ethacrynic acid has been researched along with Status Epilepticus in 1 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ethacrynic acid was more potent than other loop diuretics such as furosemide and bumetanide." | 5.28 | Intracerebroventricular injection of ethacrynic acid induces status epilepticus. ( Hara, M; Inagaki, C; Inoue, M; Omori, K; Otani, H; Uriu, T, 1989) |
| "Ethacrynic acid was more potent than other loop diuretics such as furosemide and bumetanide." | 1.28 | Intracerebroventricular injection of ethacrynic acid induces status epilepticus. ( Hara, M; Inagaki, C; Inoue, M; Omori, K; Otani, H; Uriu, T, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inoue, M | 1 |
| Uriu, T | 1 |
| Otani, H | 1 |
| Hara, M | 1 |
| Omori, K | 1 |
| Inagaki, C | 1 |
1 other study available for ethacrynic acid and Status Epilepticus
| Article | Year |
|---|---|
Intracerebroventricular injection of ethacrynic acid induces status epilepticus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Ethacrynic Acid; Injections, Intraventricular; Male; Mic | 1989 |