 2002 |
Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS.
Topics: Animals; Animals, Newborn; Brain Tissue Transplantation; Cell Movement; Demyelinating Diseases; Enzy | 2002 |
Demyelination and remyelination in the rat central nervous system following ethidium bromide injection.
Topics: Animals; Brain; Demyelinating Diseases; Ethidium; Male; Myelin Sheath; Oligodendroglia; Phagocytes; | 1979 |
The behaviour of meningeal cells following glial cell transplantation into chemically-induced areas of demyelination in the CNS.
Topics: Animals; Astrocytes; Brain Tissue Transplantation; Central Nervous System; Demyelinating Diseases; E | 1992 |
Remyelination of demyelinated rat axons by transplanted mouse oligodendrocytes.
Topics: Animals; Axons; Cells, Cultured; Cyclosporins; Demyelinating Diseases; Ethidium; Mice; Mice, Inbred | 1991 |
[Toxic demyelination of the central nervous system. II. Biological aspects of Schwann cells observed during the tissue repair process].
Topics: Animals; Axons; Demyelinating Diseases; Ethidium; Female; Injections, Spinal; Male; Myelin Sheath; R | 1989 |
[Toxic demyelination of the central nervous system. I. Effect of an intercalating gliotoxic drug on the spinal cord in Wistar rats].
Topics: Animals; Demyelinating Diseases; Ethidium; Female; Injections, Spinal; Macrophage Activation; Male; | 1989 |
The relationship between type-1 astrocytes, Schwann cells and oligodendrocytes following transplantation of glial cell cultures into demyelinating lesions in the adult rat spinal cord.
Topics: Animals; Astrocytes; Cells, Cultured; Demyelinating Diseases; Ethidium; Myelin Sheath; Neuroglia; Ol | 1989 |
The presence of lymphocytes in a toxically induced demyelinating process of the central nervous system.
Topics: Animals; Demyelinating Diseases; Ethidium; Female; Inflammation; Lymphocytes; Macrophages; Male; Rat | 1988 |
Extensive oligodendrocyte remyelination following injection of cultured central nervous system cells into demyelinating lesions in adult central nervous system.
Topics: Animals; Animals, Newborn; Axons; Cells, Cultured; Demyelinating Diseases; Ethidium; Microscopy, Ele | 1988 |
The interaction of Schwann cells with CNS axons in regions containing normal astrocytes.
Topics: Animals; Astrocytes; Brain Diseases; Cats; Cell Communication; Cerebral Cortex; Demyelinating Diseas | 1986 |
The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system.
Topics: Animals; Cats; Cells, Cultured; Demyelinating Diseases; Ethidium; Female; Male; Microscopy, Electron | 1985 |