ethacrynic acid has been researched along with Renal Insufficiency, Chronic in 2 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Veverimer is not systemically absorbed, so potential drug-drug interactions (DDIs) are limited to effects on the absorption of other oral drugs through binding to veverimer in the gastrointestinal tract or increases in gastric pH caused by veverimer binding to hydrochloric acid." | 3.01 | Assessment of the Potential for Veverimer Drug-Drug Interactions. ( Biyani, K; Guttendorf, R; Klaerner, G; Lee, A; Li, E; Mathur, V; Parsell, D; Shao, J; Stasiv, Y; Tabakman, S; Tsao, L; Wu, YS, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parsell, D | 1 |
| Shao, J | 1 |
| Guttendorf, R | 1 |
| Mathur, V | 1 |
| Li, E | 1 |
| Wu, YS | 1 |
| Tsao, L | 1 |
| Tabakman, S | 1 |
| Stasiv, Y | 1 |
| Lee, A | 1 |
| Biyani, K | 1 |
| Klaerner, G | 1 |
| HAGEDORN, CW | 1 |
| KAPLAN, AA | 1 |
| HULET, WH | 1 |
1 trial available for ethacrynic acid and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Assessment of the Potential for Veverimer Drug-Drug Interactions.
Topics: Absorption, Physicochemical; Acidosis; Administration, Oral; Adolescent; Adult; Aspirin; Cross-Over | 2021 |
1 other study available for ethacrynic acid and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
PROLONGED ADMINISTRATION OF ETHACRYNIC ACID IN PATIENTS WITH CHRONIC RENAL DISEASE.
Topics: Acid-Base Equilibrium; Diabetic Nephropathies; Diarrhea; Diuretics; Drug Therapy; Edema; Ethacrynic | 1965 |