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ethacrynic acid and Status Epilepticus

ethacrynic acid has been researched along with Status Epilepticus in 1 studies

Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)

Research Excerpts

ExcerptRelevanceReference
"Ethacrynic acid was more potent than other loop diuretics such as furosemide and bumetanide."5.28Intracerebroventricular injection of ethacrynic acid induces status epilepticus. ( Hara, M; Inagaki, C; Inoue, M; Omori, K; Otani, H; Uriu, T, 1989)
"Ethacrynic acid was more potent than other loop diuretics such as furosemide and bumetanide."1.28Intracerebroventricular injection of ethacrynic acid induces status epilepticus. ( Hara, M; Inagaki, C; Inoue, M; Omori, K; Otani, H; Uriu, T, 1989)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19901 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Inoue, M1
Uriu, T1
Otani, H1
Hara, M1
Omori, K1
Inagaki, C1

Other Studies

1 other study available for ethacrynic acid and Status Epilepticus

ArticleYear
Intracerebroventricular injection of ethacrynic acid induces status epilepticus.
    European journal of pharmacology, 1989, Jul-04, Volume: 166, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Ethacrynic Acid; Injections, Intraventricular; Male; Mic

1989