ethacrynic acid has been researched along with Renal Insufficiency in 1 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The sensitivity of this species to renal failure restricted the dose of EA that could be safely administered." | 1.29 | Partial hearing loss in the macaque following the co-administration of kanamycin and ethacrynic acid. ( Clark, GM; Shepherd, RK; Xu, SA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shepherd, RK | 1 |
| Xu, SA | 1 |
| Clark, GM | 1 |
1 other study available for ethacrynic acid and Renal Insufficiency
| Article | Year |
|---|---|
Partial hearing loss in the macaque following the co-administration of kanamycin and ethacrynic acid.
Topics: Animals; Auditory Threshold; Dose-Response Relationship, Drug; Drug Synergism; Ethacrynic Acid; Evok | 1994 |