ethacrynic acid has been researched along with Skin Neoplasms in 2 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Skin Neoplasms: Tumors or cancer of the SKIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Curcumin was the most potent inhibitor (96% inhibition at 25 microM), while 67 and 61% inhibition at 25 microM was observed for ethacrynic acid and trans-2-hexenal, respectively." | 5.29 | Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal. ( Iersel, ML; Keyzer, AE; Ploemen, JP; Schefferlie, JG; Struik, I; van Amersfoort, C; van Bladeren, PJ, 1996) |
| "Curcumin was the most potent inhibitor (96% inhibition at 25 microM), while 67 and 61% inhibition at 25 microM was observed for ethacrynic acid and trans-2-hexenal, respectively." | 1.29 | Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal. ( Iersel, ML; Keyzer, AE; Ploemen, JP; Schefferlie, JG; Struik, I; van Amersfoort, C; van Bladeren, PJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McGuire, S | 1 |
| Yuan, F | 1 |
| Iersel, ML | 1 |
| Ploemen, JP | 1 |
| Struik, I | 1 |
| van Amersfoort, C | 1 |
| Keyzer, AE | 1 |
| Schefferlie, JG | 1 |
| van Bladeren, PJ | 1 |
2 other studies available for ethacrynic acid and Skin Neoplasms
| Article | Year |
|---|---|
Improving interstitial transport of macromolecules through reduction in cell volume fraction in tumor tissues.
Topics: Animals; Biological Transport; Cell Size; Cytotoxins; Dextrans; Drug Delivery Systems; Ethacrynic Ac | 2012 |
Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal.
Topics: Acrolein; Acyclic Monoterpenes; Aldehydes; Chromatography, High Pressure Liquid; Curcumin; Enzyme In | 1996 |