ethamolin and Liver-Cirrhosis--Alcoholic

Topics: Angiography; Catheterization; Collateral Circulation; Endoscopy, Digestive System; Esophageal and Gastric Varices; Follow-Up Studies; Gastric Fundus; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Oleic Acids; Renal Veins; Sclerosing Solutions; Sclerotherapy; Stomach

We report here three cases of squamous-cell carcinoma of the esophagus following endoscopic injection sclerotherapy for esophageal varices. All three patients were men and cigarette smokers, with a mean age of 58.3 +/- 5.0 years. Hepatitis B and C virus infection tests were negative, and alcoholic cirrhosis was present in each patient. The interval between sclerotherapy and the development of carcinoma was 9, 10, and 33 months, in the respective cases. The sclerosant used was 5% ethanolamine oleate with a mean total volume of 51.0 +/- 18.9 ml. While we have no evidence of a direct relationship between sclerotherapy and esophageal cancer, in patients with alcoholic cirrhosis who have risk factors for esophageal cancer there may be an acceleration of the potential malignancy, as a result of the chronic inflammation related to sclerotherapy. Such patients should be closely followed, using endoscopy.

Topics: Carcinoma, Squamous Cell; Cocarcinogenesis; Esophageal and Gastric Varices; Esophageal Neoplasms; Esophagus; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Oleic Acids; Sclerosing Solutions; Sclerotherapy; Smoking

Topics: Adult; Esophageal and Gastric Varices; Esophagoscopy; Esophagus; Ethanolamines; Female; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Oleic Acids; Sclerosing Solutions