ethacrynic acid has been researched along with Seizures in 9 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic administration of ETA (12." | 5.35 | Effect of ethacrynic acid on the anticonvulsant activity of the second-generation antiepileptics against maximal electroshock-induced seizures in mice. ( Czuczwar, SJ; Swiderska, G; Łukawski, K, 2009) |
| "The purpose of this study was to determine whether the loop diuretics furosemide, bumetanide and ethacrynic acid, which block the KCC1 potassium-chloride transporter in the kidney loop of Henle and the KCC2 potassium-chloride transporter in neuronal membranes, would prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats." | 3.70 | Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats. ( Guo, SZ; Iyer, VG; Reid, KH, 2000) |
| " Chronic administration of ETA (12." | 1.35 | Effect of ethacrynic acid on the anticonvulsant activity of the second-generation antiepileptics against maximal electroshock-induced seizures in mice. ( Czuczwar, SJ; Swiderska, G; Łukawski, K, 2009) |
| "In ethacrynic acid-induced convulsions, these neurotransmitter systems may be differentially modulated, probably through activation of glutaminergic neurons in the brain." | 1.28 | Ethacrynic acid-induced convulsions and brain neurotransmitters in mice. ( Hirose, T; Inagaki, C; Inoue, M; Yasukura, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bonnet, U | 1 |
| Wiemann, M | 1 |
| Łukawski, K | 1 |
| Swiderska, G | 1 |
| Czuczwar, SJ | 1 |
| Reid, KH | 1 |
| Guo, SZ | 1 |
| Iyer, VG | 1 |
| Brown, RD | 1 |
| Feldman, AM | 1 |
| Inoue, M | 2 |
| Hirose, T | 2 |
| Yasukura, T | 2 |
| Inagaki, C | 2 |
| Fukai, Y | 1 |
| Zeng, XT | 1 |
| Ohnishi, S | 1 |
| Uriu, T | 1 |
| Sasaki, M | 1 |
| Manaka, S | 1 |
| Takakura, K | 1 |
| Bergmann, F | 2 |
| Costin, A | 1 |
| Chaimovitz, M | 2 |
| Zerachia, A | 2 |
| Gutman, Y | 1 |
1 review available for ethacrynic acid and Seizures
| Article | Year |
|---|---|
Pharmacology of hearing and ototoxicity.
Topics: Adrenal Glands; Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bumetanid | 1978 |
8 other studies available for ethacrynic acid and Seizures
| Article | Year |
|---|---|
Verapamil and ethacrynic acid are associated with neuronal acidification in hippocampal CA3-neurons (slice preparation, guinea pig): Contribution to their anti-seizure potency?
Topics: Animals; Anticonvulsants; CA3 Region, Hippocampal; Ethacrynic Acid; Guinea Pigs; Hydrogen-Ion Concen | 2016 |
Effect of ethacrynic acid on the anticonvulsant activity of the second-generation antiepileptics against maximal electroshock-induced seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Brain; Brain Chemistry; Carbamaz | 2009 |
Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats.
Topics: Acoustic Stimulation; Animals; Auditory Pathways; Brain; Bumetanide; Carrier Proteins; Diuretics; Ep | 2000 |
Ethacrynic acid-induced convulsions and brain neurotransmitters in mice.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Brain; Chloride Channels; Ethacrynic Acid; gamm | 1992 |
Ethacrynic acid-induced convulsions and brain noradrenaline in mice.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine beta-Hydroxylase; Ethacryni | 1990 |
[Protective effect on the brain of ion-blockers in experimental head injury].
Topics: Animals; Brain Injuries; Consciousness Disorders; Ethacrynic Acid; Flunarizine; Ion Channels; Male; | 1987 |
Seizure activity evoked by implantation of ouabain and related drugs into cortical and subcortical regions of the rabbit brain.
Topics: Acetates; Animals; Brain; Caudate Nucleus; Digitoxin; Electroencephalography; Ethacrynic Acid; Femal | 1970 |
Influence of drugs, implanted into the hypothalamus, on the water consumption of rats.
Topics: Animals; Behavior, Animal; Diazoxide; Digitoxin; Diuretics; Drinking; Ethacrynic Acid; Furosemide; H | 1968 |